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Ezetimibe (3R,4R,3'S)-Isomer

SZ CAT No SZ-E026028
CAS No 1478664-02-6
Mol.F. C24H21F2NO3
Mol.Wt. 409.4
Inv. Status Under Synthesis


Chemical Name: (3R,4R)-1-(4-Fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one

Synonym: (3’S,3R,4R)-Ezetimibe

Smiles: O[C@H](C1=CC=C(F)C=C1)CC[C@@H]2[C@H](C3=CC=C(O)C=C3)N(C4=CC=C(F)C=C4)C2=O

Inchi: InChI=1S/C24H21F2NO3/c25-18-8-4-16(5-9-18)2-1-3-22(24(29)30)23(17-6-14-21(28)15-7-17)27-20-12-10-19(26)11-13-20/h1-2,4-15,22-23,27-28H,3H2,(H,29,30)/b2-1+/t22-,23-/m1/s1

Related substances by HPLC method for the detection and evaluation of impurities in ezetimibe drug material
By Rapeti, Durgababu; Reddy, Gudibanda Chandra Sekhar; Narayanarao, Kapavarapu Maruthi Venkata; Shyamala, Pulipaka; Krishna, Rallabhandi Murali
From International Journal of Pharmaceutical Sciences and Research (2021), 12(1), 217-225
 
Stability-​indicating liquid chromatographic method for the simultaneous determination of rosuvastatin and ezetimibe from pharmaceuticals and biological samples
By Kurbanoglu, Sevinc; Esim, Ozgur; Ozkan, Cansel Kose; Savaser, Ayhan; Ozkan, Yalcin; Uslu, Bengi; Ozkan, Sibel A.
From Journal of the Turkish Chemical Society, Section A: Chemistry (2020), 7(3), 865-874
 
Stability-​indicating analytical method development using quality by design approach for simultaneous estimation of ezetimibe and glimepiride
By Shah, U.; Shah, Kunti; Patel, Rupal
From Indian Journal of Pharmaceutical Sciences (2019), 81(2), 273-281