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Apixaban Impurity B

SZ CAT No SZ-A062049
CAS No 2512213-45-3
Mol.F. C11H11ClN2O3
Mol.Wt. 254.7
Inv. Status In Stock


Chemical Name: 3-Chloro-1-(4-nitrophenyl)piperidin-2-one

Smiles: O=C1N(C2=CC=C([N+]([O-])=O)C=C2)CCCC1Cl

Inchi: InChI=1S/C27H29NO/c1-2-22-19-21(13-14-26(22)29)15-17-28-18-16-25(20-28)27(23-9-5-3-6-10-23)24-11-7-4-8-12-24/h2-14,19,25,27,29H,1,15-18,20H2/t25-/m1/s1

Evaluation of Crushed Tablet for Oral Administration and the Effect of Food on Apixaban Pharmacokinetics in Healthy Adults
YanSongPhD1MingChangPhD1AkiyukiSuzukiMS2Robert J.A.FrostMD, PhD3AnneKellyPhD4FrankLaCretaPhD3CharlesFrostPharmD
Clinical Therapeutics Volume 38, Issue 7, July 2016, Pages 1674-1685.e1
 
Development and validation of seven phenyl hydrazine chloro ester isomers (pgis) by rp-hplc-uv method in anticoagulant drug substance; apixaban
Saradhi venkata ramana v.a,b*, durga raja k.a,b, raghu babu k.a, padma m.a, jagadeesh kumar v.b, pavan kumar k. s. r.b, hemant kumar sharma
Int J Curr Pharm Res, Vol 12, Issue 2, 119-123
 
Stability-Indicating High-Perform ance Liquid Chrom atographie Determ ination of Apixaban in the Presence of Degradation Products
Swarup Suresh Prabhune *, Rajendra Shankar Jaguste, Prakash Laxman Kondalkar, Nitin Sharadchandra Pradhan
Sei Pharm. 2014; 82: 777-785
 
Analytical Quality by Design Approach for a Stability‑Indicating Method to Determine Apixaban and Its Related Impurities
Jéssica B. Ellwanger1  · Nathalie Ribeiro Wingert1  · Nadia Maria Volpato1  · Cássia Virginia Garcia1  · Elfrides E. S. Schapoval1  · Martin Steppe
Chromatographia volume 83, pages65–75(2020)