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Apixaban Impurity 32

SZ CAT No SZ-A062043
CAS No 1998079-16-5
Mol.F. C30H34N6O5 
Mol.Wt. 558.6
Inv. Status Custom Synthesis


Chemical Name: (Z)-1,2-Bis(4-(5-morpholino-6-oxo-3,6-dihydropyridin-1(2H)-yl)phenyl)diazene 1-oxide

Smiles: O=C(C(N1CCOCC1)=CCC2)N2C3=CC=C(/N=[N+]([O-])/C4=CC=C(N5C(C(N6CCOCC6)=CCC5)=O)C=C4)C=C3

Inchi: InChI=1/C16H16ClNO2S/c1-11(19)20-16(12-2-4-14(17)5-3-12)18-8-6-15-13(10-18)7-9-21-15/h2-5,7,9,16H,6,8,10H2,1H3

Evaluation of Crushed Tablet for Oral Administration and the Effect of Food on Apixaban Pharmacokinetics in Healthy Adults
YanSongPhD1MingChangPhD1AkiyukiSuzukiMS2Robert J.A.FrostMD, PhD3AnneKellyPhD4FrankLaCretaPhD3CharlesFrostPharmD
Clinical Therapeutics Volume 38, Issue 7, July 2016, Pages 1674-1685.e1
 
Development and validation of seven phenyl hydrazine chloro ester isomers (pgis) by rp-hplc-uv method in anticoagulant drug substance; apixaban
Saradhi venkata ramana v.a,b*, durga raja k.a,b, raghu babu k.a, padma m.a, jagadeesh kumar v.b, pavan kumar k. s. r.b, hemant kumar sharma
Int J Curr Pharm Res, Vol 12, Issue 2, 119-123
 
Stability-Indicating High-Perform ance Liquid Chrom atographie Determ ination of Apixaban in the Presence of Degradation Products
Swarup Suresh Prabhune *, Rajendra Shankar Jaguste, Prakash Laxman Kondalkar, Nitin Sharadchandra Pradhan
Sei Pharm. 2014; 82: 777-785
 
Analytical Quality by Design Approach for a Stability‑Indicating Method to Determine Apixaban and Its Related Impurities
Jéssica B. Ellwanger1  · Nathalie Ribeiro Wingert1  · Nadia Maria Volpato1  · Cássia Virginia Garcia1  · Elfrides E. S. Schapoval1  · Martin Steppe
Chromatographia volume 83, pages65–75(2020)