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Apixaban Impurity 44

SZ CAT No SZ-A062064
CAS No NA
Mol.F. C27H26N4O5
Mol.Wt. 486.5
Inv. Status Custom Synthesis


Chemical Name: N-Formyl-1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-indazole-3-carboxamide

Smiles: O=C(C1=NN(C2=CC=C(OC)C=C2)C3=C1CCC(C4=CC=C(N5C(CCCC5)=O)C=C4)C3=O)NC=O

Inchi: InChI=1S/C16H16N2O2/c19-18(20)16-8-6-15(7-9-16)11-13-17-12-10-14-4-2-1-3-5-14/h1-10,12,17H,11,13H2/b12-10+

Evaluation of Crushed Tablet for Oral Administration and the Effect of Food on Apixaban Pharmacokinetics in Healthy Adults
YanSongPhD1MingChangPhD1AkiyukiSuzukiMS2Robert J.A.FrostMD, PhD3AnneKellyPhD4FrankLaCretaPhD3CharlesFrostPharmD
Clinical Therapeutics Volume 38, Issue 7, July 2016, Pages 1674-1685.e1
 
Development and validation of seven phenyl hydrazine chloro ester isomers (pgis) by rp-hplc-uv method in anticoagulant drug substance; apixaban
Saradhi venkata ramana v.a,b*, durga raja k.a,b, raghu babu k.a, padma m.a, jagadeesh kumar v.b, pavan kumar k. s. r.b, hemant kumar sharma
Int J Curr Pharm Res, Vol 12, Issue 2, 119-123
 
Stability-Indicating High-Perform ance Liquid Chrom atographie Determ ination of Apixaban in the Presence of Degradation Products
Swarup Suresh Prabhune *, Rajendra Shankar Jaguste, Prakash Laxman Kondalkar, Nitin Sharadchandra Pradhan
Sei Pharm. 2014; 82: 777-785
 
Analytical Quality by Design Approach for a Stability‑Indicating Method to Determine Apixaban and Its Related Impurities
Jéssica B. Ellwanger1  · Nathalie Ribeiro Wingert1  · Nadia Maria Volpato1  · Cássia Virginia Garcia1  · Elfrides E. S. Schapoval1  · Martin Steppe
Chromatographia volume 83, pages65–75(2020)