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Apixaban Impurity 9

SZ CAT No SZ-A062020
CAS No 503614-91-3
Mol.F. C27H28N4O5 
Mol.Wt. 488.6
Inv. Status In Stock


Chemical Name: Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate

Synonym: Apixaban ethyl ester

Smiles: O=C(N(C1=CC=C(N(CCCC2)C2=O)C=C1)CC3)C4=C3C(C(OCC)=O)=NN4C5=CC=C(OC)C=C5

Inchi: InChI=1S/C24H23N5O4/c1-33-18-10-8-17(9-11-18)29-22-19(21(26-29)23(25)31)12-14-28(24(22)32)16-6-4-15(5-7-16)27-13-2-3-20(27)30/h4-11H,2-3,12-14H2,1H3,(H2,25,31)

Evaluation of Crushed Tablet for Oral Administration and the Effect of Food on Apixaban Pharmacokinetics in Healthy Adults
YanSongPhD1MingChangPhD1AkiyukiSuzukiMS2Robert J.A.FrostMD, PhD3AnneKellyPhD4FrankLaCretaPhD3CharlesFrostPharmD
Clinical Therapeutics Volume 38, Issue 7, July 2016, Pages 1674-1685.e1
 
Development and validation of seven phenyl hydrazine chloro ester isomers (pgis) by rp-hplc-uv method in anticoagulant drug substance; apixaban
Saradhi venkata ramana v.a,b*, durga raja k.a,b, raghu babu k.a, padma m.a, jagadeesh kumar v.b, pavan kumar k. s. r.b, hemant kumar sharma
Int J Curr Pharm Res, Vol 12, Issue 2, 119-123
 
Stability-Indicating High-Perform ance Liquid Chrom atographie Determ ination of Apixaban in the Presence of Degradation Products
Swarup Suresh Prabhune *, Rajendra Shankar Jaguste, Prakash Laxman Kondalkar, Nitin Sharadchandra Pradhan
Sei Pharm. 2014; 82: 777-785
 
Analytical Quality by Design Approach for a Stability‑Indicating Method to Determine Apixaban and Its Related Impurities
Jéssica B. Ellwanger1  · Nathalie Ribeiro Wingert1  · Nadia Maria Volpato1  · Cássia Virginia Garcia1  · Elfrides E. S. Schapoval1  · Martin Steppe
Chromatographia volume 83, pages65–75(2020)