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Apixaban Impurity 66

SZ CAT No SZ-A062088
CAS No NA
Mol.F. C16H18N2O3
Mol.Wt. 286.3
Inv. Status Custom Synthesis


Chemical Name: (2Z,4Z)-5-((4-(2-Oxopiperidin-1-yl)phenyl)amino)penta-2,4-dienoic acid

Smiles: O=C(O)/C=C\C=C/NC1=CC=C(N2C(CCCC2)=O)C=C1

Inchi: InChI=1S/C16H16N2O2/c19-15-5-1-3-11-17(15)13-7-9-14(10-8-13)18-12-4-2-6-16(18)20/h1,3,5,7-11H,2,4,6,12H2

Evaluation of Crushed Tablet for Oral Administration and the Effect of Food on Apixaban Pharmacokinetics in Healthy Adults
YanSongPhD1MingChangPhD1AkiyukiSuzukiMS2Robert J.A.FrostMD, PhD3AnneKellyPhD4FrankLaCretaPhD3CharlesFrostPharmD
Clinical Therapeutics Volume 38, Issue 7, July 2016, Pages 1674-1685.e1
 
Development and validation of seven phenyl hydrazine chloro ester isomers (pgis) by rp-hplc-uv method in anticoagulant drug substance; apixaban
Saradhi venkata ramana v.a,b*, durga raja k.a,b, raghu babu k.a, padma m.a, jagadeesh kumar v.b, pavan kumar k. s. r.b, hemant kumar sharma
Int J Curr Pharm Res, Vol 12, Issue 2, 119-123
 
Stability-Indicating High-Perform ance Liquid Chrom atographie Determ ination of Apixaban in the Presence of Degradation Products
Swarup Suresh Prabhune *, Rajendra Shankar Jaguste, Prakash Laxman Kondalkar, Nitin Sharadchandra Pradhan
Sei Pharm. 2014; 82: 777-785
 
Analytical Quality by Design Approach for a Stability‑Indicating Method to Determine Apixaban and Its Related Impurities
Jéssica B. Ellwanger1  · Nathalie Ribeiro Wingert1  · Nadia Maria Volpato1  · Cássia Virginia Garcia1  · Elfrides E. S. Schapoval1  · Martin Steppe
Chromatographia volume 83, pages65–75(2020)