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Apixaban Ethyl Ester Dimer Impurity

SZ CAT No SZ-A062096
CAS No NA
Mol.F. C36H32N6O8
Mol.Wt. 676.7
Inv. Status Custom Synthesis


Chemical Name: Dimethyl 3,6-bis(4-methoxyphenyl)-5-oxo-4-(4-(2-oxopiperidin-1-yl)phenyl)-3,4,5,6-tetrahydrodipyrazolo[3,4-b:4',3'-d]pyridine-1,8-dicarboxylate

Smiles: COC(C=C1)=CC=C1N(N=C2C(OC)=O)C3=C2C(C(C(OC)=O)=NN4C5=CC=C(OC)C=C5)=C4C(N3C6=CC=C(N7CCCCC7=O)C=C6)=O

Inchi: InChI=1S/C17H19NO4/c1-18(21)7-6-17-10-3-5-13(20)16(17)22-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-,18-/m0/s1

Evaluation of Crushed Tablet for Oral Administration and the Effect of Food on Apixaban Pharmacokinetics in Healthy Adults
YanSongPhD1MingChangPhD1AkiyukiSuzukiMS2Robert J.A.FrostMD, PhD3AnneKellyPhD4FrankLaCretaPhD3CharlesFrostPharmD
Clinical Therapeutics Volume 38, Issue 7, July 2016, Pages 1674-1685.e1
 
Development and validation of seven phenyl hydrazine chloro ester isomers (pgis) by rp-hplc-uv method in anticoagulant drug substance; apixaban
Saradhi venkata ramana v.a,b*, durga raja k.a,b, raghu babu k.a, padma m.a, jagadeesh kumar v.b, pavan kumar k. s. r.b, hemant kumar sharma
Int J Curr Pharm Res, Vol 12, Issue 2, 119-123
 
Stability-Indicating High-Perform ance Liquid Chrom atographie Determ ination of Apixaban in the Presence of Degradation Products
Swarup Suresh Prabhune *, Rajendra Shankar Jaguste, Prakash Laxman Kondalkar, Nitin Sharadchandra Pradhan
Sei Pharm. 2014; 82: 777-785
 
Analytical Quality by Design Approach for a Stability‑Indicating Method to Determine Apixaban and Its Related Impurities
Jéssica B. Ellwanger1  · Nathalie Ribeiro Wingert1  · Nadia Maria Volpato1  · Cássia Virginia Garcia1  · Elfrides E. S. Schapoval1  · Martin Steppe
Chromatographia volume 83, pages65–75(2020)