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Apixaban Impurity 45

SZ CAT No SZ-A062065
CAS No 1619934-76-7
Mol.F. C31H37N5O6
Mol.Wt. 575.7
Inv. Status Under Synthesis


Chemical Name: Ethyl 1-(4-methoxyphenyl)-7amorpholin-4-yl-7-oxo6-[4-(2-oxopiperidin1-yl)phenyl]-4,5-dihydro-3aHpyrazolo[3,4-c]pyridine-3-carboxylate

Smiles: O=C(C1=NN(C2=CC=C(OC)C=C2)C(C1CCN3C4=CC=C(N5C(CCCC5)=O)C=C4)(N6CCOCC6)C3=O)OCC

Inchi: InChI=1S/C22H32FO11PS.2Na/c1-11-6-15-14-5-4-12-7-13(24)8-18(36(31,32)33)20(12,3)21(14,23)16(25)9-19(15,2)22(11,27)17(26)10-34-35(28,29)30;;/h7,11,14-16,18,25,27H,4-6,8-10H2,1-3H3,(H2,28,29,30)(H,31,32,33);;/q;2*+1/p-3/t11-,14+,15+,16+,18?,19+,20-,21+,22+;;/m1../s1

Evaluation of Crushed Tablet for Oral Administration and the Effect of Food on Apixaban Pharmacokinetics in Healthy Adults
YanSongPhD1MingChangPhD1AkiyukiSuzukiMS2Robert J.A.FrostMD, PhD3AnneKellyPhD4FrankLaCretaPhD3CharlesFrostPharmD
Clinical Therapeutics Volume 38, Issue 7, July 2016, Pages 1674-1685.e1
 
Development and validation of seven phenyl hydrazine chloro ester isomers (pgis) by rp-hplc-uv method in anticoagulant drug substance; apixaban
Saradhi venkata ramana v.a,b*, durga raja k.a,b, raghu babu k.a, padma m.a, jagadeesh kumar v.b, pavan kumar k. s. r.b, hemant kumar sharma
Int J Curr Pharm Res, Vol 12, Issue 2, 119-123
 
Stability-Indicating High-Perform ance Liquid Chrom atographie Determ ination of Apixaban in the Presence of Degradation Products
Swarup Suresh Prabhune *, Rajendra Shankar Jaguste, Prakash Laxman Kondalkar, Nitin Sharadchandra Pradhan
Sei Pharm. 2014; 82: 777-785
 
Analytical Quality by Design Approach for a Stability‑Indicating Method to Determine Apixaban and Its Related Impurities
Jéssica B. Ellwanger1  · Nathalie Ribeiro Wingert1  · Nadia Maria Volpato1  · Cássia Virginia Garcia1  · Elfrides E. S. Schapoval1  · Martin Steppe
Chromatographia volume 83, pages65–75(2020)