Apixaban N-Oxide Dimer Impurity

SZ CAT No:	SZ-A062056
CAS No	1998079-12-1
Mol.F.	C40H34N10O7
Mol.Wt.	766.8
Inv. Status	Custom Synthesis

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Chemical Name: (Z)-1,2-Bis(4-(3-carbamoyl-1-(4-methoxyphenyl)-7-oxo-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)phenyl)diazene 1-oxide

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: O=C(N(C1=CC=C(N=[N](C2=CC=C(N(CCC3=C4N(C5=CC=C(OC)C=C5)N=C3C(N)=O)C4=O)C=C2)=O)C=C1)CC6)C7=C6C(C(N)=O)=NN7C8=CC=C(OC)C=C8

Evaluation of Crushed Tablet for Oral Administration and the Effect of Food on Apixaban Pharmacokinetics in Healthy Adults
YanSongPhD1MingChangPhD1AkiyukiSuzukiMS2Robert J.A.FrostMD, PhD3AnneKellyPhD4FrankLaCretaPhD3CharlesFrostPharmD
Clinical Therapeutics Volume 38, Issue 7, July 2016, Pages 1674-1685.e1

Development and validation of seven phenyl hydrazine chloro ester isomers (pgis) by rp-hplc-uv method in anticoagulant drug substance; apixaban
Saradhi venkata ramana v.a,b*, durga raja k.a,b, raghu babu k.a, padma m.a, jagadeesh kumar v.b, pavan kumar k. s. r.b, hemant kumar sharma
Int J Curr Pharm Res, Vol 12, Issue 2, 119-123

Stability-Indicating High-Perform ance Liquid Chrom atographie Determ ination of Apixaban in the Presence of Degradation Products
Swarup Suresh Prabhune *, Rajendra Shankar Jaguste, Prakash Laxman Kondalkar, Nitin Sharadchandra Pradhan
Sei Pharm. 2014; 82: 777-785

Analytical Quality by Design Approach for a Stability‑Indicating Method to Determine Apixaban and Its Related Impurities
Jéssica B. Ellwanger1 · Nathalie Ribeiro Wingert1 · Nadia Maria Volpato1 · Cássia Virginia Garcia1 · Elfrides E. S. Schapoval1 · Martin Steppe
Chromatographia volume 83, pages65–75(2020)

Apixaban N-Oxide Dimer Impurity is chemically (Z)-1,2-Bis(4-(3-carbamoyl-1-(4-methoxyphenyl)-7-oxo-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)phenyl)diazene 1-oxide. Apixaban N-Oxide Dimer Impurity is supplied with detailed characterization data compliant with regulatory guideline. Apixaban N-Oxide Dimer Impurity can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Apixaban.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

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Mol.F.	: C36H32N6O8
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Apixaban USP Related Compound D

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Apixaban Impurity 11

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Apixaban Impurity 14

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Mol.Wt.	: 378.4
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Apixaban Impurity 15

SZ CAT No:	: SZ-A062026
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Mol.Wt.	: 392.4
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Apixaban Impurity 16

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Mol.F.	: C26H29N5O5
Mol.Wt.	: 491.5
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Apixaban Impurity 17

SZ CAT No:	: SZ-A062028
CAS No	: 1423803-24-0
Mol.F.	: C20H19N5O3
Mol.Wt.	: 377.4
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Apixaban Impurity 18

SZ CAT No:	: SZ-A062029
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Mol.F.	: C20H26ClN3O3
Mol.Wt.	: 391.9
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Apixaban Impurity 19

SZ CAT No:	: SZ-A062030
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Mol.F.	: C22H22N4O4
Mol.Wt.	: 406.4
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Apixaban Open Ring Amide (USP)

SZ CAT No:	: SZ-A062013
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Mol.F.	: C25H28N6O4
Mol.Wt.	: 476.5
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Apixaban USP Related Compound H

SZ CAT No:	: SZ-A062031
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Mol.F.	: C27H29ClN4O5
Mol.Wt.	: 525.0
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Apixaban Impurity 22

SZ CAT No:	: SZ-A062033
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Mol.F.	: C11H13ClN2O3
Mol.Wt.	: 256.7
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Apixaban Impurity 23

SZ CAT No:	: SZ-A062034
CAS No	: 1801881-17-3
Mol.F.	: C24H23N5O3
Mol.Wt.	: 429.5
Inv. Status	: In Stock

Apixaban Impurity 24

SZ CAT No:	: SZ-A062035
CAS No	: 1928718-22-2
Mol.F.	: C26H27N5O4
Mol.Wt.	: 473.5
Inv. Status	: In Stock

Apixaban Impurity 26

SZ CAT No:	: SZ-A062037
CAS No	: 1449510-64-8
Mol.F.	: C25H26ClN5O4
Mol.Wt.	: 496.0
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Apixaban Impurity 27

SZ CAT No:	: SZ-A062038
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Mol.F.	: C26H27ClN4O5
Mol.Wt.	: 511.0
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Apixaban Impurity 28

SZ CAT No:	: SZ-A062039
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Mol.F.	: C25H25N5O5
Mol.Wt.	: 475.5
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Apixaban Impurity 29

SZ CAT No:	: SZ-A062040
CAS No	: 2413365-22-5
Mol.F.	: C20H23N3O3
Mol.Wt.	: 353.4
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Apixaban Impurity 3

SZ CAT No:	: SZ-A062014
CAS No	: NA
Mol.F.	: C21H18N4O6
Mol.Wt.	: 422.4
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Apixaban Impurity 30

SZ CAT No:	: SZ-A062041
CAS No	: NA
Mol.F.	: C15H17N3O5
Mol.Wt.	: 319.3
Inv. Status	: Custom Synthesis

Apixaban Impurity 31

SZ CAT No:	: SZ-A062042
CAS No	: NA
Mol.F.	: C16H16ClNO2S
Mol.Wt.	: 321.8
Inv. Status	: Custom Synthesis

Apixaban Impurity 32

SZ CAT No:	: SZ-A062043
CAS No	: 1998079-16-5
Mol.F.	: C30H34N6O5
Mol.Wt.	: 558.6
Inv. Status	: Custom Synthesis

Apixaban Impurity 33

SZ CAT No:	: SZ-A062044
CAS No	: 1686149-78-9
Mol.F.	: C21H27N3O3
Mol.Wt.	: 369.5
Inv. Status	: Under Synthesis

Apixaban Impurity 34

SZ CAT No:	: SZ-A062045
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Mol.F.	: C21H27N3O3
Mol.Wt.	: 369.5
Inv. Status	: Custom Synthesis

Dehydro Apixaban Impurity

SZ CAT No:	: SZ-A062046
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Mol.F.	: C25H23N5O4
Mol.Wt.	: 457.5
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Apixaban Impurity 35

SZ CAT No:	: SZ-A062047
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SZ CAT No:	: SZ-A062051
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Mol.Wt.	: 256.7
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SZ CAT No:	: SZ-A062054
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Mol.F.	: C44H40N8O8
Mol.Wt.	: 808.9
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SZ CAT No:	: SZ-A062055
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Apixaban Chloro Impurity

SZ CAT No:	: SZ-A062057
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Mol.F.	: C24H22ClN5O3
Mol.Wt.	: 463.9
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Apixaban Impurity 41

SZ CAT No:	: SZ-A062059
CAS No	: NA
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Mol.Wt.	: 567.0
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Apixaban Impurity 42

SZ CAT No:	: SZ-A062060
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Mol.F.	: C18H18N2O6
Mol.Wt.	: 358.4
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Apixaban Impurity 43

SZ CAT No:	: SZ-A062062
CAS No	: 1998079-15-4
Mol.F.	: C30H34N6O4
Mol.Wt.	: 542.6
Inv. Status	: Custom Synthesis

Apixaban Impurity 44

SZ CAT No:	: SZ-A062064
CAS No	: NA
Mol.F.	: C27H26N4O5
Mol.Wt.	: 486.5
Inv. Status	: Custom Synthesis

Apixaban Impurity 45

SZ CAT No:	: SZ-A062065
CAS No	: 1619934-76-7
Mol.F.	: C31H37N5O6
Mol.Wt.	: 575.7
Inv. Status	: In Stock

Apixaban Impurity 46

SZ CAT No:	: SZ-A062066
CAS No	: NA
Mol.F.	: C31H37N5O6
Mol.Wt.	: 575.7
Inv. Status	: Custom Synthesis

Apixaban Impurity 47

SZ CAT No:	: SZ-A062067
CAS No	: 1267610-26-3
Mol.F.	: C15H19N3O2
Mol.Wt.	: 273.3
Inv. Status	: In Stock

Apixaban Impurity 48

SZ CAT No:	: SZ-A062068
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Mol.F.	: C19H24ClN3O3
Mol.Wt.	: 377.9
Inv. Status	: Custom Synthesis

Apixaban Impurity 49

SZ CAT No:	: SZ-A062069
CAS No	: NA
Mol.F.	: C29H34N6O5
Mol.Wt.	: 546.6
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Apixaban Impurity 5

SZ CAT No:	: SZ-A062016
CAS No	: NA
Mol.F.	: C10H11ClN2O3
Mol.Wt.	: 242.7
Inv. Status	: Custom Synthesis

Apixaban Impurity 50

SZ CAT No:	: SZ-A062070
CAS No	: NA
Mol.F.	: C25H26N4O5
Mol.Wt.	: 462.5
Inv. Status	: Custom Synthesis

Apixaban Impurity 51

SZ CAT No:	: SZ-A062071
CAS No	: NA
Mol.F.	: C26H28N4O5
Mol.Wt.	: 476.5
Inv. Status	: Custom Synthesis

Apixaban Impurity 52

SZ CAT No:	: SZ-A062072
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Mol.F.	: C15H19N3O2
Mol.Wt.	: 273.3
Inv. Status	: Custom Synthesis

Apixaban Impurity 53

SZ CAT No:	: SZ-A062073
CAS No	: 2444918-46-9
Mol.F.	: C15H19N3O2
Mol.Wt.	: 273.3
Inv. Status	: Custom Synthesis

Apixaban Impurity 54

SZ CAT No:	: SZ-A062074
CAS No	: NA
Mol.F.	: C15H21N3O2
Mol.Wt.	: 275.4
Inv. Status	: Custom Synthesis

Apixaban Impurity 55

SZ CAT No:	: SZ-A062075
CAS No	: NA
Mol.F.	: C30H35N6O5
Mol.Wt.	: 559.6
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Apixaban Impurity 56

SZ CAT No:	: SZ-A062078
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Mol.F.	: C6H11ClO2
Mol.Wt.	: 150.6
Inv. Status	: Custom Synthesis

Apixaban Impurity 57

SZ CAT No:	: SZ-A062079
CAS No	: 2323-81-1
Mol.F.	: C7H13ClO2
Mol.Wt.	: 164.6
Inv. Status	: Custom Synthesis

Apixaban Impurity 58

SZ CAT No:	: SZ-A062080
CAS No	: 881386-01-2
Mol.F.	: C11H10Cl2N2O3
Mol.Wt.	: 289.1
Inv. Status	: In Stock

Apixaban Impurity 59

SZ CAT No:	: SZ-A062081
CAS No	: 1039914-85-6
Mol.F.	: C11H13ClN2O3
Mol.Wt.	: 256.7
Inv. Status	: In Stock

Apixaban USP Related Compound E

SZ CAT No:	: SZ-A062017
CAS No	: 1074365-84-6
Mol.F.	: C26H26N4O5
Mol.Wt.	: 474.5
Inv. Status	: In Stock

Apixaban Impurity 60

SZ CAT No:	: SZ-A062082
CAS No	: NA
Mol.F.	: C11H9N3O3
Mol.Wt.	: 231.2
Inv. Status	: Custom Synthesis

Apixaban Impurity 61

SZ CAT No:	: SZ-A062083
CAS No	: NA
Mol.F.	: C11H12N2O2
Mol.Wt.	: 204.2
Inv. Status	: Custom Synthesis

Apixaban Impurity 63

SZ CAT No:	: SZ-A062085
CAS No	: 13143-47-0
Mol.F.	: C11H10N2O
Mol.Wt.	: 186.2
Inv. Status	: Custom Synthesis

Apixaban Impurity 64

SZ CAT No:	: SZ-A062086
CAS No	: NA
Mol.F.	: C16H15N3O4
Mol.Wt.	: 313.3
Inv. Status	: Custom Synthesis

Apixaban Impurity 65

SZ CAT No:	: SZ-A062087
CAS No	: NA
Mol.F.	: C16H16N2O2
Mol.Wt.	: 268.3
Inv. Status	: Custom Synthesis

Apixaban Impurity 66

SZ CAT No:	: SZ-A062088
CAS No	: NA
Mol.F.	: C16H18N2O3
Mol.Wt.	: 286.3
Inv. Status	: Custom Synthesis

Apixaban Impurity 68

SZ CAT No:	: SZ-A062097
CAS No	: 2228050-22-2
Mol.F.	: C11H13ClN2O3
Mol.Wt.	: 256.7
Inv. Status	: Custom Synthesis

Apixaban Impurity 69

SZ CAT No:	: SZ-A062098
CAS No	: 1801881-18-4
Mol.F.	: C25H25N5O4
Mol.Wt.	: 459.5
Inv. Status	: Custom Synthesis

Apixaban Impurity 7

SZ CAT No:	: SZ-A062018
CAS No	: 1074549-87-3
Mol.F.	: C26H27N5O4
Mol.Wt.	: 473.5
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Apixaban Impurity 70

SZ CAT No:	: SZ-A062099
CAS No	: NA
Mol.F.	: C20H25N3O3
Mol.Wt.	: 355.4
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Apixaban Impurity 71

SZ CAT No:	: SZ-A062100
CAS No	: 1872894-62-6
Mol.F.	: C9H18N2O2
Mol.Wt.	: 186.3
Inv. Status	: Custom Synthesis

Apixaban Impurity 72

SZ CAT No:	: SZ-A062009
CAS No	: 19347-73-0
Mol.F.	: C6H10Cl2O
Mol.Wt.	: 169.0
Inv. Status	: Custom Synthesis

Apixaban Impurity 73

SZ CAT No:	: SZ-A062101
CAS No	: 40345-06-0
Mol.F.	: C9H9ClN2O3
Mol.Wt.	: 228.6
Inv. Status	: Custom Synthesis

Apixaban Impurity 74

SZ CAT No:	: SZ-A062102
CAS No	: 2067-33-6
Mol.F.	: C5H9BrO2
Mol.Wt.	: 181.0
Inv. Status	: Custom Synthesis

Apixaban Impurity 75

SZ CAT No:	: SZ-A062103
CAS No	: 5454-83-1
Mol.F.	: C6H11BrO2
Mol.Wt.	: 195.1
Inv. Status	: Custom Synthesis

Apixaban Impurity 76

SZ CAT No:	: SZ-A062104
CAS No	: 52534-24-4
Mol.F.	: C5H10BrNO
Mol.Wt.	: 180.0
Inv. Status	: Custom Synthesis

Apixaban USP Related Compound G

SZ CAT No:	: SZ-A062106
CAS No	: 881386-12-5
Mol.F.	: C27H29BrN4O5
Mol.Wt.	: 569.5
Inv. Status	: In Stock

Apixaban Impurity 78

SZ CAT No:	: SZ-A062107
CAS No	: 1620386-62-0
Mol.F.	: C26H29N5O7
Mol.Wt.	: 523.5
Inv. Status	: Custom Synthesis

Apixaban Impurity 79

SZ CAT No:	: SZ-A062110
CAS No	: NA
Mol.F.	: C12H16N2O4
Mol.Wt.	: 252.3
Inv. Status	: In Stock

Apixaban Impurity 8

SZ CAT No:	: SZ-A062019
CAS No	: 1777781-49-3
Mol.F.	: C24H23N5O4
Mol.Wt.	: 445.5
Inv. Status	: Custom Synthesis

Apixaban Impurity 9

SZ CAT No:	: SZ-A062020
CAS No	: 503614-91-3
Mol.F.	: C27H28N4O5
Mol.Wt.	: 488.6
Inv. Status	: In Stock

Apixaban Carboxylic Acid Impurity

SZ CAT No:	: SZ-A062048
CAS No	: 503614-92-4
Mol.F.	: C25H24N4O5
Mol.Wt.	: 460.5
Inv. Status	: In Stock

Apixaban Impurity B

SZ CAT No:	: SZ-A062049
CAS No	: 2512213-45-3
Mol.F.	: C11H11ClN2O3
Mol.Wt.	: 254.7
Inv. Status	: In Stock

Apixaban Impurity C

SZ CAT No:	: SZ-A062061
CAS No	: 1904628-10-9
Mol.F.	: C27H28N4O6
Mol.Wt.	: 504.5
Inv. Status	: In Stock

Apixaban Impurity E

SZ CAT No:	: SZ-A062058
CAS No	: 1609409-53-1
Mol.F.	: C20H22N2O6
Mol.Wt.	: 386.4
Inv. Status	: In Stock

Apixaban Methyl Impurity

SZ CAT No:	: SZ-A062076
CAS No	: 70736-27-5
Mol.F.	: C10H11ClN2O3
Mol.Wt.	: 242.7
Inv. Status	: Custom Synthesis

Apixaban Nitroso Impurity 1

SZ CAT No:	: SZ-A062105
CAS No	: NA
Mol.F.	: C11H12ClN3O4
Mol.Wt.	: 285.7
Inv. Status	: Inquire

Apixaban Nitroso Impurity 2

SZ CAT No:	: SZ-A062108
CAS No	: NA
Mol.F.	: C27H28ClN5O6
Mol.Wt.	: 554.0
Inv. Status	: Inquire

Apixaban Nitroso Impurity 3

SZ CAT No:	: SZ-A062109
CAS No	: NA
Mol.F.	: C11H12ClN3O4
Mol.Wt.	: 285.7
Inv. Status	: Custom Synthesis