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Empagliflozin Hydroxy Impurity

SZ CAT No SZ-E009045
CAS No NA
Mol.F. C23H28O7
Mol.Wt. 416.5
Inv. Status Custom Synthesis


Chemical Name: (2R,3S,4R,6R)-6-(3-(Hydroxy(4-((tetrahydrofuran-3-yl)oxy)phenyl)methyl)phenyl)-2-(hydroxymethyl)tetrahydro-2H-pyran-3,4-diol

Smiles: O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](C2=CC(C(O)C3=CC=C(OC4COCC4)C=C3)=CC=C2)C1

Inchi: InChI=1S/C23H27ClO9/c24-17-6-3-13(23-21(28)20(27)19(26)18(10-25)32-23)9-16(17)22(33-29)12-1-4-14(5-2-12)31-15-7-8-30-11-15/h1-6,9,15,18-23,25-29H,7-8,10-11H2/t15?,18-,19-,20+,21-,22?,23+/m1/s1

Stability indicating HPLC-​Fluorescence detection method for the simultaneous determination of linagliptin and empagliflozin in their combined pharmaceutical preparation
By Rizk, Mohamed; Attia, Ali Kamal; Mohamed, Heba Yosry; Elshahed, Mona
From European Journal of Chemistry (2021), 12(2), 168-178
 
Stability indicating hplc method for the quantification of (R)​-​Isomer in empagliflozin drug substance
By Korlakunta, Vijaya Gouri; Sreenivas, N.; Sharma, Hemant Kumar; Nowduri, Annapurna; Bonige, Kishore Babu; Chavakula, Ramadas
From European Journal of Biomedical and Pharmaceutical Sciences (2021), 8(4), 177-184.

Simultaneous determination, validation and forced degradation studies of metformin and empagliflozin using new HPLC analytical method
By Riaz, Muhammad Kashif; Niaz, Sultan; Asghar, Muhammad Arif; Shafiq, Yousra; Zehravi, Mehrukh; Shah, Syed Suffdar Hussain; Abdul Rehman, Ahad; Khan, Kamran
From Latin American Journal of Pharmacy (2020), 39(11), 2257-2265.