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Cabazitaxel Impurity (DeTroc-Oxazolidine)

SZ CAT No SZ-C056032
CAS No NA
Mol.F. C46H57NO14
Mol.Wt. 848.0
Inv. Status Custom Synthesis


Chemical Name: 5-((2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-Acetoxy-12-(benzoyloxy)-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-9-yl) 3-(tert-butyl) (4R,5S)-2,2-dimethyl-4-phenyloxazolidine-3,5-dicarboxylate

Smiles: CC(C1=C(C)[C@@H](OC([C@@H](OC2(C)C)[C@@H](C3=CC=CC=C3)N2C(OC(C)(C)C)=O)=O)C4)(C)[C@]4(O)[C@@H](OC(C5=CC=CC=C5)=O)[C@@]([C@@]6(OC(C)=O)[C@H](OC6)C[C@@H]7O)([H])[C@]7(C)C([C@@H]1O)=O

Inchi: InChI=1S/C35H38Cl6O14/c1-16-19(43)12-33(48)26(54-27(45)18-9-7-6-8-10-18)24-31(5,25(44)23(22(16)30(33,3)4)53-29(47)51-15-35(39,40)41)20(52-28(46)50-14-34(36,37)38)11-21-32(24,13-49-21)55-17(2)42/h6-10,19-21,23-24,26,43,48H,11-15H2,1-5H3/t19-,20-,21+,23+,24-,26-,31+,32-,33+/m0/s1

Development and Validation of a Stability-​indicating HPLC Method for the Analysis of Cabazitaxel in Jevtana Concentrate-​solvent Leftover Samples
By Arnamo, Hedvig; Hillebrand, Michel J. X.; Huitema, Alwin D. R.; Nuijen, Bastiaan; Rosing, Hilde; Beijnen, Jos H.
From Current Pharmaceutical Analysis (2021), 17(6), 691-701
 
Development and Validation of a Stability-​Indicating HPLC Method for the Determination of the Impurities in Cabazitaxel
By Li, Chengyan; Lan, Gongjian; Jiang, Jinyuan; Sun, Mingjie; Hang, Taijun
From Chromatographia (2015), 78(11-12), 825-831
 
Development and validation of a stability-​indicating liquid chromatographic method for the assay of cabazitaxel
By Mathrusri Annapurna, M.; Venkatesh, B.; Pramadvara, K.; Hemchand, S.
From Chemical Science Transactions (2014), 3(2), 854-860, 7 pp.