Sacubitril Impurity 9

SZ CAT No:	SZ-S020012
CAS No	149690-12-0
Mol.F.	C20H25NO2 : HCl
Mol.Wt.	311.4 : 36.5
Inv. Status	In Stock
Rel. CAS No	752174-62-2 (free base) ; 1038924-98-9 (HBr salt)

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Chemical Name: Ethyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate hydrochloride

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: N[C@@H](C[C@@H](C)C(OCC)=O)CC1=CC=C(C2=CC=CC=C2)C=C1.Cl

A liquid chromatographic method for separation of sacubitril–valsartan and their stereoisomeric impurities
Lu Zhou, Liang Zou, Lili Sun, Hui Zhang, Wenkai Hui and Qiaogen Zou
Anal. Methods, 2018,10, 1046-1053

Quantification of potential genotoxic impurity in sacubitril/valsartan drug substance at ppm level by LC-MS/MS
Ravi Uppala, M.Arthanareeswari, S.Devikala,T.Pushpamalini, J. ArockiaSelvi
Materials Today: Proceedings Volume 14, Part 2, 2019, Pages 640-645

Experimental Design Approach in HPLC Method Development: Application for the Simultaneous Determination of Sacubitril and Valsartan in Presence of Their Impurities and Investigation of Degradation Kinetics
Bahia A. Moussa, Hanaa M. A. Hashem, Marianne A. Mahrouse & Sally T. Mahmoud
Chromatographia volume 81, pages139–156(2018)

Development and validation of a stability indicating UHPLC method for Sacubitril/Valsartan complex in the presence of impurities and degradation products
Pintu Prajapati, Dhara Bhayani, Priti Mehta.
J App Pharm Sci. 2020; 10(2): 97-107

Sacubitril Impurity 9 is chemically Ethyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate hydrochloride. Sacubitril Impurity 9 is supplied with detailed characterization data compliant with regulatory guideline. Sacubitril Impurity 9 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Sacubitril.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

Sacubitril Impurity 9

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SZ CAT No:	: SZ-S020001
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Mol.F.	: C24H28NO5 : 1/2(Ca)
Mol.Wt.	: 410.5 : 1/2(40.1)
Inv. Status	: In Stock

SZ CAT No:	: SZ-S020002
CAS No	: 149709-63-7
Mol.F.	: C24H29NO5
Mol.Wt.	: 411.5
Inv. Status	: Out of Stock

SZ CAT No:	: SZ-S020003
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Mol.F.	: C24H29NO5
Mol.Wt.	: 411.5
Inv. Status	: In Stock

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Mol.F.	: C18H19NO
Mol.Wt.	: 265.4
Inv. Status	: In Stock

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Mol.F.	: C24H27NO4
Mol.Wt.	: 393.5
Inv. Status	: In Stock

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Mol.F.	: C22H25NO5
Mol.Wt.	: 383.5
Inv. Status	: In Stock

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CAS No	: 1012341-56-8
Mol.F.	: C23H29NO4
Mol.Wt.	: 383.5
Inv. Status	: Out of Stock

SZ CAT No:	: SZ-S020009
CAS No	: 1012341-54-6
Mol.F.	: C23H29NO4
Mol.Wt.	: 383.5
Inv. Status	: In Stock

SZ CAT No:	: SZ-S020010
CAS No	: 1012341-52-4
Mol.F.	: C23H29NO4
Mol.Wt.	: 383.5
Inv. Status	: In Stock

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CAS No	: 1012341-50-2
Mol.F.	: C23H29NO4
Mol.Wt.	: 383.5
Inv. Status	: In Stock

SZ CAT No:	: SZ-S020012
CAS No	: 149690-12-0
Mol.F.	: C20H25NO2 : HCl
Mol.Wt.	: 311.4 : 36.5
Inv. Status	: In Stock

SZ CAT No:	: SZ-S020013
CAS No	: 149709-60-4
Mol.F.	: C25H33NO4
Mol.Wt.	: 411.6
Inv. Status	: In Stock

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CAS No	: 1038924-71-8
Mol.F.	: C18H21NO2 : HCl
Mol.Wt.	: 283.4 : 36.5
Inv. Status	: In Stock

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CAS No	: 1015037-46-3
Mol.F.	: C23H27NO4
Mol.Wt.	: 381.5
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-S020016
CAS No	: 2459446-51-4
Mol.F.	: C25H31NO5
Mol.Wt.	: 425.5
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-S020017
CAS No	: 2216755-67-6
Mol.F.	: C28H37NO5
Mol.Wt.	: 467.6
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-S020018
CAS No	: 2459446-53-6
Mol.F.	: C27H35NO5
Mol.Wt.	: 453.6
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-S020019
CAS No	: 149709-49-9
Mol.F.	: C24H29NO5
Mol.Wt.	: 411.5
Inv. Status	: Custom Synthesis

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CAS No	: 2376611-98-0
Mol.F.	: C26H33NO5
Mol.Wt.	: 439.6
Inv. Status	: Limited Stock

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CAS No	: 1426129-50-1
Mol.F.	: C20H25NO3
Mol.Wt.	: 327.4
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-S020022
CAS No	: 2459446-54-7
Mol.F.	: C22H23NO4
Mol.Wt.	: 365.4
Inv. Status	: In Stock

SZ CAT No:	: SZ-S020023
CAS No	: 2459446-55-8
Mol.F.	: C25H29NO4
Mol.Wt.	: 407.5
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-S020024
CAS No	: 1817838-91-7
Mol.F.	: C25H31NO4
Mol.Wt.	: 409.5
Inv. Status	: In Stock

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CAS No	: 1012341-48-8
Mol.F.	: C23H27NO4
Mol.Wt.	: 381.5
Inv. Status	: In Stock

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CAS No	: NA
Mol.F.	: C18H19NO2 : HCl
Mol.Wt.	: 281.4 : 36.5
Inv. Status	: In Stock

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CAS No	: 2957885-25-3
Mol.F.	: C20H23NO2 : HCl
Mol.Wt.	: 309.4 : 36.5
Inv. Status	: In Stock

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CAS No	: 2984580-03-0
Mol.F.	: C24H27NO5
Mol.Wt.	: 409.5
Inv. Status	: In Stock

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Mol.F.	: C23H27NO5
Mol.Wt.	: 397.5
Inv. Status	: In Stock

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Mol.F.	: C24H29NO5
Mol.Wt.	: 411.5
Inv. Status	: In Stock

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CAS No	: 2413471-13-1
Mol.F.	: C24H27NO4
Mol.Wt.	: 393.5
Inv. Status	: Limited Stock