Sacubitril Impurity 40

SZ CAT No:	SZ-S020052
CAS No	2514965-95-6
Mol.F.	C25H31NO5
Mol.Wt.	425.5
Inv. Status	In Stock

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Chemical Name: 4-(((2S,4R)-1-([1,1'-Biphenyl]-4-yl)-5-isopropoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: O=C(CCC(O)=O)N[C@@H](C[C@@H](C)C(OC(C)C)=O)CC(C=C1)=CC=C1C2=CC=CC=C2

A liquid chromatographic method for separation of sacubitril–valsartan and their stereoisomeric impurities
Lu Zhou, Liang Zou, Lili Sun, Hui Zhang, Wenkai Hui and Qiaogen Zou
Anal. Methods, 2018,10, 1046-1053

Quantification of potential genotoxic impurity in sacubitril/valsartan drug substance at ppm level by LC-MS/MS
Ravi Uppala, M.Arthanareeswari, S.Devikala,T.Pushpamalini, J. ArockiaSelvi
Materials Today: Proceedings Volume 14, Part 2, 2019, Pages 640-645

Experimental Design Approach in HPLC Method Development: Application for the Simultaneous Determination of Sacubitril and Valsartan in Presence of Their Impurities and Investigation of Degradation Kinetics
Bahia A. Moussa, Hanaa M. A. Hashem, Marianne A. Mahrouse & Sally T. Mahmoud
Chromatographia volume 81, pages139–156(2018)

Development and validation of a stability indicating UHPLC method for Sacubitril/Valsartan complex in the presence of impurities and degradation products
Pintu Prajapati, Dhara Bhayani, Priti Mehta.
J App Pharm Sci. 2020; 10(2): 97-107

Sacubitril Impurity 40 is chemically 4-(((2S,4R)-1-([1,1'-Biphenyl]-4-yl)-5-isopropoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid. Sacubitril Impurity 40 is supplied with detailed characterization data compliant with regulatory guideline. Sacubitril Impurity 40 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Sacubitril.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

SZ CAT No:	: SZ-S020001
CAS No	: 1369773-39-6
Mol.F.	: C24H28NO5 : 1/2(Ca)
Mol.Wt.	: 410.5 : 1/2(40.1)
Inv. Status	: In Stock
Rel. CAS No	: 149709-62-6 (free base) ; 149690-05-1 (Sodium salt)

SZ CAT No:	: SZ-S020012
CAS No	: 149690-12-0
Mol.F.	: C20H25NO2 : HCl
Mol.Wt.	: 311.4 : 36.5
Inv. Status	: In Stock
Rel. CAS No	: 752174-62-2 (free base) ; 1038924-98-9 (HBr salt)

SZ CAT No:	: SZ-S020014
CAS No	: 1038924-71-8
Mol.F.	: C18H21NO2 : HCl
Mol.Wt.	: 283.4 : 36.5
Inv. Status	: In Stock
Rel. CAS No	: 1039307-95-3 (free base)

SZ CAT No:	: SZ-S020026
CAS No	: NA
Mol.F.	: C18H19NO2 : HCl
Mol.Wt.	: 281.4 : 36.5
Inv. Status	: In Stock
Rel. CAS No	: 2459446-56-9 (free base)

SZ CAT No:	: SZ-S020027
CAS No	: 2957885-25-3
Mol.F.	: C20H23NO2 : HCl
Mol.Wt.	: 309.4 : 36.5
Inv. Status	: In Stock
Rel. CAS No	: 2459446-57-0 (free base)

Sacubitril Impurity 40

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SZ CAT No:	: SZ-S020002
CAS No	: 149709-63-7
Mol.F.	: C24H29NO5
Mol.Wt.	: 411.5
Inv. Status	: Limited Stock

SZ CAT No:	: SZ-S020003
CAS No	: 2259708-00-2
Mol.F.	: C24H29NO5
Mol.Wt.	: 411.5
Inv. Status	: In Stock

SZ CAT No:	: SZ-S020004
CAS No	: 1038924-70-7
Mol.F.	: C18H19NO
Mol.Wt.	: 265.4
Inv. Status	: In Stock

SZ CAT No:	: SZ-S020005
CAS No	: 1038924-97-8
Mol.F.	: C24H27NO4
Mol.Wt.	: 393.5
Inv. Status	: In Stock

SZ CAT No:	: SZ-S020007
CAS No	: 149709-44-4
Mol.F.	: C22H25NO5
Mol.Wt.	: 383.5
Inv. Status	: Limited Stock

SZ CAT No:	: SZ-S020008
CAS No	: 1012341-56-8
Mol.F.	: C23H29NO4
Mol.Wt.	: 383.5
Inv. Status	: Out of Stock

SZ CAT No:	: SZ-S020009
CAS No	: 1012341-54-6
Mol.F.	: C23H29NO4
Mol.Wt.	: 383.5
Inv. Status	: In Stock

SZ CAT No:	: SZ-S020010
CAS No	: 1012341-52-4
Mol.F.	: C23H29NO4
Mol.Wt.	: 383.5
Inv. Status	: In Stock

SZ CAT No:	: SZ-S020011
CAS No	: 1012341-50-2
Mol.F.	: C23H29NO4
Mol.Wt.	: 383.5
Inv. Status	: In Stock

SZ CAT No:	: SZ-S020013
CAS No	: 149709-60-4
Mol.F.	: C25H33NO4
Mol.Wt.	: 411.6
Inv. Status	: In Stock

SZ CAT No:	: SZ-S020015
CAS No	: 1015037-46-3
Mol.F.	: C23H27NO4
Mol.Wt.	: 381.5
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-S020016
CAS No	: 2459446-51-4
Mol.F.	: C25H31NO5
Mol.Wt.	: 425.5
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-S020017
CAS No	: 2216755-67-6
Mol.F.	: C28H37NO5
Mol.Wt.	: 467.6
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-S020018
CAS No	: 2459446-53-6
Mol.F.	: C27H35NO5
Mol.Wt.	: 453.6
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-S020019
CAS No	: 149709-49-9
Mol.F.	: C24H29NO5
Mol.Wt.	: 411.5
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-S020020
CAS No	: 2376611-98-0
Mol.F.	: C26H33NO5
Mol.Wt.	: 439.6
Inv. Status	: Limited Stock

SZ CAT No:	: SZ-S020021
CAS No	: 1426129-50-1
Mol.F.	: C20H25NO3
Mol.Wt.	: 327.4
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-S020022
CAS No	: 2459446-54-7
Mol.F.	: C22H23NO4
Mol.Wt.	: 365.4
Inv. Status	: In Stock

SZ CAT No:	: SZ-S020023
CAS No	: 2459446-55-8
Mol.F.	: C25H29NO4
Mol.Wt.	: 407.5
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-S020024
CAS No	: 1817838-91-7
Mol.F.	: C25H31NO4
Mol.Wt.	: 409.5
Inv. Status	: In Stock

SZ CAT No:	: SZ-S020025
CAS No	: 1012341-48-8
Mol.F.	: C23H27NO4
Mol.Wt.	: 381.5
Inv. Status	: In Stock

SZ CAT No:	: SZ-S020028
CAS No	: 2984580-03-0
Mol.F.	: C24H27NO5
Mol.Wt.	: 409.5
Inv. Status	: In Stock

SZ CAT No:	: SZ-S020029
CAS No	: 2408053-56-3
Mol.F.	: C23H27NO5
Mol.Wt.	: 397.5
Inv. Status	: In Stock
Rel. CAT No	: SZ-S020099 , SZ-S020106 ,

SZ CAT No:	: SZ-S020030
CAS No	: 761373-05-1
Mol.F.	: C24H29NO5
Mol.Wt.	: 411.5
Inv. Status	: In Stock

SZ CAT No:	: SZ-S020031
CAS No	: 2413471-13-1
Mol.F.	: C24H27NO4
Mol.Wt.	: 393.5
Inv. Status	: Limited Stock

SZ CAT No:	: SZ-S020D01
CAS No	: 1884269-07-1
Mol.F.	: C24H25D4NO5
Mol.Wt.	: 415.5
Inv. Status	: In Stock

SZ CAT No:	: SZ-S020D02
CAS No	: NA
Mol.F.	: C24H25D4NO5
Mol.Wt.	: 415.5
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-S020032
CAS No	: NA
Mol.F.	: C23H25NO5
Mol.Wt.	: 395.5
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-S020034
CAS No	: 2101222-42-6
Mol.F.	: C18H19NO
Mol.Wt.	: 265.4
Inv. Status	: In Stock

SZ CAT No:	: SZ-S020037
CAS No	: 5717-37-3
Mol.F.	: C23H23O2P
Mol.Wt.	: 362.4
Inv. Status	: Custom Synthesis