Sacubitril Impurity 30

SZ CAT No:	SZ-S020036
CAS No	128779-47-5
Mol.F.	C20H23NO4
Mol.Wt.	341.4
Inv. Status	Custom Synthesis

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Chemical Name: (R)-3-(Biphenyl-4-yl)-2-[(tert-butoxycarbonyl)amino]propionic Acid

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: O=C(O)[C@H](NC(OC(C)(C)C)=O)CC1=CC=C(C2=CC=CC=C2)C=C1

A liquid chromatographic method for separation of sacubitril–valsartan and their stereoisomeric impurities
Lu Zhou, Liang Zou, Lili Sun, Hui Zhang, Wenkai Hui and Qiaogen Zou
Anal. Methods, 2018,10, 1046-1053

Quantification of potential genotoxic impurity in sacubitril/valsartan drug substance at ppm level by LC-MS/MS
Ravi Uppala, M.Arthanareeswari, S.Devikala,T.Pushpamalini, J. ArockiaSelvi
Materials Today: Proceedings Volume 14, Part 2, 2019, Pages 640-645

Experimental Design Approach in HPLC Method Development: Application for the Simultaneous Determination of Sacubitril and Valsartan in Presence of Their Impurities and Investigation of Degradation Kinetics
Bahia A. Moussa, Hanaa M. A. Hashem, Marianne A. Mahrouse & Sally T. Mahmoud
Chromatographia volume 81, pages139–156(2018)

Development and validation of a stability indicating UHPLC method for Sacubitril/Valsartan complex in the presence of impurities and degradation products
Pintu Prajapati, Dhara Bhayani, Priti Mehta.
J App Pharm Sci. 2020; 10(2): 97-107

Sacubitril Impurity 30 is chemically (R)-3-(Biphenyl-4-yl)-2-[(tert-butoxycarbonyl)amino]propionic Acid. Sacubitril Impurity 30 is supplied with detailed characterization data compliant with regulatory guideline. Sacubitril Impurity 30 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Sacubitril.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

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Sacubitril Calcium

SZ CAT No:	: SZ-S020001
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Mol.Wt.	: 410.5 : 1/2(40.1)
Inv. Status	: In Stock
Rel. CAS No	: 149709-62-6 (free base) ; 149690-05-1 (Sodium salt)

Sacubitril-(2S,4S)-Isomer

SZ CAT No:	: SZ-S020002
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Mol.F.	: C24H29NO5
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Sacubitril-(2R,4R)-Isomer

SZ CAT No:	: SZ-S020003
CAS No	: 2259708-00-2
Mol.F.	: C24H29NO5
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Sacubitril (3R,5S)-Pyrrolidinone Impurity

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2,5-Dioxopyrrolidine Sacubitril

SZ CAT No:	: SZ-S020005
CAS No	: 1038924-97-8
Mol.F.	: C24H27NO4
Mol.Wt.	: 393.5
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Sacubitrilat

SZ CAT No:	: SZ-S020007
CAS No	: 149709-44-4
Mol.F.	: C22H25NO5
Mol.Wt.	: 383.5
Inv. Status	: Limited Stock

Sacubitril Impurity 5

SZ CAT No:	: SZ-S020008
CAS No	: 1012341-56-8
Mol.F.	: C23H29NO4
Mol.Wt.	: 383.5
Inv. Status	: Out of Stock

Sacubitril Impurity 6

SZ CAT No:	: SZ-S020009
CAS No	: 1012341-54-6
Mol.F.	: C23H29NO4
Mol.Wt.	: 383.5
Inv. Status	: In Stock

Sacubitril Impurity 7

SZ CAT No:	: SZ-S020010
CAS No	: 1012341-52-4
Mol.F.	: C23H29NO4
Mol.Wt.	: 383.5
Inv. Status	: In Stock

Sacubitril Impurity 8

SZ CAT No:	: SZ-S020011
CAS No	: 1012341-50-2
Mol.F.	: C23H29NO4
Mol.Wt.	: 383.5
Inv. Status	: In Stock

Sacubitril Impurity 9

SZ CAT No:	: SZ-S020012
CAS No	: 149690-12-0
Mol.F.	: C20H25NO2 : HCl
Mol.Wt.	: 311.4 : 36.5
Inv. Status	: In Stock
Rel. CAS No	: 752174-62-2 (free base) ; 1038924-98-9 (HBr salt)

Sacubitril Impurity 10

SZ CAT No:	: SZ-S020013
CAS No	: 149709-60-4
Mol.F.	: C25H33NO4
Mol.Wt.	: 411.6
Inv. Status	: In Stock

Sacubitril Impurity 11

SZ CAT No:	: SZ-S020014
CAS No	: 1038924-71-8
Mol.F.	: C18H21NO2 : HCl
Mol.Wt.	: 283.4 : 36.5
Inv. Status	: In Stock
Rel. CAS No	: 1039307-95-3 (free base)

Sacubitril Impurity 12

SZ CAT No:	: SZ-S020015
CAS No	: 1015037-46-3
Mol.F.	: C23H27NO4
Mol.Wt.	: 381.5
Inv. Status	: Custom Synthesis

Sacubitril Impurity 13

SZ CAT No:	: SZ-S020016
CAS No	: 2459446-51-4
Mol.F.	: C25H31NO5
Mol.Wt.	: 425.5
Inv. Status	: Custom Synthesis

Sacubitril Impurity 14

SZ CAT No:	: SZ-S020017
CAS No	: 2216755-67-6
Mol.F.	: C28H37NO5
Mol.Wt.	: 467.6
Inv. Status	: Custom Synthesis

Sacubitril Impurity 15

SZ CAT No:	: SZ-S020018
CAS No	: 2459446-53-6
Mol.F.	: C27H35NO5
Mol.Wt.	: 453.6
Inv. Status	: Custom Synthesis

Sacubitril Impurity 16

SZ CAT No:	: SZ-S020019
CAS No	: 149709-49-9
Mol.F.	: C24H29NO5
Mol.Wt.	: 411.5
Inv. Status	: Custom Synthesis

Sacubitril Impurity 17

SZ CAT No:	: SZ-S020020
CAS No	: 2376611-98-0
Mol.F.	: C26H33NO5
Mol.Wt.	: 439.6
Inv. Status	: Limited Stock

Sacubitril Impurity 18

SZ CAT No:	: SZ-S020021
CAS No	: 1426129-50-1
Mol.F.	: C20H25NO3
Mol.Wt.	: 327.4
Inv. Status	: Custom Synthesis

Sacubitril Impurity 19

SZ CAT No:	: SZ-S020022
CAS No	: 2459446-54-7
Mol.F.	: C22H23NO4
Mol.Wt.	: 365.4
Inv. Status	: In Stock

Sacubitril Impurity 20

SZ CAT No:	: SZ-S020023
CAS No	: 2459446-55-8
Mol.F.	: C25H29NO4
Mol.Wt.	: 407.5
Inv. Status	: Custom Synthesis

Sacubitril Impurity 21

SZ CAT No:	: SZ-S020024
CAS No	: 1817838-91-7
Mol.F.	: C25H31NO4
Mol.Wt.	: 409.5
Inv. Status	: In Stock

Sacubitril Impurity 22

SZ CAT No:	: SZ-S020025
CAS No	: 1012341-48-8
Mol.F.	: C23H27NO4
Mol.Wt.	: 381.5
Inv. Status	: In Stock

Sacubitril Impurity 23

SZ CAT No:	: SZ-S020026
CAS No	: NA
Mol.F.	: C18H19NO2 : HCl
Mol.Wt.	: 281.4 : 36.5
Inv. Status	: In Stock
Rel. CAS No	: 2459446-56-9 (free base)

Sacubitril Impurity 24

SZ CAT No:	: SZ-S020027
CAS No	: 2957885-25-3
Mol.F.	: C20H23NO2 : HCl
Mol.Wt.	: 309.4 : 36.5
Inv. Status	: In Stock
Rel. CAS No	: 2459446-57-0 (free base)

Sacubitril Maleic Acid (E-Isomer)

SZ CAT No:	: SZ-S020028
CAS No	: 2984580-03-0
Mol.F.	: C24H27NO5
Mol.Wt.	: 409.5
Inv. Status	: In Stock

Sacubitril Methyl Ester

SZ CAT No:	: SZ-S020029
CAS No	: 2408053-56-3
Mol.F.	: C23H27NO5
Mol.Wt.	: 397.5
Inv. Status	: In Stock
Rel. CAT No	: SZ-S020099 , SZ-S020106 ,

(2R,4S)-Sacubitril

SZ CAT No:	: SZ-S020030
CAS No	: 761373-05-1
Mol.F.	: C24H29NO5
Mol.Wt.	: 411.5
Inv. Status	: In Stock

Sacubitril Impurity 25

SZ CAT No:	: SZ-S020031
CAS No	: 2413471-13-1
Mol.F.	: C24H27NO4
Mol.Wt.	: 393.5
Inv. Status	: Limited Stock

Sacubitril D4

SZ CAT No:	: SZ-S020D01
CAS No	: 1884269-07-1
Mol.F.	: C24H25D4NO5
Mol.Wt.	: 415.5
Inv. Status	: In Stock

(2S,4S)-Sacubitril D4

SZ CAT No:	: SZ-S020D02
CAS No	: NA
Mol.F.	: C24H25D4NO5
Mol.Wt.	: 415.5
Inv. Status	: Custom Synthesis

Sacubitril Impurity 26

SZ CAT No:	: SZ-S020032
CAS No	: NA
Mol.F.	: C23H25NO5
Mol.Wt.	: 395.5
Inv. Status	: Custom Synthesis

Sacubitril Impurity 28

SZ CAT No:	: SZ-S020034
CAS No	: 2101222-42-6
Mol.F.	: C18H19NO
Mol.Wt.	: 265.4
Inv. Status	: In Stock

Sacubitril Impurity 31

SZ CAT No:	: SZ-S020037
CAS No	: 5717-37-3
Mol.F.	: C23H23O2P
Mol.Wt.	: 362.4
Inv. Status	: Custom Synthesis

Sacubitril Impurity 30

SZ CAT No:	: SZ-S020036
CAS No	: 128779-47-5
Mol.F.	: C20H23NO4
Mol.Wt.	: 341.4
Inv. Status	: Custom Synthesis

Valsartan Sacubitril

SZ CAT No:	: SZ-S020038
CAS No	: 936623-90-4
Mol.F.	: C24H28NO5 : C24H27N5O3 : 3Na : 5/2(H20)
Mol.Wt.	: 410.5 : 433.5 : 3(23.0) : 5/2(18.0)
Inv. Status	: In Stock

Sacubitril Impurity 32

SZ CAT No:	: SZ-S020039
CAS No	: 2957885-24-2
Mol.F.	: C24H27NO5
Mol.Wt.	: 409.5
Inv. Status	: In Stock

Sacubitril Sodium

SZ CAT No:	: SZ-S020040
CAS No	: 149690-05-1
Mol.F.	: C24H28NO5 : Na
Mol.Wt.	: 410.5 : 23.0
Inv. Status	: In Stock
Rel. CAS No	: 149709-62-6 (free base) ; 1924620-62-1 (K salt)

Sacubitril Impurity 33

SZ CAT No:	: SZ-S020041
CAS No	: 219718-02-2
Mol.F.	: C22H27NO4
Mol.Wt.	: 369.5
Inv. Status	: In Stock

Sacubitril Impurity 34

SZ CAT No:	: SZ-S020042
CAS No	: 1660147-07-8
Mol.F.	: C17H19NO2
Mol.Wt.	: 269.3
Inv. Status	: Custom Synthesis

Sacubitril Impurity 35

SZ CAT No:	: SZ-S020043
CAS No	: 1810778-75-6
Mol.F.	: C20H25NO3
Mol.Wt.	: 327.4
Inv. Status	: Custom Synthesis

Sacubitril N-Acetyl Impurity

SZ CAT No:	: SZ-S020044
CAS No	: NA
Mol.F.	: C22H27NO3
Mol.Wt.	: 353.5
Inv. Status	: In Stock

Sacubitril Propyl Ester

SZ CAT No:	: SZ-S020045
CAS No	: 2751722-76-4
Mol.F.	: C25H31NO5
Mol.Wt.	: 425.5
Inv. Status	: In Stock

Sacubitril Impurity 36

SZ CAT No:	: SZ-S020046
CAS No	: 149709-58-0
Mol.F.	: C20H23NO3
Mol.Wt.	: 325.4
Inv. Status	: In Stock

Sacubitril TBA Salt

SZ CAT No:	: SZ-S020047
CAS No	: 1924620-55-2
Mol.F.	: C24H28NO5 : C4H12N
Mol.Wt.	: 410.5 : 74.1
Inv. Status	: Limited Stock
Rel. CAS No	: 149690-05-1 (Sodium salt) ; 1369773-39-6 (calcium salt) ; 1924620-62-1 (potassium salt)

Sacubitril Impurity 37

SZ CAT No:	: SZ-S020048
CAS No	: 1573000-36-8
Mol.F.	: C19H18ClNO2
Mol.Wt.	: 327.8
Inv. Status	: In Stock

Sacubitril

SZ CAT No:	: SZ-S020049
CAS No	: 149709-62-6
Mol.F.	: C24H29NO5
Mol.Wt.	: 411.5
Inv. Status	: In Stock
Rel. CAS No	: 149690-05-1 (Sodium salt)

Sacubitril Impurity 38

SZ CAT No:	: SZ-S020050
CAS No	: 153037-40-2
Mol.F.	: C20H25NO3
Mol.Wt.	: 327.4
Inv. Status	: In Stock

Sacubitril Impurity 40

SZ CAT No:	: SZ-S020052
CAS No	: 2514965-95-6
Mol.F.	: C25H31NO5
Mol.Wt.	: 425.5
Inv. Status	: In Stock

Sacubitril Impurity 41

SZ CAT No:	: SZ-S020053
CAS No	: NA
Mol.F.	: C20H25NO2 : HCl
Mol.Wt.	: 311.4 : 36.5
Inv. Status	: In Stock
Rel. CAS No	: 1995860-03-1 (free base)

Sacubitril Impurity 42

SZ CAT No:	: SZ-S020054
CAS No	: NA
Mol.F.	: C20H25NO2 : HCl
Mol.Wt.	: 311.4 : 36.5
Inv. Status	: In Stock
Rel. CAS No	: 1995860-05-3 (free base)

Sacubitril Impurity 43

SZ CAT No:	: SZ-S020055
CAS No	: 149690-13-1
Mol.F.	: C20H25NO2 : HCl
Mol.Wt.	: 311.4 : 36.5
Inv. Status	: Custom Synthesis
Rel. CAS No	: 753421-85-1 (free base)

N-Nitroso Sacubitril Valsartan

SZ CAT No:	: SZ-S020056
CAS No	: NA
Mol.F.	: C24H29NO5 : C24H28N6O4
Mol.Wt.	: 411.5 : 464.5
Inv. Status	: Inquire

N-Nitroso Sacubitril

SZ CAT No:	: SZ-S020058
CAS No	: NA
Mol.F.	: C24H28N2O6
Mol.Wt.	: 440.5
Inv. Status	: Inquire

Sacubitril Maleic Acid (Z-Isomer)

SZ CAT No:	: SZ-S020059
CAS No	: 2751722-77-5
Mol.F.	: C24H27NO5
Mol.Wt.	: 409.5
Inv. Status	: In Stock

Sacubitrilat-13C4

SZ CAT No:	: SZ-S020D03
CAS No	: NA
Mol.F.	: C1813C4H25NO5
Mol.Wt.	: 387.4
Inv. Status	: Custom Synthesis

N-Nitroso Sacubitril Impurity 1

SZ CAT No:	: SZ-S020061
CAS No	: NA
Mol.F.	: C18H18N2O2
Mol.Wt.	: 294.4
Inv. Status	: In Stock

Sacubitril Impurity 30

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