Afatinib D4

SZ CAT No:	SZ-A054D01
CAS No	NA
Mol.F.	C24H21D4ClFN5O3
Mol.Wt.	490.0
Inv. Status	Custom Synthesis
Rel. CAS No	850140-72-6(Unlabeled)

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Chemical Name: (S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl-2,2,5,5-d4)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: ClC1=C(F)C=CC(NC2=NC=NC3=C2C=C(NC(/C=C/CN(C)C)=O)C(O[C@H]4CC([2H])([2H])OC4([2H])[2H])=C3)=C1

Afatinib D4 is chemically (S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl-2,2,5,5-d4)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide. Afatinib D4 is supplied with detailed characterization data compliant with regulatory guideline. Afatinib D4 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Afatinib.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

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SZ CAT No:	: SZ-A054001
CAS No	: 850140-72-6
Mol.F.	: C24H25ClFN5O3
Mol.Wt.	: 485.9
Inv. Status	: In Stock
Rel. CAS No	: 1398312-49-6 (HCl salt) ; 1398312-36-1 (Sulfate salt) ; 850140-73-7 (Dimaleat salt)

Afatinib Butoxy Analog

SZ CAT No:	: SZ-A054039
CAS No	: NA
Mol.F.	: C24H27ClFN5O2
Mol.Wt.	: 472.0
Inv. Status	: Custom Synthesis

Afatinib D4

SZ CAT No:	: SZ-A054D01
CAS No	: NA
Mol.F.	: C24H21D4ClFN5O3
Mol.Wt.	: 490.0
Inv. Status	: Custom Synthesis
Rel. CAS No	: 850140-72-6(Unlabeled)

Afatinib D6

SZ CAT No:	: SZ-A054D02
CAS No	: 1313874-96-2
Mol.F.	: C24H19D6ClFN5O3
Mol.Wt.	: 492.0
Inv. Status	: Custom Synthesis

Afatinib Dimaleate

SZ CAT No:	: SZ-A054035
CAS No	: 850140-73-7
Mol.F.	: C24H25ClFN5O3 : 2(C4H4O4)
Mol.Wt.	: 485.9 : 2(116.1)
Inv. Status	: In Stock
Rel. CAS No	: 850140-72-6 (free base) ; 1398312-49-6 (HCl salt) ; 1398312-36-1 (Sulfate salt)

Afatinib Impurity 10

SZ CAT No:	: SZ-A054022
CAS No	: NA
Mol.F.	: C48H50Cl2F2N10O6
Mol.Wt.	: 971.9
Inv. Status	: Custom Synthesis

Afatinib Impurity 11

SZ CAT No:	: SZ-A054023
CAS No	: 2413212-17-4
Mol.F.	: C22H20ClFN4O3
Mol.Wt.	: 442.9
Inv. Status	: Custom Synthesis

Afatinib Impurity 12

SZ CAT No:	: SZ-A054024
CAS No	: 2121530-37-6
Mol.F.	: C22H20ClFN4O4
Mol.Wt.	: 458.9
Inv. Status	: Custom Synthesis

Afatinib Impurity 13

SZ CAT No:	: SZ-A054025
CAS No	: 2413212-19-6
Mol.F.	: C22H20ClFN4O4
Mol.Wt.	: 458.9
Inv. Status	: In Stock

Afatinib Impurity 14

SZ CAT No:	: SZ-A054026
CAS No	: 2413212-21-0
Mol.F.	: C24H27ClFN5O4
Mol.Wt.	: 504.0
Inv. Status	: Custom Synthesis

Afatinib Impurity 15

SZ CAT No:	: SZ-A054027
CAS No	: 2413212-23-2
Mol.F.	: C24H27ClFN5O4
Mol.Wt.	: 504.0
Inv. Status	: Custom Synthesis

Afatinib Impurity 16

SZ CAT No:	: SZ-A054028
CAS No	: 2223677-60-7
Mol.F.	: C19H16ClFN4O3
Mol.Wt.	: 402.8
Inv. Status	: Under Synthesis

Afatinib Impurity 17

SZ CAT No:	: SZ-A054029
CAS No	: NA
Mol.F.	: C21H22ClFN5O2
Mol.Wt.	: 430.9
Inv. Status	: Custom Synthesis

Afatinib Impurity 18

SZ CAT No:	: SZ-A054030
CAS No	: 2413212-25-4
Mol.F.	: C24H26FN5O3
Mol.Wt.	: 451.5
Inv. Status	: Custom Synthesis

Afatinib Impurity 19

SZ CAT No:	: SZ-A054031
CAS No	: 1245555-42-3
Mol.F.	: C21H21ClFN5O2
Mol.Wt.	: 429.9
Inv. Status	: Custom Synthesis

Afatinib Impurity 2

SZ CAT No:	: SZ-A054014
CAS No	: 1449430-45-8
Mol.F.	: C14H8ClFN4O3
Mol.Wt.	: 334.7
Inv. Status	: Custom Synthesis

Afatinib Impurity 20

SZ CAT No:	: SZ-A054032
CAS No	: 2085843-51-0
Mol.F.	: C22H23ClFN5O2
Mol.Wt.	: 443.9
Inv. Status	: In Stock
Rel. CAS No	: 2085843-52-1 (2HCl salt)

Afatinib Impurity 21

SZ CAT No:	: SZ-A054033
CAS No	: 2044709-72-8
Mol.F.	: C18H16F2N4O2
Mol.Wt.	: 358.4
Inv. Status	: Custom Synthesis

Afatinib Impurity 22

SZ CAT No:	: SZ-A054034
CAS No	: NA
Mol.F.	: C28H29ClFN5O7
Mol.Wt.	: 601.1
Inv. Status	: Under Synthesis

Afatinib Impurity 40

SZ CAT No:	: SZ-A054041
CAS No	: NA
Mol.F.	: C20H18ClFN4O3
Mol.Wt.	: 416.8
Inv. Status	: Under Synthesis

Afatinib Impurity 41

SZ CAT No:	: SZ-A054042
CAS No	: 2475095-50-0
Mol.F.	: C14H7ClF2N4O2
Mol.Wt.	: 336.7
Inv. Status	: In Stock

Afatinib Impurity 23

SZ CAT No:	: SZ-A054036
CAS No	: 2223677-58-3
Mol.F.	: C22H20ClFN4O4
Mol.Wt.	: 458.9
Inv. Status	: In Stock

Afatinib Impurity 24

SZ CAT No:	: SZ-A054043
CAS No	: 1255078-56-8
Mol.F.	: C8H15NO2 : HCl
Mol.Wt.	: 157.2 : 36.5
Inv. Status	: In Stock
Rel. CAS No	: 1086268-91-8 (free base)

Afatinib Impurity 25

SZ CAT No:	: SZ-A054044
CAS No	: 212776-19-7
Mol.F.	: C7H13NO2
Mol.Wt.	: 143.2
Inv. Status	: In Stock
Rel. CAS No	: 1259519-60-2 (HCl salt)

Afatinib Impurity 26

SZ CAT No:	: SZ-A054045
CAS No	: 314771-88-5
Mol.F.	: C18H14ClFN4O4
Mol.Wt.	: 404.8
Inv. Status	: Custom Synthesis

Afatinib Impurity 27

SZ CAT No:	: SZ-A054046
CAS No	: 618061-76-0
Mol.F.	: C24H27ClFN4O6P
Mol.Wt.	: 552.9
Inv. Status	: In Stock

Afatinib Impurity 28

SZ CAT No:	: SZ-A054047
CAS No	: NA
Mol.F.	: C22H20ClFN4O4
Mol.Wt.	: 458.9
Inv. Status	: Custom Synthesis

Afatinib Impurity 29

SZ CAT No:	: SZ-A054048
CAS No	: NA
Mol.F.	: C22H23ClFN4O6P
Mol.Wt.	: 524.9
Inv. Status	: Custom Synthesis

Afatinib Impurity 3

SZ CAT No:	: SZ-A054015
CAS No	: 2475094-96-1
Mol.F.	: C14H7ClF2N4O2
Mol.Wt.	: 336.7
Inv. Status	: Custom Synthesis

Afatinib Impurity 32

SZ CAT No:	: SZ-A054051
CAS No	: 2323570-72-3
Mol.F.	: C24H27ClFN5O4
Mol.Wt.	: 504.0
Inv. Status	: In Stock

Afatinib Impurity 4

SZ CAT No:	: SZ-A054016
CAS No	: 2512206-82-3
Mol.F.	: C14H7Cl2FN4O2
Mol.Wt.	: 353.1
Inv. Status	: In Stock

Afatinib Impurity 5

SZ CAT No:	: SZ-A054017
CAS No	: 179552-74-0
Mol.F.	: C15H10ClFN4O3
Mol.Wt.	: 348.7
Inv. Status	: Custom Synthesis
Rel. CAS No	: 1012057-48-5 (HCl salt)

Afatinib Impurity 6

SZ CAT No:	: SZ-A054018
CAS No	: 2413212-07-2
Mol.F.	: C18H17FN4O2
Mol.Wt.	: 340.4
Inv. Status	: Custom Synthesis

Afatinib Impurity 7

SZ CAT No:	: SZ-A054019
CAS No	: 2413212-08-3
Mol.F.	: C18H18N4O2
Mol.Wt.	: 322.4
Inv. Status	: Custom Synthesis

Afatinib Impurity 8

SZ CAT No:	: SZ-A054020
CAS No	: 2413212-09-4
Mol.F.	: C18H17ClN4O2
Mol.Wt.	: 356.8
Inv. Status	: Custom Synthesis

Afatinib Impurity 9

SZ CAT No:	: SZ-A054021
CAS No	: 2413212-10-7
Mol.F.	: C30H36ClFN6O5
Mol.Wt.	: 615.1
Inv. Status	: Custom Synthesis

Afatinib Impurity A

SZ CAT No:	: SZ-A054002
CAS No	: 402855-07-6
Mol.F.	: C18H14ClFN4O4
Mol.Wt.	: 404.8
Inv. Status	: In Stock

Afatinib Impurity B

SZ CAT No:	: SZ-A054003
CAS No	: 314771-76-1
Mol.F.	: C18H16ClFN4O2
Mol.Wt.	: 374.8
Inv. Status	: In Stock
Rel. CAS No	: 2047333-82-2 (HCl salt)

Afatinib Impurity C

SZ CAT No:	: SZ-A054004
CAS No	: 945553-91-3
Mol.F.	: C24H25ClFN5O3
Mol.Wt.	: 486.0
Inv. Status	: In Stock

Afatinib Impurity D

SZ CAT No:	: SZ-A054005
CAS No	: 1680184-59-1
Mol.F.	: C24H25ClFN5O3
Mol.Wt.	: 485.9
Inv. Status	: Limited Stock

Afatinib Impurity E

SZ CAT No:	: SZ-A054006
CAS No	: 2223677-63-0
Mol.F.	: C24H25Cl2N5O3
Mol.Wt.	: 502.4
Inv. Status	: Custom Synthesis

Afatinib Impurity F

SZ CAT No:	: SZ-A054007
CAS No	: 2223677-62-9
Mol.F.	: C24H25F2N5O3
Mol.Wt.	: 469.5
Inv. Status	: Custom Synthesis

Afatinib Impurity G

SZ CAT No:	: SZ-A054008
CAS No	: NA
Mol.F.	: C24H25ClFN5O3
Mol.Wt.	: 486.0
Inv. Status	: Custom Synthesis

Afatinib Impurity I

SZ CAT No:	: SZ-A054010
CAS No	: NA
Mol.F.	: C22H19BrClFN4O3
Mol.Wt.	: 521.8
Inv. Status	: Custom Synthesis

Afatinib Impurity J

SZ CAT No:	: SZ-A054011
CAS No	: 1456696-14-2
Mol.F.	: C18H22N4O4
Mol.Wt.	: 358.4
Inv. Status	: Custom Synthesis

Afatinib Nitroso Impurity 1

SZ CAT No:	: SZ-A054040
CAS No	: NA
Mol.F.	: C24H24ClFN6O4
Mol.Wt.	: 514.9
Inv. Status	: Inquire

Afatinib N-Oxide

SZ CAT No:	: SZ-A054013
CAS No	: 2413212-11-8
Mol.F.	: C24H25ClFN5O4
Mol.Wt.	: 501.9
Inv. Status	: In Stock

Afatinib Sulfonic Acid Analog

SZ CAT No:	: SZ-A054037
CAS No	: 2283295-16-7
Mol.F.	: C24H27ClFN5O6S
Mol.Wt.	: 568.0
Inv. Status	: Custom Synthesis

N-Desmethyl Afatinib

SZ CAT No:	: SZ-A054012
CAS No	: 2413212-13-0
Mol.F.	: C23H23ClFN5O3
Mol.Wt.	: 471.9
Inv. Status	: Custom Synthesis

Afatinib D4

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