Methotrexate Hydrate EP Impurity B

N° de SZ CAT:	SZ-M019003
Número CAS	1217459-90-9
Mol.F.	C19H20N8O5 : H2O
Peso Molecular	440.4 : 18.0
Status de Fatura	In Stock
Rel. CAS No	54-62-6 (free base)

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Nome Químico: (2S)-2-[[4-[[(2,4-diaminopteridin-6-yl)methyl]amino]benzoyl]amino]pentanedioic acid hydrate (as per EP) ; (S)-2-{4-[(2,4-diaminopteridin-6-yl)methylamino]benzamido}pentanedioic acid hydrate (as per USP)

Sinônimo: Methotrexate USP Related Compound B ; (4-Aminofolic acid, Aminopterin (EP))

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Sorrisos: NC1=NC(N)=C2C(N=CC(CNC3=CC=C(C(N[C@]([H])(C(O)=O)CCC(O)=O)=O)C=C3)=N2)=N1.O

Identification and Quantitation of Impurities in Methotrexate
dulal c. chatterji, altice g. frazier, and joseph f. gallell
Journal of Pharmaceutical Sciences Volume 67, Issue 5, May 1978, Pages 622-624

determination of methotrexate and its major metabolite, 7_hydroxymethotrexate, using capillary zone electrophoresis and laser-induced fluorescence detection
mark c. roach, philippe gozel and richard n. zare
Journal of Chromatography, 426 (1988) 129-140

Analytical methodologies for determination of methotrexate and its metabolites in pharmaceutical, biological and environmental samples
Forough Karami , Sara Ranjbar , Younes Ghasemi , Manica Negahdaripour
Journal of Pharmaceutical Analysis 9 (2019) 373-391

Perspectives of Methotrexate-Based Radioagents for Application in Nuclear Medicine
Paweł Krzysztof Halik,* Przemysław Kozmin ́ ski, and Ewa Gniazdowska
Mol. Pharmaceutics 2021, 18, 1, 33–43

Methotrexate Hydrate EP Impurity B is chemically (2S)-2-[[4-[[(2,4-diaminopteridin-6-yl)methyl]amino]benzoyl]amino]pentanedioic acid hydrate (as per EP) ; (S)-2-{4-[(2,4-diaminopteridin-6-yl)methylamino]benzamido}pentanedioic acid hydrate (as per USP). It is also known as Methotrexate USP Related Compound B ; (4-Aminofolic acid, Aminopterin (EP)). Methotrexate Hydrate EP Impurity B is supplied with detailed characterization data compliant with regulatory guideline. Methotrexate Hydrate EP Impurity B can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Methotrexate.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

Methotrexate Hydrate EP Impurity B

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