Methotrexate EP Impurity H

N° de SZ CAT:	SZ-M019009
Número CAS	67022-39-3
Mol.F.	C21H24N8O5
Peso Molecular	468.5
Status de Fatura	In Stock

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Nome Químico: (2S)-2-[[4-[[(2,4-diaminopteridin-6-yl)methyl]methylamino]benzoyl]amino]-5-methoxy-5-oxopentanoic acid (as per EP) ; (S)-2-(4-{[(2,4-Diaminopteridin-6-yl)methyl](methyl)amino}benzamido)-5-methoxy-5-oxopentanoic acid (as per USP)

Sinônimo: Methotrexate 5-Methyl Ester (EP) ; Methotrexate USP Related Compound H

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Sorrisos: NC1=NC(N=CC(CN(C)C2=CC=C(C(N[C@@](CCC(OC)=O)(C(O)=O)[H])=O)C=C2)=N3)=C3C(N)=N1

Identification and Quantitation of Impurities in Methotrexate
dulal c. chatterji, altice g. frazier, and joseph f. gallell
Journal of Pharmaceutical Sciences Volume 67, Issue 5, May 1978, Pages 622-624

determination of methotrexate and its major metabolite, 7_hydroxymethotrexate, using capillary zone electrophoresis and laser-induced fluorescence detection
mark c. roach, philippe gozel and richard n. zare
Journal of Chromatography, 426 (1988) 129-140

Analytical methodologies for determination of methotrexate and its metabolites in pharmaceutical, biological and environmental samples
Forough Karami , Sara Ranjbar , Younes Ghasemi , Manica Negahdaripour
Journal of Pharmaceutical Analysis 9 (2019) 373-391

Perspectives of Methotrexate-Based Radioagents for Application in Nuclear Medicine
Paweł Krzysztof Halik,* Przemysław Kozmin ́ ski, and Ewa Gniazdowska
Mol. Pharmaceutics 2021, 18, 1, 33–43

Methotrexate EP Impurity H is chemically (2S)-2-[[4-[[(2,4-diaminopteridin-6-yl)methyl]methylamino]benzoyl]amino]-5-methoxy-5-oxopentanoic acid (as per EP) ; (S)-2-(4-{[(2,4-Diaminopteridin-6-yl)methyl](methyl)amino}benzamido)-5-methoxy-5-oxopentanoic acid (as per USP). It is also known as Methotrexate 5-Methyl Ester (EP) ; Methotrexate USP Related Compound H. Methotrexate EP Impurity H is supplied with detailed characterization data compliant with regulatory guideline. Methotrexate EP Impurity H can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Methotrexate.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

Methotrexate EP Impurity H

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N° de SZ CAT:	: SZ-M019005
Número CAS	: 5623-18-7
Mol.F.	: C15H14N6O3
Peso Molecular	: 326.3
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-M019001
Número CAS	: 1212284-68-8
Mol.F.	: C20H22N8O5 : 2(H2O)
Peso Molecular	: 454.4 : 2(18.0)
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-M019002
Número CAS	: 945-24-4
Mol.F.	: C7H8N6O
Peso Molecular	: 192.1
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-M019003
Número CAS	: 1217459-90-9
Mol.F.	: C19H20N8O5 : H2O
Peso Molecular	: 440.4 : 18.0
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-M019004
Número CAS	: 2410-93-7
Mol.F.	: C20H21N7O6
Peso Molecular	: 455.4
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-M019006
Número CAS	: 19741-14-1
Mol.F.	: C15H15N7O2
Peso Molecular	: 325.3
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-M019007
Número CAS	: 51865-79-3
Mol.F.	: C20H22N8O5
Peso Molecular	: 454.4
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-M019008
Número CAS	: 2519848-42-9
Mol.F.	: C28H29N9O6
Peso Molecular	: 587.6
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-M019009
Número CAS	: 67022-39-3
Mol.F.	: C21H24N8O5
Peso Molecular	: 468.5
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-M019010
Número CAS	: 66147-29-3
Mol.F.	: C21H24N8O5
Peso Molecular	: 468.5
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-M019011
Número CAS	: 34378-65-9
Mol.F.	: C22H26N8O5
Peso Molecular	: 482.5
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-M019012
Número CAS	: 4271-30-1
Mol.F.	: C12H14N2O5
Peso Molecular	: 266.3
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-M019013
Número CAS	: 52980-68-4
Mol.F.	: C13H16N2O5
Peso Molecular	: 280.3
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-M019014
Número CAS	: 5939-37-7
Mol.F.	: C20H22N8O6
Peso Molecular	: 470.4
Status de Fatura	: Limited Stock

N° de SZ CAT:	: SZ-M019015
Número CAS	: 1189252-22-9
Mol.F.	: C14H12N6O3 : H2O
Peso Molecular	: 312.3 : 18.0
Status de Fatura	: Limited Stock

N° de SZ CAT:	: SZ-M019018
Número CAS	: 73978-41-3
Mol.F.	: C7H8N6O : HCl
Peso Molecular	: 192.2 : 36.5
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-M019D01
Número CAS	: 432545-63-6
Mol.F.	: C20H19D3N8O5
Peso Molecular	: 457.5
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-M019019
Número CAS	: 71074-44-7
Mol.F.	: C22H27N9O4
Peso Molecular	: 481.5
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-M019020
Número CAS	: 1127-93-1
Mol.F.	: C6H6N6
Peso Molecular	: 162.2
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-M019021
Número CAS	: 708-74-7
Mol.F.	: C7H8N6
Peso Molecular	: 176.2
Status de Fatura	: Custom Synthesis

Methotrexate EP Impurity H

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N° de SZ CAT:	: SZ-M019022
Número CAS	: 57444-70-9
Mol.F.	: C12H12ClNO5
Peso Molecular	: 285.7
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-M019023
Número CAS	: 2378-95-2
Mol.F.	: C17H24N2O5
Peso Molecular	: 336.4
Status de Fatura	: Under Synthesis

N° de SZ CAT:	: SZ-M019024
Número CAS	: 1029980-84-4
Mol.F.	: C17H24N2O5
Peso Molecular	: 336.4
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-M019025
Número CAS	: 51865-66-8
Mol.F.	: C17H24N2O5
Peso Molecular	: 336.4
Status de Fatura	: Under Synthesis

N° de SZ CAT:	: SZ-M019026
Número CAS	: 54-62-6
Mol.F.	: C19H20N8O5
Peso Molecular	: 440.4
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-M019027
Número CAS	: NA
Mol.F.	: C25H31N3O6
Peso Molecular	: 469.5
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-M019016
Número CAS	: 119843-02-6
Mol.F.	: C12H13NO6
Peso Molecular	: 267.2
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-M019028
Número CAS	: NA
Mol.F.	: C19H19N9O6
Peso Molecular	: 469.4
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-M019029
Número CAS	: NA
Mol.F.	: C13H15N3O6
Peso Molecular	: 309.3
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-M019030
Número CAS	: 60388-53-6
Mol.F.	: C20H22N8O5
Peso Molecular	: 454.4
Status de Fatura	: Custom Synthesis