Sorafenib Hydrochloride

SZ CAT No:	SZ-S012018
CAS No	1199618-57-9
Mol.F.	C21H16ClF3N4O3 : HCl
Mol.Wt.	464.8 : 36.5
Inv. Status	Custom Synthesis
Rel. CAS No	284461-73-0 (free base) ; SZ-S012019 (HBr salt) ; 1280217-32-4 (sulfate salt) ; 475207-59-1 (tosylate salt)

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Chemical Name: 4-[4-[[[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl]amino]phenoxy]-N-methylpyridine-2-carboxamide Hydrochloride (as per EP);4-(4-{3-[4-Chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)-N2-methylpyridine-2-carboxamide mono (Hydrochloride) (as per USP)

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: CNC(C1=CC(OC2=CC=C(NC(NC3=CC=C(Cl)C(C(F)(F)F)=C3)=O)C=C2)=CC=N1)=O.Cl

Fragmentation pathways and differentiation of positional isomers of sorafenib and structural analogues by ESI-IT-MSn and ESI-Q-TOF-MS/MS coupled with DFT calculations
By Yu, Dandan; Liang, Xianrui
From Journal of Mass Spectrometry (2018), 53(7), 579-589.

Box-Behnken design based statistical modelling for optimization of U PLC-MS/MS method for analysis of sorafenib in bulk and tablets
By Wanii, Tanveer A.; Alanazi, Amer M.; Zargar, Seema; Ahmad, Ajaz; Drawish, Ibrahim A.
From Journal of Computational and Theoretical Nanoscience (2015), 12(10), 3598-3604

Determination of sorafenib in human plasma by HPLC
By Liu, Weifeng; Cao, Pengjian; Zhang, Chunfang; Xia, Dongxia; Che, Shujuan; Lou, Dan; Qiu, Xiangjun
From Zhongguo Xiandai Yingyong Yaoxue (2015), 32(2), 182-185

Sorafenib Hydrochloride is chemically 4-[4-[[[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl]amino]phenoxy]-N-methylpyridine-2-carboxamide Hydrochloride (as per EP);4-(4-{3-[4-Chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)-N2-methylpyridine-2-carboxamide mono (Hydrochloride) (as per USP). Sorafenib Hydrochloride is supplied with detailed characterization data compliant with regulatory guideline. Sorafenib Hydrochloride can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Sorafenib.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

Sorafenib Hydrochloride

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SZ CAT No:	: SZ-S012001
CAS No	: 284461-73-0
Mol.F.	: C21H16ClF3N4O3
Mol.Wt.	: 464.8
Inv. Status	: Custom Synthesis
Rel. CAS No	: 475207-59-1 (Tosylate salt) ; 1199618-57-9 (HCl salt) ; 1199618-58-0 (HBr salt) ; 1280217-32-4 (Sulfate salt)

SZ CAT No:	: SZ-S012002
CAS No	: 2004659-85-0
Mol.F.	: C13H12N2O2
Mol.Wt.	: 228.3
Inv. Status	: In Stock

SZ CAT No:	: SZ-S012004
CAS No	: 18585-06-3
Mol.F.	: C10H9ClF3NO2
Mol.Wt.	: 267.6
Inv. Status	: In Stock

SZ CAT No:	: SZ-S012005
CAS No	: 1285533-84-7
Mol.F.	: C21H17F3N4O3
Mol.Wt.	: 430.4
Inv. Status	: In Stock
Rel. CAS No	: 1285534-09-9 (HCl salt) ; 1285534-33-9 (Tosylate)

SZ CAT No:	: SZ-S012006
CAS No	: 320-51-4
Mol.F.	: C7H5ClF3N
Mol.Wt.	: 195.6
Inv. Status	: In Stock
Rel. CAS No	: 53313-44-3 (HCl salt)

SZ CAT No:	: SZ-S012008
CAS No	: 2206827-14-5
Mol.F.	: C17H19N3O4
Mol.Wt.	: 329.4
Inv. Status	: In Stock

SZ CAT No:	: SZ-S012009
CAS No	: 2206827-12-3
Mol.F.	: C16H17N3O4
Mol.Wt.	: 315.3
Inv. Status	: In Stock

SZ CAT No:	: SZ-S012017
CAS No	: 284670-98-0
Mol.F.	: C27H24N6O5
Mol.Wt.	: 512.5
Inv. Status	: In Stock

SZ CAT No:	: SZ-S012022
CAS No	: 1431697-81-2
Mol.F.	: C21H16ClF3N4O3
Mol.Wt.	: 464.8
Inv. Status	: In Stock

SZ CAT No:	: SZ-S012023
CAS No	: 583840-03-3
Mol.F.	: C21H16ClF3N4O4
Mol.Wt.	: 480.8
Inv. Status	: In Stock

SZ CAT No:	: SZ-S012024
CAS No	: 370-50-3
Mol.F.	: C15H8Cl2F6N2O
Mol.Wt.	: 417.1
Inv. Status	: In Stock

SZ CAT No:	: SZ-S012025
CAS No	: 2204442-52-2
Mol.F.	: C27H23N5O6
Mol.Wt.	: 513.5
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-S012026
CAS No	: 284462-37-9
Mol.F.	: C13H13N3O2
Mol.Wt.	: 243.3
Inv. Status	: In Stock

SZ CAT No:	: SZ-S012027
CAS No	: 573673-43-5
Mol.F.	: C21H15ClF3N3O4
Mol.Wt.	: 465.8
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-S012028
CAS No	: 583840-04-4
Mol.F.	: C20H14ClF3N4O4
Mol.Wt.	: 466.8
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-S012030
CAS No	: 1129683-88-0
Mol.F.	: C14H14N4O3
Mol.Wt.	: 286.3
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-S012031
CAS No	: 475207-59-1
Mol.F.	: C21H16ClF3N4O3 : C7H8O3S
Mol.Wt.	: 464.8 : 172.2
Inv. Status	: In Stock
Rel. CAS No	: 284461-73-0 (free base) ; 1199618-57-9 (HCl salt) ; 1199618-58-0 (HBr salt) ; 1280217-32-4 (Sulfate salt)

SZ CAT No:	: SZ-S012032
CAS No	: 220000-87-3
Mol.F.	: C7H7ClN2O
Mol.Wt.	: 170.6
Inv. Status	: In Stock
Rel. CAS No	: 882167-77-3 (HCl salt)

SZ CAT No:	: SZ-S012033
CAS No	: 2004659-84-9
Mol.F.	: C14H13N3O3
Mol.Wt.	: 271.3
Inv. Status	: In Stock

SZ CAT No:	: SZ-S012034
CAS No	: 1129683-83-5
Mol.F.	: C14H10ClF3N2O2
Mol.Wt.	: 330.7
Inv. Status	: In Stock

SZ CAT No:	: SZ-S012035
CAS No	: 284461-74-1
Mol.F.	: C20H14ClF3N4O3
Mol.Wt.	: 450.8
Inv. Status	: Limited Stock
Rel. CAS No	: 943024-27-9 (Tosylate)

SZ CAT No:	: SZ-S012036
CAS No	: 2514724-45-7
Mol.F.	: C25H14Cl2F4N2O
Mol.Wt.	: 505.3
Inv. Status	: In Stock

SZ CAT No:	: SZ-S012037
CAS No	: 871555-75-8
Mol.F.	: C14H9ClF3NO2
Mol.Wt.	: 315.7
Inv. Status	: In Stock

SZ CAT No:	: SZ-S012038
CAS No	: 6192-52-5
Mol.F.	: C7H8O3S : H2O
Mol.Wt.	: 172.2 : 18.0
Inv. Status	: In Stock
Rel. CAS No	: 104-15-4 (anhydrous)

SZ CAT No:	: SZ-S012040
CAS No	: 284462-82-4
Mol.F.	: C14H15N3O2
Mol.Wt.	: 257.3
Inv. Status	: In Stock

SZ CAT No:	: SZ-S012D01
CAS No	: 1130115-44-4
Mol.F.	: C21H13D3ClF3N4O3
Mol.Wt.	: 467.9
Inv. Status	: In Stock

SZ CAT No:	: SZ-S012D02
CAS No	: 1207560-07-3
Mol.F.	: C21H12D4ClF3N4O3
Mol.Wt.	: 468.9
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-S012D03
CAS No	: 1210608-86-8
Mol.F.	: C2013CH13D3ClF3N4O3
Mol.Wt.	: 468.8
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-S012041
CAS No	: 1012058-78-4
Mol.F.	: C20H13ClF3N3O4
Mol.Wt.	: 451.8
Inv. Status	: In Stock

SZ CAT No:	: SZ-S012042
CAS No	: 6144-78-1
Mol.F.	: C7H8N2O
Mol.Wt.	: 136.2
Inv. Status	: Custom Synthesis