Quetiapine Carboxylate Impurity

SZ CAT No:	SZ-Q001029
CAS No	1011758-00-1
Mol.F.	C22H25N3O4S
Mol.Wt.	427.5
Inv. Status	Custom Synthesis

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SynZeal will update these details as per new development or finding in product specification without further noticed.

Chemical Name: 4-Dibenzothiazepin-11-yl-1-piperazinecarboxylic acid 2-(2-hydroxyethoxy) ethyl ester

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: O=C(OCCOCCO)N(CC1)CCN1C2=NC(C=CC=C3)=C3SC4=C2C=CC=C4

Identification and Characterization of Potential Impurities of Quetiapine Fumarate
Elżbieta U. Stolarczyk,Łukasz Kaczmarek,Kamil Eksanow,Marek Kubiszewski,Magdalena Glice &Andrzej Kutner
Pharmaceutical Development and Technology Volume 14, 2009 - Issue 1 Pages 29-39

An Improved and Single Pot Process for the Production of Quetiapine Hemifumarate Substantially Free from Potential Impurities
Navnath C. Niphade, Anil C. Mali, Bhushan S. Pandit, Kunal M. Jagtap, Sanjay A. Jadhav, Madhukar N. Jachak, and Vijayavitthal T. Mathad
Org. Process Res. Dev. 2009, 13, 4, 792–797

Stability indicating fast LC method for determination of quetiapine fumarate related substances in bulk and pharmaceutical formulation
R.Narendra Kumar, *G.Nageswara Rao, P.Y.Naidu
Der Pharmacia Lettre, 2011, 3(3): 457-469

Quetiapine Carboxylate Impurity is chemically 4-Dibenzothiazepin-11-yl-1-piperazinecarboxylic acid 2-(2-hydroxyethoxy) ethyl ester . Quetiapine Carboxylate Impurity is supplied with detailed characterization data compliant with regulatory guideline. Quetiapine Carboxylate Impurity can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Quetiapine.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

Related products

Quetiapine Hemifumarate

SZ CAT No:	: SZ-Q001001
CAS No	: 111974-72-2
Mol.F.	: C21H25N3O2S : 1/2(C4H4O4)
Mol.Wt.	: 383.5 : 1/2(116.1)
Inv. Status	: In Stock
Rel. CAS No	: 111974-69-7 (free base)

Quetiapine EP Impurity A

SZ CAT No:	: SZ-Q001002
CAS No	: 844639-07-2
Mol.F.	: C23H27N3O3S
Mol.Wt.	: 425.5
Inv. Status	: In Stock

Quetiapine EP Impurity B (dihydrochloride salt)

SZ CAT No:	: SZ-Q001003
CAS No	: 111974-74-4
Mol.F.	: C17H17N3S : 2(HCl)
Mol.Wt.	: 295.4 : 2(36.5)
Inv. Status	: In Stock
Rel. CAS No	: 5747-48-8 (free base)

Quetiapine EP Impurity C

SZ CAT No:	: SZ-Q001004
CAS No	: 1798840-31-9
Mol.F.	: C40H42N6O3S2
Mol.Wt.	: 718.9
Inv. Status	: In Stock

Quetiapine EP Impurity D

SZ CAT No:	: SZ-Q001005
CAS No	: NA
Mol.F.	: C30H24N4S2 : HCl
Mol.Wt.	: 504.7 : 36.5
Inv. Status	: Out of Stock
Rel. CAS No	: 945668-94-0 (free base)
Rel. CAT No	: SZ-Q001087 ,

Quetiapine EP Impurity E

SZ CAT No:	: SZ-Q001006
CAS No	: 1371638-05-9
Mol.F.	: C40H44N6O2S2
Mol.Wt.	: 704.9
Inv. Status	: Out of Stock

Quetiapine EP Impurity F

SZ CAT No:	: SZ-Q001007
CAS No	: 848814-27-7
Mol.F.	: C21H27N3O3S
Mol.Wt.	: 401.5
Inv. Status	: In Stock

Quetiapine EP Impurity G

SZ CAT No:	: SZ-Q001008
CAS No	: 3159-07-7
Mol.F.	: C13H9NOS
Mol.Wt.	: 227.3
Inv. Status	: In Stock

Quetiapine EP Impurity H

SZ CAT No:	: SZ-Q001009
CAS No	: 1076199-40-0
Mol.F.	: C21H25N3O3S
Mol.Wt.	: 399.5
Inv. Status	: In Stock

Quetiapine EP Impurity I (2HCl Salt)

SZ CAT No:	: SZ-Q001010
CAS No	: 329218-14-6
Mol.F.	: C19H21N3OS : 2HCl
Mol.Wt.	: 339.5 : 2(36.5)
Inv. Status	: In Stock
Rel. CAS No	: 329216-67-3 (free base)

Quetiapine EP Impurity J

SZ CAT No:	: SZ-Q001011
CAS No	: 1356906-17-6
Mol.F.	: C25H33N3O4S
Mol.Wt.	: 471.6
Inv. Status	: In Stock
Rel. CAS No	: 1825392-15-1 (2HCl salt) ; 2470243-24-2 (Fumarate Salt)

Quetiapine EP Impurity K

SZ CAT No:	: SZ-Q001012
CAS No	: 1371638-10-6
Mol.F.	: C23H29N3O4S
Mol.Wt.	: 443.6
Inv. Status	: In Stock

Quetiapine EP Impurity L

SZ CAT No:	: SZ-Q001013
CAS No	: 1371638-11-7
Mol.F.	: C21H24ClN3O2S
Mol.Wt.	: 418
Inv. Status	: In Stock

Quetiapine EP Impurity N

SZ CAT No:	: SZ-Q001014
CAS No	: 1800291-86-4
Mol.F.	: C29H41N5O3S
Mol.Wt.	: 539.7
Inv. Status	: In Stock

Quetiapine EP Impurity O

SZ CAT No:	: SZ-Q001015
CAS No	: 844639-06-1
Mol.F.	: C40H39N3O2S
Mol.Wt.	: 625.8
Inv. Status	: In Stock

Quetiapine EP Impurity P HCl Salt

SZ CAT No:	: SZ-Q001016
CAS No	: NA
Mol.F.	: C19H21N3S : HCl
Mol.Wt.	: 323.5 : 36.5
Inv. Status	: In Stock

Quetiapine EP Impurity Q

SZ CAT No:	: SZ-Q001017
CAS No	: NA
Mol.F.	: C25H34N3O4S : I
Mol.Wt.	: 472.6 : 126.9
Inv. Status	: In Stock

Quetiapine Impurity R

SZ CAT No:	: SZ-Q001018
CAS No	: 2459-05-4
Mol.F.	: C6H8O4
Mol.Wt.	: 144.1
Inv. Status	: In Stock

Quetiapine EP Impurity S HCl Salt

SZ CAT No:	: SZ-Q001019
CAS No	: 329218-11-3
Mol.F.	: C21H25N3O3S : 2HCl
Mol.Wt.	: 399.5 : 2(36.5)
Inv. Status	: Limited Stock
Rel. CAS No	: 329216-63-9 (free base)

Quetiapine EP Impurity T

SZ CAT No:	: SZ-Q001020
CAS No	: 5747-46-6
Mol.F.	: C17H16N2OS
Mol.Wt.	: 296.4
Inv. Status	: In Stock

Quetiapine EP Impurity U

SZ CAT No:	: SZ-Q001021
CAS No	: 5786-26-5
Mol.F.	: C13H10N2S
Mol.Wt.	: 226.3
Inv. Status	: In Stock

Quetiapine EP Impurity V

SZ CAT No:	: SZ-Q001022
CAS No	: 2204369-14-0
Mol.F.	: C21H25N3O2
Mol.Wt.	: 351.5
Inv. Status	: In Stock

Quetiapine EP Impurity W

SZ CAT No:	: SZ-Q001023
CAS No	: 1800608-95-0
Mol.F.	: C34H32N4O2S2
Mol.Wt.	: 592.8
Inv. Status	: In Stock

Quetiapine Ethyl Ether (Fumarate)

SZ CAT No:	: SZ-Q001024
CAS No	: 2470241-46-2
Mol.F.	: C23H29N3O2S : C4H4O4
Mol.Wt.	: 411.6 : 116.1
Inv. Status	: Custom Synthesis
Rel. CAS No	: 1011758-06-7 (free base)

Quetiapine HEEP Impurity

SZ CAT No:	: SZ-Q001025
CAS No	: 13349-82-1
Mol.F.	: C8H18N2O2
Mol.Wt.	: 174.2
Inv. Status	: In Stock

Quetiapine Sulfone (HCl Salt)

SZ CAT No:	: SZ-Q001026
CAS No	: 329218-13-5
Mol.F.	: C21H25N3O4S : HCl
Mol.Wt.	: 415.5 : 36.5
Inv. Status	: Custom Synthesis
Rel. CAS No	: 329216-65-1 (free base)

Quetiapine 7-Hydroxy Impurity

SZ CAT No:	: SZ-Q001027
CAS No	: NA
Mol.F.	: C21H25N3O3S : HCl
Mol.Wt.	: 399.5 : 36.5
Inv. Status	: Custom Synthesis
Rel. CAS No	: 139079-39-3 (free base) ; 329218-08-8 (2HCl salt)

Quetiapine 7-Hydroxy Sulfoxide

SZ CAT No:	: SZ-Q001028
CAS No	: 1185170-04-0
Mol.F.	: C21H25N3O4S
Mol.Wt.	: 415.5
Inv. Status	: Custom Synthesis

Quetiapine Carboxylate Impurity

SZ CAT No:	: SZ-Q001029
CAS No	: 1011758-00-1
Mol.F.	: C22H25N3O4S
Mol.Wt.	: 427.5
Inv. Status	: Custom Synthesis

Quetiapine 11 Chloro Impurity

SZ CAT No:	: SZ-Q001030
CAS No	: 13745-86-3
Mol.F.	: C13H8ClNS
Mol.Wt.	: 245.7
Inv. Status	: In Stock

Quetiapine DBTC Sulfone

SZ CAT No:	: SZ-Q001031
CAS No	: 52264-22-9
Mol.F.	: C13H8ClNO2S
Mol.Wt.	: 277.7
Inv. Status	: Custom Synthesis

Quetiapine DBTO Sulfone

SZ CAT No:	: SZ-Q001032
CAS No	: 22871-33-6
Mol.F.	: C13H9NO3S
Mol.Wt.	: 259.3
Inv. Status	: In Stock

Quetiapine DBTP 7-Hydroxy Metabolite

SZ CAT No:	: SZ-Q001033
CAS No	: 232597-73-8
Mol.F.	: C17H17N3OS
Mol.Wt.	: 311.4
Inv. Status	: Custom Synthesis
Rel. CAS No	: 1347387-95-4 (HCl salt) ; 1397181-83-7 (2HCl salt)

Quetiapine DBTP N-Methyl Impurity

SZ CAT No:	: SZ-Q001034
CAS No	: 1977-09-9
Mol.F.	: C18H19N3S
Mol.Wt.	: 309.4
Inv. Status	: In Stock

Quetiapine Diether Alcohol (HCl salt)

SZ CAT No:	: SZ-Q001035
CAS No	: NA
Mol.F.	: C23H29N3O3S . HCl
Mol.Wt.	: 427.6 : 36.5
Inv. Status	: In Stock
Rel. CAS No	: 329216-69-5 (free base) ; 329218-16-8 (2HCl salt)

Quetiapine Dipiperazine Monoether Impurity

SZ CAT No:	: SZ-Q001036
CAS No	: NA
Mol.F.	: C27H37N5O2S : HCl
Mol.Wt.	: 495.7 : 36.5
Inv. Status	: Custom Synthesis
Rel. CAS No	: 2206606-92-8 (free base)

2-Nitro-4'-Chlorodiphenyl Sulfide

SZ CAT No:	: SZ-Q001037
CAS No	: 6764-10-9
Mol.F.	: C12H8ClNO2S
Mol.Wt.	: 265.7
Inv. Status	: Custom Synthesis

Quetiapine Related Compound (Phenyl-2-(phenyl thio)phenyl carbamide)

SZ CAT No:	: SZ-Q001038
CAS No	: 111974-73-3
Mol.F.	: C19H15NO2S
Mol.Wt.	: 321.4
Inv. Status	: In Stock

Quetiapine Impurity (2-Aminodiphenyl Sulfide)

SZ CAT No:	: SZ-Q001039
CAS No	: 1134-94-7
Mol.F.	: C12H11NS
Mol.Wt.	: 201.3
Inv. Status	: In Stock, 3-4 days for Dispatch
Rel. CAS No	: 6764-13-2 (HCl salt)

Quetiapine

SZ CAT No:	: SZ-Q001040
CAS No	: 111974-69-7
Mol.F.	: C21H25N3O2S
Mol.Wt.	: 383.5
Inv. Status	: Custom Synthesis

Quetiapine Impurity 1

SZ CAT No:	: SZ-Q001042
CAS No	: 2749415-72-1
Mol.F.	: C24H33N3O2S
Mol.Wt.	: 427.6
Inv. Status	: Custom Synthesis

Quetiapine Impurity 2

SZ CAT No:	: SZ-Q001043
CAS No	: 2748292-45-5
Mol.F.	: C22H27N3O4S
Mol.Wt.	: 429.5
Inv. Status	: Custom Synthesis

Quetiapine Impurity 3

SZ CAT No:	: SZ-Q001044
CAS No	: 102893-57-2
Mol.F.	: C25H20N2OS2
Mol.Wt.	: 428.6
Inv. Status	: In Stock

Quetiapine Impurity 5

SZ CAT No:	: SZ-Q001045
CAS No	: 837383-82-1
Mol.F.	: C17H19N3OS
Mol.Wt.	: 313.4
Inv. Status	: In Stock

Quetiapine Impurity 8

SZ CAT No:	: SZ-Q001046
CAS No	: 1126432-68-5
Mol.F.	: C30H28N4O2S2
Mol.Wt.	: 540.7
Inv. Status	: In Stock

Quetiapine Hemifumarate Ester

SZ CAT No:	: SZ-Q001047
CAS No	: 2209488-73-1
Mol.F.	: C25H27N3O5S
Mol.Wt.	: 481.6
Inv. Status	: Custom Synthesis

Quetiapine 2-Hydroxy Impurity

SZ CAT No:	: SZ-Q001048
CAS No	: 1241800-24-7
Mol.F.	: C21H27N3O3S
Mol.Wt.	: 401.5
Inv. Status	: Limited Stock

Quetiapine Impurity 6

SZ CAT No:	: SZ-Q001049
CAS No	: 1514918-27-4
Mol.F.	: C21H25N3O4S
Mol.Wt.	: 415.5
Inv. Status	: Custom Synthesis

Quetiapine Impurity 7

SZ CAT No:	: SZ-Q001050
CAS No	: 2206606-97-3
Mol.F.	: C21H25N3O5S
Mol.Wt.	: 431.5
Inv. Status	: Custom Synthesis

Quetiapine Impurity 9

SZ CAT No:	: SZ-Q001051
CAS No	: 2206606-99-5
Mol.F.	: C22H26N4OS
Mol.Wt.	: 394.5
Inv. Status	: In Stock

Quetiapine Impurity 10

SZ CAT No:	: SZ-Q001052
CAS No	: 2206135-48-8
Mol.F.	: C14H11NOS
Mol.Wt.	: 241.3
Inv. Status	: Custom Synthesis

Quetiapine Impurity 11

SZ CAT No:	: SZ-Q001053
CAS No	: 2206607-04-5
Mol.F.	: C15H13NOS
Mol.Wt.	: 255.3
Inv. Status	: Custom Synthesis

Quetiapine Impurity 12

SZ CAT No:	: SZ-Q001054
CAS No	: 2206135-50-2
Mol.F.	: C25H18N2S2
Mol.Wt.	: 410.6
Inv. Status	: Custom Synthesis

Quetiapine Impurity 13

SZ CAT No:	: SZ-Q001055
CAS No	: NA
Mol.F.	: C21H24N3OS : Cl
Mol.Wt.	: 366.5 : 35.5
Inv. Status	: Custom Synthesis

Quetiapine Impurity 14

SZ CAT No:	: SZ-Q001056
CAS No	: 2206607-05-6
Mol.F.	: C23H28ClN3O2S
Mol.Wt.	: 446
Inv. Status	: Custom Synthesis

Quetiapine Impurity 15

SZ CAT No:	: SZ-Q001057
CAS No	: 37539-80-3
Mol.F.	: C13H8ClNS
Mol.Wt.	: 245.7
Inv. Status	: In Stock

2-amino biphenyl sulphide and phenyl-2-(phenylthio)-phenylcarbamate

SZ CAT No:	: SZ-Q001060
CAS No	: NA
Mol.F.	: C19H14NO2S : C12H11NS
Mol.Wt.	: 320.4 : 201.3
Inv. Status	: Custom Synthesis

Quetiapine D4 Fumarate (Possibility 1)

SZ CAT No:	: SZ-Q001D01
CAS No	: 1287376-15-1
Mol.F.	: C21H21D4N3O2S : C4H4O4
Mol.Wt.	: 387.5 : 116.1
Inv. Status	: Custom Synthesis
Rel. CAS No	: 1031703-37-3 (free base)

Quetiapine EP Impurity I

SZ CAT No:	: SZ-Q001063
CAS No	: 329216-67-3
Mol.F.	: C19H21N3OS
Mol.Wt.	: 339.5
Inv. Status	: In Stock

Quetiapine EP Impurity P

SZ CAT No:	: SZ-Q001064
CAS No	: 1011758-03-4
Mol.F.	: C19H21N3S
Mol.Wt.	: 323.5
Inv. Status	: In Stock

Quetiapine EP Impurity S

SZ CAT No:	: SZ-Q001065
CAS No	: 329216-63-9
Mol.F.	: C21H25N3O3S
Mol.Wt.	: 399.5
Inv. Status	: In Stock

Quetiapine Diether Alcohol

SZ CAT No:	: SZ-Q001066
CAS No	: 329216-69-5
Mol.F.	: C23H29N3O3S
Mol.Wt.	: 427.6
Inv. Status	: In Stock

Quetiapine EP Impurity B (Fumarate salt)

SZ CAT No:	: SZ-Q001068
CAS No	: 937731-18-5
Mol.F.	: C17H17N3S : C4H4O4
Mol.Wt.	: 295.4 : 116.1
Inv. Status	: In Stock
Rel. CAS No	: 5747-48-8 (free base)

Quetiapine impurity IV

SZ CAT No:	: SZ-Q001069
CAS No	: NA
Mol.F.	: C23H30N3O3S
Mol.Wt.	: 428.6
Inv. Status	: Custom Synthesis

Quetiapine EP Impurity I (Fumarate salt)

SZ CAT No:	: SZ-Q001070
CAS No	: 2734403-85-9
Mol.F.	: C19H21N3OS : C4H4O4
Mol.Wt.	: 339.5 : 116.1
Inv. Status	: In Stock
Rel. CAS No	: 329216-67-3 (free base)

7-Hydroxy Quetiapine

SZ CAT No:	: SZ-Q001071
CAS No	: 139079-39-3
Mol.F.	: C21H25N3O3S
Mol.Wt.	: 399.5
Inv. Status	: Custom Synthesis

N-Nitroso Quetiapine Impurity

SZ CAT No:	: SZ-Q001072
CAS No	: 73486-81-4
Mol.F.	: C8H17N3O3
Mol.Wt.	: 203.2
Inv. Status	: In Stock

Quetiapine Nitroso EP Impurity B

SZ CAT No:	: SZ-Q001073
CAS No	: NA
Mol.F.	: C17H16N4OS
Mol.Wt.	: 324.4
Inv. Status	: In Stock

N-Nitroso Quetiapine EP Impurity B D8

SZ CAT No:	: SZ-Q001D02
CAS No	: NA
Mol.F.	: C17H8D8N4OS
Mol.Wt.	: 332.5
Inv. Status	: In Stock

Quetiapine Impurity 21

SZ CAT No:	: SZ-Q001074
CAS No	: 2108892-53-9
Mol.F.	: C21H25N3O2S
Mol.Wt.	: 383.5
Inv. Status	: Custom Synthesis

Quetiapine Impurity 22

SZ CAT No:	: SZ-Q001075
CAS No	: 140425-65-6
Mol.F.	: C13H10N2S
Mol.Wt.	: 226.3
Inv. Status	: Custom Synthesis

Quetiapine Impurity 23

SZ CAT No:	: SZ-Q001076
CAS No	: 54920-98-8
Mol.F.	: C13H11NO2S
Mol.Wt.	: 245.3
Inv. Status	: Custom Synthesis

N-Nitroso Quetiapine EP Impurity G

SZ CAT No:	: SZ-Q001077
CAS No	: NA
Mol.F.	: C13H8N2O2S
Mol.Wt.	: 256.3
Inv. Status	: Inquire

Quetiapine Carboxylate Impurity

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