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Pemetrexed EP Impurity C

SZ CAT No SZ-P014004
CAS No 1802552-16-4
Mol.F. C40H40N10O13
Mol.Wt. 868.8
Inv. Status In Stock


Chemical Name: (2S,2′S)-2,2′-[(45S)-42,52-Diamino-44,46,54-trioxo-41,44,46,47,54,57-hexahydro-45H,51H-4(5,5),5(6,5)-dipyrrolo[2,3-d]pyrimidina-1,8(1)-dibenzenaoctaphane-14,84-dicarboxamido]dipentanedioic acid (as per EP)

Smiles: O=C(N[C@@](CCC(O)=O)(C(O)=O)[H])C(C=C1)=CC=C1CCC2=C([C@](C(N3)=O)(CCC4=CC=C(C(N[C@]([H])(C(O)=O)CCC(O)=O)=O)C=C4)C5=C3NC(N)=NC5=O)NC(NC(N)=N6)=C2C6=O

Inchi: InChI=1S/C40H40N10O13/c41-38-47-29-26(33(57)49-38)21(10-5-17-1-6-19(7-2-17)31(55)43-22(35(59)60)11-13-24(51)52)28(45-29)40(27-30(46-37(40)63)48-39(42)50-34(27)58)16-15-18-3-8-20(9-4-18)32(56)44-23(36(61)62)12-14-25(53)54/h1-4,6-9,22-23H,5,10-16H2,(H,43,55)(H,44,56)(H,51,52)(H,53,54)(H,59,60)(H,61,62)(H4,41,45,47,49,57)(H4,42,46,48,50,58,63)/t22-,23-,40+/m0/s1

A stability-​indicating LC-​MS​/MS method optimization for Pemetrexed through design of experiments: Identification and characterization of major oxidative degradation product
By Narenderan, S. T.; Ramesh, J.; Babu, B.; Meyyanathan, S. N.
From Journal of Pharmaceutical and Biomedical Analysis (2020), 183, 113150
 
A new validated stability-​indicating gradient RP-​HPLC method for the determination of pemetrexed disodium and its process related substances
By Hemchand, S.; Babu, R. Ravi Chandra; Annapurna, Mukthinuthalapati Mathrusri
From Journal of Drug Delivery and Therapeutics (2019), 9(3Suppl.), 588-610

Content determination of related impurity-​L-​isomer in Pemetrexed Disodium for injection by HPLC
By Li, Jinhua; Yang, Mei
From Heilongjiang Yiyao (2014), 27(3), 498-500