Methotrexate N-Desmethyl Impurity

SZ CAT No:	SZ-M019015
CAS No	1189252-22-9
Mol.F.	C14H12N6O3 : H2O
Mol.Wt.	312.3 : 18.0
Inv. Status	Limited Stock
Rel. CAS No	119-24-4 (free base)

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Chemical Name: 4-(((2-amino-4-hydroxypteridin-6-yl)methyl)amino)benzoic acid, 4-[[(2-Amino-4-hydroxypteridin-6-yl)methyl]amino]benzoic acid hydrate

Synonym: N-Desmethyl Impurity

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: OC(C(C=C1)=CC=C1NCC2=NC3=C(O)N=C(N)N=C3N=C2)=O.O

Identification and Quantitation of Impurities in Methotrexate
dulal c. chatterji, altice g. frazier, and joseph f. gallell
Journal of Pharmaceutical Sciences Volume 67, Issue 5, May 1978, Pages 622-624

determination of methotrexate and its major metabolite, 7_hydroxymethotrexate, using capillary zone electrophoresis and laser-induced fluorescence detection
mark c. roach, philippe gozel and richard n. zare
Journal of Chromatography, 426 (1988) 129-140

Analytical methodologies for determination of methotrexate and its metabolites in pharmaceutical, biological and environmental samples
Forough Karami , Sara Ranjbar , Younes Ghasemi , Manica Negahdaripour
Journal of Pharmaceutical Analysis 9 (2019) 373-391

Perspectives of Methotrexate-Based Radioagents for Application in Nuclear Medicine
Paweł Krzysztof Halik,* Przemysław Kozmin ́ ski, and Ewa Gniazdowska
Mol. Pharmaceutics 2021, 18, 1, 33–43

Methotrexate N-Desmethyl Impurity is chemically 4-(((2-amino-4-hydroxypteridin-6-yl)methyl)amino)benzoic acid, 4-[[(2-Amino-4-hydroxypteridin-6-yl)methyl]amino]benzoic acid hydrate. It is also known as N-Desmethyl Impurity. Methotrexate N-Desmethyl Impurity is supplied with detailed characterization data compliant with regulatory guideline. Methotrexate N-Desmethyl Impurity can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Methotrexate.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

Methotrexate N-Desmethyl Impurity

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