• A
  • B
  • C
  • D
  • E
  • F
  • G
  • H
  • I
  • J
  • K
  • L
  • M
  • N
  • O
  • P
  • Q
  • R
  • S
  • T
  • U
  • V
  • W
  • X
  • Y
  • Z

Methotrexate Related Products


SynZeal is a leading innovator in pharmaceutical reference standards. We supply high-quality Reference Standards of Methotrexate, pharmacopeial and non-pharmacopeial Methotrexate impurities, metabolites, stable isotope products, and nitrosamines (N-NO products). Methotrexate impurities reference standards are useful in pharmaceutical research. They are useful in product development, ANDA and DMF filing, quality control (QC), method validation, and stability studies. It is also useful in the identification of unknown impurities and the assessment of genotoxic potential.

Methotrexate-related products are thoroughly characterized. Methotrexate products are supplied with detailed COA & analytical data meeting regulatory compliance. We can also provide EP/USP traceable standards based on your requirements. The supplied products are re-tested at regular intervals.

Pharmaceutical Reference Standards

Methotrexate

Picture of Methotrexate
SZ CAT No:: SZ-M019035
CAS No: 59-05-2
Mol.F.: C20H22N8O5
Mol.Wt.: 454.4
Inv. Status: In Stock

Methotrexate Dihydrate

Picture of Methotrexate Dihydrate
SZ CAT No:: SZ-M019001
CAS No: 1212284-68-8
Mol.F.: C20H22N8O5 : 2(H2O)
Mol.Wt.: 454.4 : 2(18.0)
Inv. Status: In Stock

Methotrexate Dimethylamide (USP)

Picture of Methotrexate Dimethylamide (USP)
SZ CAT No:: SZ-M019019
CAS No: 71074-44-7
Mol.F.: C22H27N9O4
Mol.Wt.: 481.5
Inv. Status: In Stock

Methotrexate Disodium

Picture of Methotrexate Disodium
SZ CAT No:: SZ-M019059
CAS No: 7413-34-5
Mol.F.: C20H20N8O52 : 2(Na)
Mol.Wt.: 452.4 : 2(23.0)
Inv. Status: In Stock

Methotrexate Disodium Tetrahydrate

Picture of Methotrexate Disodium Tetrahydrate
SZ CAT No:: SZ-M019034
CAS No: NA
Mol.F.: C20H20N8O52 : 2(Na) : 4(H2O)
Mol.Wt.: 452.4 : 2(23.0) : 4(18.0)
Inv. Status: In Stock

Methotrexate EP Impurity A

Picture of Methotrexate EP Impurity A
SZ CAT No:: SZ-M019002
CAS No: 945-24-4
Mol.F.: C7H8N6O
Mol.Wt.: 192.1
Inv. Status: In Stock

Methotrexate EP Impurity A (HCl salt)

Picture of Methotrexate EP Impurity A (HCl salt)
SZ CAT No:: SZ-M019018
CAS No: 73978-41-3
Mol.F.: C7H8N6O : HCl
Mol.Wt.: 192.2 : 36.5
Inv. Status: In Stock

Methotrexate EP Impurity B

Picture of Methotrexate EP Impurity B
SZ CAT No:: SZ-M019026
CAS No: 54-62-6
Mol.F.: C19H20N8O5
Mol.Wt.: 440.4
Inv. Status: In Stock

Methotrexate EP Impurity C

Picture of Methotrexate EP Impurity C
SZ CAT No:: SZ-M019004
CAS No: 2410-93-7
Mol.F.: C20H21N7O6
Mol.Wt.: 455.4
Inv. Status: In Stock

Methotrexate EP Impurity D

Picture of Methotrexate EP Impurity D
SZ CAT No:: SZ-M019005
CAS No: 5623-18-7
Mol.F.: C15H14N6O3
Mol.Wt.: 326.3
Inv. Status: In Stock

Methotrexate EP Impurity E

Picture of Methotrexate EP Impurity E
SZ CAT No:: SZ-M019006
CAS No: 19741-14-1
Mol.F.: C15H15N7O2
Mol.Wt.: 325.3
Inv. Status: In Stock

Methotrexate EP Impurity F

Picture of Methotrexate EP Impurity F
SZ CAT No:: SZ-M019007
CAS No: 51865-79-3
Mol.F.: C20H22N8O5
Mol.Wt.: 454.4
Inv. Status: In Stock

Methotrexate EP Impurity G

Picture of Methotrexate EP Impurity G
SZ CAT No:: SZ-M019008
CAS No: 2519848-42-9
Mol.F.: C28H29N9O6
Mol.Wt.: 587.6
Inv. Status: In Stock

Methotrexate EP Impurity H

Picture of Methotrexate EP Impurity H
SZ CAT No:: SZ-M019009
CAS No: 67022-39-3
Mol.F.: C21H24N8O5
Mol.Wt.: 468.5
Inv. Status: In Stock

Methotrexate EP Impurity I

Picture of Methotrexate EP Impurity I
SZ CAT No:: SZ-M019010
CAS No: 66147-29-3
Mol.F.: C21H24N8O5
Mol.Wt.: 468.5
Inv. Status: In Stock

Methotrexate EP Impurity J

Picture of Methotrexate EP Impurity J
SZ CAT No:: SZ-M019011
CAS No: 34378-65-9
Mol.F.: C22H26N8O5
Mol.Wt.: 482.5
Inv. Status: In Stock

Methotrexate EP Impurity K

Picture of Methotrexate EP Impurity K
SZ CAT No:: SZ-M019012
CAS No: 4271-30-1
Mol.F.: C12H14N2O5
Mol.Wt.: 266.3
Inv. Status: In Stock

Methotrexate EP Impurity L

Picture of Methotrexate EP Impurity L
SZ CAT No:: SZ-M019013
CAS No: 52980-68-4
Mol.F.: C13H16N2O5
Mol.Wt.: 280.3
Inv. Status: In Stock

Methotrexate Hydrate EP Impurity B

Picture of Methotrexate Hydrate EP Impurity B
SZ CAT No:: SZ-M019003
CAS No: 1217459-90-9
Mol.F.: C19H20N8O5 : H2O
Mol.Wt.: 440.4 : 18.0
Inv. Status: In Stock

Methotrexate Impurity 1

Picture of Methotrexate Impurity 1
SZ CAT No:: SZ-M019024
CAS No: 1029980-84-4
Mol.F.: C17H24N2O5
Mol.Wt.: 336.4
Inv. Status: In Stock

Methotrexate Impurity 12

Picture of Methotrexate Impurity 12
SZ CAT No:: SZ-M019053
CAS No: 881-33-4
Mol.F.: C7H8N6O
Mol.Wt.: 192.2
Inv. Status: In Stock

Methotrexate Impurity 16

Picture of Methotrexate Impurity 16
SZ CAT No:: SZ-M019058
CAS No: 65148-63-2
Mol.F.: C22H26N8O5
Mol.Wt.: 482.5
Inv. Status: In Stock

Methotrexate Impurity 2

Picture of Methotrexate Impurity 2
SZ CAT No:: SZ-M019025
CAS No: 51865-66-8
Mol.F.: C17H24N2O5
Mol.Wt.: 336.4
Inv. Status: In Stock

Methotrexate Impurity 7

Picture of Methotrexate Impurity 7
SZ CAT No:: SZ-M019040
CAS No: 57963-63-0
Mol.F.: C16H21NO6
Mol.Wt.: 323.3
Inv. Status: In Stock

Methotrexate Impurity 8

Picture of Methotrexate Impurity 8
SZ CAT No:: SZ-M019041
CAS No: 909874-43-7
Mol.F.: C18H26N2O5
Mol.Wt.: 350.4
Inv. Status: In Stock

S-methylaminobenzoyl glutamicester

Picture of S-methylaminobenzoyl glutamicester
SZ CAT No:: SZ-M019023
CAS No: 2378-95-2
Mol.F.: C17H24N2O5
Mol.Wt.: 336.4
Inv. Status: In Stock

Methotrexate 7-Hydroxy Metabolite

Picture of Methotrexate 7-Hydroxy Metabolite
SZ CAT No:: SZ-M019014
CAS No: 5939-37-7
Mol.F.: C20H22N8O6
Mol.Wt.: 470.4
Inv. Status: Limited Stock

Methotrexate N-Desmethyl Impurity

Picture of Methotrexate N-Desmethyl Impurity
SZ CAT No:: SZ-M019015
CAS No: 1189252-22-9
Mol.F.: C14H12N6O3 : H2O
Mol.Wt.: 312.3 : 18.0
Inv. Status: Limited Stock

(+/-)Amethopterin

Picture of (+/-)Amethopterin
SZ CAT No:: SZ-M019030
CAS No: 60388-53-6
Mol.F.: C20H22N8O5
Mol.Wt.: 454.4
Inv. Status: Custom Synthesis

2,4-Diaminopteridine

Picture of 2,4-Diaminopteridine
SZ CAT No:: SZ-M019020
CAS No: 1127-93-1
Mol.F.: C6H6N6
Mol.Wt.: 162.2
Inv. Status: Custom Synthesis

6-Methyl-2,4-pteridinediamine 

Picture of 6-Methyl-2,4-pteridinediamine 
SZ CAT No:: SZ-M019021
CAS No: 708-74-7
Mol.F.: C7H8N6
Mol.Wt.: 176.2
Inv. Status: Custom Synthesis

Methotrexate Diethyl Ester

Picture of Methotrexate Diethyl Ester
SZ CAT No:: SZ-M019054
CAS No: 43170-88-3
Mol.F.: C24H30N8O5
Mol.Wt.: 510.6
Inv. Status: Custom Synthesis

Methotrexate Impurity 10

Picture of Methotrexate Impurity 10
SZ CAT No:: SZ-M019043
CAS No: NA
Mol.F.: C16H20ClNO5
Mol.Wt.: 341.8
Inv. Status: Custom Synthesis

Methotrexate Impurity 11

Picture of Methotrexate Impurity 11
SZ CAT No:: SZ-M019044
CAS No: 34794-87-1
Mol.F.: C15H14N6O3
Mol.Wt.: 326.3
Inv. Status: Custom Synthesis

Methotrexate Impurity 13

Picture of Methotrexate Impurity 13
SZ CAT No:: SZ-M019055
CAS No: NA
Mol.F.: C15H20N2O5
Mol.Wt.: 308.3
Inv. Status: Custom Synthesis

Methotrexate Impurity 14

Picture of Methotrexate Impurity 14
SZ CAT No:: SZ-M019056
CAS No: NA
Mol.F.: C15H20N2O5
Mol.Wt.: 308.3
Inv. Status: Custom Synthesis

Methotrexate Impurity 15

Picture of Methotrexate Impurity 15
SZ CAT No:: SZ-M019057
CAS No: 65148-64-3
Mol.F.: C22H26N8O5
Mol.Wt.: 482.5
Inv. Status: Custom Synthesis

Methotrexate Impurity 17

Picture of Methotrexate Impurity 17
SZ CAT No:: SZ-M019060
CAS No: 2820151-35-5
Mol.F.: C17H24N2O5
Mol.Wt.: 336.4
Inv. Status: Custom Synthesis

Methotrexate Impurity 18

Picture of Methotrexate Impurity 18
SZ CAT No:: SZ-M019061
CAS No: NA
Mol.F.: C23H28N8O5
Mol.Wt.: 496.5
Inv. Status: Custom Synthesis

Methotrexate Impurity 19

Picture of Methotrexate Impurity 19
SZ CAT No:: SZ-M019062
CAS No: NA
Mol.F.: C23H28N8O5
Mol.Wt.: 496.5
Inv. Status: Custom Synthesis

Methotrexate Impurity 3

Picture of Methotrexate Impurity 3
SZ CAT No:: SZ-M019027
CAS No: NA
Mol.F.: C25H31N3O6
Mol.Wt.: 469.5
Inv. Status: Custom Synthesis

Methotrexate Impurity 4

Picture of Methotrexate Impurity 4
SZ CAT No:: SZ-M019036
CAS No: 52030-86-1
Mol.F.: C13H16N2O5
Mol.Wt.: 280.3
Inv. Status: Custom Synthesis

Methotrexate Impurity 5

Picture of Methotrexate Impurity 5
SZ CAT No:: SZ-M019037
CAS No: 4215-07-0
Mol.F.: C7H8N6
Mol.Wt.: 176.2
Inv. Status: Custom Synthesis

Methotrexate Impurity 9

Picture of Methotrexate Impurity 9
SZ CAT No:: SZ-M019042
CAS No: 10541-83-0
Mol.F.: C8H9NO2
Mol.Wt.: 151.2
Inv. Status: Custom Synthesis

N-(4-chlorobenzoyl)-L-glutamic acid

Picture of N-(4-chlorobenzoyl)-L-glutamic acid
SZ CAT No:: SZ-M019022
CAS No: 57444-70-9
Mol.F.: C12H12ClNO5
Mol.Wt.: 285.7
Inv. Status: Custom Synthesis

N-(4-hydroxybenzoyl)-L-Glutamic acid

Picture of N-(4-hydroxybenzoyl)-L-Glutamic acid
SZ CAT No:: SZ-M019016
CAS No: 119843-02-6
Mol.F.: C12H13NO6
Mol.Wt.: 267.2
Inv. Status: Custom Synthesis

Methotrexate Impurity 6

Picture of Methotrexate Impurity 6
SZ CAT No:: SZ-M019038
CAS No: NA
Mol.F.: C8H10N6O2
Mol.Wt.: 222.2
Inv. Status: Under Synthesis

Methotrexate EP Impurity F (Sodium salt)

Picture of Methotrexate EP Impurity F (Sodium salt)
SZ CAT No:: SZ-M019063
CAS No: NA
Mol.F.: C20H20N8O5 : 2(Na)
Mol.Wt.: 452.4 : 2(23.0)
Inv. Status:

Stable Isotopes and Metabolites

Methotrexate D3

Picture of Methotrexate D3
SZ CAT No:: SZ-M019D01
CAS No: 432545-63-6
Mol.F.: C20H19D3N8O5
Mol.Wt.: 457.5
Inv. Status: Custom Synthesis

N-Nitroso Methotrexate EP Impurity B D6

Picture of N-Nitroso Methotrexate EP Impurity B D6
SZ CAT No:: SZ-M019D02
CAS No: NA
Mol.F.: C19H13D6N9O6
Mol.Wt.: 475.5
Inv. Status: Inquire

Possible Nitroso Standards

N-Nitroso Methotrexate EP Impurity B

Picture of N-Nitroso Methotrexate EP Impurity B
SZ CAT No:: SZ-M019028
CAS No: NA
Mol.F.: C19H19N9O6
Mol.Wt.: 469.4
Inv. Status: In Stock

N-Nitroso Methotrexate EP Impurity-L

Picture of N-Nitroso Methotrexate EP Impurity-L
SZ CAT No:: SZ-M019029
CAS No: NA
Mol.F.: C13H15N3O6
Mol.Wt.: 309.3
Inv. Status: In Stock

N-Nitroso S-Methylaminobenzoyl Glutamicester

Picture of N-Nitroso S-Methylaminobenzoyl Glutamicester
SZ CAT No:: SZ-M019039
CAS No: NA
Mol.F.: C17H23N3O6
Mol.Wt.: 365.4
Inv. Status: In Stock

Methotrexate Nitroso Impurity 2

Picture of Methotrexate Nitroso Impurity 2
SZ CAT No:: SZ-M019045
CAS No: NA
Mol.F.: C20H19N9O7
Mol.Wt.: 497.4
Inv. Status: Custom Synthesis

Methotrexate Nitroso Impurity 3

Picture of Methotrexate Nitroso Impurity 3
SZ CAT No:: SZ-M019047
CAS No: NA
Mol.F.: C17H23N3O6
Mol.Wt.: 365.4
Inv. Status: Custom Synthesis

Methotrexate diethyl ester Nitroso Impurity

Picture of Methotrexate diethyl ester Nitroso Impurity
SZ CAT No:: SZ-M019050
CAS No: NA
Mol.F.: C24H29N9O6
Mol.Wt.: 539.6
Inv. Status: Inquire

Methotrexate Nitroso Impurity 1

Picture of Methotrexate Nitroso Impurity 1
SZ CAT No:: SZ-M019031
CAS No: NA
Mol.F.: C21H21N9O6 : 2(Na)
Mol.Wt.: 495.5 : 2(23.0)
Inv. Status: Inquire

Methotrexate Nitroso Impurity 4

Picture of Methotrexate Nitroso Impurity 4
SZ CAT No:: SZ-M019048
CAS No: NA
Mol.F.: C17H23N3O6
Mol.Wt.: 365.4
Inv. Status: Inquire

Methotrexate Nitroso Impurity 5

Picture of Methotrexate Nitroso Impurity 5
SZ CAT No:: SZ-M019049
CAS No: NA
Mol.F.: C17H22N4O7
Mol.Wt.: 394.4
Inv. Status: Inquire

N,N-Dinitroso Methotrexate EP Impurity L

Picture of N,N-Dinitroso Methotrexate EP Impurity L
SZ CAT No:: SZ-M019033
CAS No: NA
Mol.F.: C13H14N4O7
Mol.Wt.: 338.3
Inv. Status: Inquire

N-Nitroso Methotrexate

Picture of N-Nitroso Methotrexate
SZ CAT No:: SZ-M019051
CAS No: NA
Mol.F.: C20H21N9O6
Mol.Wt.: 483.4
Inv. Status: Inquire

N-Nitroso Methotrexate EP Impurity F

Picture of N-Nitroso Methotrexate EP Impurity F
SZ CAT No:: SZ-M019046
CAS No: NA
Mol.F.: C20H21N9O6
Mol.Wt.: 483.4
Inv. Status: Inquire
Categories