Lenvatinib D4

SZ CAT No:	SZ-L038D01
CAS No	2264050-65-7
Mol.F.	C21H15D4ClN4O4
Mol.Wt.	430.9
Inv. Status	Custom Synthesis

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Chemical Name: 4-(3-Chloro-4-(3-(cyclopropyl-2,2,3,3-d4)ureido)phenoxy)-7-methoxyquinoline-6-carboxamide

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: ClC1=C(NC(NC2C([2H])([2H])C2([2H])[2H])=O)C=CC(OC3=CC=NC4=C3C=C(C(N)=O)C(OC)=C4)=C1

Stability indicating UPLC method development and validation of lenvatinib
By Sai, Prasanna A.; Kumar, Meruva Sathish; Kumari, R. V. Valli; Marakatham, S.
From International Journal of Pharmacy and Biological Sciences (2019), 9(3), 605-614

Method validation studies and an inter-laboratory cross validation study of lenvatinib assay in human plasma using LC-MS/MS
By Mano Yuji
From Practical laboratory medicine (2018), 12, e00103

Lenvatinib D4 is chemically 4-(3-Chloro-4-(3-(cyclopropyl-2,2,3,3-d4)ureido)phenoxy)-7-methoxyquinoline-6-carboxamide. Lenvatinib D4 is supplied with detailed characterization data compliant with regulatory guideline. Lenvatinib D4 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Lenvatinib.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

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Lenvatinib Mesylate

SZ CAT No:	: SZ-L038001
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Mol.F.	: C21H19ClN4O4 : CH4O3S
Mol.Wt.	: 426.9 : 96.1
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Lenvatinib N-Oxide

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Mol.F.	: C21H19ClN4O5
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Desamino Hydroxy Lenvatinib

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CAS No	: 417717-21-6
Mol.F.	: C21H18ClN3O5
Mol.Wt.	: 427.8
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Desamino Hydroxy Descyclopropyl Lenvatinib

SZ CAT No:	: SZ-L038004
CAS No	: 2733083-03-7
Mol.F.	: C18H14ClN3O5
Mol.Wt.	: 387.8
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Lenvatinib Impurity 3

SZ CAT No:	: SZ-L038005
CAS No	: 2250242-56-7
Mol.F.	: C23H19ClN4O4
Mol.Wt.	: 450.9
Inv. Status	: Under Synthesis

Lenvatinib Impurity 4

SZ CAT No:	: SZ-L038006
CAS No	: 2380197-90-8
Mol.F.	: C28H22ClN5O5
Mol.Wt.	: 544.0
Inv. Status	: Under Synthesis

Lenvatinib Impurity 5

SZ CAT No:	: SZ-L038007
CAS No	: 2613141-84-5
Mol.F.	: C31H29ClN6O6
Mol.Wt.	: 617.1
Inv. Status	: Under Synthesis

Lenvatinib Impurity 6

SZ CAT No:	: SZ-L038008
CAS No	: 205448-66-4
Mol.F.	: C12H10ClNO3
Mol.Wt.	: 251.7
Inv. Status	: In Stock
Rel. CAS No	: 417724-97-1 (HCl salt)

Lenvatinib Impurity 7

SZ CAT No:	: SZ-L038009
CAS No	: 17609-80-2
Mol.F.	: C6H6ClNO
Mol.Wt.	: 143.6
Inv. Status	: In Stock
Rel. CAS No	: 52671-64-4 (HCl salt)

Lenvatinib Impurity 8

SZ CAT No:	: SZ-L038010
CAS No	: 417721-36-9
Mol.F.	: C11H9ClN2O2
Mol.Wt.	: 236.7
Inv. Status	: In Stock

Lenvatinib Impurity 9

SZ CAT No:	: SZ-L038011
CAS No	: 417717-20-5
Mol.F.	: C22H20ClN3O5
Mol.Wt.	: 441.9
Inv. Status	: In Stock

Lenvatinib Impurity 10

SZ CAT No:	: SZ-L038012
CAS No	: 2817417-36-8
Mol.F.	: C19H16ClN3O5
Mol.Wt.	: 401.8
Inv. Status	: In Stock

Lenvatinib D4

SZ CAT No:	: SZ-L038D01
CAS No	: 2264050-65-7
Mol.F.	: C21H15D4ClN4O4
Mol.Wt.	: 430.9
Inv. Status	: Custom Synthesis

Lenvatinib D5

SZ CAT No:	: SZ-L038D02
CAS No	: NA
Mol.F.	: C21H14D5ClN4O4
Mol.Wt.	: 431.9
Inv. Status	: Custom Synthesis

Lenvatinib Impurity 11

SZ CAT No:	: SZ-L038013
CAS No	: 2712530-40-8
Mol.F.	: C45H42Cl2N8O8
Mol.Wt.	: 893.8
Inv. Status	: Custom Synthesis

Descyclopropyl Lenvatinib

SZ CAT No:	: SZ-L038014
CAS No	: 417719-51-8
Mol.F.	: C18H15ClN4O4
Mol.Wt.	: 386.8
Inv. Status	: In Stock
Rel. CAT No	: SZ-L038039 ,

Lenvatinib Impurity 12

SZ CAT No:	: SZ-L038015
CAS No	: 2712290-12-3
Mol.F.	: C17H13ClN2O4
Mol.Wt.	: 344.8
Inv. Status	: In Stock

Lenvatinib Impurity 13

SZ CAT No:	: SZ-L038016
CAS No	: 417722-93-1
Mol.F.	: C17H14ClN3O3
Mol.Wt.	: 343.8
Inv. Status	: In Stock
Rel. CAS No	: 1808104-65-5 (HCl salt)

Lenvatinib Impurity 14

SZ CAT No:	: SZ-L038017
CAS No	: 417722-95-3
Mol.F.	: C24H18ClN3O5
Mol.Wt.	: 463.9
Inv. Status	: In Stock

Lenvatinib Impurity 15

SZ CAT No:	: SZ-L038018
CAS No	: 2023826-16-4
Mol.F.	: C17H12ClN3O2
Mol.Wt.	: 325.8
Inv. Status	: In Stock

Lenvatinib Impurity 16

SZ CAT No:	: SZ-L038019
CAS No	: 1882873-21-3
Mol.F.	: C21H17ClN4O3
Mol.Wt.	: 408.8
Inv. Status	: In Stock

Lenvatinib Impurity O

SZ CAT No:	: SZ-L038020
CAS No	: 2143930-76-9
Mol.F.	: C20H19ClN4O4
Mol.Wt.	: 414.8
Inv. Status	: Limited Stock
Rel. CAT No	: SZ-L038040 ,

Lenvatinib Methoxy Impurity

SZ CAT No:	: SZ-L038021
CAS No	: 417724-81-3
Mol.F.	: C11H10N2O3
Mol.Wt.	: 218.2
Inv. Status	: In Stock

Lenvatinib Impurity 17

SZ CAT No:	: SZ-L038022
CAS No	: 417721-34-7
Mol.F.	: C11H9NO4
Mol.Wt.	: 219.2
Inv. Status	: In Stock

Lenvatinib Impurity 18

SZ CAT No:	: SZ-L038023
CAS No	: 2143930-75-8
Mol.F.	: C35H26Cl2N6O7
Mol.Wt.	: 713.5
Inv. Status	: Custom Synthesis

Cyclopropylamine

SZ CAT No:	: SZ-L038024
CAS No	: 765-30-0
Mol.F.	: C3H7N
Mol.Wt.	: 57.1
Inv. Status	: In Stock, 3-4 days for Dispatch
Rel. CAS No	: 18600-39-0 (HCl salt) ; 56383-93-8 (HBr salt) ; 949005-94-1 (Sulfate salt)

2-Chloronitrobenzene

SZ CAT No:	: SZ-L038025
CAS No	: 88-73-3
Mol.F.	: C6H4ClNO2
Mol.Wt.	: 157.6
Inv. Status	: In Stock

Cyclopropane Carboxamide

SZ CAT No:	: SZ-L038026
CAS No	: 6228-73-5
Mol.F.	: C4H7NO
Mol.Wt.	: 85.1
Inv. Status	: Custom Synthesis
Rel. CAS No	: 2415920-61-3 (Na salt)

Lenvatinib Hydroxy Amide Impurity

SZ CAT No:	: SZ-L038028
CAS No	: 2110414-05-4
Mol.F.	: C11H10N2O3
Mol.Wt.	: 218.2
Inv. Status	: Out of Stock

Cyclopropyl Urea Impurity

SZ CAT No:	: SZ-L038029
CAS No	: 796848-79-8
Mol.F.	: C10H11ClN2O2
Mol.Wt.	: 226.7
Inv. Status	: In Stock

Lenvatinib Impurity 19

SZ CAT No:	: SZ-L038030
CAS No	: 2839104-94-6
Mol.F.	: C12H12N2O3
Mol.Wt.	: 232.2
Inv. Status	: Custom Synthesis

Lenvatinib

SZ CAT No:	: SZ-L038031
CAS No	: 417716-92-8
Mol.F.	: C21H19ClN4O4
Mol.Wt.	: 426.9
Inv. Status	: In Stock
Rel. CAS No	: 857890-39-2 (free base)

Lenvatinib 4-Chloro Impurity

SZ CAT No:	: SZ-L038027
CAS No	: 771464-30-3
Mol.F.	: C11H8ClNO3
Mol.Wt.	: 237.6
Inv. Status	: Custom Synthesis
Rel. CAS No	: 289707-59-1 (HCl salt)

Lenvatinib N-Ethyl Impurity

SZ CAT No:	: SZ-L038032
CAS No	: NA
Mol.F.	: C20H19ClN4O4 : CH4O3S
Mol.Wt.	: 414.8 : 96.1
Inv. Status	: In Stock
Rel. CAS No	: 417719-46-1 (free base)

Lenvatinib Impurity 20

SZ CAT No:	: SZ-L038033
CAS No	: NA
Mol.F.	: C19H16ClN3O4
Mol.Wt.	: 385.8
Inv. Status	: In Stock

N-Methyl Lenvatinib

SZ CAT No:	: SZ-L038034
CAS No	: 417719-45-0
Mol.F.	: C19H17ClN4O4
Mol.Wt.	: 400.8
Inv. Status	: In Stock

Lenvatinib Impurity 21

SZ CAT No:	: SZ-L038035
CAS No	: 2023826-82-4
Mol.F.	: C12H11NO4
Mol.Wt.	: 233.2
Inv. Status	: Custom Synthesis

Lenvatinib Impurity 22

SZ CAT No:	: SZ-L038036
CAS No	: NA
Mol.F.	: C10H11ClN2O2
Mol.Wt.	: 226.7
Inv. Status	: Custom Synthesis

Lenvatinib Impurity 24

SZ CAT No:	: SZ-L038038
CAS No	: NA
Mol.F.	: C21H17ClN4O3
Mol.Wt.	: 408.8
Inv. Status	: Custom Synthesis

Lenvatinib Descyclopropyl Impurity

SZ CAT No:	: SZ-L038039
CAS No	: NA
Mol.F.	: C18H15ClN4O4 :CH4O3S
Mol.Wt.	: 386.8 : 96.1
Inv. Status	: In Stock
Rel. CAS No	: 417719-51-8 (free base)
Rel. CAT No	: SZ-L038014 ,

Lenvatinib Dimethyl Impurity

SZ CAT No:	: SZ-L038040
CAS No	: NA
Mol.F.	: C20H19ClN4O4 : CH4O3S
Mol.Wt.	: 414.8 : 96.1
Inv. Status	: In Stock
Rel. CAS No	: 2143930-76-9 (free base)
Rel. CAT No	: SZ-L038020 ,

O-Desmethyl Lenvatinib

SZ CAT No:	: SZ-L038041
CAS No	: 417717-04-5
Mol.F.	: C20H17ClN4O4
Mol.Wt.	: 412.8
Inv. Status	: In Stock

Meldrum’s Acid

SZ CAT No:	: SZ-L038042
CAS No	: 2033-24-1
Mol.F.	: C6H8O4
Mol.Wt.	: 144.1
Inv. Status	: Custom Synthesis

5-(Methoxymethylene) Meldrum’s Acid

SZ CAT No:	: SZ-L038043
CAS No	: 15568-85-1
Mol.F.	: C8H10O5
Mol.Wt.	: 186.2
Inv. Status	: Custom Synthesis

Lenvatinib Impurity 25

SZ CAT No:	: SZ-L038044
CAS No	: 205448-64-2
Mol.F.	: C16H17NO7
Mol.Wt.	: 335.3
Inv. Status	: Custom Synthesis

Lenvatinib Impurity 26

SZ CAT No:	: SZ-L038045
CAS No	: 205448-65-3
Mol.F.	: C12H11NO4
Mol.Wt.	: 233.2
Inv. Status	: Custom Synthesis

Lenvatinib Impurity 27

SZ CAT No:	: SZ-L038046
CAS No	: 253801-34-2
Mol.F.	: C12H9ClN2O4S
Mol.Wt.	: 312.7
Inv. Status	: Custom Synthesis
Rel. CAS No	: 2491-60-3 (sodium salt)

Lenvatinib Impurity 28

SZ CAT No:	: SZ-L038047
CAS No	: 2412398-76-4
Mol.F.	: C25H24ClN5O5
Mol.Wt.	: 509.9
Inv. Status	: Limited Stock

Lenvatinib D4

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