Irinotecan EP Impurity A

SZ CAT No:	SZ-I010013
CAS No	158406-44-1
Mol.F.	C31H34N4O6 : HCl : 3(H2O)
Mol.Wt.	558.6 : 36.5 : 3(18.0)
Inv. Status	In Stock
Rel. CAS No	103816-16-6 (free base) ; 207683-84-9 (HCl salt) ; 883718-83-0 (Sulfate salt)

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Chemical Name: (4S)-4-Ethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl 1,4′-bipiperidine-1′-carboxylate hydrochloride trihydrate (as per EP); (S)-4-Ethyl-4-hydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quin oline-3,14(4H,12H)-dione-9-yl (1,4′-bipiperidine)-1′-carboxylate hydrochloride trihydrate (as per USP)

Synonym: 11-Desethyl Irinotecan (as per EP)

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: O[C@@](C(OC1)=O)(CC)C2=C1C(N3C(C4=NC5=CC=C(OC(N6CCC(N7CCCCC7)CC6)=O)C=C5C=C4C3)=C2)=O.[3H2O].Cl

RP-HPLC method development and validation for the simultaneous estimation of Irinotecan hydrochloride and Capecitabine in Active Pharmaceutical Ingredients (APIs)
By Vijaya Jyothi, M.; Bhargav, E.; Keerthana, B.; Varalakshmi, Devi K.
From International Journal of Research in Pharmaceutical Sciences (Madurai, India) (2018), 9(1), 63-67

Method development, validation and forced degradation studies of Irinotecan in bulk and pharmaceutical dosage form
By Swathi, Koduru; Farooqui, Tahmeena; Muntaha, Sidra Tul; Ayesha, Syeda Amtul; Shama, Syeda; Siddiqui, Sarah Imam
From World Journal of Pharmacy and Pharmaceutical Sciences (2018), 7(8), 996-1009

Irinotecan EP Impurity A is chemically (4S)-4-Ethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl 1,4′-bipiperidine-1′-carboxylate hydrochloride trihydrate (as per EP); (S)-4-Ethyl-4-hydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quin oline-3,14(4H,12H)-dione-9-yl (1,4′-bipiperidine)-1′-carboxylate hydrochloride trihydrate (as per USP) . It is also known as 11-Desethyl Irinotecan (as per EP). Irinotecan EP Impurity A is supplied with detailed characterization data compliant with regulatory guideline. Irinotecan EP Impurity A can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Irinotecan.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

SZ CAT No:	: SZ-I010002
CAS No	: 19685-09-7
Mol.F.	: C20H16N2O5
Mol.Wt.	: 364.4
Inv. Status	: In Stock
Rel. CAS No	: 1174930-07-4 (HCl salt) ; 77987-01-0 (Na salt)
Rel. CAT No	: SZ-C064021 ,

SZ CAT No:	: SZ-I010003
CAS No	: 86639-52-3
Mol.F.	: C22H20N2O5
Mol.Wt.	: 392.4
Inv. Status	: In Stock
Rel. CAT No	: SZ-C064018 ,

Irinotecan EP Impurity A

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SZ CAT No:	: SZ-I010001
CAS No	: 136572-09-3
Mol.F.	: C33H38N4O6 : HCl : 3(H2O)
Mol.Wt.	: 586.7 : 36.5 : 3(18.0)
Inv. Status	: In Stock
Rel. CAS No	: 97682-44-5 (free base) ; 100286-90-6 (HCl salt)

SZ CAT No:	: SZ-I010005
CAS No	: NA
Mol.F.	: C33H38N4O6 : C2HF3O2
Mol.Wt.	: 586.7 : 114.0
Inv. Status	: In Stock
Rel. CAS No	: 1255644-71-3 (free base) ; 1992961-26-8 (HCl salt)

SZ CAT No:	: SZ-I010006
CAS No	: 78287-27-1
Mol.F.	: C22H20N2O4
Mol.Wt.	: 376.4
Inv. Status	: In Stock

SZ CAT No:	: SZ-I010007
CAS No	: 947687-01-6
Mol.F.	: C24H24N2O5
Mol.Wt.	: 420.5
Inv. Status	: In Stock

SZ CAT No:	: SZ-I010008
CAS No	: NA
Mol.F.	: C33H38N4O7 : C2HF3O2
Mol.Wt.	: 602.7 : 114.0
Inv. Status	: In Stock
Rel. CAS No	: 185336-12-3 (free base)

SZ CAT No:	: SZ-I010010
CAS No	: 176515-52-9
Mol.F.	: C32H38N4O4
Mol.Wt.	: 542.7
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-I010012
CAS No	: 157770-58-6
Mol.F.	: C21H20N2O3
Mol.Wt.	: 348.4
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-I010013
CAS No	: 158406-44-1
Mol.F.	: C31H34N4O6 : HCl : 3(H2O)
Mol.Wt.	: 558.6 : 36.5 : 3(18.0)
Inv. Status	: In Stock
Rel. CAS No	: 103816-16-6 (free base) ; 207683-84-9 (HCl salt) ; 883718-83-0 (Sulfate salt)

SZ CAT No:	: SZ-I010014
CAS No	: 947687-02-7
Mol.F.	: C35H42N4O6
Mol.Wt.	: 614.7
Inv. Status	: In Stock

SZ CAT No:	: SZ-I010015
CAS No	: NA
Mol.F.	: C32H37N4O5 : Cl
Mol.Wt.	: 557.7 : 35.5
Inv. Status	: In Stock
Rel. CAS No	: 143490-53-3 (free base)

SZ CAT No:	: SZ-I010016
CAS No	: 143490-54-4
Mol.F.	: C32H38N4O5
Mol.Wt.	: 558.7
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-I010018
CAS No	: 121080-63-5
Mol.F.	: C28H28N2O11
Mol.Wt.	: 568.5
Inv. Status	: Custom Synthesis
Rel. CAS No	: 121080-64-6 (Na salt)

SZ CAT No:	: SZ-I010019
CAS No	: 2656-50-0
Mol.F.	: C8H9NO2 : HCl
Mol.Wt.	: 151.2 : 18.0
Inv. Status	: Custom Synthesis
Rel. CAS No	: 30954-71-3 (Free base)

SZ CAT No:	: SZ-I010D01
CAS No	: 1309283-21-3
Mol.F.	: C22H16D4N2O5
Mol.Wt.	: 396.4
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-I010D02
CAS No	: 718612-62-5
Mol.F.	: C33H28D10N4O6 : HCl
Mol.Wt.	: 596.8 : 36.5
Inv. Status	: Custom Synthesis
Rel. CAS No	: 718613-28-6 (free base)

SZ CAT No:	: SZ-I010020
CAS No	: NA
Mol.F.	: C24H24N2O5 : C2HF3O2
Mol.Wt.	: 420.5 : 114.0
Inv. Status	: Limited Stock
Rel. CAS No	: 947687-01-6 (free base)

SZ CAT No:	: SZ-I010021
CAS No	: 200619-21-2
Mol.F.	: C22H20N2O6
Mol.Wt.	: 408.4
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-I010022
CAS No	: NA
Mol.F.	: C12H21ClN2O2
Mol.Wt.	: 260.8
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-I010023
CAS No	: NA
Mol.F.	: C35H42N4O7
Mol.Wt.	: 630.7
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-I010024
CAS No	: NA
Mol.F.	: C13H23ClN2O2
Mol.Wt.	: 274.8
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-I010011
CAS No	: NA
Mol.F.	: C35H42N4O6 : C2HF3O2
Mol.Wt.	: 614.7 : 114.0
Inv. Status	: Out of Stock, Custom Synthesis
Rel. CAS No	: 947687-02-7 (free base)

SZ CAT No:	: SZ-I010025
CAS No	: NA
Mol.F.	: C11H19ClN2O2
Mol.Wt.	: 246.7
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-I010030
CAS No	: 2508174-07-8
Mol.F.	: C34H40N4O7
Mol.Wt.	: 616.7
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-I010031
CAS No	: 7689-03-4
Mol.F.	: C20H16N2O4
Mol.Wt.	: 348.4
Inv. Status	: In Stock
Rel. CAS No	: 72517-83-0 (Na salt)

SZ CAT No:	: SZ-I010032
CAS No	: NA
Mol.F.	: C31H34N4O5
Mol.Wt.	: 542.6
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-I010033
CAS No	: 185304-41-0
Mol.F.	: C32H40N4O5
Mol.Wt.	: 560.7
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-I010034
CAS No	: 97682-44-5
Mol.F.	: C33H38N4O6
Mol.Wt.	: 586.7
Inv. Status	: Custom Synthesis
Rel. CAS No	: 136572-09-3 (HCl trihydrate) ; 100286-90-6 (HCl salt)

SZ CAT No:	: SZ-I010036
CAS No	: NA
Mol.F.	: C32H36N4O6 : HCl
Mol.Wt.	: 572.7 : 36.5
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-I010037
CAS No	: 1608617-71-5
Mol.F.	: C32H36N4O6
Mol.Wt.	: 572.7
Inv. Status	: Custom Synthesis
Rel. CAS No	: 1608463-33-7 (HCl salt)

SZ CAT No:	: SZ-I010038
CAS No	: 142706-06-7
Mol.F.	: C33H40N4O7
Mol.Wt.	: 604.7
Inv. Status	: Custom Synthesis
Rel. CAS No	: 1329502-92-2 (Na salt) ; 509107-82-8 (HCl salt) ; 2216738-99-5 (disodium salt)