Hydroxychloroquine Sulfate EP Impurity B

SZ CAT No:	SZ-H004008
CAS No	103152-84-7
Mol.F.	C18H26ClN3O4S
Mol.Wt.	415.9
Inv. Status	In Stock

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Chemical Name: 2-[[(4RS)-4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethyl hydrogen sulfate (as per EP); 2-({4-[(7-Chloroquinolin-4-yl)amino]pentyl}ethylamino)ethyl hydrogen sulfate (as per USP)

Synonym: Hydroxychloroquine O-Sulfate

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: ClC1=CC=C(C(NC(C)CCCN(CC)CCOS(O)(=O)=O)=CC=N2)C2=C1

Identification and characterization of process related impurities in chloroquine and hydroxychloroquine by LC/IT/MS, LC/TOF/MS and NMR
By Dongre, Vaijanath G.; Ghugare, Pradeep D.; Karmuse, Pravin; Singh, Dharmendra; Jadhav, Atul; Kumar, Ashok
From Journal of Pharmaceutical and Biomedical Analysis (2009), 49(4), 873-879

Analytical and semi-preparative high-performance liquid chromatographic separation and assay of hydroxychloroquine enantiomers
By Brocks, Dion R.; Pasutto, Franco M.; Jamali, Fakhreddin
From Journal of Chromatography, Biomedical Applications (1992), 581(1), 83-92

Estimation of plasma hydroxychloroquine by high-performance liquid chromatography with ultraviolet detection
By Morris, Raymond G.
From Journal of Chromatography, Biomedical Applications (1985), 338(2), 422-7

Hydroxychloroquine Sulfate EP Impurity B is chemically 2-[[(4RS)-4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethyl hydrogen sulfate (as per EP); 2-({4-[(7-Chloroquinolin-4-yl)amino]pentyl}ethylamino)ethyl hydrogen sulfate (as per USP). It is also known as Hydroxychloroquine O-Sulfate. Hydroxychloroquine Sulfate EP Impurity B is supplied with detailed characterization data compliant with regulatory guideline. Hydroxychloroquine Sulfate EP Impurity B can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Hydroxychloroquine.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

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Hydroxychloroquine Sulfate

SZ CAT No:	: SZ-H004001
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Mol.F.	: C18H26ClN3O: H2SO4
Mol.Wt.	: 335.9 : 98.1
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Hydroxychloroquine EP Impurity C (2HCl salt)

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Hydroxychloroquine N-desethyl Impurity

SZ CAT No:	: SZ-H004004
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Mol.F.	: C16H22ClN3O
Mol.Wt.	: 307.8
Inv. Status	: Custom Synthesis

Hydroxychloroquine R-isomer Impurity

SZ CAT No:	: SZ-H004005
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Mol.F.	: C18H26ClN3O
Mol.Wt.	: 335.9
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Hydroxychloroquine S-isomer Impurity

SZ CAT No:	: SZ-H004006
CAS No	: 137433-24-0
Mol.F.	: C18H26ClN3O
Mol.Wt.	: 335.9
Inv. Status	: Custom Synthesis
Rel. CAS No	: 155204-09-4 (Sulfate salt)

Hydroxychloroquine-O-Acetate

SZ CAT No:	: SZ-H004007
CAS No	: 47493-14-1
Mol.F.	: C20H28ClN3O2
Mol.Wt.	: 377.9
Inv. Status	: In Stock

Hydroxychloroquine Sulfate EP Impurity B

SZ CAT No:	: SZ-H004008
CAS No	: 103152-84-7
Mol.F.	: C18H26ClN3O4S
Mol.Wt.	: 415.9
Inv. Status	: In Stock

Hydroxychloroquine Impurity I

SZ CAT No:	: SZ-H004009
CAS No	: NA
Mol.F.	: C25H26Cl2N4O
Mol.Wt.	: 469.4
Inv. Status	: In Stock

Hydroxychloroquine EP Impurity A

SZ CAT No:	: SZ-H004010
CAS No	: 1449223-88-4
Mol.F.	: C18H26ClN3O2
Mol.Wt.	: 351.9
Inv. Status	: In Stock

Hydroxychloroquine Dimer

SZ CAT No:	: SZ-H004011
CAS No	: NA
Mol.F.	: C36H50Cl2N6O : 2(HCl)
Mol.Wt.	: 653.7 : 2(36.5)
Inv. Status	: In Stock
Rel. CAS No	: 2732209-42-4 (free base)

Hydroxychloroquine Impurity 1

SZ CAT No:	: SZ-H004012
CAS No	: 2518282-96-5
Mol.F.	: C25H26Cl2N4
Mol.Wt.	: 453.4
Inv. Status	: Custom Synthesis

Hydroxychloroquine Impurity 2

SZ CAT No:	: SZ-H004013
CAS No	: NA
Mol.F.	: C18H26ClN3O
Mol.Wt.	: 335.9
Inv. Status	: Custom Synthesis

Hydroxychloroquine Impurity 3

SZ CAT No:	: SZ-H004014
CAS No	: 2411340-31-1
Mol.F.	: C18H26ClN3O
Mol.Wt.	: 335.9
Inv. Status	: Custom Synthesis

Hydroxychloroquine EP Impurity D Hydrochloride

SZ CAT No:	: SZ-H004015
CAS No	: 4298-11-7
Mol.F.	: C16H22ClN3 : HCl
Mol.Wt.	: 291.8 : 36.5
Inv. Status	: In Stock
Rel. CAS No	: 1476-52-4 (free base)

Hydroxychloroquine EP Impurity E

SZ CAT No:	: SZ-H004016
CAS No	: 10500-64-8
Mol.F.	: C14H17ClN2O
Mol.Wt.	: 264.8
Inv. Status	: In Stock
Rel. CAS No	: 5456-04-2 (HCl salt)

Hydroxychloroquine EP impurity F Hydrochloride

SZ CAT No:	: SZ-H004017
CAS No	: NA
Mol.F.	: C14H15ClN2 : HCl
Mol.Wt.	: 246.7 : 36.5
Inv. Status	: In Stock
Rel. CAS No	: 6281-58-9 (free base)

Cletoquine-d4 Oxalate

SZ CAT No:	: SZ-H004D01
CAS No	: 1216461-57-2
Mol.F.	: C16H18D4ClN3O : C2H2O4
Mol.Wt.	: 311.8 : 90.0
Inv. Status	: Custom Synthesis
Rel. CAS No	: 1216461-56-1 (free base)

Synthetic impurity mixture of HCQS

SZ CAT No:	: SZ-H004018
CAS No	: NA
Mol.F.	: C16H22ClN3O : C18H26ClN3O4S
Mol.Wt.	: 307.8 : 415.9
Inv. Status	: Custom Synthesis

Hydroxychloroquine-d4 O-Sulfate

SZ CAT No:	: SZ-H004D03
CAS No	: 2714483-73-3
Mol.F.	: C18H22D4ClN3O4S
Mol.Wt.	: 420
Inv. Status	: Custom Synthesis
Rel. CAS No	: 103152-84-7 (Unlabelled)

4-Amino-1-pentanol-d4

SZ CAT No:	: SZ-H004D04
CAS No	: 1216666-53-3
Mol.F.	: C5H9D4NO
Mol.Wt.	: 107.2
Inv. Status	: Custom Synthesis
Rel. CAS No	: 1216414-18-4 (HCl salt)

4-Amino-1-pentanol-d4 Benzyl Ether

SZ CAT No:	: SZ-H004D05
CAS No	: NA
Mol.F.	: C12H13D4NO2
Mol.Wt.	: 211.3
Inv. Status	: Custom Synthesis

N-Didestethyl Chloroquine-d4 Phthalimide

SZ CAT No:	: SZ-H004D06
CAS No	: NA
Mol.F.	: C22H16D4ClN3O2
Mol.Wt.	: 397.9
Inv. Status	: Custom Synthesis

Quensyl-1-acetate-d3

SZ CAT No:	: SZ-H004D07
CAS No	: NA
Mol.F.	: C20H25D3ClN3O2
Mol.Wt.	: 380.9
Inv. Status	: Custom Synthesis
Rel. CAS No	: 47493-14-1 (Unlabelled)

Hydroxychloroquine 3-Bromo Impurity

SZ CAT No:	: SZ-H004019
CAS No	: 2054859-08-2
Mol.F.	: C18H25BrClN3O
Mol.Wt.	: 414.8
Inv. Status	: Custom Synthesis

Hydroxychloroquine Acid

SZ CAT No:	: SZ-H004020
CAS No	: 645406-24-2
Mol.F.	: C18H24ClN3O3
Mol.Wt.	: 365.9
Inv. Status	: Custom Synthesis

Hydroxychloroquine Diethanol

SZ CAT No:	: SZ-H004022
CAS No	: 103396-22-1
Mol.F.	: C19H28ClN3O2
Mol.Wt.	: 365.9
Inv. Status	: Custom Synthesis

7-Chloro-3-iodo Hydroxychloroquine

SZ CAT No:	: SZ-H004023
CAS No	: 161618-30-0
Mol.F.	: C18H25ClIN3O
Mol.Wt.	: 461.8
Inv. Status	: Custom Synthesis

Hydroxychloroquine Impurity 3

SZ CAT No:	: SZ-H004024
CAS No	: 2512202-70-7
Mol.F.	: C22H20ClN3O2
Mol.Wt.	: 393.9
Inv. Status	: Custom Synthesis

N-Chloromethyl Hydroxychloroquine

SZ CAT No:	: SZ-H004026
CAS No	: 1159208-89-5
Mol.F.	: C19H28Cl2N3O
Mol.Wt.	: 385.4
Inv. Status	: Custom Synthesis

3-Cyclopropyl Hydroxychloroquine

SZ CAT No:	: SZ-H004027
CAS No	: 2054859-10-6
Mol.F.	: C21H30ClN3O
Mol.Wt.	: 375.9
Inv. Status	: Custom Synthesis
Rel. CAS No	: 2054859-41-3 (Sulfate salt)

5,7-Dichloro Hydroxychloroquine

SZ CAT No:	: SZ-H004028
CAS No	: 2054858-98-7
Mol.F.	: C18H25Cl2N3O
Mol.Wt.	: 370.3
Inv. Status	: Custom Synthesis
Rel. CAS No	: 2054859-33-3 (Sulfate salt)

3,7-Dichloro Hydroxychloroquine

SZ CAT No:	: SZ-H004029
CAS No	: 2054858-86-3
Mol.F.	: C18H25Cl2N3O
Mol.Wt.	: 370.3
Inv. Status	: Custom Synthesis
Rel. CAS No	: 2054859-15-1 (Sulfate salt)

6,7-Dichloro Hydroxychloroquine

SZ CAT No:	: SZ-H004030
CAS No	: 2054859-04-8
Mol.F.	: C18H25Cl2N3O
Mol.Wt.	: 370.3
Inv. Status	: Custom Synthesis

7-Fluoro Hydroxychloroquine

SZ CAT No:	: SZ-H004031
CAS No	: 478784-65-5
Mol.F.	: C18H26FN3O
Mol.Wt.	: 319.4
Inv. Status	: Custom Synthesis

N-(Glycoloyloxy)-succinimide

SZ CAT No:	: SZ-H004032
CAS No	: 19374-87-9
Mol.F.	: C6H7NO5
Mol.Wt.	: 173.1
Inv. Status	: Custom Synthesis

Hydroxychloroquine 3-Carbonitrile

SZ CAT No:	: SZ-H004033
CAS No	: 2054858-84-1
Mol.F.	: C19H25ClN4O
Mol.Wt.	: 360.9
Inv. Status	: Custom Synthesis

N-Propiononitrile Hydroxychloroquine

SZ CAT No:	: SZ-H004034
CAS No	: 1606176-76-4
Mol.F.	: C21H29ClN4O
Mol.Wt.	: 388.9
Inv. Status	: Custom Synthesis

3-Trifluoromethyl Hydroxychloroquine

SZ CAT No:	: SZ-H004035
CAS No	: 2054858-88-5
Mol.F.	: C19H25ClF3N3O
Mol.Wt.	: 403.9
Inv. Status	: Custom Synthesis

Desethyl Hydroxy Chloroquine-d4

SZ CAT No:	: SZ-H004D08
CAS No	: 1854126-47-8
Mol.F.	: C16H18D4ClN3O
Mol.Wt.	: 311.8
Inv. Status	: Custom Synthesis

S-Hydroxychloroquine-d4

SZ CAT No:	: SZ-H004D09
CAS No	: NA
Mol.F.	: C18H22D4ClN3O
Mol.Wt.	: 339.9
Inv. Status	: Custom Synthesis

R-Hydroxychloroquine-d5

SZ CAT No:	: SZ-H004D10
CAS No	: NA
Mol.F.	: C18H22D4ClN3O
Mol.Wt.	: 339.9
Inv. Status	: Custom Synthesis

Hydroxychloroquine Impurity 4

SZ CAT No:	: SZ-H004036
CAS No	: 21617-12-9
Mol.F.	: C9H5Cl2N
Mol.Wt.	: 198
Inv. Status	: Custom Synthesis

Hydroxychloroquine Impurity 5

SZ CAT No:	: SZ-H004037
CAS No	: 159346-86-8
Mol.F.	: C9H22N2O
Mol.Wt.	: 174.3
Inv. Status	: Custom Synthesis

Hydroxychloroquine Impurity 6

SZ CAT No:	: SZ-H004038
CAS No	: NA
Mol.F.	: C18H26ClN3O
Mol.Wt.	: 335.9
Inv. Status	: Custom Synthesis

Hydroxychloroquine Impurity 7

SZ CAT No:	: SZ-H004039
CAS No	: 927-55-9
Mol.F.	: C5H13NO
Mol.Wt.	: 103.2
Inv. Status	: In Stock
Rel. CAS No	: 1649982-24-0 (HCl salt)

Hydroxychloroquine Impurity 9

SZ CAT No:	: SZ-H004041
CAS No	: 86-47-5
Mol.F.	: C10H6ClNO3
Mol.Wt.	: 223.6
Inv. Status	: In Stock
Rel. CAS No	: 3720-95-4 (Na salt)

Hydroxychloroquine Impurity 10

SZ CAT No:	: SZ-H004042
CAS No	: 860544-46-3
Mol.F.	: C7H18N2
Mol.Wt.	: 130.2
Inv. Status	: Custom Synthesis

Hydroxychloroquine Impurity 11

SZ CAT No:	: SZ-H004043
CAS No	: 630067-21-9
Mol.F.	: C10H5Cl2NO2
Mol.Wt.	: 242.1
Inv. Status	: Custom Synthesis

Hydroxychloroquine-d4 Sulfate

SZ CAT No:	: SZ-H004D02
CAS No	: 1216432-56-2
Mol.F.	: C18H22D4ClN3O : H2O4S
Mol.Wt.	: 339.9 : 98.1
Inv. Status	: Custom Synthesis
Rel. CAS No	: 1216432-55-1 (free base)

Hydroxychloroquine EP Impurity G

SZ CAT No:	: SZ-H004044
CAS No	: 86-98-6
Mol.F.	: C9H5Cl2N
Mol.Wt.	: 198.1
Inv. Status	: In Stock
Rel. CAS No	: 1198-39-6 (HCl salt) ; 863028-21-1 (HBr salt)

Hydroxychloroquine Impurity 12

SZ CAT No:	: SZ-H004045
CAS No	: NA
Mol.F.	: C27H30Cl2N4O
Mol.Wt.	: 497.5
Inv. Status	: Custom Synthesis

Hydroxychloroquine Impurity 13

SZ CAT No:	: SZ-H004046
CAS No	: 2411340-32-2
Mol.F.	: C27H30Cl2N4O
Mol.Wt.	: 497.5
Inv. Status	: Custom Synthesis

Hydroxychloroquine Impurity 14

SZ CAT No:	: SZ-H004047
CAS No	: NA
Mol.F.	: C16H22ClN3O
Mol.Wt.	: 307.8
Inv. Status	: Custom Synthesis

N-Nitroso-Hydroxychloroquine

SZ CAT No:	: SZ-H004048
CAS No	: NA
Mol.F.	: C18H25ClN4O2
Mol.Wt.	: 364.9
Inv. Status	: Inquire

Cletoquine-d4

SZ CAT No:	: SZ-H004D11
CAS No	: 1216461-56-1
Mol.F.	: C16H18D4ClN3O
Mol.Wt.	: 311.8
Inv. Status	: Custom Synthesis
Rel. CAS No	: 1216461-57-2 (Oxalate salt)

Hydroxychloroquine-d4

SZ CAT No:	: SZ-H004D12
CAS No	: 1216432-55-1
Mol.F.	: C18H22D4ClN3O
Mol.Wt.	: 339.9
Inv. Status	: Custom Synthesis
Rel. CAS No	: 1216432-56-2 (sulfate salt)

4-Amino-1-pentanol-d4 Hydrochloride

SZ CAT No:	: SZ-H004D13
CAS No	: 1216414-18-4
Mol.F.	: C5H9D4NO : HCl
Mol.Wt.	: 107.2 : 36.5
Inv. Status	: Custom Synthesis
Rel. CAS No	: 1216666-53-3 (free base)

Hydroxychloroquine

SZ CAT No:	: SZ-H004025
CAS No	: 118-42-3
Mol.F.	: C18H26ClN3O
Mol.Wt.	: 335.9
Inv. Status	: In Stock
Rel. CAS No	: 747-36-4 (sulfate salt)

Hydroxychloroquine EP Impurity D

SZ CAT No:	: SZ-H004049
CAS No	: 1476-52-4
Mol.F.	: C16H22ClN3
Mol.Wt.	: 291.8
Inv. Status	: In Stock
Rel. CAS No	: 4298-11-7 (HCl salt)

Hydroxychloroquine Impurity 15

SZ CAT No:	: SZ-H004054
CAS No	: 91911-59-0
Mol.F.	: C13H15ClN2O
Mol.Wt.	: 250.7
Inv. Status	: Custom Synthesis

Desethyl hydrochloroquine-O-Acetate

SZ CAT No:	: SZ-H004055
CAS No	: NA
Mol.F.	: C18H24ClN3O2
Mol.Wt.	: 349.9
Inv. Status	: Custom Synthesis

Hydroxychloroquine Impurity 16

SZ CAT No:	: SZ-H004056
CAS No	: NA
Mol.F.	: C20H26ClN3O4
Mol.Wt.	: 407.9
Inv. Status	: Custom Synthesis

4-Amino-1-(diethylamino)pentane

SZ CAT No:	: SZ-H004057
CAS No	: 140-80-7
Mol.F.	: C9H22N2
Mol.Wt.	: 158.3
Inv. Status	: Custom Synthesis

Hydroxychloroquine Impurity 18

SZ CAT No:	: SZ-H004058
CAS No	: NA
Mol.F.	: C16H21ClN2O2
Mol.Wt.	: 308.8
Inv. Status	: Custom Synthesis

Hydroxychloroquine Sulfate EP Impurity B

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