Aprepitant Impurity 3

SZ CAT No:	SZ-A030042
CAS No	287930-75-0
Mol.F.	C21H19F6NO3
Mol.Wt.	447.4
Inv. Status	Custom Synthesis

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Chemical Name: (R)-4-Benzyl-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)morpholin-3-one

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: C[C@H](C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)O[C@@H](OCCN2CC3=CC=CC=C3)C2=O

Application of analytical quality by design principles for the determination of alkyl p-toluenesulfonates impurities in Aprepitant by HPLC. Validation using total-error concept
Constantinos K. Zacharis, Elli Vastardi
Journal of Pharmaceutical and Biomedical Analysis Volume 150, 20 February 2018, Pages 152-161

Characterization and Quantitation of Aprepitant Drug Substance Polymorphs by Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy
Roy Helmy,* George X. Zhou, Yadan W. Chen, Louis Crocker, Tao Wang, Robert M. Wenslow, Jr., and Anant Vailaya*
Anal. Chem. 2003, 75, 605-611

Development and Optimization of Liquid Chromatography Analytical Methods by Using AQbD Principles: Overview and Recent Advances
Tim Tome,†,Nina Ž igart, Zdenko Č asar,, and AlešObreza
Org. Process Res. Dev. 2019, 23, 1784−1802

Aprepitant Impurity 3 is chemically (R)-4-Benzyl-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)morpholin-3-one. Aprepitant Impurity 3 is supplied with detailed characterization data compliant with regulatory guideline. Aprepitant Impurity 3 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Aprepitant.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

Aprepitant Impurity 3

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SZ CAT No:	: SZ-A030001
CAS No	: 170729-80-3
Mol.F.	: C23H21F7N4O3
Mol.Wt.	: 534.4
Inv. Status	: In Stock

SZ CAT No:	: SZ-A030002
CAS No	: 1185502-97-9
Mol.F.	: C23H21F7N4O3
Mol.Wt.	: 534.4
Inv. Status	: In Stock

SZ CAT No:	: SZ-A030003
CAS No	: 172822-28-5
Mol.F.	: C23H21F7N4O3
Mol.Wt.	: 534.4
Inv. Status	: In Stock

SZ CAT No:	: SZ-A030004
CAS No	: 1242175-34-3
Mol.F.	: C23H21F7N4O3
Mol.Wt.	: 534.4
Inv. Status	: In Stock

SZ CAT No:	: SZ-A030005
CAS No	: 170902-81-5
Mol.F.	: C23H21F7N4O3
Mol.Wt.	: 534.4
Inv. Status	: In Stock

SZ CAT No:	: SZ-A030006
CAS No	: 1242175-40-1
Mol.F.	: C23H21F7N4O3
Mol.Wt.	: 534.4
Inv. Status	: In Stock

SZ CAT No:	: SZ-A030D01
CAS No	: 1133387-60-6
Mol.F.	: C23H17D4F7N4O3
Mol.Wt.	: 538.46
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A030007
CAS No	: 170729-76-7
Mol.F.	: C23H22F6N4O3
Mol.Wt.	: 516.4
Inv. Status	: In Stock

SZ CAT No:	: SZ-A030008
CAS No	: 2348441-62-1
Mol.F.	: C29H25F7N4O3
Mol.Wt.	: 610.5
Inv. Status	: In Stock

SZ CAT No:	: SZ-A030009
CAS No	: 2348441-63-2
Mol.F.	: C29H25F7N4O3
Mol.Wt.	: 610.5
Inv. Status	: In Stock

SZ CAT No:	: SZ-A030031
CAS No	: 155742-64-6
Mol.F.	: C4H8ClN3O2
Mol.Wt.	: 165.6
Inv. Status	: In Stock

SZ CAT No:	: SZ-A030041
CAS No	: 171338-33-3
Mol.F.	: C20H19F6NO2
Mol.Wt.	: 419.4
Inv. Status	: In Stock

SZ CAT No:	: SZ-A030042
CAS No	: 287930-75-0
Mol.F.	: C21H19F6NO3
Mol.Wt.	: 447.4
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A030043
CAS No	: 380499-07-0
Mol.F.	: C20H16F7NO2
Mol.Wt.	: 435.3
Inv. Status	: In Stock

SZ CAT No:	: SZ-A030012
CAS No	: 380499-06-9
Mol.F.	: C20H18F7NO2
Mol.Wt.	: 437.4
Inv. Status	: In Stock

SZ CAT No:	: SZ-A030014
CAS No	: 1185503-48-3
Mol.F.	: C20H18F7NO2
Mol.Wt.	: 437.4
Inv. Status	: In Stock

SZ CAT No:	: SZ-A030015
CAS No	: 170902-80-4
Mol.F.	: C20H18F7NO2
Mol.Wt.	: 437.4
Inv. Status	: In Stock

SZ CAT No:	: SZ-A030016
CAS No	: 1242175-36-5
Mol.F.	: C20H18F7NO2
Mol.Wt.	: 437.4
Inv. Status	: In Stock

SZ CAT No:	: SZ-A030017
CAS No	: 170729-79-0
Mol.F.	: C20H18F7NO2
Mol.Wt.	: 437.4
Inv. Status	: In Stock

SZ CAT No:	: SZ-A030018
CAS No	: 327623-37-0
Mol.F.	: C20H18F7NO2
Mol.Wt.	: 437.4
Inv. Status	: Out of Stock, Custom Synthesis

SZ CAT No:	: SZ-A030019
CAS No	: 1242175-38-7
Mol.F.	: C20H18F7NO2
Mol.Wt.	: 437.4
Inv. Status	: In Stock

SZ CAT No:	: SZ-A030020
CAS No	: 419574-33-7
Mol.F.	: C20H16F7NO3
Mol.Wt.	: 451.3
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A030021
CAS No	: NA
Mol.F.	: C20H16F7NO3
Mol.Wt.	: 451.3
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A030022
CAS No	: 419574-04-2
Mol.F.	: C20H16F7NO3
Mol.Wt.	: 451.3
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A030023
CAS No	: NA
Mol.F.	: C20H16F7NO3
Mol.Wt.	: 451.3
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A030024
CAS No	: NA
Mol.F.	: C20H16F7NO3
Mol.Wt.	: 451.3
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A030025
CAS No	: 2514951-25-6
Mol.F.	: C20H16F7NO3
Mol.Wt.	: 451.3
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A030026
CAS No	: NA
Mol.F.	: C20H16F7NO3
Mol.Wt.	: 451.3
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A030027
CAS No	: NA
Mol.F.	: C20H16F7NO3
Mol.Wt.	: 451.3
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A030028
CAS No	: 172676-88-9
Mol.F.	: C23H21F7N4O3
Mol.Wt.	: 534.4
Inv. Status	: Custom Synthesis