Chemical Name: (2-butylbenzofuran-3-yl)(4-hydroxy-3,5-diiodophenyl)methanone (as per EP) ; (2-Butylbenzofuran-3-yl)(4-hydroxy-3,5-diiodophenyl) methanone (as per USP)
Synonym: Amiodarone USP Related Compound D ; Amiodarone Metabolite B2 ;
Smiles: O=C(C1=C(CCCC)OC2=CC=CC=C12)C3=CC(I)=C(O)C(I)=C3
Inchi: InChI=1S/C25H30INO3.ClH/c1-4-7-11-23-24(19-10-8-9-12-21(19)30-23)25(28)18-13-14-22(20(26)17-18)29-16-15-27(5-2)6-3;/h8-10,12-14,17H,4-7,11,15-16H2,1-3H3;1H
Quality by design (QbD) based development and validation of an HPLC method for amiodarone hydrochloride and its impurities in the drug substance
S. Karmarkar ∗, X. Yang, R. Garber, A. Szajkovics, M. Koberda
Journal of Pharmaceutical and Biomedical Analysis 100 (2014) 167–174
Validation of a Stability-Indicating HPLC Method for the Determination of Amiodarone HCl and Its Related Substances in Amiodarone HCl Injection
Matthew J. Christopherson,* Kenton J. Yoder, and R. Brent Miller
Journal of liquid chromatography & related technologies vol. 27, No. 1, pp. 95–111, 2004
Stability-indicating HPLC method for determination of amiodarone hydrochloride and its impurities in tablets: a detailed forced degradation study
Ana Silva Coelho1 , Igor Felipe Rodrigues Ribeiro1 , Eduardo Burgarelli Lages
Braz. J. Pharm. Sci. vol.56
Validation of a Stability Indicating LC Method for Amiodarone HCL and Related Substances
M. A. Khan, S. Kumar, J. Jayachandran, S. V. Vartak, A. Bhartiya, S. Sinha
Chromatographia volume 61, pages599–607(2005)