Sacubitrilat

N° de SZ CAT:	SZ-S020007
Número CAS	149709-44-4
Mol.F.	C22H25NO5
Peso Molecular	383.5
Status de Fatura	In Stock
Shipping Condition	Ambient Temperature

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Nome Químico: (2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-(3-carboxypropanamido)-2-methylpentanoic acid

Sinônimo: Sacubitril Desethyl Impurity ; Sacubitril Diacid Impurity

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Sorrisos: C[C@@H](C(O)=O)C[C@H](NC(CCC(O)=O)=O)CC1=CC=C(C2=CC=CC=C2)C=C1

A liquid chromatographic method for separation of sacubitril–valsartan and their stereoisomeric impurities
Lu Zhou, Liang Zou, Lili Sun, Hui Zhang, Wenkai Hui and Qiaogen Zou
Anal. Methods, 2018,10, 1046-1053

Quantification of potential genotoxic impurity in sacubitril/valsartan drug substance at ppm level by LC-MS/MS
Ravi Uppala, M.Arthanareeswari, S.Devikala,T.Pushpamalini, J. ArockiaSelvi
Materials Today: Proceedings Volume 14, Part 2, 2019, Pages 640-645

Experimental Design Approach in HPLC Method Development: Application for the Simultaneous Determination of Sacubitril and Valsartan in Presence of Their Impurities and Investigation of Degradation Kinetics
Bahia A. Moussa, Hanaa M. A. Hashem, Marianne A. Mahrouse & Sally T. Mahmoud
Chromatographia volume 81, pages139–156(2018)

Development and validation of a stability indicating UHPLC method for Sacubitril/Valsartan complex in the presence of impurities and degradation products
Pintu Prajapati, Dhara Bhayani, Priti Mehta.
J App Pharm Sci. 2020; 10(2): 97-107

Sacubitrilat is chemically (2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-(3-carboxypropanamido)-2-methylpentanoic acid. It is also known as Sacubitril Desethyl Impurity ; Sacubitril Diacid Impurity. Sacubitrilat is supplied with detailed characterization data compliant with regulatory guideline. Sacubitrilat can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Sacubitril.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

Sacubitrilat

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N° de SZ CAT:	: SZ-S020001
Número CAS	: 1369773-39-6
Mol.F.	: C24H28NO5 : 1/2(Ca)
Peso Molecular	: 410.5 : 1/2(40.1)
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-S020002
Número CAS	: 149709-63-7
Mol.F.	: C24H29NO5
Peso Molecular	: 411.5
Status de Fatura	: Out of Stock

N° de SZ CAT:	: SZ-S020003
Número CAS	: 2259708-00-2
Mol.F.	: C24H29NO5
Peso Molecular	: 411.5
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-S020004
Número CAS	: 1038924-70-7
Mol.F.	: C18H19NO
Peso Molecular	: 265.4
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-S020005
Número CAS	: 1038924-97-8
Mol.F.	: C24H27NO4
Peso Molecular	: 393.5
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-S020007
Número CAS	: 149709-44-4
Mol.F.	: C22H25NO5
Peso Molecular	: 383.5
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-S020008
Número CAS	: 1012341-56-8
Mol.F.	: C23H29NO4
Peso Molecular	: 383.5
Status de Fatura	: Out of Stock

N° de SZ CAT:	: SZ-S020009
Número CAS	: 1012341-54-6
Mol.F.	: C23H29NO4
Peso Molecular	: 383.5
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-S020010
Número CAS	: 1012341-52-4
Mol.F.	: C23H29NO4
Peso Molecular	: 383.5
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-S020011
Número CAS	: 1012341-50-2
Mol.F.	: C23H29NO4
Peso Molecular	: 383.5
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-S020012
Número CAS	: 149690-12-0
Mol.F.	: C20H25NO2 : HCl
Peso Molecular	: 311.4 : 36.5
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-S020013
Número CAS	: 149709-60-4
Mol.F.	: C25H33NO4
Peso Molecular	: 411.6
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-S020014
Número CAS	: 1038924-71-8
Mol.F.	: C18H21NO2 : HCl
Peso Molecular	: 283.4 : 36.5
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-S020015
Número CAS	: 1015037-46-3
Mol.F.	: C23H27NO4
Peso Molecular	: 381.5
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-S020016
Número CAS	: 2459446-51-4
Mol.F.	: C25H31NO5
Peso Molecular	: 425.5
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-S020017
Número CAS	: 2216755-67-6
Mol.F.	: C28H37NO5
Peso Molecular	: 467.6
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-S020018
Número CAS	: 2459446-53-6
Mol.F.	: C27H35NO5
Peso Molecular	: 453.6
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-S020019
Número CAS	: 149709-49-9
Mol.F.	: C24H29NO5
Peso Molecular	: 411.5
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-S020020
Número CAS	: 2376611-98-0
Mol.F.	: C26H33NO5
Peso Molecular	: 439.6
Status de Fatura	: Limited Stock

N° de SZ CAT:	: SZ-S020021
Número CAS	: 1426129-50-1
Mol.F.	: C20H25NO3
Peso Molecular	: 327.4
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-S020022
Número CAS	: 2459446-54-7
Mol.F.	: C22H23NO4
Peso Molecular	: 365.4
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-S020023
Número CAS	: 2459446-55-8
Mol.F.	: C25H29NO4
Peso Molecular	: 407.5
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-S020024
Número CAS	: 1817838-91-7
Mol.F.	: C25H31NO4
Peso Molecular	: 409.5
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-S020025
Número CAS	: 1012341-48-8
Mol.F.	: C23H27NO4
Peso Molecular	: 381.5
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-S020026
Número CAS	: NA
Mol.F.	: C18H19NO2 : HCl
Peso Molecular	: 281.4 : 36.5
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-S020027
Número CAS	: 2957885-25-3
Mol.F.	: C20H23NO2 : HCl
Peso Molecular	: 309.4 : 36.5
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-S020028
Número CAS	: 2984580-03-0
Mol.F.	: C24H27NO5
Peso Molecular	: 409.5
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-S020029
Número CAS	: 2408053-56-3
Mol.F.	: C23H27NO5
Peso Molecular	: 397.5
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-S020030
Número CAS	: 761373-05-1
Mol.F.	: C24H29NO5
Peso Molecular	: 411.5
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-S020031
Número CAS	: 2413471-13-1
Mol.F.	: C24H27NO4
Peso Molecular	: 393.5
Status de Fatura	: Limited Stock