Sacubitril Impurity 22

N° de SZ CAT:	SZ-S020025
Número CAS	1012341-48-8
Mol.F.	C23H27NO4
Peso Molecular	381.5
Status de Fatura	In Stock

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Nome Químico: (R,E)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Sorrisos: OC(/C(C)=C/[C@H](NC(OC(C)(C)C)=O)CC(C=C1)=CC=C1C2=CC=CC=C2)=O

A liquid chromatographic method for separation of sacubitril–valsartan and their stereoisomeric impurities
Lu Zhou, Liang Zou, Lili Sun, Hui Zhang, Wenkai Hui and Qiaogen Zou
Anal. Methods, 2018,10, 1046-1053

Quantification of potential genotoxic impurity in sacubitril/valsartan drug substance at ppm level by LC-MS/MS
Ravi Uppala, M.Arthanareeswari, S.Devikala,T.Pushpamalini, J. ArockiaSelvi
Materials Today: Proceedings Volume 14, Part 2, 2019, Pages 640-645

Experimental Design Approach in HPLC Method Development: Application for the Simultaneous Determination of Sacubitril and Valsartan in Presence of Their Impurities and Investigation of Degradation Kinetics
Bahia A. Moussa, Hanaa M. A. Hashem, Marianne A. Mahrouse & Sally T. Mahmoud
Chromatographia volume 81, pages139–156(2018)

Development and validation of a stability indicating UHPLC method for Sacubitril/Valsartan complex in the presence of impurities and degradation products
Pintu Prajapati, Dhara Bhayani, Priti Mehta.
J App Pharm Sci. 2020; 10(2): 97-107

Sacubitril Impurity 22 is chemically (R,E)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid. Sacubitril Impurity 22 is supplied with detailed characterization data compliant with regulatory guideline. Sacubitril Impurity 22 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Sacubitril.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

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Sacubitril Calcium

N° de SZ CAT:	: SZ-S020001
Número CAS	: 1369773-39-6
Mol.F.	: C24H28NO5 : 1/2(Ca)
Peso Molecular	: 410.5 : 1/2(40.1)
Status de Fatura	: In Stock

Sacubitril-(2S,4S)-Isomer

N° de SZ CAT:	: SZ-S020002
Número CAS	: 149709-63-7
Mol.F.	: C24H29NO5
Peso Molecular	: 411.5
Status de Fatura	: In Stock

Sacubitril-(2R,4R)-Isomer

N° de SZ CAT:	: SZ-S020003
Número CAS	: 2259708-00-2
Mol.F.	: C24H29NO5
Peso Molecular	: 411.5
Status de Fatura	: In Stock

Sacubitril (3R,5S)-Pyrrolidinone Impurity

N° de SZ CAT:	: SZ-S020004
Número CAS	: 1038924-70-7
Mol.F.	: C18H19NO
Peso Molecular	: 265.4
Status de Fatura	: In Stock

2,5-Dioxopyrrolidine Sacubitril

N° de SZ CAT:	: SZ-S020005
Número CAS	: 1038924-97-8
Mol.F.	: C24H27NO4
Peso Molecular	: 393.5
Status de Fatura	: In Stock

Sacubitrilat

N° de SZ CAT:	: SZ-S020007
Número CAS	: 149709-44-4
Mol.F.	: C22H25NO5
Peso Molecular	: 383.5
Status de Fatura	: In Stock

Sacubitril Impurity 5

N° de SZ CAT:	: SZ-S020008
Número CAS	: 1012341-56-8
Mol.F.	: C23H29NO4
Peso Molecular	: 383.5
Status de Fatura	: In Stock

Sacubitril Impurity 6

N° de SZ CAT:	: SZ-S020009
Número CAS	: 1012341-54-6
Mol.F.	: C23H29NO4
Peso Molecular	: 383.5
Status de Fatura	: In Stock

Sacubitril Impurity 7

N° de SZ CAT:	: SZ-S020010
Número CAS	: 1012341-52-4
Mol.F.	: C23H29NO4
Peso Molecular	: 383.5
Status de Fatura	: In Stock

Sacubitril Impurity 8

N° de SZ CAT:	: SZ-S020011
Número CAS	: 1012341-50-2
Mol.F.	: C23H29NO4
Peso Molecular	: 383.5
Status de Fatura	: In Stock

Sacubitril Impurity 9

N° de SZ CAT:	: SZ-S020012
Número CAS	: 149690-12-0
Mol.F.	: C20H25NO2 : HCl
Peso Molecular	: 311.4 : 36.5
Status de Fatura	: In Stock

Sacubitril Impurity 10

N° de SZ CAT:	: SZ-S020013
Número CAS	: 149709-60-4
Mol.F.	: C25H33NO4
Peso Molecular	: 411.6
Status de Fatura	: In Stock

Sacubitril Impurity 11

N° de SZ CAT:	: SZ-S020014
Número CAS	: 1038924-71-8
Mol.F.	: C18H21NO2 : HCl
Peso Molecular	: 283.4 : 36.5
Status de Fatura	: In Stock

Sacubitril Impurity 12

N° de SZ CAT:	: SZ-S020015
Número CAS	: 1015037-46-3
Mol.F.	: C23H27NO4
Peso Molecular	: 381.5
Status de Fatura	: Custom Synthesis

Sacubitril Impurity 13

N° de SZ CAT:	: SZ-S020016
Número CAS	: 2459446-51-4
Mol.F.	: C25H31NO5
Peso Molecular	: 425.5
Status de Fatura	: Custom Synthesis

Sacubitril Impurity 14

N° de SZ CAT:	: SZ-S020017
Número CAS	: 2216755-67-6
Mol.F.	: C28H37NO5
Peso Molecular	: 467.6
Status de Fatura	: Custom Synthesis

Sacubitril Impurity 15

N° de SZ CAT:	: SZ-S020018
Número CAS	: 2459446-53-6
Mol.F.	: C27H35NO5
Peso Molecular	: 453.6
Status de Fatura	: Custom Synthesis

Sacubitril Impurity 16

N° de SZ CAT:	: SZ-S020019
Número CAS	: 149709-49-9
Mol.F.	: C24H29NO5
Peso Molecular	: 411.5
Status de Fatura	: Custom Synthesis

Sacubitril Impurity 17

N° de SZ CAT:	: SZ-S020020
Número CAS	: 2376611-98-0
Mol.F.	: C26H33NO5
Peso Molecular	: 439.6
Status de Fatura	: In Stock

Sacubitril Impurity 18

N° de SZ CAT:	: SZ-S020021
Número CAS	: 1426129-50-1
Mol.F.	: C20H25NO3
Peso Molecular	: 327.4
Status de Fatura	: Custom Synthesis

Sacubitril Impurity 19

N° de SZ CAT:	: SZ-S020022
Número CAS	: 2459446-54-7
Mol.F.	: C22H23NO4
Peso Molecular	: 365.4
Status de Fatura	: Under Synthesis

Sacubitril Impurity 20

N° de SZ CAT:	: SZ-S020023
Número CAS	: 2459446-55-8
Mol.F.	: C25H29NO4
Peso Molecular	: 407.5
Status de Fatura	: Custom Synthesis

Sacubitril Impurity 21

N° de SZ CAT:	: SZ-S020024
Número CAS	: 1817838-91-7
Mol.F.	: C25H31NO4
Peso Molecular	: 409.5
Status de Fatura	: In Stock