Methotrexate EP Impurity E

SZ CAT No:	SZ-M019006
CAS No	19741-14-1
Mol.F.	C15H15N7O2
Mol.Wt.	325.3
Inv. Status	In Stock
Rel. CAS No	70844-48-3 (hemihydrochloride salt)

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Chemical Name: 4-[[(2,4-Diaminopteridin-6-yl)methyl]methylamino]benzoic acid (as per EP & USP)

Synonym: Methotrexate USP Related Compound E ; (4-amino-N10-methylpteroic acid, APA (EP))

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: NC1=NC(N=CC(CN(C)C2=CC=C(C(O)=O)C=C2)=N3)=C3C(N)=N1

Identification and Quantitation of Impurities in Methotrexate
dulal c. chatterji, altice g. frazier, and joseph f. gallell
Journal of Pharmaceutical Sciences Volume 67, Issue 5, May 1978, Pages 622-624

determination of methotrexate and its major metabolite, 7_hydroxymethotrexate, using capillary zone electrophoresis and laser-induced fluorescence detection
mark c. roach, philippe gozel and richard n. zare
Journal of Chromatography, 426 (1988) 129-140

Analytical methodologies for determination of methotrexate and its metabolites in pharmaceutical, biological and environmental samples
Forough Karami , Sara Ranjbar , Younes Ghasemi , Manica Negahdaripour
Journal of Pharmaceutical Analysis 9 (2019) 373-391

Perspectives of Methotrexate-Based Radioagents for Application in Nuclear Medicine
Paweł Krzysztof Halik,* Przemysław Kozmin ́ ski, and Ewa Gniazdowska
Mol. Pharmaceutics 2021, 18, 1, 33–43

Methotrexate EP Impurity E is chemically 4-[[(2,4-Diaminopteridin-6-yl)methyl]methylamino]benzoic acid (as per EP & USP). It is also known as Methotrexate USP Related Compound E ; (4-amino-N10-methylpteroic acid, APA (EP)). Methotrexate EP Impurity E is supplied with detailed characterization data compliant with regulatory guideline. Methotrexate EP Impurity E can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Methotrexate.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

Methotrexate EP Impurity E

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SZ CAT No:	: SZ-M019005
CAS No	: 5623-18-7
Mol.F.	: C15H14N6O3
Mol.Wt.	: 326.3
Inv. Status	: In Stock

SZ CAT No:	: SZ-M019001
CAS No	: 1212284-68-8
Mol.F.	: C20H22N8O5 : 2(H2O)
Mol.Wt.	: 454.4 : 2(18.0)
Inv. Status	: In Stock
Rel. CAS No	: 59-05-2 (free base)

SZ CAT No:	: SZ-M019002
CAS No	: 945-24-4
Mol.F.	: C7H8N6O
Mol.Wt.	: 192.1
Inv. Status	: In Stock
Rel. CAS No	: 73978-41-3 (HCl salt)

SZ CAT No:	: SZ-M019003
CAS No	: 1217459-90-9
Mol.F.	: C19H20N8O5 : H2O
Mol.Wt.	: 440.4 : 18.0
Inv. Status	: In Stock
Rel. CAS No	: 54-62-6 (free base)

SZ CAT No:	: SZ-M019004
CAS No	: 2410-93-7
Mol.F.	: C20H21N7O6
Mol.Wt.	: 455.4
Inv. Status	: In Stock

SZ CAT No:	: SZ-M019006
CAS No	: 19741-14-1
Mol.F.	: C15H15N7O2
Mol.Wt.	: 325.3
Inv. Status	: In Stock
Rel. CAS No	: 70844-48-3 (hemihydrochloride salt)

SZ CAT No:	: SZ-M019007
CAS No	: 51865-79-3
Mol.F.	: C20H22N8O5
Mol.Wt.	: 454.4
Inv. Status	: In Stock

SZ CAT No:	: SZ-M019008
CAS No	: 2519848-42-9
Mol.F.	: C28H29N9O6
Mol.Wt.	: 587.6
Inv. Status	: In Stock

SZ CAT No:	: SZ-M019009
CAS No	: 67022-39-3
Mol.F.	: C21H24N8O5
Mol.Wt.	: 468.5
Inv. Status	: In Stock

SZ CAT No:	: SZ-M019010
CAS No	: 66147-29-3
Mol.F.	: C21H24N8O5
Mol.Wt.	: 468.5
Inv. Status	: In Stock

SZ CAT No:	: SZ-M019011
CAS No	: 34378-65-9
Mol.F.	: C22H26N8O5
Mol.Wt.	: 482.5
Inv. Status	: In Stock

SZ CAT No:	: SZ-M019012
CAS No	: 4271-30-1
Mol.F.	: C12H14N2O5
Mol.Wt.	: 266.3
Inv. Status	: In Stock

SZ CAT No:	: SZ-M019013
CAS No	: 52980-68-4
Mol.F.	: C13H16N2O5
Mol.Wt.	: 280.3
Inv. Status	: In Stock

SZ CAT No:	: SZ-M019014
CAS No	: 5939-37-7
Mol.F.	: C20H22N8O6
Mol.Wt.	: 470.4
Inv. Status	: Limited Stock

SZ CAT No:	: SZ-M019015
CAS No	: 1189252-22-9
Mol.F.	: C14H12N6O3 : H2O
Mol.Wt.	: 312.3 : 18.0
Inv. Status	: Limited Stock
Rel. CAS No	: 119-24-4 (free base)

SZ CAT No:	: SZ-M019018
CAS No	: 73978-41-3
Mol.F.	: C7H8N6O : HCl
Mol.Wt.	: 192.2 : 36.5
Inv. Status	: In Stock
Rel. CAS No	: 945-24-4 (free base)

SZ CAT No:	: SZ-M019D01
CAS No	: 432545-63-6
Mol.F.	: C20H19D3N8O5
Mol.Wt.	: 457.5
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-M019019
CAS No	: 71074-44-7
Mol.F.	: C22H27N9O4
Mol.Wt.	: 481.5
Inv. Status	: In Stock

SZ CAT No:	: SZ-M019020
CAS No	: 1127-93-1
Mol.F.	: C6H6N6
Mol.Wt.	: 162.2
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-M019021
CAS No	: 708-74-7
Mol.F.	: C7H8N6
Mol.Wt.	: 176.2
Inv. Status	: Custom Synthesis

Methotrexate EP Impurity E

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SZ CAT No:	: SZ-M019022
CAS No	: 57444-70-9
Mol.F.	: C12H12ClNO5
Mol.Wt.	: 285.7
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-M019023
CAS No	: 2378-95-2
Mol.F.	: C17H24N2O5
Mol.Wt.	: 336.4
Inv. Status	: Under Synthesis

SZ CAT No:	: SZ-M019024
CAS No	: 1029980-84-4
Mol.F.	: C17H24N2O5
Mol.Wt.	: 336.4
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-M019025
CAS No	: 51865-66-8
Mol.F.	: C17H24N2O5
Mol.Wt.	: 336.4
Inv. Status	: Under Synthesis

SZ CAT No:	: SZ-M019026
CAS No	: 54-62-6
Mol.F.	: C19H20N8O5
Mol.Wt.	: 440.4
Inv. Status	: In Stock
Rel. CAS No	: 1217459-90-9 (hydrate)

SZ CAT No:	: SZ-M019027
CAS No	: NA
Mol.F.	: C25H31N3O6
Mol.Wt.	: 469.5
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-M019016
CAS No	: 119843-02-6
Mol.F.	: C12H13NO6
Mol.Wt.	: 267.2
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-M019028
CAS No	: NA
Mol.F.	: C19H19N9O6
Mol.Wt.	: 469.4
Inv. Status	: In Stock

SZ CAT No:	: SZ-M019029
CAS No	: NA
Mol.F.	: C13H15N3O6
Mol.Wt.	: 309.3
Inv. Status	: In Stock

SZ CAT No:	: SZ-M019030
CAS No	: 60388-53-6
Mol.F.	: C20H22N8O5
Mol.Wt.	: 454.4
Inv. Status	: Custom Synthesis