Varenicline Impurity 46

SZ CAT No:	SZ-V015084
CAS No	NA
Mol.F.	C13H12F3N3O3
Mol.Wt.	315.3
Inv. Status	Custom Synthesis

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Chemical Name: 1-((1R,5S)-8-Amino-6-nitro-1,2,4,5-tetrahydro-3H-1,5-methanobenzo[d]azepin-3-yl)-2,2,2-trifluoroethan-1-one

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: O=C(N1C[C@@](C2)([H])C3=CC(N)=CC([N+]([O-])=O)=C3[C@@]2([H])C1)C(F)(F)F

Varenicline Impurity 46 is chemically 1-((1R,5S)-8-Amino-6-nitro-1,2,4,5-tetrahydro-3H-1,5-methanobenzo[d]azepin-3-yl)-2,2,2-trifluoroethan-1-one. Varenicline Impurity 46 is supplied with detailed characterization data compliant with regulatory guideline. Varenicline Impurity 46 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Varenicline.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

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SZ CAT No:	: SZ-V015021
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Mol.F.	: C13H14F3N3O
Mol.Wt.	: 285.3
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Varenicline Tartrate

SZ CAT No:	: SZ-V015001
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Mol.F.	: C13H13N3 : C4H6O6
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Varenicline Dioxo Impurity

SZ CAT No:	: SZ-V015002
CAS No	: 357424-07-8
Mol.F.	: C13H13N3O2
Mol.Wt.	: 243.3
Inv. Status	: Custom Synthesis

Varenicline N-Formyl Impurity

SZ CAT No:	: SZ-V015003
CAS No	: 796865-82-2
Mol.F.	: C14H13N3O
Mol.Wt.	: 239.3
Inv. Status	: Out of Stock

Varenicline Ortho-Dinitro Impurity

SZ CAT No:	: SZ-V015004
CAS No	: 230615-59-5
Mol.F.	: C13H10F3N3O5
Mol.Wt.	: 345.2
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Varenicline N-Trifluoroacetyl Impurity

SZ CAT No:	: SZ-V015006
CAS No	: 230615-70-0
Mol.F.	: C15H12F3N3O
Mol.Wt.	: 307.3
Inv. Status	: In Stock

Varenicline Meta-Dinitro Impurity

SZ CAT No:	: SZ-V015007
CAS No	: 853946-18-6
Mol.F.	: C13H10F3N3O5
Mol.Wt.	: 345.2
Inv. Status	: Custom Synthesis

Varenicline Impurity 1

SZ CAT No:	: SZ-V015008
CAS No	: NA
Mol.F.	: C14H15N3 : C4H8O6
Mol.Wt.	: 225.3 : 152.1
Inv. Status	: Custom Synthesis

Varenicline N-Methyl Impurity

SZ CAT No:	: SZ-V015009
CAS No	: 328055-92-1
Mol.F.	: C14H15N3
Mol.Wt.	: 225.3
Inv. Status	: In Stock

Varenicline D4

SZ CAT No:	: SZ-V015D01
CAS No	: NA
Mol.F.	: C13H9D4N3 : HCl
Mol.Wt.	: 215.3 : 36.5
Inv. Status	: Out of Stock

Varenicline Impurity 2

SZ CAT No:	: SZ-V015022
CAS No	: 230615-08-4
Mol.F.	: C11H11N3O4
Mol.Wt.	: 249.2
Inv. Status	: In Stock

Varenicline Impurity 3

SZ CAT No:	: SZ-V015023
CAS No	: NA
Mol.F.	: C12H13N3 : 2(HCl)
Mol.Wt.	: 199.3 : 2(36.5)
Inv. Status	: In Stock
Rel. CAS No	: 357424-12-5 (free base) ; 230615-10-8 ( HCl salt)

Varenicline Impurity 4

SZ CAT No:	: SZ-V015024
CAS No	: 950781-94-9
Mol.F.	: C11H11N3O4
Mol.Wt.	: 249.2
Inv. Status	: Custom Synthesis

Varenicline Impurity 5

SZ CAT No:	: SZ-V015025
CAS No	: NA
Mol.F.	: C13H13N3O
Mol.Wt.	: 227.3
Inv. Status	: In Stock

Varenicline Impurity 6

SZ CAT No:	: SZ-V015026
CAS No	: 808120-35-6
Mol.F.	: C11H15N3
Mol.Wt.	: 189.3
Inv. Status	: In Stock

Varenicline Impurity 7

SZ CAT No:	: SZ-V015027
CAS No	: NA
Mol.F.	: C13H13N3O
Mol.Wt.	: 227.3
Inv. Status	: Custom Synthesis

Varenicline Impurity 8

SZ CAT No:	: SZ-V015028
CAS No	: 950781-89-2
Mol.F.	: C13H12F3N3O3
Mol.Wt.	: 315.3
Inv. Status	: In Stock

Varenicline N-Glucoside

SZ CAT No:	: SZ-V015029
CAS No	: 873302-31-9
Mol.F.	: C19H23N3O5
Mol.Wt.	: 373.4
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N-Hydroxy Varenicline

SZ CAT No:	: SZ-V015030
CAS No	: 2724982-86-7
Mol.F.	: C13H13N3O
Mol.Wt.	: 227.3
Inv. Status	: Custom Synthesis

Varenicline N- Dioxide

SZ CAT No:	: SZ-V015031
CAS No	: 1337563-47-9
Mol.F.	: C13H13N3O2
Mol.Wt.	: 243.3
Inv. Status	: Custom Synthesis

Varenicline Tartrate Impurity F

SZ CAT No:	: SZ-V015033
CAS No	: 357426-10-9
Mol.F.	: C15H12F3N3O2
Mol.Wt.	: 323.3
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4-Nitrobenzoyl Varenicline

SZ CAT No:	: SZ-V015034
CAS No	: 1329651-19-5
Mol.F.	: C20H16N4O4
Mol.Wt.	: 376.4
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Varenicline Lactam

SZ CAT No:	: SZ-V015035
CAS No	: 873302-30-8
Mol.F.	: C13H11N3O
Mol.Wt.	: 225.3
Inv. Status	: Custom Synthesis

Varenicline Carbamoyl β-D-Glucuronide

SZ CAT No:	: SZ-V015036
CAS No	: 535920-98-0
Mol.F.	: C20H21N3O8
Mol.Wt.	: 431.4
Inv. Status	: Custom Synthesis

Varenicline Nitroso Impurity 1

SZ CAT No:	: SZ-V015037
CAS No	: 2755871-02-2
Mol.F.	: C13H12N4O
Mol.Wt.	: 240.3
Inv. Status	: In Stock

Varenicline Nitroso Impurity 4

SZ CAT No:	: SZ-V015038
CAS No	: 2803960-63-4
Mol.F.	: C11H10N4O5
Mol.Wt.	: 278.2
Inv. Status	: In Stock

Varenicline Impurity 11

SZ CAT No:	: SZ-V015040
CAS No	: NA
Mol.F.	: C11H16N4
Mol.Wt.	: 204.3
Inv. Status	: Custom Synthesis

Varenicline Impurity 12

SZ CAT No:	: SZ-V015041
CAS No	: 230615-53-9
Mol.F.	: C13H11F3N2O3
Mol.Wt.	: 300.2
Inv. Status	: Custom Synthesis

Varenicline Impurity 13

SZ CAT No:	: SZ-V015042
CAS No	: NA
Mol.F.	: C13H14F3N3O
Mol.Wt.	: 285.3
Inv. Status	: Custom Synthesis

Varenicline Impurity 14

SZ CAT No:	: SZ-V015043
CAS No	: 230615-56-2
Mol.F.	: C13H13F3N2O
Mol.Wt.	: 270.3
Inv. Status	: Custom Synthesis

Varenicline Nitroso Impurity 3

SZ CAT No:	: SZ-V015044
CAS No	: 2803960-64-5
Mol.F.	: C11H14N4O
Mol.Wt.	: 218.3
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Varenicline Impurity 16

SZ CAT No:	: SZ-V015045
CAS No	: NA
Mol.F.	: C13H14N4
Mol.Wt.	: 226.3
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Varenicline Nitroso Impurity 5

SZ CAT No:	: SZ-V015046
CAS No	: NA
Mol.F.	: C11H12N2O
Mol.Wt.	: 188.2
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Varenicline Impurity 18

SZ CAT No:	: SZ-V015047
CAS No	: 2306217-15-0
Mol.F.	: C17H17N3O5
Mol.Wt.	: 343.3
Inv. Status	: Limited Stock

Varenicline N-Oxide

SZ CAT No:	: SZ-V015048
CAS No	: 2306217-12-7
Mol.F.	: C13H13N3O
Mol.Wt.	: 227.3
Inv. Status	: Custom Synthesis

Varenicline Impurity 19

SZ CAT No:	: SZ-V015049
CAS No	: 2832128-82-0
Mol.F.	: C14H15N3O
Mol.Wt.	: 241.3
Inv. Status	: Custom Synthesis

Varenicline Impurity 22

SZ CAT No:	: SZ-V015052
CAS No	: 832089-32-4
Mol.F.	: C15H14F3N3O
Mol.Wt.	: 309.3
Inv. Status	: Under Synthesis

Varenicline Impurity 23

SZ CAT No:	: SZ-V015053
CAS No	: NA
Mol.F.	: C27H24N6O
Mol.Wt.	: 448.5
Inv. Status	: Custom Synthesis

Varenicline Impurity 26

SZ CAT No:	: SZ-V015056
CAS No	: 1333145-89-3
Mol.F.	: C14H15N3
Mol.Wt.	: 225.3
Inv. Status	: Custom Synthesis

Varenicline Impurity 27

SZ CAT No:	: SZ-V015057
CAS No	: 357424-22-7
Mol.F.	: C11H14N2
Mol.Wt.	: 174.2
Inv. Status	: Custom Synthesis

Varenicline Impurity 28

SZ CAT No:	: SZ-V015058
CAS No	: NA
Mol.F.	: C13H13N3O
Mol.Wt.	: 227.3
Inv. Status	: Custom Synthesis

Varenicline Impurity 29

SZ CAT No:	: SZ-V015059
CAS No	: 230615-52-8
Mol.F.	: C11H13N : HCl
Mol.Wt.	: 159.2 : 36.5
Inv. Status	: Custom Synthesis
Rel. CAS No	: 69718-72-5 (free base)

Varenicline Impurity 30

SZ CAT No:	: SZ-V015060
CAS No	: 230615-51-7
Mol.F.	: C13H12F3NO
Mol.Wt.	: 255.2
Inv. Status	: Custom Synthesis

Varenicline Impurity 31

SZ CAT No:	: SZ-V015061
CAS No	: 230615-48-2
Mol.F.	: C18H19N
Mol.Wt.	: 249.4
Inv. Status	: Custom Synthesis

Varenicline Impurity 32

SZ CAT No:	: SZ-V015063
CAS No	: 26326-70-5
Mol.F.	: C11H12O2
Mol.Wt.	: 176.2
Inv. Status	: Custom Synthesis

Varenicline Impurity 33

SZ CAT No:	: SZ-V015064
CAS No	: 4453-90-1
Mol.F.	: C11H10
Mol.Wt.	: 142.2
Inv. Status	: Custom Synthesis

N-Nitroso Varenicline-d12

SZ CAT No:	: SZ-V015D02
CAS No	: NA
Mol.F.	: C13D12N4O
Mol.Wt.	: 252.3
Inv. Status	: Custom Synthesis

2-Hydroxy-4-Oxo-Varenicline

SZ CAT No:	: SZ-V015066
CAS No	: 2306217-11-6
Mol.F.	: C13H13N3O2
Mol.Wt.	: 243.3
Inv. Status	: Custom Synthesis

Varenicline Impurity 35

SZ CAT No:	: SZ-V015067
CAS No	: 2306217-13-8
Mol.F.	: C15H15N3O2
Mol.Wt.	: 269.3
Inv. Status	: Custom Synthesis

Varenicline Impurity 36

SZ CAT No:	: SZ-V015068
CAS No	: 2306217-14-9
Mol.F.	: C15H17N3O2
Mol.Wt.	: 271.3
Inv. Status	: Custom Synthesis

Varenicline Impurity 37

SZ CAT No:	: SZ-V015069
CAS No	: 2306217-16-1
Mol.F.	: C28H26N6O
Mol.Wt.	: 462.6
Inv. Status	: Custom Synthesis

Varenicline Nitroso Impurity 2

SZ CAT No:	: SZ-V015070
CAS No	: NA
Mol.F.	: C13H12N4O
Mol.Wt.	: 240.3
Inv. Status	: Custom Synthesis

Varenicline Impurity 38

SZ CAT No:	: SZ-V015075
CAS No	: 2759288-58-7
Mol.F.	: C14H12F3N3O
Mol.Wt.	: 295.3
Inv. Status	: Custom Synthesis

Varenicline Maltose Adduct Impurity

SZ CAT No:	: SZ-V015076
CAS No	: NA
Mol.F.	: C25H33N3O10
Mol.Wt.	: 535.6
Inv. Status	: Custom Synthesis

Varenicline Impurity 40

SZ CAT No:	: SZ-V015077
CAS No	: NA
Mol.F.	: C13H11F3N2O2
Mol.Wt.	: 284.2
Inv. Status	: Custom Synthesis

Varenicline Impurity 41

SZ CAT No:	: SZ-V015078
CAS No	: NA
Mol.F.	: C13H13F3N2O2
Mol.Wt.	: 286.3
Inv. Status	: Custom Synthesis

Varenicline Impurity 42

SZ CAT No:	: SZ-V015079
CAS No	: NA
Mol.F.	: C13H14F3N3O3
Mol.Wt.	: 317.3
Inv. Status	: Custom Synthesis

Varenicline Impurity 43

SZ CAT No:	: SZ-V015080
CAS No	: NA
Mol.F.	: C13H10F3N3O3
Mol.Wt.	: 313.2
Inv. Status	: Custom Synthesis

Varenicline

SZ CAT No:	: SZ-V015081
CAS No	: 249296-44-4
Mol.F.	: C13H13N3
Mol.Wt.	: 211.3
Inv. Status	: In Stock
Rel. CAS No	: 375815-87-5 (Tartrate salt) ; 230615-23-3 (HCl salt) ; 536696-70-5 (citrate salt)

Varenicline Maltotriose impurity

SZ CAT No:	: SZ-V015082
CAS No	: NA
Mol.F.	: C31H43N3O15
Mol.Wt.	: 697.7
Inv. Status	: Custom Synthesis

Varenicline Impurity 45

SZ CAT No:	: SZ-V015083
CAS No	: NA
Mol.F.	: C11H11N3O3
Mol.Wt.	: 233.2
Inv. Status	: Custom Synthesis

Varenicline Impurity 46

SZ CAT No:	: SZ-V015084
CAS No	: NA
Mol.F.	: C13H12F3N3O3
Mol.Wt.	: 315.3
Inv. Status	: Custom Synthesis

Varenicline Impurity 47

SZ CAT No:	: SZ-V015085
CAS No	: NA
Mol.F.	: C13H12F3N3O3
Mol.Wt.	: 315.3
Inv. Status	: Custom Synthesis

Varenicline Impurity 48

SZ CAT No:	: SZ-V015086
CAS No	: NA
Mol.F.	: C11H13N3O2
Mol.Wt.	: 219.2
Inv. Status	: Custom Synthesis

Varenicline Impurity 49

SZ CAT No:	: SZ-V015087
CAS No	: NA
Mol.F.	: C11H13N3O2
Mol.Wt.	: 219.2
Inv. Status	: Custom Synthesis

Varenicline Impurity 46

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