Valsartan EP Impurity B

SZ CAT No:	SZ-V001004
CAS No	137863-20-8
Mol.F.	C31H35N5O3
Mol.Wt.	525.6
Inv. Status	In Stock
Shipping Condition	Ambient Temperature

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Chemical Name: [(S-N-Valeryl-N-([2'-(1H-tetrazole-5-yl)biphen-4-yl]methyl)-valine benzyl ester ; benzyl (2S)-3-methyl-2-[pentanoyl[[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]amino]butanoate,

Synonym: Valsartan USP Related Compound C ; Valsartan Benzyl Ester

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: CC(C)[C@@H](C(OCC1=CC=CC=C1)=O)N(C(CCCC)=O)CC2=CC=C(C3=CC=CC=C3C4=NNN=N4)C=C2

Identification and characterization of potential impurities of valsartan, AT1 receptor antagonist
A.Sampath, A. Raghupathi Reddy, B.Yakambaram, A.Thirupathi, M.Prabhakar, P. Pratap Reddy, V. Prabhakar Reddy
Journal of Pharmaceutical and Biomedical Analysis Volume 50, Issue 3, 15 October 2009, Pages 405-412

Monitoring of Impurity Level of Valsartan and Hydrochlorothiazide Employing an RP–HPLC Gradient Mode
Darko Ivanović,Anđelija Malenović,Biljana Jančić,Prof. Dr. Mirjana Medenica &Marija Mašković
Journal of Liquid Chromatography & Related Technologies Volume 30, 2007 - Issue 19 Pages 2879-2890

A liquid chromatographic method for separation of sacubitril–valsartan and their stereoisomeric impurities
Lu Zhou, Liang Zou, Lili Sun, Hui Zhang, Wenkai Hui and Qiaogen Zou
Anal. Methods, 2018,10, 1046-1053

Valsartan EP Impurity B is chemically [(S-N-Valeryl-N-([2'-(1H-tetrazole-5-yl)biphen-4-yl]methyl)-valine benzyl ester ; benzyl (2S)-3-methyl-2-[pentanoyl[[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]amino]butanoate,. It is also known as Valsartan USP Related Compound C ; Valsartan Benzyl Ester. Valsartan EP Impurity B is supplied with detailed characterization data compliant with regulatory guideline. Valsartan EP Impurity B can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Valsartan .

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

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Valsartan EP Impurity A

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Valsartan EP Impurity C

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Valsartan EP Impurity B

SZ CAT No:	: SZ-V001004
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Mol.F.	: C31H35N5O3
Mol.Wt.	: 525.6
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Valsartan

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Mol.F.	: C24H29N5O3
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Valsartan USP Related Compound E

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Mol.F.	: C25H31N5O3
Mol.Wt.	: 449.6
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Valsartan Ethyl Ester

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CAS No	: 1111177-30-0
Mol.F.	: C26H33N5O3
Mol.Wt.	: 463.6
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Valsartan Isopropyl Ester

SZ CAT No:	: SZ-V001007
CAS No	: 1245820-09-0
Mol.F.	: C27H35N5O3
Mol.Wt.	: 477.6
Inv. Status	: In Stock

Valsartan Desvaleryl Benzyl Impurity

SZ CAT No:	: SZ-V001008
CAS No	: 676129-93-4
Mol.F.	: C26H27N5O2
Mol.Wt.	: 441.5
Inv. Status	: Custom Synthesis

Valsartan Desvaleryl Impurity

SZ CAT No:	: SZ-V001009
CAS No	: 676129-92-3
Mol.F.	: C19H21N5O2
Mol.Wt.	: 351.4
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Valsartan Desvaleryl Methyl Ester

SZ CAT No:	: SZ-V001010
CAS No	: 1111177-24-2
Mol.F.	: C20H23N5O2
Mol.Wt.	: 365.4
Inv. Status	: In Stock

Valery 4-Hydroxy Valsartan

SZ CAT No:	: SZ-V001011
CAS No	: 188259-69-0
Mol.F.	: C24H29N5O4
Mol.Wt.	: 451.5
Inv. Status	: In Stock

Valsartan Decarboxylic Acid

SZ CAT No:	: SZ-V001012
CAS No	: 1314799-74-0
Mol.F.	: C23H29N5O
Mol.Wt.	: 391.5
Inv. Status	: In Stock

Valsartan N-Oxide 1

SZ CAT No:	: SZ-V001013
CAS No	: NA
Mol.F.	: C24H29N5O4
Mol.Wt.	: 451.5
Inv. Status	: Out of Stock, Custom Synthesis

Valsartan DP-2

SZ CAT No:	: SZ-V001014
CAS No	: 1314799-75-1
Mol.F.	: C23H27N3O
Mol.Wt.	: 361.5
Inv. Status	: Custom Synthesis

Valsartan Cyano Desvaleryl Methyl Ester

SZ CAT No:	: SZ-V001015
CAS No	: 482577-59-3
Mol.F.	: C20H22N2O2 : HCl
Mol.Wt.	: 322.4 : 36.5
Inv. Status	: In Stock
Rel. CAS No	: 137863-89-9 (free base)

Isoleucine Valsartan (Impurity D)

SZ CAT No:	: SZ-V001016
CAS No	: 137862-78-3
Mol.F.	: C25H31N5O3
Mol.Wt.	: 449.6
Inv. Status	: In Stock

5-Hydroxy Valsartan

SZ CAT No:	: SZ-V001017
CAS No	: 1186103-57-0
Mol.F.	: C24H29N5O4
Mol.Wt.	: 451.5
Inv. Status	: Custom Synthesis

N-Nitroso-N-Methyl-4-Aminobutyric Acid

SZ CAT No:	: SZ-V001018
CAS No	: 61445-55-4
Mol.F.	: C5H10N2O3
Mol.Wt.	: 146.1
Inv. Status	: In Stock

N-Nitrosoethylisopropylamine

SZ CAT No:	: SZ-V001019
CAS No	: 16339-04-1
Mol.F.	: C5H12N2O
Mol.Wt.	: 116.2
Inv. Status	: In Stock

N-Nitrosodiisopropylamine

SZ CAT No:	: SZ-V001020
CAS No	: 601-77-4
Mol.F.	: C6H14N2O
Mol.Wt.	: 130.2
Inv. Status	: In Stock

Valsartan N-Oxide 2

SZ CAT No:	: SZ-V001021
CAS No	: NA
Mol.F.	: C24H29N5O4
Mol.Wt.	: 451.5
Inv. Status	: Under Synthesis

N-Ethylisopropylamine

SZ CAT No:	: SZ-V001022
CAS No	: 19961-27-4
Mol.F.	: C5H13N
Mol.Wt.	: 87.2
Inv. Status	: In Stock

N-Nitroso-N-Methyl-4-Aminobutyric Acid-d3

SZ CAT No:	: SZ-V001D01
CAS No	: 1184996-41-5
Mol.F.	: C5H7D3N2O3
Mol.Wt.	: 149.2
Inv. Status	: In Stock

Valsartan Formyl Impurity

SZ CAT No:	: SZ-V001023
CAS No	: 1418314-03-0
Mol.F.	: C20H21N5O3
Mol.Wt.	: 379.4
Inv. Status	: Custom Synthesis

Valsartan D9

SZ CAT No:	: SZ-V001D02
CAS No	: 1089736-73-1
Mol.F.	: C24H20D9N5O3
Mol.Wt.	: 444.6
Inv. Status	: Custom Synthesis

Valsartan D3

SZ CAT No:	: SZ-V001D03
CAS No	: 1331908-02-1
Mol.F.	: C24H26D3N5O3
Mol.Wt.	: 438.6
Inv. Status	: Custom Synthesis

Valsartan D4

SZ CAT No:	: SZ-V001D04
CAS No	: 1089736-75-3
Mol.F.	: C24H25D4N5O3
Mol.Wt.	: 439.6
Inv. Status	: Custom Synthesis

Valsartan D8

SZ CAT No:	: SZ-V001D05
CAS No	: 1089736-72-0
Mol.F.	: C24H21D8N5O3
Mol.Wt.	: 443.6
Inv. Status	: Custom Synthesis

Valsartan Cyano Analog Methyl Ester

SZ CAT No:	: SZ-V001024
CAS No	: 137863-90-2
Mol.F.	: C25H30N2O3
Mol.Wt.	: 406.5
Inv. Status	: In Stock

N-Nitroso Valsartan Impurity 1

SZ CAT No:	: SZ-V001025
CAS No	: 2254485-68-0
Mol.F.	: C19H20N6O3
Mol.Wt.	: 380.4
Inv. Status	: In Stock

Valsartan Dimer Impurity

SZ CAT No:	: SZ-V001026
CAS No	: 1353844-77-5
Mol.F.	: C34H31N3O2
Mol.Wt.	: 513.6
Inv. Status	: Custom Synthesis

Valsartan Desvalyl Impurity

SZ CAT No:	: SZ-V001027
CAS No	: 914465-68-2
Mol.F.	: C19H21N5O
Mol.Wt.	: 335.4
Inv. Status	: Custom Synthesis

Valsartan Ditetrazole Impurity

SZ CAT No:	: SZ-V001028
CAS No	: NA
Mol.F.	: C34H33N9O2
Mol.Wt.	: 599.7
Inv. Status	: In Stock

N-Nitroso Valsartan Methyl Ester

SZ CAT No:	: SZ-V001030
CAS No	: NA
Mol.F.	: C20H22N6O3
Mol.Wt.	: 394.4
Inv. Status	: In Stock

N-Nitroso Valsartan Impurity 2

SZ CAT No:	: SZ-V001031
CAS No	: NA
Mol.F.	: C24H28N6O4
Mol.Wt.	: 464.5
Inv. Status	: Inquire

Valsartan Impurity 12

SZ CAT No:	: SZ-V001033
CAS No	: 1127249-17-5
Mol.F.	: C14H10Br2N4
Mol.Wt.	: 394.1
Inv. Status	: In Stock

Valsartan Impurity 13

SZ CAT No:	: SZ-V001034
CAS No	: 152708-24-2
Mol.F.	: C14H11N7
Mol.Wt.	: 277.3
Inv. Status	: In Stock

Valsartan Impurity 14

SZ CAT No:	: SZ-V001035
CAS No	: 135689-93-9
Mol.F.	: C14H9NO
Mol.Wt.	: 207.2
Inv. Status	: Custom Synthesis

Valsartan Impurity 15

SZ CAT No:	: SZ-V001036
CAS No	: 164265-78-5
Mol.F.	: C14H10N4O2
Mol.Wt.	: 266.3
Inv. Status	: Custom Synthesis

Valsartan Impurity 16

SZ CAT No:	: SZ-V001037
CAS No	: NA
Mol.F.	: C20H21BrN2O2
Mol.Wt.	: 401.3
Inv. Status	: Custom Synthesis

Valsartan Impurity 17

SZ CAT No:	: SZ-V001038
CAS No	: NA
Mol.F.	: C24H28N8O3
Mol.Wt.	: 476.5
Inv. Status	: Custom Synthesis

Valsartan Impurity 18

SZ CAT No:	: SZ-V001039
CAS No	: 443093-86-5
Mol.F.	: C24H28N2O3
Mol.Wt.	: 392.5
Inv. Status	: In Stock

L-Valine Methyl Ester Hydrochloride

SZ CAT No:	: SZ-V001040
CAS No	: 6306-52-1
Mol.F.	: C6H13NO2 : HCl
Mol.Wt.	: 131.2 : 36.5
Inv. Status	: In Stock
Rel. CAS No	: 4070-48-8 (free base)

Biphenyl Amyl Ester Impurity

SZ CAT No:	: SZ-V001042
CAS No	: NA
Mol.F.	: C19H23NO2
Mol.Wt.	: 297.4
Inv. Status	: Custom Synthesis

Isoleucine

SZ CAT No:	: SZ-V001043
CAS No	: 73-32-5
Mol.F.	: C6H13NO2
Mol.Wt.	: 131.2
Inv. Status	: In Stock, 3-4 days for Dispatch

4-(Bromomethyl)biphenyl

SZ CAT No:	: SZ-V001044
CAS No	: 2567-29-5
Mol.F.	: C13H11Br
Mol.Wt.	: 247.1
Inv. Status	: Custom Synthesis

4-Phenyltoluene

SZ CAT No:	: SZ-V001045
CAS No	: 644-08-6
Mol.F.	: C13H12
Mol.Wt.	: 168.2
Inv. Status	: Custom Synthesis

Valsartan Impurity 20

SZ CAT No:	: SZ-V001046
CAS No	: 124806-66-2
Mol.F.	: C33H25N7
Mol.Wt.	: 519.6
Inv. Status	: In Stock

Valsartan Impurity 11

SZ CAT No:	: SZ-V001047
CAS No	: NA
Mol.F.	: C26H33N5O3
Mol.Wt.	: 463.6
Inv. Status	: Custom Synthesis

Nitroso Valsartan-II

SZ CAT No:	: SZ-V001048
CAS No	: NA
Mol.F.	: C45H40N6O3
Mol.Wt.	: 712.9
Inv. Status	: In Stock

Nitroso Valsartan Benzyl Ester

SZ CAT No:	: SZ-V001049
CAS No	: NA
Mol.F.	: C26H26N6O3
Mol.Wt.	: 470.5
Inv. Status	: Custom Synthesis

Valsartan Impurity 23

SZ CAT No:	: SZ-V001052
CAS No	: 2459446-44-5
Mol.F.	: C18H19N5
Mol.Wt.	: 305.4
Inv. Status	: Custom Synthesis

Valsartan Impurity 24

SZ CAT No:	: SZ-V001053
CAS No	: 1283097-98-2
Mol.F.	: C24H27N5O3
Mol.Wt.	: 433.5
Inv. Status	: Custom Synthesis

Valsartan Desvaleryl Methyl Ester N1-Trityl Impurity

SZ CAT No:	: SZ-V001055
CAS No	: 783369-50-6
Mol.F.	: C39H37N5O2
Mol.Wt.	: 607.8
Inv. Status	: Custom Synthesis

Trityl Valsartan

SZ CAT No:	: SZ-V001056
CAS No	: 783369-52-8
Mol.F.	: C43H43N5O3
Mol.Wt.	: 677.8
Inv. Status	: Custom Synthesis

Valsartan Sacubitril Propyl Ester

SZ CAT No:	: SZ-V001059
CAS No	: 2751722-76-4
Mol.F.	: C25H31NO5
Mol.Wt.	: 425.5
Inv. Status	: In Stock

Valsartan Nitroso Impurity 1

SZ CAT No:	: SZ-V001060
CAS No	: NA
Mol.F.	: C20H21N3O3
Mol.Wt.	: 351.4
Inv. Status	: In Stock

Valsartan Impurity 26

SZ CAT No:	: SZ-V001061
CAS No	: 2734713-84-7
Mol.F.	: C20H23N5O2
Mol.Wt.	: 365.4
Inv. Status	: Custom Synthesis

Valsartan Impurity 27

SZ CAT No:	: SZ-V001062
CAS No	: NA
Mol.F.	: C19H21N5O2
Mol.Wt.	: 351.4
Inv. Status	: Custom Synthesis

Valsartan Impurity 28

SZ CAT No:	: SZ-V001063
CAS No	: 934736-45-5
Mol.F.	: C24H28N2O3
Mol.Wt.	: 392.5
Inv. Status	: In Stock

Valsartan Impurity 29

SZ CAT No:	: SZ-V001064
CAS No	: 622-95-7
Mol.F.	: C7H6BrCl
Mol.Wt.	: 205.5
Inv. Status	: Custom Synthesis

Valsartan Impurity 30

SZ CAT No:	: SZ-V001065
CAS No	: 50670-51-4
Mol.F.	: C14H10BrN
Mol.Wt.	: 272.1
Inv. Status	: Custom Synthesis

Valsartan Impurity 31

SZ CAT No:	: SZ-V001066
CAS No	: 20248-86-6
Mol.F.	: C14H12Br2
Mol.Wt.	: 340.1
Inv. Status	: Custom Synthesis

N-Nitroso Ethyl Isopropyl Amine-d12

SZ CAT No:	: SZ-V001D06
CAS No	: NA
Mol.F.	: C5D12N2O
Mol.Wt.	: 128.2
Inv. Status	: In Stock

N-Nitroso Ethyl Isopropyl Amine-d5

SZ CAT No:	: SZ-V001D07
CAS No	: NA
Mol.F.	: C5H7D5N2O
Mol.Wt.	: 121.2
Inv. Status	: In Stock

N-Nitroso Valsartan

SZ CAT No:	: SZ-V001067
CAS No	: NA
Mol.F.	: C24H28N6O4
Mol.Wt.	: 464.5
Inv. Status	: Inquire

Valsartan Impurity 32

SZ CAT No:	: SZ-V001068
CAS No	: NA
Mol.F.	: C14H10N4
Mol.Wt.	: 234.3
Inv. Status	: Custom Synthesis

Valsartan Disodium

SZ CAT No:	: SZ-V001069
CAS No	: NA
Mol.F.	: C24H29N5O3 : 2(Na)
Mol.Wt.	: 435.5 : 2(23.0)
Inv. Status	: Custom Synthesis
Rel. CAS No	: 137862-53-4 (free base)

Valsartan EP Impurity B

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