Sofosbuvir Impurity 74

SZ CAT No:	SZ-S010097
CAS No	1233335-78-8
Mol.F.	C13H19FN3O9P
Mol.Wt.	411.3
Inv. Status	Out of Stock

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Chemical Name: ((((2R,3R,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)-L-alanine

Synonym: Sofosbuvir GS 566500

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: C[C@@]1([C@H](N(C=CC2=O)C(N2)=O)O[C@H](CO[P](N[C@@H](C)C(O)=O)(O)=O)[C@H]1O)F

Method development and validation for the simultaneous estimation of sofosbuvir and velpatasvir in bulk and tablet dosage forms by RP-HPLC
By Suma, M. S. M.; Gowthami, M.; Latha, P. V. Madhavi; Devi, P. Uma
From Journal of Global Trends in Pharmaceutical Sciences (2021), 12(1), 9037-9043.

Development and validation of RP-HPLC method for the estimation of Sofosbuvir and Ledipasvir in combined dosage form
By Prabhaker, Naik Desai Prabhat; Pankaj, Kapupara
From International Journal of Research in Pharmaceutical Sciences (Madurai, India) (2021), 12(1), 523-529.

Eco-friendly HPTLC method for simultaneous analysis of sofosbuvir and ledipasvir in biological and pharmaceutical samples: Stability indicating study
By El-Yazbi, Amira F.; Elashkar, Nourhan E.; Abdel-Hay, Karim M.; Talaat, Wael; Ahmed, Hytham M.
From Microchemical Journal (2020), 154, 104584.

Sofosbuvir Impurity 74 is chemically ((((2R,3R,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)-L-alanine. It is also known as Sofosbuvir GS 566500. Sofosbuvir Impurity 74 is supplied with detailed characterization data compliant with regulatory guideline. Sofosbuvir Impurity 74 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Sofosbuvir.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

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