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Rivaroxaban Open-Ring N-Methyl Impurity

SZ CAT No SZ-R017013
CAS No 1807455-76-0
Mol.F. C25H24Cl2N4O6S2
Mol.Wt. 611.5
Inv. Status In Stock


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Chemical Name: (S)-2-(2-(2-Chloro-N-(4-(5-((2-chlorothiophene-5-carboxamido)methyl)-2-oxooxazolidin-3-yl)phenyl)thiophene-5-carboxamido)ethoxy)-n-methyl-acetamide

Synonym: Rivaroxaban Open Chain Dithiophene Analog (USP)

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: O=C(NC)COCCN(C1=CC=C(N2C(O[C@@H](CNC(C3=CC=C(Cl)S3)=O)C2)=O)C=C1)C(C4=CC=C(Cl)S4)=O

Rivaroxaban Open-Ring N-Methyl Impurity is chemically (S)-2-(2-(2-Chloro-N-(4-(5-((2-chlorothiophene-5-carboxamido)methyl)-2-oxooxazolidin-3-yl)phenyl)thiophene-5-carboxamido)ethoxy)-n-methyl-acetamide . It is also known as Rivaroxaban Open Chain Dithiophene Analog (USP). Rivaroxaban Open-Ring N-Methyl Impurity is supplied with detailed characterization data compliant with regulatory guideline. Rivaroxaban Open-Ring N-Methyl Impurity can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Rivaroxaban.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

Development and validation of stability indicating UPLC method for the determination of Rivaroxaban in bulk and finished products and identification of degradation products by LCMS
By Ali, Syed Mastan; Ramachandran, D.
From Journal of Applicable Chemistry (Lumami, India) (2021), 10(3), 291-301
Validated LC-​MS​/MS method for the determination of three genotoxic impurities in rivaroxaban drug substance
By Korlakunta, Vijaya Gouri; Dasari, Vijaya Bharathi; Sharma, Hemant Kumar; Nowduri, Annapurna; Bonige, Kishore Babu; Chavakula, Ramadas
From European Journal of Biomedical and Pharmaceutical Sciences (2020), 7(8), 492-500
Development of a stability-​indicating HPLC method and a dissolution test for rivaroxaban dosage forms
By Souri, Effat; Mottaghi, Siavash; Zargarpoor, Mohammad; Ahmadkhaniha, Reza; Jalalizadeh, Hassan
From Acta Chromatographica (2016), 28(3), 347-361

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