Pitavastatin Lactone

SZ CAT No:	SZ-P023008
CAS No	141750-63-2
Mol.F.	C25H22FNO3
Mol.Wt.	403.5
Inv. Status	In Stock
Rel. CAS No	497098-84-7 (Calcium salt)

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Chemical Name: (4R,6S)-6-((E)-2-(2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)vinyl)-4-hydroxytetrahydro-2H-pyran-2-one;(4R,6S,E)-6-[2-[2-Cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl] vinyl] tetrahydro-4-hydroxypyran-2-one

Synonym: Nisvastatin

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: FC1=CC=C(C2=C(/C=C/[C@@H]3C[C@@H](O)CC(O3)=O)C(C4CC4)=NC5=CC=CC=C52)C=C1

Development and validation of stability indicating UV spectrophotometric method for the determination of Pitavastatin calcium
By Aglawe, Konica Vijay; Kharat, Umesh Pralhad; Dongaonkar, Chaitali C.; Chavan, Vijayalaxmi A.
From World Journal of Pharmacy and Pharmaceutical Sciences (2016), 5(7), 1773-1787

Stability indicating HPTLC method for the estimation of pitavastatin calcium in presence of acid induced degradation product
By Damle, Mrinalini C.; Polawar, Anuradha R.
From International Journal of ChemTech Research (2014), 6(5), 2824-2833

Degradation pathway for pitavastatin calcium by validated stability indicating UPLC method
By Gomas, Antony Raj; Ram, Pannala Raghu; Srinivas, Nimmakayala; Sriramulu, Jadi
From American Journal of Analytical Chemistry (2010), 1(2), 83-90

Pitavastatin Lactone is chemically (4R,6S)-6-((E)-2-(2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)vinyl)-4-hydroxytetrahydro-2H-pyran-2-one;(4R,6S,E)-6-[2-[2-Cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl] vinyl] tetrahydro-4-hydroxypyran-2-one. It is also known as Nisvastatin. Pitavastatin Lactone is supplied with detailed characterization data compliant with regulatory guideline. Pitavastatin Lactone can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Pitavastatin.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

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Pitavastatin Sodium (Z)-Isomer

SZ CAT No:	: SZ-P023010
CAS No	: 1633767-50-6
Mol.F.	: C25H23FNO4 : Na
Mol.Wt.	: 420.5 : 23.0
Inv. Status	: In Stock
Rel. CAS No	: 1159631-31-8 (free base)

Pitavastatin Dihydrobenzophenanthridine Impurity (Na salt)

SZ CAT No:	: SZ-P023011
CAS No	: NA
Mol.F.	: C25H23FNO4 : Na
Mol.Wt.	: 420.5 : 23.0
Inv. Status	: In Stock
Rel. CAS No	: 1187966-91-1 (free base)

Pitavastatin Calcium Pentahydrate

SZ CAT No:	: SZ-P023012
CAS No	: 1852536-33-4
Mol.F.	: C25H24FNO4 : 1/2(Ca) : 5(H2O)
Mol.Wt.	: 421.5 : 1/2(40.1) : 5(18.0)
Inv. Status	: Under Synthesis
Rel. CAS No	: 147526-32-7 (Ca salt) ; 574705-92-3 (Na salt) ; 147511-69-1 (free base)

Pitavastatin 5-Oxo Impurity Calcium Salt

SZ CAT No:	: SZ-P023001
CAS No	: 2180095-22-9
Mol.F.	: C25H21FNO4 : 1/2(Ca)
Mol.Wt.	: 418.4 : 1/2(40.1)
Inv. Status	: In Stock
Rel. CAS No	: 222306-15-2 (Free base)

Pitavastatin 3-Oxo Sodium

SZ CAT No:	: SZ-P023002
CAS No	: NA
Mol.F.	: C25H21FNO4 : Na
Mol.Wt.	: 418.4 : 23.0
Inv. Status	: Custom Synthesis
Rel. CAS No	: 2245811-12-3 (Free base)

Pitavastatin 5-Oxo Ethyl Ester

SZ CAT No:	: SZ-P023003
CAS No	: 444732-68-7
Mol.F.	: C27H26FNO4
Mol.Wt.	: 447.5
Inv. Status	: Custom Synthesis

Pitavastatin 3-Oxo Ethyl Ester

SZ CAT No:	: SZ-P023004
CAS No	: 148901-69-3
Mol.F.	: C27H26FNO4
Mol.Wt.	: 447.5
Inv. Status	: Custom Synthesis

Pitavastatin Acetonide t-Butyl Ester

SZ CAT No:	: SZ-P023005
CAS No	: 147489-06-3
Mol.F.	: C32H36FNO4
Mol.Wt.	: 517.6
Inv. Status	: In Stock

Pitavastatin Methyl Ester

SZ CAT No:	: SZ-P023006
CAS No	: 849811-78-5
Mol.F.	: C26H26FNO4
Mol.Wt.	: 435.5
Inv. Status	: In Stock

Pitavastatin Ethyl Ester

SZ CAT No:	: SZ-P023007
CAS No	: 167073-19-0
Mol.F.	: C27H28FNO4
Mol.Wt.	: 449.5
Inv. Status	: In Stock

Pitavastatin Lactone

SZ CAT No:	: SZ-P023008
CAS No	: 141750-63-2
Mol.F.	: C25H22FNO3
Mol.Wt.	: 403.5
Inv. Status	: In Stock
Rel. CAS No	: 497098-84-7 (Calcium salt)

Pitavastatin Calcium

SZ CAT No:	: SZ-P023009
CAS No	: 147526-32-7
Mol.F.	: C25H23FNO4 : 1/2(Ca)
Mol.Wt.	: 420.5 : 1/2(40.1)
Inv. Status	: In Stock
Rel. CAS No	: 147511-69-1 (free base) ; 574705-92-3 (Na salt) ; 147511-70-4 (Phenylethylamine salt)

Pitavastatin Hydroxymethyl Impurity

SZ CAT No:	: SZ-P023013
CAS No	: 121660-11-5
Mol.F.	: C19H16FNO
Mol.Wt.	: 293.3
Inv. Status	: In Stock

Pitavastatin Benzophenanthridine Impurity

SZ CAT No:	: SZ-P023014
CAS No	: 1187966-93-3
Mol.F.	: C25H22FNO4
Mol.Wt.	: 419.4
Inv. Status	: Custom Synthesis

Pitavastatin t-Butyl Ester

SZ CAT No:	: SZ-P023015
CAS No	: 586966-54-3
Mol.F.	: C29H32FNO4
Mol.Wt.	: 477.6
Inv. Status	: Limited Stock

Pitavastatin (3S,5R)-Isomer Calcium Salt

SZ CAT No:	: SZ-P023016
CAS No	: 254452-88-5
Mol.F.	: C25H23FNO4 : 1/2(Ca)
Mol.Wt.	: 420.5 : 1/2(40.1)
Inv. Status	: In Stock
Rel. CAS No	: 254452-86-3 (Free base)

Pitavastatin (3R,5R)-Isomer Sodium Salt

SZ CAT No:	: SZ-P023017
CAS No	: NA
Mol.F.	: C25H23FNO4 : Na
Mol.Wt.	: 420.5 : 23.0
Inv. Status	: Limited Stock
Rel. CAS No	: 769908-13-6 (free base) ; 254452-96-5 (Calcium salt)

Pitavastatin Sodium Desfluoro Impurity

SZ CAT No:	: SZ-P023018
CAS No	: NA
Mol.F.	: C25H24NO4 : Na
Mol.Wt.	: 402.5 : 23.0
Inv. Status	: In Stock
Rel. CAS No	: 847849-67-6 (free base)

Pitavastatin (3R,5R)-Isomer Ethyl Ester

SZ CAT No:	: SZ-P023019
CAS No	: 380848-32-8
Mol.F.	: C27H28FNO4
Mol.Wt.	: 449.5
Inv. Status	: Custom Synthesis

Pitavastatin (3S,5S)-Isomer Calcium

SZ CAT No:	: SZ-P023020
CAS No	: 254452-92-1
Mol.F.	: C25H23FNO4 : 1/2(Ca)
Mol.Wt.	: 420.5 : 1/2(40.1)
Inv. Status	: Out of Stock
Rel. CAS No	: 688735-41-3 (Free base)

Pitavastatin (3S,5S)-Isomer Ethyl Ester

SZ CAT No:	: SZ-P023021
CAS No	: 380848-30-6
Mol.F.	: C27H28FNO4
Mol.Wt.	: 449.5
Inv. Status	: Custom Synthesis

Pitavastatin Sodium

SZ CAT No:	: SZ-P023022
CAS No	: 574705-92-3
Mol.F.	: C25H24FNO4 : Na
Mol.Wt.	: 421.5 : 23.0
Inv. Status	: In Stock
Rel. CAS No	: 147511-69-1 (free base) ; 147526-32-7 (Ca salt) ; 147511-70-4 (Phenylethylamine salt)

Pitavastatin Desfluoro t-Butyl Ester

SZ CAT No:	: SZ-P023023
CAS No	: NA
Mol.F.	: C29H33NO4
Mol.Wt.	: 459.6
Inv. Status	: In Stock

Pitavastatin Desfluoro Acetonide t-Butyl Ester

SZ CAT No:	: SZ-P023024
CAS No	: NA
Mol.F.	: C32H37NO4
Mol.Wt.	: 499.7
Inv. Status	: In Stock

5-Oxo-Pitavastatin Methyl Ester

SZ CAT No:	: SZ-P023027
CAS No	: 917752-45-5
Mol.F.	: C26H24FNO4
Mol.Wt.	: 433.5
Inv. Status	: Custom Synthesis

Pitavastatin (5S)-Oxo Impurity

SZ CAT No:	: SZ-P023029
CAS No	: 2274791-42-1
Mol.F.	: C26H24FNO4
Mol.Wt.	: 433.5
Inv. Status	: Custom Synthesis

Pitavastatin-3-Oxo Sodium Salt

SZ CAT No:	: SZ-P023030
CAS No	: NA
Mol.F.	: C25H21FNO4 : Na
Mol.Wt.	: 418.4 : 23.0
Inv. Status	: Out of Stock

Pitavastatin 5-Oxo Impurity Sodium Salt

SZ CAT No:	: SZ-P023031
CAS No	: NA
Mol.F.	: C25H21FNO4 : Na
Mol.Wt.	: 418.4 : 23.0
Inv. Status	: Out of Stock, Custom Synthesis
Rel. CAS No	: 222306-15-2 (free base)

Pitavastatin 8-Hydroxy Impurity

SZ CAT No:	: SZ-P023032
CAS No	: 224320-09-6
Mol.F.	: C25H23FNO5
Mol.Wt.	: 436.5
Inv. Status	: Custom Synthesis

Pitavastatin 3-O-Glucuronide

SZ CAT No:	: SZ-P023033
CAS No	: 224320-11-0
Mol.F.	: C31H32FNO10
Mol.Wt.	: 597.6
Inv. Status	: Custom Synthesis

Pitavastatin Desfluoro Impurity (Calcium Salt)

SZ CAT No:	: SZ-P023034
CAS No	: 1258947-30-6
Mol.F.	: C25H24NO4 : 1/2(Ca)
Mol.Wt.	: 402.5 : 1/2(40.1)
Inv. Status	: In Stock
Rel. CAS No	: 847849-67-6 (Free base)

Pitavastatin Impurity 3

SZ CAT No:	: SZ-P023037
CAS No	: 1187966-94-4
Mol.F.	: C20H16FN
Mol.Wt.	: 289.4
Inv. Status	: Custom Synthesis

Pitavastatin Impurity 4

SZ CAT No:	: SZ-P023038
CAS No	: 1187966-95-5
Mol.F.	: C20H14FN
Mol.Wt.	: 287.4
Inv. Status	: Custom Synthesis

Pitavastatin Impurity 5

SZ CAT No:	: SZ-P023039
CAS No	: 167934-29-4
Mol.F.	: C32H36FNO4
Mol.Wt.	: 517.7
Inv. Status	: Custom Synthesis

Pitavastatin Impurity 6

SZ CAT No:	: SZ-P023040
CAS No	: 2347430-68-4
Mol.F.	: C32H36FNO4
Mol.Wt.	: 517.7
Inv. Status	: Custom Synthesis

Pitavastatin Impurity 7

SZ CAT No:	: SZ-P023041
CAS No	: 1044518-75-3
Mol.F.	: C13H22O5
Mol.Wt.	: 258.3
Inv. Status	: Custom Synthesis

Pitavastatin Impurity 8

SZ CAT No:	: SZ-P023042
CAS No	: NA
Mol.F.	: C33H33FN2O3
Mol.Wt.	: 524.6
Inv. Status	: In Stock

Pitavastatin Impurity 9

SZ CAT No:	: SZ-P023043
CAS No	: 176593-07-0
Mol.F.	: C27H28FNO4 : C8H11N
Mol.Wt.	: 449.5 : 121.2
Inv. Status	: Custom Synthesis
Rel. CAS No	: 167073-18-9 (Free base)

Pitavastatin 2,4,6-Triene Impurity

SZ CAT No:	: SZ-P023044
CAS No	: 2086271-67-0
Mol.F.	: C25H20FNO2
Mol.Wt.	: 385.4
Inv. Status	: Custom Synthesis

Pitavastatin Impurity 11

SZ CAT No:	: SZ-P023045
CAS No	: NA
Mol.F.	: C25H23FNO4 : Na
Mol.Wt.	: 421.5 : 23.0
Inv. Status	: In Stock

Pitavastatin Impurity 12

SZ CAT No:	: SZ-P023046
CAS No	: 2180095-31-0
Mol.F.	: C25H22FNO3
Mol.Wt.	: 403.5
Inv. Status	: Custom Synthesis

Pitavastatin Impurity 13

SZ CAT No:	: SZ-P023047
CAS No	: 847849-72-3
Mol.F.	: C25H25NO5
Mol.Wt.	: 419.5
Inv. Status	: Custom Synthesis

Pitavastatin Impurity 15

SZ CAT No:	: SZ-P023049
CAS No	: 1611499-16-1
Mol.F.	: C25H24FNO5
Mol.Wt.	: 437.5
Inv. Status	: Custom Synthesis
Rel. CAS No	: 1799857-53-6 (Ca salt) ; 2276678-27-2 (Na salt)

Pitavastatin Impurity 16

SZ CAT No:	: SZ-P023050
CAS No	: 160495-72-7
Mol.F.	: C32H36FNO4
Mol.Wt.	: 517.6
Inv. Status	: Custom Synthesis

Pitavastatin Impurity 17

SZ CAT No:	: SZ-P023051
CAS No	: 154026-94-5
Mol.F.	: C13H23ClO4
Mol.Wt.	: 278.8
Inv. Status	: In Stock

Pitavastatin Desfluoro (Z) Isomer

SZ CAT No:	: SZ-P023052
CAS No	: NA
Mol.F.	: C25H24NO4 : Na
Mol.Wt.	: 402.5 : 23.0
Inv. Status	: In Stock
Rel. CAS No	: 1611991-85-5 (free base)

Pitavastatin Lactone Dimer

SZ CAT No:	: SZ-P023053
CAS No	: NA
Mol.F.	: C50H44F2N2O6
Mol.Wt.	: 806.9
Inv. Status	: Under Synthesis

Pitavastatin D4 Calcium Salt

SZ CAT No:	: SZ-P023D01
CAS No	: NA
Mol.F.	: C25H20D4FNO4 : 1/2(Ca)
Mol.Wt.	: 425.5 : 1/2(40.1)
Inv. Status	: Custom Synthesis
Rel. CAS No	: 2070009-71-9 (Free base)

Pitavastatin Lactone D4

SZ CAT No:	: SZ-P023D02
CAS No	: NA
Mol.F.	: C25H18D4FNO3
Mol.Wt.	: 407.5
Inv. Status	: Custom Synthesis
Rel. CAS No	: 141750-63-2 (Unlabeled)

Pitavastatin Lactone D5

SZ CAT No:	: SZ-P023D03
CAS No	: NA
Mol.F.	: C25H17D5FNO3
Mol.Wt.	: 408.5
Inv. Status	: Custom Synthesis

Pitavastatin Impurity 18

SZ CAT No:	: SZ-P023054
CAS No	: 148516-11-4
Mol.F.	: C21H18FNO2
Mol.Wt.	: 335.4
Inv. Status	: In Stock

Pitavastatin Impurity 19

SZ CAT No:	: SZ-P023055
CAS No	: 3800-06-4
Mol.F.	: C13H10FNO
Mol.Wt.	: 215.2
Inv. Status	: In Stock
Rel. CAS No	: 3800-07-5 (HCl salt)

Pitavastatin (+)-Phenylethylamine Salt

SZ CAT No:	: SZ-P023056
CAS No	: 147511-70-4
Mol.F.	: C25H24FNO4 : C8H11N
Mol.Wt.	: 421.5 : 121.2
Inv. Status	: In Stock
Rel. CAS No	: 147511-69-1 (free base) ; 147526-32-7 (Ca salt) ; 574705-92-3 (Na salt)

Pitavastatin Impurity 2

SZ CAT No:	: SZ-P023036
CAS No	: 154057-58-6
Mol.F.	: C37H30FNP : Br
Mol.Wt.	: 538.6 : 79.9
Inv. Status	: In Stock
Rel. CAS No	: 771448-84-1 (Free base)

Pitavastatin Anti Isomer Impurity

SZ CAT No:	: SZ-P023057
CAS No	: 254452-96-5
Mol.F.	: C25H23FNO4 : 1/2(ca)
Mol.Wt.	: 420.5 : 1/2(40.1)
Inv. Status	: In Stock
Rel. CAS No	: 769908-13-6 (free base)

Pitavastatin 5-Oxo Impurity Phenylethylamine Salt

SZ CAT No:	: SZ-P023058
CAS No	: NA
Mol.F.	: C25H21FNO4 : C8H12N
Mol.Wt.	: 418.4 : 122.2
Inv. Status	: In Stock
Rel. CAS No	: 222306-15-2 (free base)

Pitavastatin Impurity 22

SZ CAT No:	: SZ-P023059
CAS No	: 1980814-87-6
Mol.F.	: C25H24FNO5
Mol.Wt.	: 437.5
Inv. Status	: Custom Synthesis

Pitavastatin Impurity 23

SZ CAT No:	: SZ-P023060
CAS No	: 121659-86-7
Mol.F.	: C20H16FNO2
Mol.Wt.	: 321.4
Inv. Status	: Custom Synthesis

Pitavastatin Lactone

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