Palbociclib Impurity 21

SZ CAT No:	SZ-P015022
CAS No	2458234-37-0
Mol.F.	C31H39N11O
Mol.Wt.	581.7
Inv. Status	Custom Synthesis

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Chemical Name: 8-Cyclopentyl-5-methyl-2,6-bis((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: CC(C(C=NC(NC1=CC=C(N2CCNCC2)C=N1)=N3)=C3N(C4CCCC4)C5=O)=C5NC(C=C6)=NC=C6N7CCNCC7

New stability-indicating liquid chromatographic method for determination of palbociclib (an anti-breast cancer drug)
By Kallepalli, Pramadvara; Annapurna, Mukthinuthalapati Mathrusri
From International Journal of Green Pharmacy (2018), 12(1Suppl.), S270-S275

Optimization and validation of RP-HPLC method for simultaneous estimation of palbociclib and letrozole
By Dange, Yuvraj; Bhinge, Somnath; Salunkhe, Vijay
From Toxicology Mechanisms and Methods (2018), 28(3), 187-194

Palbociclib Impurity 21 is chemically 8-Cyclopentyl-5-methyl-2,6-bis((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one. Palbociclib Impurity 21 is supplied with detailed characterization data compliant with regulatory guideline. Palbociclib Impurity 21 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Palbociclib.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

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Palbociclib

SZ CAT No:	: SZ-P015001
CAS No	: 571190-30-2
Mol.F.	: C24H29N7O2
Mol.Wt.	: 447.5
Inv. Status	: In Stock
Rel. CAS No	: 827022-32-2 (HCl salt) ; 1985666-03-2 (HBr salt) ; 1942024-36-3 (Sulfate salt)

Palbociclib Deacetyl Impurity

SZ CAT No:	: SZ-P015002
CAS No	: 571190-22-2
Mol.F.	: C22H27N7O
Mol.Wt.	: 405.5
Inv. Status	: In Stock
Rel. CAS No	: 571189-66-7 (HCl salt)

Desoxo-Palbociclib

SZ CAT No:	: SZ-P015003
CAS No	: 2204863-06-7
Mol.F.	: C24H29N7O
Mol.Wt.	: 431.5
Inv. Status	: Out of Stock, Custom Synthesis

Palbociclib Acetyl Boc Impurity

SZ CAT No:	: SZ-P015004
CAS No	: 1651214-74-2
Mol.F.	: C29H37N7O4
Mol.Wt.	: 547.7
Inv. Status	: In Stock
Rel. CAS No	: 1883672-48-7 (HCl salt)

Palbociclib Impurity 4

SZ CAT No:	: SZ-P015005
CAS No	: 1376615-91-6
Mol.F.	: C24H31N7O2
Mol.Wt.	: 449.6
Inv. Status	: In Stock

Palbociclib Pyridine N-Oxide

SZ CAT No:	: SZ-P015006
CAS No	: 2098673-40-4
Mol.F.	: C24H29N7O3
Mol.Wt.	: 463.5
Inv. Status	: In Stock
Rel. CAS No	: 2098673-44-8 (HCl salt)

Palbociclib Piperazine N-Oxide

SZ CAT No:	: SZ-P015007
CAS No	: 2174002-29-8
Mol.F.	: C24H29N7O3
Mol.Wt.	: 463.5
Inv. Status	: In Stock

Palbociclib Impurity 7

SZ CAT No:	: SZ-P015008
CAS No	: 827022-35-5
Mol.F.	: C33H45N7O4
Mol.Wt.	: 603.8
Inv. Status	: Custom Synthesis

Palbociclib Impurity 8

SZ CAT No:	: SZ-P015009
CAS No	: 827022-31-1
Mol.F.	: C31H41N7O4
Mol.Wt.	: 575.7
Inv. Status	: Custom Synthesis

Palbociclib 6-Acetaldehyde Analog

SZ CAT No:	: SZ-P015010
CAS No	: 2204368-66-9
Mol.F.	: C24H29N7O2
Mol.Wt.	: 447.5
Inv. Status	: Custom Synthesis

Palbociclib Impurity 10

SZ CAT No:	: SZ-P015011
CAS No	: 2206135-30-8
Mol.F.	: C41H55N11O5
Mol.Wt.	: 782.0
Inv. Status	: Custom Synthesis

Palbociclib Impurity 11

SZ CAT No:	: SZ-P015012
CAS No	: 866084-31-3
Mol.F.	: C33H45N7O4
Mol.Wt.	: 603.8
Inv. Status	: In Stock
Rel. CAS No	: 1883672-49-8 (HCl salt)

Palbociclib Impurity 12

SZ CAT No:	: SZ-P015013
CAS No	: 2204368-69-2
Mol.F.	: C27H34ClN7O3
Mol.Wt.	: 540.1
Inv. Status	: Custom Synthesis

Palbociclib Impurity 13

SZ CAT No:	: SZ-P015014
CAS No	: 2204442-50-0
Mol.F.	: C24H29N7O2
Mol.Wt.	: 447.5
Inv. Status	: Custom Synthesis

Palbociclib Sulfamic Acid

SZ CAT No:	: SZ-P015015
CAS No	: 2204863-10-3
Mol.F.	: C24H29N7O5S
Mol.Wt.	: 527.6
Inv. Status	: Custom Synthesis
Rel. CAS No	: 2469261-43-4 (Na salt)

Palbociclib Desacetyl N-BOC Analog

SZ CAT No:	: SZ-P015016
CAS No	: 571189-65-6
Mol.F.	: C27H35N7O3
Mol.Wt.	: 505.6
Inv. Status	: In Stock

Palbociclib Impurity 16

SZ CAT No:	: SZ-P015017
CAS No	: 571189-64-5
Mol.F.	: C15H18N4O2
Mol.Wt.	: 286.3
Inv. Status	: In Stock
Rel. CAS No	: 2768689-12-7 (HCl salt)

6-Desacetyl-6-Bromo Palbociclib HCl

SZ CAT No:	: SZ-P015018
CAS No	: NA
Mol.F.	: C22H26BrN7O : HCl
Mol.Wt.	: 484.4 : 36.5
Inv. Status	: In Stock
Rel. CAS No	: 851067-56-6 (free base) ; 850918-83-1 (2HCl salt)
Rel. CAT No	: SZ-P015136 ,

Palbociclib Impurity 18

SZ CAT No:	: SZ-P015019
CAS No	: 2206827-36-1
Mol.F.	: C32H43N7O4
Mol.Wt.	: 589.7
Inv. Status	: Out of Stock

Palbociclib 3-Piperazinyl Isomer

SZ CAT No:	: SZ-P015020
CAS No	: 2205035-04-5
Mol.F.	: C24H29N7O2
Mol.Wt.	: 447.5
Inv. Status	: In Stock

Palbociclib Impurity 20

SZ CAT No:	: SZ-P015021
CAS No	: 2459303-21-8
Mol.F.	: C28H37N9O2
Mol.Wt.	: 531.7
Inv. Status	: Custom Synthesis

Palbociclib Impurity 21

SZ CAT No:	: SZ-P015022
CAS No	: 2458234-37-0
Mol.F.	: C31H39N11O
Mol.Wt.	: 581.7
Inv. Status	: Custom Synthesis

Palbociclib Dimer Impurity

SZ CAT No:	: SZ-P015023
CAS No	: 2458234-34-7
Mol.F.	: C44H52Br2N14O2
Mol.Wt.	: 968.8
Inv. Status	: Under Synthesis

N-Boc Protected Palbociclib Dimer

SZ CAT No:	: SZ-P015024
CAS No	: NA
Mol.F.	: C54H68Br2N14O6
Mol.Wt.	: 1169.1
Inv. Status	: Under Synthesis

Palbociclib Impurity 22

SZ CAT No:	: SZ-P015025
CAS No	: 1922954-32-2
Mol.F.	: C13H14BrN3O2
Mol.Wt.	: 324.2
Inv. Status	: In Stock

Palbociclib-d8

SZ CAT No:	: SZ-P015D01
CAS No	: 1628752-83-9
Mol.F.	: C24H21D8N7O2
Mol.Wt.	: 455.6
Inv. Status	: Custom Synthesis

Palbociclib N-Cyclohexyl Analog

SZ CAT No:	: SZ-P015026
CAS No	: 2624141-94-0
Mol.F.	: C25H31N7O2
Mol.Wt.	: 461.6
Inv. Status	: In Stock

Palbociclib Impurity 23

SZ CAT No:	: SZ-P015027
CAS No	: 2270982-31-3
Mol.F.	: C28H37N7O2
Mol.Wt.	: 503.7
Inv. Status	: Custom Synthesis

Palbociclib Lactose Adduct Impurity

SZ CAT No:	: SZ-P015030
CAS No	: NA
Mol.F.	: C36H49N7O12
Mol.Wt.	: 771.8
Inv. Status	: In Stock

Palbociclib Millard reaction Impurity

SZ CAT No:	: SZ-P015031
CAS No	: NA
Mol.F.	: C36H49N7O12
Mol.Wt.	: 771.8
Inv. Status	: Custom Synthesis

Palbociclib N-Formyl Impurity

SZ CAT No:	: SZ-P015032
CAS No	: 2174002-16-3
Mol.F.	: C25H29N7O3
Mol.Wt.	: 475.6
Inv. Status	: In Stock

N-Hydroxy Palbociclib

SZ CAT No:	: SZ-P015033
CAS No	: 2231085-26-8
Mol.F.	: C24H29N7O3
Mol.Wt.	: 463.5
Inv. Status	: Custom Synthesis

Palbociclib Oxidation Impurity

SZ CAT No:	: SZ-P015034
CAS No	: 2363160-84-1
Mol.F.	: C22H24N6O4
Mol.Wt.	: 436.5
Inv. Status	: In Stock

Palbociclib Impurity 29

SZ CAT No:	: SZ-P015037
CAS No	: 571191-15-6
Mol.F.	: C22H27N7O2
Mol.Wt.	: 421.5
Inv. Status	: In Stock

Palbociclib Impurity 30

SZ CAT No:	: SZ-P015038
CAS No	: 2324831-15-2
Mol.F.	: C13H12Br2ClN3O
Mol.Wt.	: 421.5
Inv. Status	: Custom Synthesis

Palbociclib Impurity 31

SZ CAT No:	: SZ-P015039
CAS No	: 1974279-21-4
Mol.F.	: C28H33N7O5
Mol.Wt.	: 547.6
Inv. Status	: In Stock

Palbociclib Des Acetyl N-Oxide

SZ CAT No:	: SZ-P015028
CAS No	: NA
Mol.F.	: C22H27N7O2
Mol.Wt.	: 421.5
Inv. Status	: Custom Synthesis

Palbociclib Impurity 32

SZ CAT No:	: SZ-P015040
CAS No	: NA
Mol.F.	: C13H14ClN3O2
Mol.Wt.	: 279.7
Inv. Status	: Custom Synthesis

Palbociclib Impurity 33

SZ CAT No:	: SZ-P015041
CAS No	: NA
Mol.F.	: C33H43N7O4
Mol.Wt.	: 601.8
Inv. Status	: Custom Synthesis

Palbociclib Impurity 34

SZ CAT No:	: SZ-P015042
CAS No	: NA
Mol.F.	: C35H49N7O4
Mol.Wt.	: 631.8
Inv. Status	: In Stock

Palbociclib Impurity A

SZ CAT No:	: SZ-P015043
CAS No	: 1082876-26-3
Mol.F.	: C9H14N4
Mol.Wt.	: 178.2
Inv. Status	: In Stock
Rel. CAS No	: 1956322-95-4 (HCl salt)

Palbociclib Impurity 35

SZ CAT No:	: SZ-P015045
CAS No	: 571188-59-5
Mol.F.	: C14H22N4O2
Mol.Wt.	: 278.4
Inv. Status	: In Stock, 3-4 days for Dispatch

Palbociclib N-Glucuronide

SZ CAT No:	: SZ-P015046
CAS No	: NA
Mol.F.	: C30H37N7O8
Mol.Wt.	: 623.7
Inv. Status	: Custom Synthesis

N-Fumaryl Palbociclib

SZ CAT No:	: SZ-P015047
CAS No	: NA
Mol.F.	: C28H31N7O5
Mol.Wt.	: 545.6
Inv. Status	: Custom Synthesis

Palbociclib Maleic Acid Adduct

SZ CAT No:	: SZ-P015048
CAS No	: NA
Mol.F.	: C28H31N7O5
Mol.Wt.	: 545.6
Inv. Status	: Out of Stock

Palbociclib Citric Acid Adduct

SZ CAT No:	: SZ-P015049
CAS No	: NA
Mol.F.	: C30H35N7O8
Mol.Wt.	: 621.7
Inv. Status	: In Stock

Palbociclib Tartaric Acid adduct

SZ CAT No:	: SZ-P015050
CAS No	: NA
Mol.F.	: C28H33N7O7
Mol.Wt.	: 579.6
Inv. Status	: In Stock

Palbociclib Chlorobromo Impurity

SZ CAT No:	: SZ-P015051
CAS No	: 1016636-76-2
Mol.F.	: C13H13BrClN3O
Mol.Wt.	: 342.6
Inv. Status	: In Stock

Palbociclib Acetic Acid Adduct

SZ CAT No:	: SZ-P015052
CAS No	: 1974279-20-3
Mol.F.	: C26H31N7O3
Mol.Wt.	: 489.6
Inv. Status	: In Stock

Palbociclib Impurity 25

SZ CAT No:	: SZ-P015029
CAS No	: NA
Mol.F.	: C36H49N7O12
Mol.Wt.	: 771.8
Inv. Status	: Custom Synthesis

Palbociclib Hydrochloride

SZ CAT No:	: SZ-P015053
CAS No	: 827022-32-2
Mol.F.	: C24H29N7O2 : HCl
Mol.Wt.	: 447.5 : 36.5
Inv. Status	: Custom Synthesis
Rel. CAS No	: 571190-30-2 (free base)

Palbociclib 2-Hydroxy Acetyl Impurity

SZ CAT No:	: SZ-P015056
CAS No	: 2172256-78-7
Mol.F.	: C15H17N3O3
Mol.Wt.	: 287.3
Inv. Status	: In Stock

Palbociclib Nitroso Impurity 1

SZ CAT No:	: SZ-P015057
CAS No	: NA
Mol.F.	: C24H28N8O3
Mol.Wt.	: 476.5
Inv. Status	: Inquire

Palbociclib Nitroso Impurity 2

SZ CAT No:	: SZ-P015058
CAS No	: NA
Mol.F.	: C24H27N9O4
Mol.Wt.	: 505.5
Inv. Status	: Inquire

Palbociclib Nitroso Impurity 3

SZ CAT No:	: SZ-P015059
CAS No	: 2955712-44-2
Mol.F.	: C24H28N8O3
Mol.Wt.	: 476.5
Inv. Status	: In Stock

Palbociclib Impurity 36

SZ CAT No:	: SZ-P015060
CAS No	: NA
Mol.F.	: C24H27N7O3
Mol.Wt.	: 461.5
Inv. Status	: Custom Synthesis

Palbociclib Impurity 38

SZ CAT No:	: SZ-P015062
CAS No	: NA
Mol.F.	: C24H25N7O4
Mol.Wt.	: 475.5
Inv. Status	: Custom Synthesis

Palbociclib Impurity 39

SZ CAT No:	: SZ-P015063
CAS No	: 2363172-64-7
Mol.F.	: C20H22N6O2
Mol.Wt.	: 378.4
Inv. Status	: In Stock

Palbociclib Impurity 40

SZ CAT No:	: SZ-P015064
CAS No	: NA
Mol.F.	: C24H27N7O4
Mol.Wt.	: 477.5
Inv. Status	: Custom Synthesis

Palbociclib Impurity 41

SZ CAT No:	: SZ-P015065
CAS No	: NA
Mol.F.	: C22H27N7O2
Mol.Wt.	: 421.5
Inv. Status	: Custom Synthesis

Palbociclib Impurity 42

SZ CAT No:	: SZ-P015066
CAS No	: 1941177-45-2
Mol.F.	: C29H37N7O3
Mol.Wt.	: 531.7
Inv. Status	: Custom Synthesis

Palbociclib Impurity 43

SZ CAT No:	: SZ-P015067
CAS No	: NA
Mol.F.	: C27H34BrN7O3
Mol.Wt.	: 584.5
Inv. Status	: Custom Synthesis

Palbociclib Impurity 44

SZ CAT No:	: SZ-P015068
CAS No	: 2242625-36-9
Mol.F.	: C13H16ClN3O2
Mol.Wt.	: 281.7
Inv. Status	: Custom Synthesis

Palbociclib Impurity 45

SZ CAT No:	: SZ-P015069
CAS No	: 1023594-49-1
Mol.F.	: C14H22N4O2
Mol.Wt.	: 278.4
Inv. Status	: Custom Synthesis

Palbociclib Impurity 46

SZ CAT No:	: SZ-P015070
CAS No	: 1023594-50-4
Mol.F.	: C14H22N4O2
Mol.Wt.	: 278.4
Inv. Status	: Custom Synthesis

Palbociclib Impurity 48

SZ CAT No:	: SZ-P015072
CAS No	: 1013916-37-4
Mol.F.	: C13H14ClN3O
Mol.Wt.	: 263.7
Inv. Status	: Custom Synthesis

Palbociclib Impurity 49

SZ CAT No:	: SZ-P015073
CAS No	: 1367858-24-9
Mol.F.	: C12H20N4O2
Mol.Wt.	: 252.3
Inv. Status	: Custom Synthesis

Palbociclib Impurity 50

SZ CAT No:	: SZ-P015074
CAS No	: NA
Mol.F.	: C17H28N4O4
Mol.Wt.	: 352.4
Inv. Status	: Custom Synthesis

Palbociclib Impurity 51

SZ CAT No:	: SZ-P015075
CAS No	: NA
Mol.F.	: C22H36N4O6
Mol.Wt.	: 452.6
Inv. Status	: Custom Synthesis

Palbociclib Impurity 52

SZ CAT No:	: SZ-P015076
CAS No	: 1248105-96-5
Mol.F.	: C7H12N4
Mol.Wt.	: 152.2
Inv. Status	: Custom Synthesis

Palbociclib N-BOC 6-Bromo Analog

SZ CAT No:	: SZ-P015079
CAS No	: 571188-82-4
Mol.F.	: C27H34BrN7O3
Mol.Wt.	: 584.5
Inv. Status	: Custom Synthesis

Palbociclib Nitroso Impurity 4

SZ CAT No:	: SZ-P015080
CAS No	: 2089333-12-8
Mol.F.	: C9H11N5O3
Mol.Wt.	: 237.2
Inv. Status	: In Stock

Palbociclib Nitroso Impurity 5

SZ CAT No:	: SZ-P015081
CAS No	: NA
Mol.F.	: C14H21N5O4
Mol.Wt.	: 323.4
Inv. Status	: Inquire

Palbociclib N-BOC 6-Bromo Analog Nitroso Impurity

SZ CAT No:	: SZ-P015082
CAS No	: NA
Mol.F.	: C27H33BrN8O4
Mol.Wt.	: 613.5
Inv. Status	: Inquire

Palbociclib Nitroso Impurity 7

SZ CAT No:	: SZ-P015083
CAS No	: NA
Mol.F.	: C33H44N8O5
Mol.Wt.	: 632.8
Inv. Status	: Inquire

Palbociclib Impurity 56

SZ CAT No:	: SZ-P015084
CAS No	: 571189-16-7
Mol.F.	: C14H20N4O4
Mol.Wt.	: 308.3
Inv. Status	: Custom Synthesis

Palbociclib Impurity 57

SZ CAT No:	: SZ-P015085
CAS No	: NA
Mol.F.	: C18H22N8O4
Mol.Wt.	: 414.4
Inv. Status	: Custom Synthesis

Palbociclib Impurity 58

SZ CAT No:	: SZ-P015086
CAS No	: 2399424-46-3
Mol.F.	: C28H40N8O4
Mol.Wt.	: 552.7
Inv. Status	: Custom Synthesis

Palbociclib Impurity 59

SZ CAT No:	: SZ-P015087
CAS No	: NA
Mol.F.	: C14H22N4O3
Mol.Wt.	: 294.4
Inv. Status	: Custom Synthesis

Palbociclib Impurity 60

SZ CAT No:	: SZ-P015088
CAS No	: NA
Mol.F.	: C9H14N4O
Mol.Wt.	: 194.2
Inv. Status	: Custom Synthesis

Palbociclib Impurity 61

SZ CAT No:	: SZ-P015089
CAS No	: 27412-69-7
Mol.F.	: C5H3BrN2O3
Mol.Wt.	: 219.0
Inv. Status	: Custom Synthesis

Palbociclib Impurity 62

SZ CAT No:	: SZ-P015090
CAS No	: 610261-34-2
Mol.F.	: C5H2Br2N2O2
Mol.Wt.	: 281.9
Inv. Status	: Custom Synthesis

Palbociclib Impurity 21

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