Nilotinib Impurity 12

SZ CAT No:	SZ-N009026
CAS No	123367-26-0
Mol.F.	C10H12N2O
Mol.Wt.	176.2
Inv. Status	Custom Synthesis

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Chemical Name: (E)-3-(Dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: CN(C)/C=C/C(C1=CC=CN=C1)=O

Nilotinib Impurity 12 is chemically (E)-3-(Dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one. Nilotinib Impurity 12 is supplied with detailed characterization data compliant with regulatory guideline. Nilotinib Impurity 12 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Nilotinib.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

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Nilotinib

SZ CAT No:	: SZ-N009001
CAS No	: 641571-10-0
Mol.F.	: C28H22F3N7O
Mol.Wt.	: 529.5
Inv. Status	: In Stock
Rel. CAS No	: 923288-95-3 (HCl salt) ; 923288-90-8 (hydrochloride hydrate)
Rel. CAT No	: SZ-N009048 , SZ-N009053 ,

Nilotinib EP Impurity A

SZ CAT No:	: SZ-N009002
CAS No	: 641571-11-1
Mol.F.	: C11H10F3N3
Mol.Wt.	: 241.2
Inv. Status	: In Stock

Nilotinib Impurity 19

SZ CAT No:	: SZ-N009003
CAS No	: 17071-24-8
Mol.F.	: C9H11NO
Mol.Wt.	: 149.2
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Nilotinib EP Impurity C

SZ CAT No:	: SZ-N009004
CAS No	: 2458-12-0
Mol.F.	: C8H9NO2
Mol.Wt.	: 151.2
Inv. Status	: In Stock

Nilotinib EP Impurity D

SZ CAT No:	: SZ-N009005
CAS No	: 641569-94-0
Mol.F.	: C17H14N4O2
Mol.Wt.	: 306.3
Inv. Status	: In Stock

Nilotinib EP Impurity E

SZ CAT No:	: SZ-N009006
CAS No	: 2119583-26-3
Mol.F.	: C27H20F3N7O
Mol.Wt.	: 515.5
Inv. Status	: In Stock

Nilotinib EP Impurity F

SZ CAT No:	: SZ-N009007
CAS No	: 2119583-24-1
Mol.F.	: C29H24F3N7O
Mol.Wt.	: 543.6
Inv. Status	: In Stock

Nilotinib EP Impurity G

SZ CAT No:	: SZ-N009008
CAS No	: 917392-54-2
Mol.F.	: C18H16N4O2
Mol.Wt.	: 320.6
Inv. Status	: In Stock

Nilotinib EP Impurity H

SZ CAT No:	: SZ-N009009
CAS No	: 641571-15-5
Mol.F.	: C28H22F3N7O
Mol.Wt.	: 529.5
Inv. Status	: In Stock

Nilotinib Iodo Impurity

SZ CAT No:	: SZ-N009010
CAS No	: 926922-18-1
Mol.F.	: C19H15F3IN3O
Mol.Wt.	: 485.3
Inv. Status	: Custom Synthesis

Nilotinib 2-Pyridinyl Impurity

SZ CAT No:	: SZ-N009011
CAS No	: 66521-65-1
Mol.F.	: C9H8N4
Mol.Wt.	: 172.2
Inv. Status	: Custom Synthesis

Nilotinib 3-Pyridinyl Impurity

SZ CAT No:	: SZ-N009012
CAS No	: 66521-66-2
Mol.F.	: C9H8N4
Mol.Wt.	: 172.2
Inv. Status	: Custom Synthesis

Nilotinib Bromo Impurity

SZ CAT No:	: SZ-N009013
CAS No	: 54962-75-3
Mol.F.	: C7H5BrF3N
Mol.Wt.	: 240.0
Inv. Status	: Out of Stock, Custom Synthesis

Nilotinib N-Oxide

SZ CAT No:	: SZ-N009014
CAS No	: 1246817-85-5
Mol.F.	: C28H22F3N7O2
Mol.Wt.	: 545.5
Inv. Status	: In Stock

Nilotinib Impurity 1

SZ CAT No:	: SZ-N009015
CAS No	: 641571-06-4
Mol.F.	: C11H10F3N3
Mol.Wt.	: 241.2
Inv. Status	: In Stock

Nilotinib Impurity 2

SZ CAT No:	: SZ-N009016
CAS No	: 943320-48-7
Mol.F.	: C10H8F3N3
Mol.Wt.	: 227.2
Inv. Status	: In Stock

Nilotinib Impurity 3

SZ CAT No:	: SZ-N009017
CAS No	: 2119583-28-5
Mol.F.	: C12H12F3N3
Mol.Wt.	: 255.2
Inv. Status	: Custom Synthesis

Nilotinib Impurity 4

SZ CAT No:	: SZ-N009018
CAS No	: 641571-16-6
Mol.F.	: C11H10F3N3
Mol.Wt.	: 241.2
Inv. Status	: Out of Stock

Nilotinib Impurity 5

SZ CAT No:	: SZ-N009019
CAS No	: 641571-05-3
Mol.F.	: C28H22F3N7O
Mol.Wt.	: 529.5
Inv. Status	: In Stock

Nilotinib Impurity 6

SZ CAT No:	: SZ-N009020
CAS No	: 2468737-73-5
Mol.F.	: C21H22N4O2
Mol.Wt.	: 362.4
Inv. Status	: Custom Synthesis

Nilotinib Impurity 7

SZ CAT No:	: SZ-N009021
CAS No	: 2119583-25-2
Mol.F.	: C29H24F3N7O
Mol.Wt.	: 543.6
Inv. Status	: Custom Synthesis

Nilotinib Impurity 8

SZ CAT No:	: SZ-N009022
CAS No	: 641571-12-2
Mol.F.	: C12H8F3N3
Mol.Wt.	: 251.2
Inv. Status	: Custom Synthesis

Nilotinib Impurity 9

SZ CAT No:	: SZ-N009023
CAS No	: 917391-28-7
Mol.F.	: C12H10F3N3O
Mol.Wt.	: 269.2
Inv. Status	: Custom Synthesis

Nilotinib Impurity 10

SZ CAT No:	: SZ-N009024
CAS No	: 641571-13-3
Mol.F.	: C12H9F3N2O2
Mol.Wt.	: 270.2
Inv. Status	: Custom Synthesis
Rel. CAS No	: 1771718-19-4 (K salt) ; 1771718-18-3 (Na salt)

Nilotinib Impurity 11

SZ CAT No:	: SZ-N009025
CAS No	: 916975-92-3
Mol.F.	: C11H8F3N3O2
Mol.Wt.	: 271.2
Inv. Status	: In Stock

Nilotinib Impurity 12

SZ CAT No:	: SZ-N009026
CAS No	: 123367-26-0
Mol.F.	: C10H12N2O
Mol.Wt.	: 176.2
Inv. Status	: Custom Synthesis

Nilotinib Amide Impurity

SZ CAT No:	: SZ-N009028
CAS No	: 851137-91-2
Mol.F.	: C17H15N5O
Mol.Wt.	: 305.3
Inv. Status	: In Stock

Nilotinib Impurity 15

SZ CAT No:	: SZ-N009029
CAS No	: 2468737-74-6
Mol.F.	: C18H16N4O
Mol.Wt.	: 304.4
Inv. Status	: Custom Synthesis

3-Bromo-5-Nitrobenzotrifluoride

SZ CAT No:	: SZ-N009030
CAS No	: 630125-49-4
Mol.F.	: C7H3BrF3NO2
Mol.Wt.	: 270.0
Inv. Status	: Custom Synthesis

Nilotinib Impurity 17

SZ CAT No:	: SZ-N009031
CAS No	: 98-46-4
Mol.F.	: C7H4F3NO2
Mol.Wt.	: 191.1
Inv. Status	: Custom Synthesis

Nilotinib Chloro Impurity

SZ CAT No:	: SZ-N009032
CAS No	: 2469039-94-7
Mol.F.	: C28H21ClF3N7O
Mol.Wt.	: 564.0
Inv. Status	: In Stock

Nilotinib EP Impurity B

SZ CAT No:	: SZ-N009033
CAS No	: 18595-18-1
Mol.F.	: C9H11NO2
Mol.Wt.	: 165.2
Inv. Status	: In Stock

Nilotinib D3

SZ CAT No:	: SZ-N009D01
CAS No	: 1215678-43-5
Mol.F.	: C28H19D3F3N7O
Mol.Wt.	: 532.6
Inv. Status	: Custom Synthesis

Nilotinib D6

SZ CAT No:	: SZ-N009D02
CAS No	: 1268356-17-7
Mol.F.	: C28H16D6F3N7O
Mol.Wt.	: 535.6
Inv. Status	: Custom Synthesis

Nilotinib Impurity 38

SZ CAT No:	: SZ-N009034
CAS No	: 915711-42-1
Mol.F.	: C19H17F3N4O
Mol.Wt.	: 374.4
Inv. Status	: In Stock
Rel. CAS No	: 2322358-68-7 (HCl salt)

Nilotinib Impurity 20

SZ CAT No:	: SZ-N009035
CAS No	: 1157857-29-8
Mol.F.	: C19H15F3N4O3
Mol.Wt.	: 404.3
Inv. Status	: In Stock
Rel. CAS No	: 1449570-25-5 (HCl salt)

Nilotinib Impurity 21

SZ CAT No:	: SZ-N009036
CAS No	: NA
Mol.F.	: C28H21ClF3N7O
Mol.Wt.	: 564.0
Inv. Status	: Custom Synthesis

Nilotinib Impurity 22

SZ CAT No:	: SZ-N009037
CAS No	: NA
Mol.F.	: C32H26F3N7O6
Mol.Wt.	: 661.6
Inv. Status	: Custom Synthesis

Nilotinib Impurity 23

SZ CAT No:	: SZ-N009038
CAS No	: NA
Mol.F.	: C32H25F3N7O5
Mol.Wt.	: 644.6
Inv. Status	: Custom Synthesis

Nilotinib 3-Imidazolyl N-oxide

SZ CAT No:	: SZ-N009039
CAS No	: 2139382-75-3
Mol.F.	: C28H22F3N7O2
Mol.Wt.	: 545.5
Inv. Status	: In Stock

Nilotinib Impurity 24

SZ CAT No:	: SZ-N009040
CAS No	: 1807606-80-9
Mol.F.	: C28H22F3N7O2
Mol.Wt.	: 545.5
Inv. Status	: Custom Synthesis

Nilotinib Impurity 25

SZ CAT No:	: SZ-N009041
CAS No	: 1807607-72-2
Mol.F.	: C28H20F3N7O3
Mol.Wt.	: 559.5
Inv. Status	: Custom Synthesis

Nilotinib Impurity 26

SZ CAT No:	: SZ-N009042
CAS No	: 1807608-52-1
Mol.F.	: C28H22F3N7O2
Mol.Wt.	: 545.5
Inv. Status	: Custom Synthesis

Nilotinib Impurity A

SZ CAT No:	: SZ-N009043
CAS No	: NA
Mol.F.	: C20H19F3N6O : 4(H2O)
Mol.Wt.	: 416.4 : 4(18.0)
Inv. Status	: In Stock
Rel. CAS No	: 1345336-53-9 (free base) ; 2101206-85-1 (HCl salt)

Nilotinib Impurity D

SZ CAT No:	: SZ-N009044
CAS No	: NA
Mol.F.	: C19H20N4O
Mol.Wt.	: 320.4
Inv. Status	: Custom Synthesis

Nilotinib Impurity E

SZ CAT No:	: SZ-N009045
CAS No	: NA
Mol.F.	: C37H28F3N11O : HCl
Mol.Wt.	: 699.7 : 36.5
Inv. Status	: Custom Synthesis

Nilotinib Impurity 27

SZ CAT No:	: SZ-N009046
CAS No	: 2119583-27-4
Mol.F.	: C12H12F3N3
Mol.Wt.	: 255.2
Inv. Status	: In Stock

Nilotinib Nitroso Impurity 1

SZ CAT No:	: SZ-N009047
CAS No	: 2925306-68-7
Mol.F.	: C28H21F3N8O2
Mol.Wt.	: 558.5
Inv. Status	: Inquire

Nilotinib Hydrochloride Dihydrate

SZ CAT No:	: SZ-N009048
CAS No	: 923289-71-8
Mol.F.	: C28H22F3N7O : HCl : 2(H2O)
Mol.Wt.	: 529.5 : 36.5 : 2(18.0)
Inv. Status	: Custom Synthesis
Rel. CAS No	: 641571-10-0 (free base) ; 923288-90-8 (hydrochloride hydrate) ; 923288-95-3 (HCl salt)
Rel. CAT No	: SZ-N009001 , SZ-N009053 ,

Nilotinib Impurity 28

SZ CAT No:	: SZ-N009049
CAS No	: NA
Mol.F.	: C12H12F3N3
Mol.Wt.	: 255.2
Inv. Status	: Custom Synthesis

Nilotinib Impurity 29

SZ CAT No:	: SZ-N009050
CAS No	: 41191-92-8
Mol.F.	: C10H13NO2
Mol.Wt.	: 179.2
Inv. Status	: In Stock

Nilotinib Impurity 30

SZ CAT No:	: SZ-N009051
CAS No	: 66521-53-7
Mol.F.	: C10H12N2O
Mol.Wt.	: 176.2
Inv. Status	: Custom Synthesis

Nilotinib Impurity 31

SZ CAT No:	: SZ-N009052
CAS No	: 1025716-99-7
Mol.F.	: C10H13N3O2 : HNO3
Mol.Wt.	: 207.2 : 63.0
Inv. Status	: Custom Synthesis
Rel. CAS No	: 1025716-98-6 (free base)

Nilotinib Hydrochloride Monohydrate

SZ CAT No:	: SZ-N009053
CAS No	: 923288-90-8
Mol.F.	: C28H22F3N7O : HCl : H2O
Mol.Wt.	: 529.5 : 36.5 : 18.0
Inv. Status	: In Stock
Rel. CAS No	: 641571-10-0 (free base) ; 923288-95-3 (HCl salt)
Rel. CAT No	: SZ-N009001 , SZ-N009048 ,

Nilotinib Impurity 32

SZ CAT No:	: SZ-N009054
CAS No	: NA
Mol.F.	: C11H10F3N3
Mol.Wt.	: 241.2
Inv. Status	: Custom Synthesis

Nilotinib Impurity 33

SZ CAT No:	: SZ-N009055
CAS No	: NA
Mol.F.	: C11H10F3N3
Mol.Wt.	: 241.2
Inv. Status	: Custom Synthesis

Nilotinib Impurity 12

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