Nebivolol Impurity 36

SZ CAT No:	SZ-N020050
CAS No	1696472-15-7
Mol.F.	C22H26FNO4
Mol.Wt.	387.5
Inv. Status	In Stock
Rel. CAS No	1696430-23-5 (HCl salt)

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Chemical Name: (R)-1-((R)-chroman-2-yl)-2-(((R)-2-((S)-6-fluorochroman-2-yl)-2-hydroxyethyl) amino)ethan-1-ol

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: O[C@@H]([C@H]1CCC2=C(O1)C=CC=C2)CNC[C@H]([C@@H]3CCC4=C(O3)C=CC(F)=C4)O

Development and validation of a stability-indicating reverse phase ultra performance liquid chromatographic method for the estimation of nebivolol impurities in active pharmaceutical ingredients and pharmaceutical formulation
Veera Raghava Raju Thummala, Mohana Krishna Lanka
Se Pu. 2015 Oct;33(10):1051-8.

Stability-Indicating RP-UPLC Method Development and Validation for the Process Related Impurities of Nebivolol and Structural Characterization of Its Forced Degradation Products by LC-MS/MS
Prasad Kancherla1* , Pallavi Alegete1 , Srinivas Keesari2 , Bhavyasri Khagga1 , Sridhar Siddiraju3 , Mukkanti Khagga1 and Parthasarathi Das
British Journal of Pharmaceutical Research 14(6): 1-13, 2016

Liquid chromatographic impurity profiling of Nebivolol Hydrochloride from bulk drug
Sachin Uttamrao Kokil*1 , Manish Sudesh Bhatia
Scholars Research Library Der Pharma Chemica, 2009, 1(2): 177-187

A Sensitive and Selective GC-MS Analysis of Process Related Genotoxic Impurities of Nebivolol Hydrochloride
Vijaya Lakshmi Maddala, K. Venugopal, P.C. Ray, K.M.V.N. Rao

Nebivolol Impurity 36 is chemically (R)-1-((R)-chroman-2-yl)-2-(((R)-2-((S)-6-fluorochroman-2-yl)-2-hydroxyethyl) amino)ethan-1-ol. Nebivolol Impurity 36 is supplied with detailed characterization data compliant with regulatory guideline. Nebivolol Impurity 36 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Nebivolol.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

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Nebivolol Impurity 11

SZ CAT No:	: SZ-N020023
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Mol.F.	: C22H25F2NO4 : HCl
Mol.Wt.	: 405.4 : 36.5
Inv. Status	: Out of Stock
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Nebivolol Impurity 12 (RRRR)

SZ CAT No:	: SZ-N020024
CAS No	: 119365-29-6
Mol.F.	: C22H25F2NO4
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Nebivolol Impurity 13

SZ CAT No:	: SZ-N020025
CAS No	: NA
Mol.F.	: C22H25F2NO4 : HCl
Mol.Wt.	: 405.5 : 36.5
Inv. Status	: Out of Stock

Nebivolol HCl

SZ CAT No:	: SZ-N020001
CAS No	: 152520-56-4
Mol.F.	: C22H25F2NO4 : HCl
Mol.Wt.	: 405.4 : 36.5
Inv. Status	: In Stock
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Levonebivolol

SZ CAT No:	: SZ-N020002
CAS No	: 118457-16-2
Mol.F.	: C22H25F2NO4
Mol.Wt.	: 405.4
Inv. Status	: In Stock
Rel. CAS No	: (-)-Nebivolol ; (R,S,S,S)-Nebivolol

Nebivolol Impurity 4 (SS,RS) Hydrochloride

SZ CAT No:	: SZ-N020003
CAS No	: 920299-27-0
Mol.F.	: C22H25F2NO4 : HCl
Mol.Wt.	: 405.4 : 36.5
Inv. Status	: In Stock
Rel. CAS No	: 119365-25-2 (free base)

Nebivolol USP Related Compound D

SZ CAT No:	: SZ-N020004
CAS No	: 793669-26-8
Mol.F.	: C11H11FO2
Mol.Wt.	: 194.2
Inv. Status	: In Stock

Nebivolol Impurity 6

SZ CAT No:	: SZ-N020006
CAS No	: 876514-31-7
Mol.F.	: C11H11FO2
Mol.Wt.	: 194.2
Inv. Status	: In Stock

Nebivolol USP Related Compound E

SZ CAT No:	: SZ-N020007
CAS No	: NA
Mol.F.	: C22H26FNO4 : HCl
Mol.Wt.	: 387.5 : 36.5
Inv. Status	: In Stock
Rel. CAS No	: 99200-13-2 (free base)

Nebivolol O-Beta-D-Glucuronide

SZ CAT No:	: SZ-N020008
CAS No	: NA
Mol.F.	: C28H33F2NO10
Mol.Wt.	: 581.6
Inv. Status	: Custom Synthesis

4-Hydroxy Nebivolol

SZ CAT No:	: SZ-N020009
CAS No	: 178383-76-1
Mol.F.	: C22H25F2NO5
Mol.Wt.	: 421.4
Inv. Status	: Custom Synthesis
Rel. CAS No	: 2717115-85-8 (HCl salt)

Nebivolol EP Impurity B (TFA salt)

SZ CAT No:	: SZ-N020010
CAS No	: NA
Mol.F.	: C22H25F2NO4 : C2HF3O2
Mol.Wt.	: 405.4 : 114.0
Inv. Status	: Out of Stock, Custom Synthesis

Nebivolol Impurity 1

SZ CAT No:	: SZ-N020011
CAS No	: 1346562-34-2
Mol.F.	: C12H17NO2
Mol.Wt.	: 207.3
Inv. Status	: In Stock

Nebivolol Impurity 2

SZ CAT No:	: SZ-N020012
CAS No	: NA
Mol.F.	: C22H21F2NO4 : HCl
Mol.Wt.	: 401.4 : 36.5
Inv. Status	: Custom Synthesis
Rel. CAS No	: 1346562-35-3 (free base)

Nebivolol Impurity 3 (RRSS) (HCl)

SZ CAT No:	: SZ-N020013
CAS No	: NA
Mol.F.	: C22H25F2NO4 : HCl
Mol.Wt.	: 405.4 : 36.5
Inv. Status	: In Stock
Rel. CAS No	: 1360598-84-0 (free base)

Nebivolol Impurity 5 (RRSR) (HCl)

SZ CAT No:	: SZ-N020015
CAS No	: 920275-20-3
Mol.F.	: C22H25F2NO4 : HCl
Mol.Wt.	: 405.4 : 36.5
Inv. Status	: In Stock
Rel. CAS No	: 119365-26-3 (free base)

Nebivolol Impurity 7

SZ CAT No:	: SZ-N020017
CAS No	: 1029684-20-5
Mol.F.	: C18H20FNO2
Mol.Wt.	: 301.4
Inv. Status	: In Stock

Nebivolol Impurity 8

SZ CAT No:	: SZ-N020018
CAS No	: 129050-27-7
Mol.F.	: C18H20FNO2
Mol.Wt.	: 301.4
Inv. Status	: In Stock
Rel. CAS No	: 152463-67-7 (HBr salt)

Nebivolol Impurity 9

SZ CAT No:	: SZ-N020019
CAS No	: 99199-91-4
Mol.F.	: C18H20FNO2
Mol.Wt.	: 301.4
Inv. Status	: In Stock

Nebivolol Impurity 10 (SS)

SZ CAT No:	: SZ-N020020
CAS No	: NA
Mol.F.	: C12H16FNO2
Mol.Wt.	: 225.3
Inv. Status	: Custom Synthesis

Nebivolol Impurity 14 (RR)

SZ CAT No:	: SZ-N020026
CAS No	: NA
Mol.F.	: C12H16FNO2
Mol.Wt.	: 225.3
Inv. Status	: Custom Synthesis

Nebivolol Impurity 15 (RS)

SZ CAT No:	: SZ-N020027
CAS No	: NA
Mol.F.	: C12H16FNO2
Mol.Wt.	: 225.3
Inv. Status	: Custom Synthesis

Nebivolol Impurity 16 (SR)

SZ CAT No:	: SZ-N020028
CAS No	: 1447800-92-1
Mol.F.	: C12H16FNO2
Mol.Wt.	: 225.3
Inv. Status	: Custom Synthesis

Nebivolol Impurity 17 (SS,RR)

SZ CAT No:	: SZ-N020029
CAS No	: 119365-30-9
Mol.F.	: C22H25F2NO4
Mol.Wt.	: 405.5
Inv. Status	: In Stock
Rel. CAS No	: 920275-23-6 (HCl salt)

Nebivolol Impurity 20 (SS,SS) (HCl)

SZ CAT No:	: SZ-N020032
CAS No	: 920275-27-0
Mol.F.	: C22H25F2NO4 : HCl
Mol.Wt.	: 405.4 : 36.5
Inv. Status	: In Stock
Rel. CAS No	: 119365-28-5 (free base)

D-Nebivolol

SZ CAT No:	: SZ-N020033
CAS No	: 118457-15-1
Mol.F.	: C22H25F2NO4
Mol.Wt.	: 405.5
Inv. Status	: In Stock
Rel. CAS No	: 213132-06-0 (HCl salt)

Nebivolol Related Compound B

SZ CAT No:	: SZ-N020035
CAS No	: NA
Mol.F.	: C22H25F2NO4 : HCl
Mol.Wt.	: 405.5 : 36.5
Inv. Status	: In Stock

Nebivolol Related Compound A

SZ CAT No:	: SZ-N020036
CAS No	: NA
Mol.F.	: C22H25F2NO4 : HCl
Mol.Wt.	: 405.4 : 36.5
Inv. Status	: In Stock

Nebivolol EP Impurity C

SZ CAT No:	: SZ-N020038
CAS No	: 929706-85-4
Mol.F.	: C29H31F2NO4
Mol.Wt.	: 495.6
Inv. Status	: In Stock

Nebivolol Impurity 27

SZ CAT No:	: SZ-N020039
CAS No	: 129050-23-3
Mol.F.	: C11H11FO2
Mol.Wt.	: 194.2
Inv. Status	: In Stock

Nebivolol Impurity 29

SZ CAT No:	: SZ-N020041
CAS No	: 197706-50-6
Mol.F.	: C11H11FO2
Mol.Wt.	: 194.2
Inv. Status	: In Stock

Nebivolol Impurity 30

SZ CAT No:	: SZ-N020042
CAS No	: 129050-26-6
Mol.F.	: C11H11FO2
Mol.Wt.	: 194.2
Inv. Status	: In Stock

Nebivolol Impurity 31(RRSS)

SZ CAT No:	: SZ-N020043
CAS No	: 119365-23-0
Mol.F.	: C22H25F2NO4
Mol.Wt.	: 405.4
Inv. Status	: In Stock

Nebivolol Impurity 32(SRRS)

SZ CAT No:	: SZ-N020044
CAS No	: 119365-24-1
Mol.F.	: C22H25F2NO4
Mol.Wt.	: 405.4
Inv. Status	: In Stock

Nebivolol Impurity 33

SZ CAT No:	: SZ-N020045
CAS No	: 943126-72-5
Mol.F.	: C11H10ClFO2
Mol.Wt.	: 228.6
Inv. Status	: In Stock

Nebivolol Impurity 34 (RSRR+RRRR)

SZ CAT No:	: SZ-N020046
CAS No	: NA
Mol.F.	: C44H50F4N2O8
Mol.Wt.	: 810.9
Inv. Status	: In Stock

Nebivolol Impurity 35

SZ CAT No:	: SZ-N020047
CAS No	: NA
Mol.F.	: C88H100F8N4O16 : HCl
Mol.Wt.	: 1621.8 : 36.5
Inv. Status	: Out of Stock, Custom Synthesis

Didesfluoro Nebivolol

SZ CAT No:	: SZ-N020048
CAS No	: 129101-33-3
Mol.F.	: C22H27NO4
Mol.Wt.	: 369.5
Inv. Status	: In Stock
Rel. CAS No	: 1698011-22-1 (HCl salt)

Nebivolol

SZ CAT No:	: SZ-N020049
CAS No	: 118457-14-0
Mol.F.	: C22H25F2NO4
Mol.Wt.	: 405.4
Inv. Status	: In Stock
Rel. CAS No	: 152520-56-4 (HCl salt)

rac Nebivolol D8

SZ CAT No:	: SZ-N020D01
CAS No	: 1219166-00-3
Mol.F.	: C22H17D8F2NO4
Mol.Wt.	: 413.5
Inv. Status	: Custom Synthesis

Nebivolol Impurity 36

SZ CAT No:	: SZ-N020050
CAS No	: 1696472-15-7
Mol.F.	: C22H26FNO4
Mol.Wt.	: 387.5
Inv. Status	: In Stock
Rel. CAS No	: 1696430-23-5 (HCl salt)

Nebivolol Impurity 37 (RRRS)

SZ CAT No:	: SZ-N020051
CAS No	: 1030385-17-1
Mol.F.	: C29H31F2NO4
Mol.Wt.	: 495.6
Inv. Status	: In Stock
Rel. CAS No	: 1180001-17-5 (HCl salt)

N-Benzyl (-)-Nebivolol (SSRS)

SZ CAT No:	: SZ-N020052
CAS No	: 1199945-26-0
Mol.F.	: C29H31F2NO4
Mol.Wt.	: 495.6
Inv. Status	: In Stock
Rel. CAS No	: 1224567-85-4 (HCl salt)

Nebivolol Impurity 38 (SR)

SZ CAT No:	: SZ-N020053
CAS No	: 905454-52-6
Mol.F.	: C18H19FO5S
Mol.Wt.	: 366.4
Inv. Status	: Custom Synthesis

Nebivolol Impurity 39 (RR)

SZ CAT No:	: SZ-N020054
CAS No	: 303176-46-7
Mol.F.	: C18H19FO5S
Mol.Wt.	: 366.4
Inv. Status	: Limited Stock

Nebivolol Impurity 40 (SRSS)

SZ CAT No:	: SZ-N020055
CAS No	: 129101-35-5
Mol.F.	: C22H26FNO4
Mol.Wt.	: 387.5
Inv. Status	: In Stock
Rel. CAS No	: 1696430-22-4 (HCl salt)

Nebivolol Impurity 41 (SRRR)

SZ CAT No:	: SZ-N020056
CAS No	: 1696472-14-6
Mol.F.	: C22H26FNO4
Mol.Wt.	: 387.5
Inv. Status	: In Stock
Rel. CAS No	: 1696430-21-3 (HCl salt)

Nebivolol Impurity 42 (RS)

SZ CAT No:	: SZ-N020057
CAS No	: 303176-40-1
Mol.F.	: C18H19FO5S
Mol.Wt.	: 366.4
Inv. Status	: In Stock

Nebivolol Impurity 43 (SS)

SZ CAT No:	: SZ-N020058
CAS No	: 905454-58-2
Mol.F.	: C18H19FO5S
Mol.Wt.	: 366.4
Inv. Status	: In Stock

Nebivolol Des-Fluoro Impurity

SZ CAT No:	: SZ-N020059
CAS No	: 99199-99-2
Mol.F.	: C11H12O2
Mol.Wt.	: 176.2
Inv. Status	: In Stock

Nebivolol Impurity 44 (SSSR + RSSS)

SZ CAT No:	: SZ-N020060
CAS No	: NA
Mol.F.	: C22H25F2NO4
Mol.Wt.	: 405.4
Inv. Status	: Custom Synthesis

Nebivolol Impurity 45 (RRSR + RSRR)

SZ CAT No:	: SZ-N020061
CAS No	: NA
Mol.F.	: C22H25F2NO4
Mol.Wt.	: 405.4
Inv. Status	: Custom Synthesis

Nebivolol Impurity 46 (RSRS + SRSR)

SZ CAT No:	: SZ-N020062
CAS No	: NA
Mol.F.	: C22H25F2NO4
Mol.Wt.	: 405.4
Inv. Status	: In Stock

Nebivolol Impurity 47 (SSRS + SRSS)

SZ CAT No:	: SZ-N020063
CAS No	: NA
Mol.F.	: C22H25F2NO4
Mol.Wt.	: 405.4
Inv. Status	: Custom Synthesis

Nebivolol Impurity 48 (RRSS + SSRR)

SZ CAT No:	: SZ-N020064
CAS No	: NA
Mol.F.	: C22H25F2NO4
Mol.Wt.	: 405.4
Inv. Status	: Custom Synthesis

Nebivolol Impurity 49 (RRRS + SSSR)

SZ CAT No:	: SZ-N020065
CAS No	: NA
Mol.F.	: C22H25F2NO4
Mol.Wt.	: 405.4
Inv. Status	: Custom Synthesis

N-Nitroso-Nebivolol

SZ CAT No:	: SZ-N020067
CAS No	: 1391051-68-5
Mol.F.	: C22H24F2N2O5
Mol.Wt.	: 434.4
Inv. Status	: In Stock

Nebivolol stage-V Isomer- A Chloride Impurity

SZ CAT No:	: SZ-N020068
CAS No	: NA
Mol.F.	: C11H12ClFO2
Mol.Wt.	: 230.7
Inv. Status	: In Stock

Nebivolol stage-V Isomer- B Chloride Impurity

SZ CAT No:	: SZ-N020069
CAS No	: NA
Mol.F.	: C11H12ClFO2
Mol.Wt.	: 230.7
Inv. Status	: In Stock

Nebivolol D4

SZ CAT No:	: SZ-N020D02
CAS No	: 2124271-47-0
Mol.F.	: C22H21D4F2NO4
Mol.Wt.	: 409.5
Inv. Status	: Custom Synthesis

Nebivolol Lactose Adduct

SZ CAT No:	: SZ-N020037
CAS No	: NA
Mol.F.	: C34H47F2NO14
Mol.Wt.	: 731.7
Inv. Status	: In Stock

Nebivolol Impurity 50

SZ CAT No:	: SZ-N020070
CAS No	: 1345202-52-9
Mol.F.	: C13H15FO4
Mol.Wt.	: 254.3
Inv. Status	: Custom Synthesis

Nebivolol EP Impurity D

SZ CAT No:	: SZ-N020073
CAS No	: 119365-22-9
Mol.F.	: C22H25F2NO4
Mol.Wt.	: 405.4
Inv. Status	: In Stock

N-Formyl Nebivolol

SZ CAT No:	: SZ-N020066
CAS No	: NA
Mol.F.	: C23H25F2NO5
Mol.Wt.	: 433.5
Inv. Status	: In Stock

Nebivolol Isomer (RSSS+SRRS)

SZ CAT No:	: SZ-N020071
CAS No	: NA
Mol.F.	: C22H25F2NO4
Mol.Wt.	: 405.4
Inv. Status	: Custom Synthesis

Desfluoro Nebivolol (SSRR and RRSS)

SZ CAT No:	: SZ-N020074
CAS No	: NA
Mol.F.	: C22H26FNO4
Mol.Wt.	: 387.5
Inv. Status	: In Stock

Nebivolol Isomer (RSSR+SRRS)

SZ CAT No:	: SZ-N020075
CAS No	: NA
Mol.F.	: C22H25F2NO4
Mol.Wt.	: 405.4
Inv. Status	: Out of Stock
Rel. CAT No	: SZ-N020104 ,

Nebivolol Impurity 3 (RR,SS)

SZ CAT No:	: SZ-N020078
CAS No	: 1360598-84-0
Mol.F.	: C22H25F2NO4
Mol.Wt.	: 405.4
Inv. Status	: Limited Stock

Nebivolol Impurity 20 (SS,SS)

SZ CAT No:	: SZ-N020079
CAS No	: 119365-28-5
Mol.F.	: C22H25F2NO4
Mol.Wt.	: 405.4
Inv. Status	: In Stock
Rel. CAS No	: 920275-27-0 (HCl salt)

Nebivolol Impurity 5 (RR,SR)

SZ CAT No:	: SZ-N020080
CAS No	: 119365-26-3
Mol.F.	: C22H25F2NO4
Mol.Wt.	: 405.4
Inv. Status	: In Stock
Rel. CAS No	: 920275-20-3 (HCl salt)

Nebivolol Related Compound D

SZ CAT No:	: SZ-N020081
CAS No	: 197706-51-7
Mol.F.	: C11H11FO2
Mol.Wt.	: 194.2
Inv. Status	: In Stock

N-Nitroso Nebivolol D4

SZ CAT No:	: SZ-N020D03
CAS No	: NA
Mol.F.	: C22H20D4F2N2O5
Mol.Wt.	: 438.5
Inv. Status	: In Stock

Nebivolol Impurity 36

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