Losartan Impurity 20

SZ CAT No:	SZ-L028055
CAS No	1407521-00-9
Mol.F.	C22H20ClN3O
Mol.Wt.	377.9
Inv. Status	Custom Synthesis

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Chemical Name: 4'-((2-butyl-5-chloro-4-formyl-1H-imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: O=CC1=C(Cl)N(CC2=CC=C(C3=CC=CC=C3C#N)C=C2)C(CCCC)=N1

Development and validation of a stability-indicating HPLC method for the simultaneous determination of Losartan potassium, hydrochlorothiazide, and their degradation products
Deanne L. Hertzog a,*, Jennifer Finnegan McCafferty b , Xueguang Fang b , R. Jeffrey Tyrrell c , Robert A. Reed
Journal of Pharmaceutical and Biomedical Analysis 30 (2002) 747–760

An Efficient, Commercially Viable, and Safe Process for Preparation of Losartan Potassium, an Angiotensin II Receptor Antagonist
Suri Babu Madasu,†,‡ N. A. Vekariya,*,† Ch Koteswaramma,† Aminul Islam,† Paul Douglas Sanasi,‡ and Raghu Babu Korupolu
Org. Process Res. Dev. 2012, 16, 12, 2025–2030

Losartan Impurity 20 is chemically 4'-((2-butyl-5-chloro-4-formyl-1H-imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile. Losartan Impurity 20 is supplied with detailed characterization data compliant with regulatory guideline. Losartan Impurity 20 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Losartan.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

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Losartan Potassium

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Losartan EP Impurity A

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Losartan EP Impurity B

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Losartan EP Impurity C

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Mol.F.	: C22H23ClN6O
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Losartan EP Impurity D

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Mol.F.	: C8H11ClN2O
Mol.Wt.	: 186.6
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Losartan EP Impurity E

SZ CAT No:	: SZ-L028006
CAS No	: 120568-11-8
Mol.F.	: C14H12N4
Mol.Wt.	: 236.3
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Losartan EP Impurity F

SZ CAT No:	: SZ-L028007
CAS No	: 1332713-64-0
Mol.F.	: C25H29ClN6O
Mol.Wt.	: 465.0
Inv. Status	: In Stock

Losartan EP Impurity G

SZ CAT No:	: SZ-L028008
CAS No	: 76-84-6
Mol.F.	: C19H16O
Mol.Wt.	: 260.3
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Losartan EP Impurity H

SZ CAT No:	: SZ-L028009
CAS No	: 133909-99-6
Mol.F.	: C41H37ClN6O
Mol.Wt.	: 665.2
Inv. Status	: In Stock

Losartan EP Impurity I

SZ CAT No:	: SZ-L028010
CAS No	: 1006062-28-7
Mol.F.	: C41H37ClN6O
Mol.Wt.	: 665.2
Inv. Status	: In Stock

Losartan EP Impurity J

SZ CAT No:	: SZ-L028011
CAS No	: 1006062-27-6
Mol.F.	: C24H25ClN6O2
Mol.Wt.	: 465.0
Inv. Status	: In Stock

Losartan EP Impurity K

SZ CAT No:	: SZ-L028012
CAS No	: 114798-36-6
Mol.F.	: C22H21ClN6O
Mol.Wt.	: 420.9
Inv. Status	: In Stock

Losartan EP Impurity L

SZ CAT No:	: SZ-L028013
CAS No	: 230971-71-8
Mol.F.	: C44H44Cl2N12O
Mol.Wt.	: 827.8
Inv. Status	: In Stock

Losartan EP Impurity M

SZ CAT No:	: SZ-L028014
CAS No	: 230971-72-9
Mol.F.	: C44H44Cl2N12O
Mol.Wt.	: 827.8
Inv. Status	: In Stock

N-Trityl Losartan Isomer

SZ CAT No:	: SZ-L028016
CAS No	: 150098-04-7
Mol.F.	: C41H37ClN6O
Mol.Wt.	: 665.2
Inv. Status	: Custom Synthesis

Losartan N,O-Ditrityl Impurity

SZ CAT No:	: SZ-L028017
CAS No	: 1796930-34-1
Mol.F.	: C60H51ClN6O
Mol.Wt.	: 907.5
Inv. Status	: Custom Synthesis

Losartan Acetyloxy Impurity

SZ CAT No:	: SZ-L028019
CAS No	: 253678-97-6
Mol.F.	: C16H14N4O2
Mol.Wt.	: 294.3
Inv. Status	: Custom Synthesis

Losartan Aldehyde N2-Trityl Impurity

SZ CAT No:	: SZ-L028020
CAS No	: 133910-00-6
Mol.F.	: C41H35ClN6O
Mol.Wt.	: 663.2
Inv. Status	: In Stock

Losartan Bromo N2-Trityl Impurity

SZ CAT No:	: SZ-L028021
CAS No	: 133051-88-4
Mol.F.	: C33H25BrN4
Mol.Wt.	: 557.5
Inv. Status	: In Stock

Losartan Carboxylic Acid

SZ CAT No:	: SZ-L028022
CAS No	: 124750-92-1
Mol.F.	: C22H21ClN6O2
Mol.Wt.	: 436.9
Inv. Status	: Custom Synthesis

4'-methyl-[1,1'-biphenyl]-2-carbonitrile

SZ CAT No:	: SZ-L028023
CAS No	: 114772-53-1
Mol.F.	: C14H11N
Mol.Wt.	: 193.3
Inv. Status	: In Stock

2’-(2H-Tetrazol-5-yl)-[1,1’-biphenyl]-4-carboxaldehyde

SZ CAT No:	: SZ-L028024
CAS No	: 151052-40-3
Mol.F.	: C14H10N4O
Mol.Wt.	: 250.3
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Losartan Impurity 35

SZ CAT No:	: SZ-L028025
CAS No	: 124750-67-0
Mol.F.	: C22H20ClN3O
Mol.Wt.	: 377.9
Inv. Status	: In Stock

Losartan Impurity 36

SZ CAT No:	: SZ-L028026
CAS No	: 114772-55-3
Mol.F.	: C22H22ClN3O
Mol.Wt.	: 379.9
Inv. Status	: In Stock

5-(4'-methylbiphenyl-2-yl)-1-trityl-1H-tetrazole

SZ CAT No:	: SZ-L028028
CAS No	: 124750-53-4
Mol.F.	: C33H26N4
Mol.Wt.	: 478.6
Inv. Status	: In Stock

Losartan D2

SZ CAT No:	: SZ-L028D01
CAS No	: 1030936-22-1
Mol.F.	: C22H21D2ClN6O
Mol.Wt.	: 424.9
Inv. Status	: Custom Synthesis

Losartan D3

SZ CAT No:	: SZ-L028D02
CAS No	: 1030936-74-3
Mol.F.	: C22H20D3ClN6O
Mol.Wt.	: 425.9
Inv. Status	: Custom Synthesis

Losartan D4

SZ CAT No:	: SZ-L028D03
CAS No	: 1030937-27-9
Mol.F.	: C22H19D4ClN6O
Mol.Wt.	: 426.9
Inv. Status	: Custom Synthesis

Losartan Azide impurity

SZ CAT No:	: SZ-L028029
CAS No	: 727718-93-6
Mol.F.	: C22H22ClN9
Mol.Wt.	: 447.9
Inv. Status	: In Stock

Losartan Cum-Alcohol

SZ CAT No:	: SZ-L028030
CAS No	: 852357-69-8
Mol.F.	: C31H33ClN6O
Mol.Wt.	: 541.1
Inv. Status	: In Stock

Losartan Nitroso Impurity 1

SZ CAT No:	: SZ-L028015
CAS No	: NA
Mol.F.	: C8H10ClN3O2
Mol.Wt.	: 215.6
Inv. Status	: Inquire

Trityl Losartan

SZ CAT No:	: SZ-L028018
CAS No	: 124751-00-4
Mol.F.	: C41H37ClN6O
Mol.Wt.	: 665.2
Inv. Status	: Custom Synthesis

N-Trityl Losartan Isomer

SZ CAT No:	: SZ-L028027
CAS No	: 133727-10-3
Mol.F.	: C41H37ClN6O
Mol.Wt.	: 665.2
Inv. Status	: Custom Synthesis

N-Trityl Losartan Carboxaldehyde

SZ CAT No:	: SZ-L028031
CAS No	: 120568-18-5
Mol.F.	: C41H35ClN6O
Mol.Wt.	: 663.2
Inv. Status	: Custom Synthesis

Losartan Azide Nitrile Impurity

SZ CAT No:	: SZ-L028032
CAS No	: 2755908-48-4
Mol.F.	: C22H21ClN6
Mol.Wt.	: 404.9
Inv. Status	: In Stock