Losartan Impurity 20

SZ CAT No:	SZ-L028055
CAS No	1407521-00-9
Mol.F.	C22H20ClN3O
Mol.Wt.	377.9
Inv. Status	Custom Synthesis

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Chemical Name: 4'-((2-butyl-5-chloro-4-formyl-1H-imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: O=CC1=C(Cl)N(CC2=CC=C(C3=CC=CC=C3C#N)C=C2)C(CCCC)=N1

Development and validation of a stability-indicating HPLC method for the simultaneous determination of Losartan potassium, hydrochlorothiazide, and their degradation products
Deanne L. Hertzog a,*, Jennifer Finnegan McCafferty b , Xueguang Fang b , R. Jeffrey Tyrrell c , Robert A. Reed
Journal of Pharmaceutical and Biomedical Analysis 30 (2002) 747–760

An Efficient, Commercially Viable, and Safe Process for Preparation of Losartan Potassium, an Angiotensin II Receptor Antagonist
Suri Babu Madasu,†,‡ N. A. Vekariya,*,† Ch Koteswaramma,† Aminul Islam,† Paul Douglas Sanasi,‡ and Raghu Babu Korupolu
Org. Process Res. Dev. 2012, 16, 12, 2025–2030

Losartan Impurity 20 is chemically 4'-((2-butyl-5-chloro-4-formyl-1H-imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile. Losartan Impurity 20 is supplied with detailed characterization data compliant with regulatory guideline. Losartan Impurity 20 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Losartan.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

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Losartan Potassium

SZ CAT No:	: SZ-L028001
CAS No	: 124750-99-8
Mol.F.	: C22H22ClN6O : K
Mol.Wt.	: 421.9 : 39.1
Inv. Status	: In Stock

Losartan EP Impurity A

SZ CAT No:	: SZ-L028002
CAS No	: 79047-41-9
Mol.F.	: C8H13ClN2O
Mol.Wt.	: 188.7
Inv. Status	: In Stock

Losartan EP Impurity B

SZ CAT No:	: SZ-L028003
CAS No	: 160514-13-6
Mol.F.	: C14H12N4O
Mol.Wt.	: 252.3
Inv. Status	: In Stock

Losartan EP Impurity C

SZ CAT No:	: SZ-L028004
CAS No	: 114799-13-2
Mol.F.	: C22H23ClN6O
Mol.Wt.	: 422.9
Inv. Status	: In Stock

Losartan EP Impurity D

SZ CAT No:	: SZ-L028005
CAS No	: 83857-96-9
Mol.F.	: C8H11ClN2O
Mol.Wt.	: 186.6
Inv. Status	: In Stock

Losartan EP Impurity E

SZ CAT No:	: SZ-L028006
CAS No	: 120568-11-8
Mol.F.	: C14H12N4
Mol.Wt.	: 236.3
Inv. Status	: In Stock

Losartan EP Impurity F

SZ CAT No:	: SZ-L028007
CAS No	: 1332713-64-0
Mol.F.	: C25H29ClN6O
Mol.Wt.	: 465.0
Inv. Status	: In Stock

Losartan EP Impurity G

SZ CAT No:	: SZ-L028008
CAS No	: 76-84-6
Mol.F.	: C19H16O
Mol.Wt.	: 260.3
Inv. Status	: In Stock

Losartan EP Impurity H

SZ CAT No:	: SZ-L028009
CAS No	: 133909-99-6
Mol.F.	: C41H37ClN6O
Mol.Wt.	: 665.2
Inv. Status	: In Stock

Losartan EP Impurity I

SZ CAT No:	: SZ-L028010
CAS No	: 1006062-28-7
Mol.F.	: C41H37ClN6O
Mol.Wt.	: 665.2
Inv. Status	: In Stock

Losartan EP Impurity J

SZ CAT No:	: SZ-L028011
CAS No	: 1006062-27-6
Mol.F.	: C24H25ClN6O2
Mol.Wt.	: 465.0
Inv. Status	: In Stock

Losartan EP Impurity K

SZ CAT No:	: SZ-L028012
CAS No	: 114798-36-6
Mol.F.	: C22H21ClN6O
Mol.Wt.	: 420.9
Inv. Status	: In Stock

Losartan EP Impurity L

SZ CAT No:	: SZ-L028013
CAS No	: 230971-71-8
Mol.F.	: C44H44Cl2N12O
Mol.Wt.	: 827.8
Inv. Status	: In Stock

Losartan EP Impurity M

SZ CAT No:	: SZ-L028014
CAS No	: 230971-72-9
Mol.F.	: C44H44Cl2N12O
Mol.Wt.	: 827.8
Inv. Status	: In Stock

N-Trityl Losartan Isomer

SZ CAT No:	: SZ-L028016
CAS No	: 150098-04-7
Mol.F.	: C41H37ClN6O
Mol.Wt.	: 665.2
Inv. Status	: Custom Synthesis

Losartan N,O-Ditrityl Impurity

SZ CAT No:	: SZ-L028017
CAS No	: 1796930-34-1
Mol.F.	: C60H51ClN6O
Mol.Wt.	: 907.5
Inv. Status	: Custom Synthesis

Losartan Acetyloxy Impurity

SZ CAT No:	: SZ-L028019
CAS No	: 253678-97-6
Mol.F.	: C16H14N4O2
Mol.Wt.	: 294.3
Inv. Status	: Custom Synthesis

Losartan Aldehyde N2-Trityl Impurity

SZ CAT No:	: SZ-L028020
CAS No	: 133910-00-6
Mol.F.	: C41H35ClN6O
Mol.Wt.	: 663.2
Inv. Status	: In Stock

Losartan Bromo N2-Trityl Impurity

SZ CAT No:	: SZ-L028021
CAS No	: 133051-88-4
Mol.F.	: C33H25BrN4
Mol.Wt.	: 557.5
Inv. Status	: In Stock

Losartan Carboxylic Acid

SZ CAT No:	: SZ-L028022
CAS No	: 124750-92-1
Mol.F.	: C22H21ClN6O2
Mol.Wt.	: 436.9
Inv. Status	: Custom Synthesis

4'-methyl-[1,1'-biphenyl]-2-carbonitrile

SZ CAT No:	: SZ-L028023
CAS No	: 114772-53-1
Mol.F.	: C14H11N
Mol.Wt.	: 193.3
Inv. Status	: In Stock

2’-(2H-Tetrazol-5-yl)-[1,1’-biphenyl]-4-carboxaldehyde

SZ CAT No:	: SZ-L028024
CAS No	: 151052-40-3
Mol.F.	: C14H10N4O
Mol.Wt.	: 250.3
Inv. Status	: In Stock

Losartan Impurity 35

SZ CAT No:	: SZ-L028025
CAS No	: 124750-67-0
Mol.F.	: C22H20ClN3O
Mol.Wt.	: 377.9
Inv. Status	: In Stock

Losartan Impurity 36

SZ CAT No:	: SZ-L028026
CAS No	: 114772-55-3
Mol.F.	: C22H22ClN3O
Mol.Wt.	: 379.9
Inv. Status	: In Stock

5-(4'-methylbiphenyl-2-yl)-1-trityl-1H-tetrazole

SZ CAT No:	: SZ-L028028
CAS No	: 124750-53-4
Mol.F.	: C33H26N4
Mol.Wt.	: 478.6
Inv. Status	: In Stock

Losartan D2

SZ CAT No:	: SZ-L028D01
CAS No	: 1030936-22-1
Mol.F.	: C22H21D2ClN6O
Mol.Wt.	: 424.9
Inv. Status	: Custom Synthesis

Losartan D3

SZ CAT No:	: SZ-L028D02
CAS No	: 1030936-74-3
Mol.F.	: C22H20D3ClN6O
Mol.Wt.	: 425.9
Inv. Status	: Custom Synthesis

Losartan D4

SZ CAT No:	: SZ-L028D03
CAS No	: 1030937-27-9
Mol.F.	: C22H19D4ClN6O
Mol.Wt.	: 426.9
Inv. Status	: Custom Synthesis

Losartan Azide impurity

SZ CAT No:	: SZ-L028029
CAS No	: 727718-93-6
Mol.F.	: C22H22ClN9
Mol.Wt.	: 447.9
Inv. Status	: In Stock

Losartan Cum-Alcohol

SZ CAT No:	: SZ-L028030
CAS No	: 852357-69-8
Mol.F.	: C31H33ClN6O
Mol.Wt.	: 541.1
Inv. Status	: In Stock

Losartan Nitroso Impurity 1

SZ CAT No:	: SZ-L028015
CAS No	: NA
Mol.F.	: C8H10ClN3O2
Mol.Wt.	: 215.6
Inv. Status	: Inquire

Trityl Losartan

SZ CAT No:	: SZ-L028018
CAS No	: 124751-00-4
Mol.F.	: C41H37ClN6O
Mol.Wt.	: 665.2
Inv. Status	: Custom Synthesis

N-Trityl Losartan Isomer

SZ CAT No:	: SZ-L028027
CAS No	: 133727-10-3
Mol.F.	: C41H37ClN6O
Mol.Wt.	: 665.2
Inv. Status	: Custom Synthesis

N-Trityl Losartan Carboxaldehyde

SZ CAT No:	: SZ-L028031
CAS No	: 120568-18-5
Mol.F.	: C41H35ClN6O
Mol.Wt.	: 663.2
Inv. Status	: Custom Synthesis

Losartan Azide Nitrile Impurity

SZ CAT No:	: SZ-L028032
CAS No	: 2755908-48-4
Mol.F.	: C22H21ClN6
Mol.Wt.	: 404.9
Inv. Status	: In Stock

Losartan Impurity 2

SZ CAT No:	: SZ-L028033
CAS No	: NA
Mol.F.	: C22H21Cl2N3
Mol.Wt.	: 398.3
Inv. Status	: Custom Synthesis

Losartan Impurity 4

SZ CAT No:	: SZ-L028035
CAS No	: NA
Mol.F.	: C22H22Cl2N6
Mol.Wt.	: 441.4
Inv. Status	: Custom Synthesis

Losartan Impurity 5

SZ CAT No:	: SZ-L028036
CAS No	: NA
Mol.F.	: C22H21ClN6
Mol.Wt.	: 404.9
Inv. Status	: Custom Synthesis

Losartan Impurity 6

SZ CAT No:	: SZ-L028037
CAS No	: NA
Mol.F.	: C22H22ClN9
Mol.Wt.	: 447.9
Inv. Status	: Custom Synthesis

Losartan Impurity 7

SZ CAT No:	: SZ-L028038
CAS No	: 159448-66-5
Mol.F.	: C8H12Cl2N2
Mol.Wt.	: 207.1
Inv. Status	: Custom Synthesis

Losartan Amine

SZ CAT No:	: SZ-L028039
CAS No	: 141949-89-5
Mol.F.	: C22H24ClN7
Mol.Wt.	: 421.9
Inv. Status	: Custom Synthesis

Losartan Nitroso Impurity

SZ CAT No:	: SZ-L028040
CAS No	: NA
Mol.F.	: C22H22ClN7O2
Mol.Wt.	: 451.9
Inv. Status	: Inquire

Losartan Methyl Ether

SZ CAT No:	: SZ-L028042
CAS No	: 114798-94-6
Mol.F.	: C23H25ClN6O
Mol.Wt.	: 436.9
Inv. Status	: Custom Synthesis

Losartan Butyl Ether

SZ CAT No:	: SZ-L028043
CAS No	: 2204442-78-2
Mol.F.	: C26H31ClN6O
Mol.Wt.	: 479.0
Inv. Status	: Custom Synthesis

Losartan Impurity 10

SZ CAT No:	: SZ-L028044
CAS No	: 2758005-15-9
Mol.F.	: C14H11N3O2
Mol.Wt.	: 253.3
Inv. Status	: In Stock

Losartan Impurity 11

SZ CAT No:	: SZ-L028045
CAS No	: NA
Mol.F.	: C22H22ClN5O2
Mol.Wt.	: 423.9
Inv. Status	: Custom Synthesis

Losartan Impurity 12

SZ CAT No:	: SZ-L028046
CAS No	: 2353190-33-5
Mol.F.	: C8H12ClN5
Mol.Wt.	: 213.7
Inv. Status	: In Stock

Losartan Tetramethylbenzidine

SZ CAT No:	: SZ-L028048
CAS No	: 54827-17-7
Mol.F.	: C16H20N2
Mol.Wt.	: 240.4
Inv. Status	: Custom Synthesis

Losartan Impurity 14

SZ CAT No:	: SZ-L028049
CAS No	: 178554-16-0
Mol.F.	: C25H26N6O3
Mol.Wt.	: 458.5
Inv. Status	: Custom Synthesis

Losartan Nitroso Impurity 3

SZ CAT No:	: SZ-L028050
CAS No	: NA
Mol.F.	: C22H22ClN7O2
Mol.Wt.	: 451.9
Inv. Status	: Inquire

Losartan Nitroso Impurity 4

SZ CAT No:	: SZ-L028051
CAS No	: NA
Mol.F.	: C8H12ClN3O2
Mol.Wt.	: 217.7
Inv. Status	: Inquire

Losartan Impurity 17

SZ CAT No:	: SZ-L028052
CAS No	: NA
Mol.F.	: C23H23ClN8
Mol.Wt.	: 446.9
Inv. Status	: Custom Synthesis

Losartan Impurity 20

SZ CAT No:	: SZ-L028055
CAS No	: 1407521-00-9
Mol.F.	: C22H20ClN3O
Mol.Wt.	: 377.9
Inv. Status	: Custom Synthesis

Losartan Impurity 21

SZ CAT No:	: SZ-L028056
CAS No	: 2763750-28-1
Mol.F.	: C14H12N4O
Mol.Wt.	: 252.3
Inv. Status	: In Stock

Losartan Impurity 22

SZ CAT No:	: SZ-L028057
CAS No	: NA
Mol.F.	: C22H24ClN9
Mol.Wt.	: 449.9
Inv. Status	: Custom Synthesis

Losartan Impurity 23

SZ CAT No:	: SZ-L028058
CAS No	: NA
Mol.F.	: C14H10N4
Mol.Wt.	: 234.3
Inv. Status	: Custom Synthesis

Losartan Impurity 24

SZ CAT No:	: SZ-L028059
CAS No	: NA
Mol.F.	: C14H11N7
Mol.Wt.	: 277.3
Inv. Status	: Custom Synthesis

Losartan Impurity 25

SZ CAT No:	: SZ-L028062
CAS No	: 73963-29-8
Mol.F.	: C10H17ClN4
Mol.Wt.	: 228.7
Inv. Status	: In Stock

Losartan Impurity 26

SZ CAT No:	: SZ-L028063
CAS No	: 73963-34-5
Mol.F.	: C10H11ClN4
Mol.Wt.	: 222.7
Inv. Status	: Custom Synthesis

Losartan Impurity 27

SZ CAT No:	: SZ-L028064
CAS No	: NA
Mol.F.	: C21H30N4O6
Mol.Wt.	: 434.5
Inv. Status	: Custom Synthesis

Losartan Impurity 28

SZ CAT No:	: SZ-L028065
CAS No	: NA
Mol.F.	: C21H30N4O6
Mol.Wt.	: 434.5
Inv. Status	: Custom Synthesis

Losartan-D4 Carboxylic Acid

SZ CAT No:	: SZ-L028D04
CAS No	: 1246820-62-1
Mol.F.	: C22H17D4ClN6O2
Mol.Wt.	: 440.9
Inv. Status	: Custom Synthesis

Losartan Dimer (Azido of Impurity-L)

SZ CAT No:	: SZ-L028066
CAS No	: 2755908-51-9
Mol.F.	: C44H43Cl2N15
Mol.Wt.	: 852.8
Inv. Status	: Custom Synthesis

Losartan Impurity 29

SZ CAT No:	: SZ-L028067
CAS No	: 1190000-72-6
Mol.F.	: C21H21ClN6
Mol.Wt.	: 392.9
Inv. Status	: Custom Synthesis

Losartan Impurity 30

SZ CAT No:	: SZ-L028068
CAS No	: 2204369-11-7
Mol.F.	: C22H22ClN3O
Mol.Wt.	: 379.9
Inv. Status	: Custom Synthesis

Losartan Impurity 31

SZ CAT No:	: SZ-L028069
CAS No	: NA
Mol.F.	: C11H19N7
Mol.Wt.	: 249.3
Inv. Status	: Custom Synthesis

Losartan Impurity 32

SZ CAT No:	: SZ-L028070
CAS No	: 114799-00-7
Mol.F.	: C22H24N2O3
Mol.Wt.	: 364.4
Inv. Status	: Custom Synthesis

Losartan Impurity 33

SZ CAT No:	: SZ-L028071
CAS No	: 114798-27-5
Mol.F.	: C22H23ClN2O3
Mol.Wt.	: 398.9
Inv. Status	: Custom Synthesis

Losartan-D3 Carboxylic Acid

SZ CAT No:	: SZ-L028D05
CAS No	: 1189729-40-5
Mol.F.	: C22H18D3ClN6O2
Mol.Wt.	: 439.9
Inv. Status	: Custom Synthesis

Losartan Impurity 34

SZ CAT No:	: SZ-L028072
CAS No	: 158365-99-2
Mol.F.	: C7H11ClN2
Mol.Wt.	: 158.6
Inv. Status	: Custom Synthesis

Losartan Impurity 20

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