Ledipasvir Impurity-19

SZ CAT No:	SZ-L010029
CAS No	1129634-44-1
Mol.F.	C12H19NO4
Mol.Wt.	241.3
Inv. Status	In Stock
Rel. CAS No	1441673-92-2 (K salt)

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SynZeal will update these details as per new development or finding in product specification without further noticed.

Chemical Name: (S)-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylic acid

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: O=C(N1CC2(CC2)C[C@H]1C(O)=O)OC(C)(C)C

Insights into the Dissolution Behavior of Ledipasvir-Copovidone Amorphous Solid Dispersions: Role of Drug Loading and Intermolecular Interactions
Chailu Que, Xiaochun Lou, Dmitry Y. Zemlyanov, Huaping Mo, Anura S. Indulkar, Yi Gao, Geoff G.Z. Zhang, and Lynne S. Taylor
Mol. Pharmaceutics 2019, 16, 12, 5054–5067

A green stability-indicating RP-HPLC-UV method using factorial design for determination of ribavirin, sofosbuvir and ledipasvir: Application to average content, acid degradation kinetics and in vitro drug interactions study
Hanan I.EL-ShorbagyacFawziElsebaeiaSherin F.HammadbAmina M.El-Brashy
Microchemical Journal Volume 158, November 2020, 105251

Simultaneous chromatographic analysis of Sofosbuvir/Ledipasvir in their combined dosage form: an application to green analytical chemistry
Ahmed Hemdan & Maya S. Eissa
Journal of Analytical Science and Technology volume 10, Article number: 39 (2019)

Chemometrically Assisted RP-HPLC and Spectroscopic Method Development for Simultaneous Multi-Component Analysis of Ledipasvir and Sofosbuvir in Pure and Pharmaceutical Formulation
Roma N Trivedi1* , Jinal N Tandel2 , Rashmika C Patel2 , Samir K Shah2
Der Pharmacia Lettre, 2018, 10 [3]: 62-75

Ledipasvir Impurity-19 is chemically (S)-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylic acid. Ledipasvir Impurity-19 is supplied with detailed characterization data compliant with regulatory guideline. Ledipasvir Impurity-19 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Ledipasvir.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

Ledipasvir Impurity-19

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SZ CAT No:	: SZ-L010D01
CAS No	: NA
Mol.F.	: C49H48D6F2N8O6
Mol.Wt.	: 895.1
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-L010D02
CAS No	: NA
Mol.F.	: C47H52F2N8O4
Mol.Wt.	: 831.0
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-L010001
CAS No	: 1256388-51-8
Mol.F.	: C49H54F2N8O6
Mol.Wt.	: 889.0
Inv. Status	: In Stock

SZ CAT No:	: SZ-L010002
CAS No	: 1256393-35-7
Mol.F.	: C49H54F2N8O6
Mol.Wt.	: 889.0
Inv. Status	: In Stock

SZ CAT No:	: SZ-L010003
CAS No	: 1256391-66-8
Mol.F.	: C49H54F2N8O6
Mol.Wt.	: 889.0
Inv. Status	: Out of Stock

SZ CAT No:	: SZ-L010004
CAS No	: NA
Mol.F.	: C49H54F2N8O6
Mol.Wt.	: 889.0
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-L010005
CAS No	: NA
Mol.F.	: C29H29BrN4O4
Mol.Wt.	: 577.5
Inv. Status	: In Stock

SZ CAT No:	: SZ-L010006
CAS No	: 2040487-43-0
Mol.F.	: C49H54N8O7
Mol.Wt.	: 867.0
Inv. Status	: In Stock

SZ CAT No:	: SZ-L010007
CAS No	: NA
Mol.F.	: C49H54F2N8O6
Mol.Wt.	: 889.0
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-L010010
CAS No	: 1256388-50-7
Mol.F.	: C29H29BrF2N4O3
Mol.Wt.	: 599.5
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-L010013
CAS No	: NA
Mol.F.	: C29H29BrF2N4O3
Mol.Wt.	: 599.5
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-L010014
CAS No	: NA
Mol.F.	: C49H54F2N8O6
Mol.Wt.	: 889.0
Inv. Status	: In Stock

SZ CAT No:	: SZ-L010015
CAS No	: NA
Mol.F.	: C49H54F2N8O6
Mol.Wt.	: 889.0
Inv. Status	: Limited Stock

SZ CAT No:	: SZ-L010016
CAS No	: NA
Mol.F.	: C49H54F2N8O6
Mol.Wt.	: 889.0
Inv. Status	: Out of Stock

SZ CAT No:	: SZ-L010017
CAS No	: 2705846-40-6
Mol.F.	: C18H23N3O2
Mol.Wt.	: 313.4
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-L010018
CAS No	: NA
Mol.F.	: C18H23N3O2
Mol.Wt.	: 313.4
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-L010019
CAS No	: NA
Mol.F.	: C18H23N3O2
Mol.Wt.	: 313.4
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-L010020
CAS No	: NA
Mol.F.	: C18H23N3O2
Mol.Wt.	: 313.4
Inv. Status	: In Stock

SZ CAT No:	: SZ-L010021
CAS No	: 1256387-87-7
Mol.F.	: C24H34BN3O4
Mol.Wt.	: 439.4
Inv. Status	: Out of Stock

SZ CAT No:	: SZ-L010022
CAS No	: NA
Mol.F.	: C24H34BN3O4
Mol.Wt.	: 439.4
Inv. Status	: In Stock

SZ CAT No:	: SZ-L010023
CAS No	: NA
Mol.F.	: C24H34BN3O4
Mol.Wt.	: 439.4
Inv. Status	: In Stock

SZ CAT No:	: SZ-L010024
CAS No	: NA
Mol.F.	: C24H34BN3O4
Mol.Wt.	: 439.4
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-L010025
CAS No	: 1378387-87-1
Mol.F.	: C26H37BN4O5
Mol.Wt.	: 496.4
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-L010026
CAS No	: NA
Mol.F.	: C26H37BN4O5
Mol.Wt.	: 496.4
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-L010027
CAS No	: NA
Mol.F.	: C26H37BN4O5
Mol.Wt.	: 496.4
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-L010028
CAS No	: NA
Mol.F.	: C26H37BN4O5
Mol.Wt.	: 496.4
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-L010029
CAS No	: 1129634-44-1
Mol.F.	: C12H19NO4
Mol.Wt.	: 241.3
Inv. Status	: In Stock

SZ CAT No:	: SZ-L010030
CAS No	: 291775-59-2
Mol.F.	: C12H19NO4
Mol.Wt.	: 241.3
Inv. Status	: Out of Stock

SZ CAT No:	: SZ-L010031
CAS No	: 1441670-89-8
Mol.F.	: C27H26BrF2N3O2
Mol.Wt.	: 542.4
Inv. Status	: Out of Stock

SZ CAT No:	: SZ-L010032
CAS No	: 2128695-48-5
Mol.F.	: C49H54F2N8O6 : HCl
Mol.Wt.	: 889.0 : 36.5
Inv. Status	: Custom Synthesis