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Estradiol Dimer Impurity

SZ CAT No SZ-E031029
Mol.F. C36H46O4
Mol.Wt. 542.8
Inv. Status Custom Synthesis

Chemical Name: (13S,17S)-2-(((13S,17S)-17-Hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl)oxy)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol compound with (13S,17S)-4-(((13S,17S)-17-hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl)oxy)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol (1:1)

Smiles: OC1=CC=C2C(CCC3C2CC[C@@]4(C)C3CC[C@@H]4O)=C1OC5=CC(CCC6C7CC[C@@]8(C)C6CC[C@@H]8O)=C7C=C5.O[C@H]9CCC%10C(C%11CC[C@@]%109C)CCC%12=C%11C=CC(OC%13=C(O)C=C(CCC%14C%15CC[C@@]%16(C)C%14CC[C@@H]%16O)C%15=C%13)=C%12

Inchi: InChI=1S/2C26H35ClN2O10/c2*1-4-38-26(35)20-16(12-37-10-9-28-24-23(33)22(32)21(31)17(11-30)39-24)29-13(2)18(25(34)36-3)19(20)14-7-5-6-8-15(14)27/h2*5-8,17,19,21-24,28-33H,4,9-12H2,1-3H3/t17-,19?,21?,22-,23-,24?;17-,19?,21+,22+,23-,24?/m11/s1

Effect of Impurities on Estradiol Crystallization in a Sustained-Release Implant
G. f. needham*’, R. r. pfeiffer’*, G. l. engel, S. rutherford, and D. j. allen
Journal of Pharmaceutical Sciences Volume 81, Issue 10, October 1992, Pages 1012-1014
HPLC Method for Simultaneous Determination of Potential Impurities of Norgestimate and Ethinyl Estradiol in Combination Drug Product Using Sub-2 µm Column
Bhaskara p. v. mantena,1 sumathi v. rao,1 k. m. ch. appa rao,2 k. ramakrishna,2 and s. p. vittal
Journal of Liquid Chromatography & Related Technologies, 38: 1014–1025, 2015
A validated simultaneous rp-hplc method for determination of desogestrel and ethinyl estradiol tablets
M sarat1, and c rambabu
Int J Pharm Pharm Sci, Vol 4, Suppl 5, 115-119
Rapid high performance liquid chromatography method development with high prediction accuracy, using 5 cm long narrow bore columns packed with sub-2 m particles and Design Space computer modeling
Szabolcs Feketea,∗, Jeno Fekete ˝ b, Imre Molnár c, Katalin Ganzler
Journal of Chromatography A, 1216 (2009) 7816–7823