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Enzalutamide Impurity 3

SZ CAT No SZ-E015009
Mol.F. C21H18F4N4O4 
Mol.Wt. 466.4 
Inv. Status Custom Synthesis

Chemical Name: 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroperoxy-5,5-dimethyl-4-oxoimidazolidin-1-yl)-2-fluoro-N-methylbenzamide

Structural elucidation of the impurities in Enzalutamide bulk drug and the development, validation of corresponding HPLC method
Xingling Mab , Wentao Zhoua , Qiaogen Zoua,*, Pingkai Ouyang
Journal of Pharmaceutical and Biomedical Analysis Volume 131, 30 November 2016, Pages 436-443
Crystal Forms of Enzalutamide and a Crystal Engineering Route to Drug Purification
Lucia Maini, Dario Braga, Francesco Farinella, Elisa Melotto, Massimo Verzini, Roberto Brescello, Ivan Michieletto, and Ilaria Munari
Cryst. Growth Des. 2018, 18, 7, 3774–3780
Quantitative Study of Impurities in Enzalutamide and Identification, Isolation, Characterization of Its Four Degradation Products Using HPLC, Semi-preparative LC, LC/ESI–MS and NMR Analyses
Ainan Zhou1,2 · Lejun Ruan1  · Gengli Duan2  · Jianqi Li
Chromatographia volume 81, pages1519–1531(2018)
Validation of a method for quantifying enzalutamide and its major metabolites in human plasma by LC–MS/MS
Daniel Bennett, Jacqueline A Gibbons, Roelof Mol, Yoshiaki Ohtsu & Clark Williard
Bioanalysis (2014) 6(6), 737–744