Diltiazem EP Impurity A

SZ CAT No:	SZ-D029002
CAS No	111188-71-7
Mol.F.	C22H26N2O4S
Mol.Wt.	414.5
Inv. Status	Out of Stock

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Chemical Name: (2R,3S)-5-[2-(Dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate (as per EP & USP)

Synonym: Diltiazem USP Related Compound A ; trans-Diltiazem (USP) ; Diltiazem (2R)-Isomer

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: O=C1[C@@H]([C@@H](C2=CC=C(OC)C=C2)SC3=CC=CC=C3N1CCN(C)C)OC(C)=O

Identification of Diltiazem Impurities/Artifacts during the Analyses of Illicit Cocaine Exhibits Containing Diltiazem
John F. Casale,1,* Pauline M. Orlando,2 Valerie L. Colley,1 and Patrick A. Hays
Microgram Journal, Volume 6, Numbers 3-4 (July - December, 2008)

Validated gradient stability indicating HPLC method for determining Diltiazem Hydrochloride and related substances in bulk drug and novel tablet formulation
Vivekanand A. ChatpalliwarPawan K. PorwalNeeraj Upmanyu
Journal of Pharmaceutical Analysis Volume 2, Issue 3, June 2012, Pages 226-237

Analytical Characterization of two new related impurities of Diltiazem by High Resolution Mass spectrometry and NMR techniques
Jagadeesh narkedimilli, y. ravindrakumar1 , sandeep mohanty1 ,t. srinivasarao1 and a. jayashree
oriental journal of chemistry vol. 31, No. (3): Pg. 1801-1809.

Diltiazem EP Impurity A is chemically (2R,3S)-5-[2-(Dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate (as per EP & USP). It is also known as Diltiazem USP Related Compound A ; trans-Diltiazem (USP) ; Diltiazem (2R)-Isomer. Diltiazem EP Impurity A is supplied with detailed characterization data compliant with regulatory guideline. Diltiazem EP Impurity A can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Diltiazem.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

SZ CAT No:	: SZ-D029021
CAS No	: 84903-82-2
Mol.F.	: C19H22N2O3S
Mol.Wt.	: 358.5
Inv. Status	: In Stock
Rel. CAS No	: 96252-32-3 (HCl salt)

SZ CAT No:	: SZ-D029026
CAS No	: 75472-91-2
Mol.F.	: C20H24N2O3S : HCl
Mol.Wt.	: 372.5 : 36.5
Inv. Status	: In Stock
Rel. CAS No	: 42399-40-6 (free base)

SZ CAT No:	: SZ-D029023
CAS No	: 142926-09-8
Mol.F.	: C18H20N2O3S : HCl
Mol.Wt.	: 344.4 : 36.5
Inv. Status	: In Stock
Rel. CAS No	: 86408-42-6 (free base)

SZ CAT No:	: SZ-D029019
CAS No	: 86408-42-6
Mol.F.	: C18H20N2O3S
Mol.Wt.	: 344.4
Inv. Status	: Out of Stock
Rel. CAS No	: 142926-09-8 (HCl salt)

SZ CAT No:	: SZ-D029027
CAS No	: 42399-41-7
Mol.F.	: C22H26N2O4S
Mol.Wt.	: 414.5
Inv. Status	: Custom Synthesis
Rel. CAS No	: 33286-22-5 (HCl salt)

Diltiazem EP Impurity A

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SZ CAT No:	: SZ-D029D03
CAS No	: 112259-40-2
Mol.F.	: C20H20D4N2O3S
Mol.Wt.	: 376.5
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-D029D04
CAS No	: 1246820-35-8
Mol.F.	: C20H18D6N2O3S
Mol.Wt.	: 378.5
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-D029009
CAS No	: 91926-66-8
Mol.F.	: C20H24N2O3S
Mol.Wt.	: 372.5
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-D029010
CAS No	: 132830-17-2
Mol.F.	: C16H15NO3S
Mol.Wt.	: 301.4
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-D029D01
CAS No	: 112259-41-3
Mol.F.	: C22H22D4N2O4S
Mol.Wt.	: 418.5
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-D029D05
CAS No	: 2012598-87-5
Mol.F.	: C20H19D5N2O3S
Mol.Wt.	: 377.5
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-D029D02
CAS No	: 1242184-41-3
Mol.F.	: C22H20D6N2O4S
Mol.Wt.	: 420.6
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-D029016
CAS No	: 30842-48-9
Mol.F.	: C19H19NO4S
Mol.Wt.	: 357.4
Inv. Status	: In Stock

SZ CAT No:	: SZ-D029017
CAS No	: NA
Mol.F.	: C20H19NO4S
Mol.Wt.	: 369.4
Inv. Status	: In Stock

SZ CAT No:	: SZ-D029002
CAS No	: 111188-71-7
Mol.F.	: C22H26N2O4S
Mol.Wt.	: 414.5
Inv. Status	: Out of Stock

SZ CAT No:	: SZ-D029003
CAS No	: 87447-47-0
Mol.F.	: C18H17NO4S
Mol.Wt.	: 343.4
Inv. Status	: In Stock

SZ CAT No:	: SZ-D029004
CAS No	: NA
Mol.F.	: C21H24N2O4S : HCl
Mol.Wt.	: 400.5 : 36.5
Inv. Status	: In Stock
Rel. CAS No	: 84903-78-6 (free base) ; 142926-07-6 (HBr salt)

SZ CAT No:	: SZ-D029005
CAS No	: 130606-60-9
Mol.F.	: C21H24N2O4S : HCl
Mol.Wt.	: 400.5 : 36.5
Inv. Status	: In Stock
Rel. CAS No	: 86408-45-9 (free base)

SZ CAT No:	: SZ-D029006
CAS No	: 42399-49-5
Mol.F.	: C16H15NO3S
Mol.Wt.	: 301.4
Inv. Status	: In Stock

SZ CAT No:	: SZ-D029007
CAS No	: 42399-40-6
Mol.F.	: C20H24N2O3S
Mol.Wt.	: 372.5
Inv. Status	: In Stock
Rel. CAS No	: 75472-91-2 (HCl salt)

SZ CAT No:	: SZ-D029008
CAS No	: 81353-09-5
Mol.F.	: C19H22N2O3S
Mol.Wt.	: 358.5
Inv. Status	: In Stock

SZ CAT No:	: SZ-D029001
CAS No	: 33286-22-5
Mol.F.	: C22H26N2O4S : HCl
Mol.Wt.	: 414.5 : 36.5
Inv. Status	: In Stock
Rel. CAS No	: 42399-41-7 (free base)

SZ CAT No:	: SZ-D029024
CAS No	: NA
Mol.F.	: C19H22N2O3S
Mol.Wt.	: 358.5
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-D029011
CAS No	: 116050-35-2
Mol.F.	: C20H22N2O4S : HCl
Mol.Wt.	: 386.5 : 36.5
Inv. Status	: Out of Stock
Rel. CAS No	: 115973-28-9 (free base)

SZ CAT No:	: SZ-D029022
CAS No	: NA
Mol.F.	: C20H22N2O4S : C2HF3O2
Mol.Wt.	: 386.5 : 114.0
Inv. Status	: Out of Stock, Custom Synthesis
Rel. CAS No	: 115973-28-9 (free base) ; 116050-35-2 (HCl salt)

SZ CAT No:	: SZ-D029012
CAS No	: 142843-04-7
Mol.F.	: C22H26N2O5S
Mol.Wt.	: 430.5
Inv. Status	: In Stock

SZ CAT No:	: SZ-D029018
CAS No	: 122619-90-3
Mol.F.	: C20H24N2O4S
Mol.Wt.	: 388.5
Inv. Status	: In Stock

SZ CAT No:	: SZ-D029014
CAS No	: 96252-32-3
Mol.F.	: C19H22N2O3S : HCl
Mol.Wt.	: 358.5 : 36.5
Inv. Status	: In Stock
Rel. CAS No	: 84903-82-2 (free base)

SZ CAT No:	: SZ-D029020
CAS No	: 370094-12-5
Mol.F.	: C22H26N2O5S
Mol.Wt.	: 430.5
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-D029028
CAS No	: NA
Mol.F.	: C22H26N2O6S
Mol.Wt.	: 446.5
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-D029029
CAS No	: NA
Mol.F.	: C22H26N2O7S
Mol.Wt.	: 462.5
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-D029015
CAS No	: NA
Mol.F.	: C17H18N2O3S : HBr
Mol.Wt.	: 330.4 : 80.9
Inv. Status	: In Stock
Rel. CAS No	: 115992-91-1 (free base)

SZ CAT No:	: SZ-D029025
CAS No	: NA
Mol.F.	: C23H26N2O5S
Mol.Wt.	: 442.5
Inv. Status	: In Stock