Citalopram EP Impurity D (HBr salt)

SZ CAT No:	SZ-C039019
CAS No	1188264-72-3
Mol.F.	C19H19FN2O : HBr
Mol.Wt.	310.4 : 80.9
Inv. Status	In Stock
Rel. CAS No	62498-67-3 (free base) ; 97743-99-2 (HCl salt)

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Chemical Name: (1RS)-1-(4-fluorophenyl)-1-[3-(methylamino)propyl]-1,3-dihydroisobenzofuran-5-carbonitrile hydrochloride (as per EP) ; 1-(4-Fluorophenyl)-1-(3-methylaminopropyl)-1,3-dihydroisobenzofuran-5-carbonitrile hydrobromide (as per USP)

Synonym: Citalopram USP Related Compound D ; N-Desmethyl Citalopram HBr

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: N#CC1=CC2=C(C(CCCNC)(C3=CC=C(F)C=C3)OC2)C=C1.Br

Semi-preparative isolation and structural elucidation of an impurity in citalopram by LC/MS/MS
Bhanu Ramana,∗, Brajesh A. Sharmaa,b, Pradeep D. Ghugare b, Pravin P. Karmuse b, Ashok Kumar b
Journal of Pharmaceutical and Biomedical Analysis 50 (2009) 377–383

Isolation and characterization of degradation products of citalopram and process-related impurities using RP-HPLC
Ramisetti Nageswara Rao Ale Narasa Raju Ramaram Narsimha
J. Sep. Sci. 2008, 31, 1729 – 1738

Improved One-Pot Synthesis of Citalopram Diol and Its Conversion to Citalopram
Ravindra Vedantham, VNKV Prasada Raju Vetukuri, Ambaiah Boini, Mukkanti Khagga, and Rakeshwar Bandichhor
Org. Process Res. Dev. 2013, 17, 5, 798–805

Characterization of an unknown impurity in citalopram hydrobromide active pharmaceutical ingredient by semi-preparative isolation and lc-esi/msn and nmr
Saji Thomas,1 Ashutosh Agarwal,1 Raghavendra Desai Rao,2 and Chandra S. Mathela
Journal of Liquid Chromatography & Related Technologies, 36:1999–2012, 2013

Citalopram EP Impurity D (HBr salt) is chemically (1RS)-1-(4-fluorophenyl)-1-[3-(methylamino)propyl]-1,3-dihydroisobenzofuran-5-carbonitrile hydrochloride (as per EP) ; 1-(4-Fluorophenyl)-1-(3-methylaminopropyl)-1,3-dihydroisobenzofuran-5-carbonitrile hydrobromide (as per USP). It is also known as Citalopram USP Related Compound D ; N-Desmethyl Citalopram HBr. Citalopram EP Impurity D (HBr salt) is supplied with detailed characterization data compliant with regulatory guideline. Citalopram EP Impurity D (HBr salt) can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Citalopram.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

SZ CAT No:	: SZ-C039005
CAS No	: 372941-54-3
Mol.F.	: C20H19FN2O2
Mol.Wt.	: 338.4
Inv. Status	: In Stock
Rel. CAS No	: 1440961-11-4 (Oxalate salt)
Rel. CAT No	: SZ-E002004 ,

SZ CAT No:	: SZ-C039024
CAS No	: 1148027-85-3
Mol.F.	: C20H22N2O : HCl
Mol.Wt.	: 306.4 : 36.5
Inv. Status	: Limited Stock
Rel. CAS No	: 1026009-77-7 (free base) ; 1332724-04-5 (HBr salt) ; 1093072-86-6 (oxalate salt)
Rel. CAT No	: SZ-C039047 ,

Citalopram EP Impurity D (HBr salt)

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SZ CAT No:	: SZ-C039012
CAS No	: 219861-53-7
Mol.F.	: C20H21FN2O : C2H2O4
Mol.Wt.	: 324.4 . 90.0
Inv. Status	: In Stock
Rel. CAS No	: 128196-02-1 (free base)

SZ CAT No:	: SZ-C039040
CAS No	: 166037-78-1
Mol.F.	: C18H17FN2O
Mol.Wt.	: 296.3
Inv. Status	: In Stock

SZ CAT No:	: SZ-C039031
CAS No	: 460-00-4
Mol.F.	: C6H4BrF
Mol.Wt.	: 175
Inv. Status	: In Stock

SZ CAT No:	: SZ-C039030
CAS No	: 5407-04-5
Mol.F.	: C5H12ClN : HCl
Mol.Wt.	: 121.6 : 36.5
Inv. Status	: In Stock
Rel. CAS No	: 109-54-6 (free base)

SZ CAT No:	: SZ-C039025
CAS No	: 65399-05-5
Mol.F.	: C8H7NO2
Mol.Wt.	: 149.2
Inv. Status	: In Stock

SZ CAT No:	: SZ-C039001
CAS No	: 85118-27-0
Mol.F.	: C20H21FN2O : HCl
Mol.Wt.	: 324.4 : 36.5
Inv. Status	: Custom Synthesis
Rel. CAS No	: 59729-33-8 (free base) ; 59729-32-7 (HBr salt)

SZ CAT No:	: SZ-C039028
CAS No	: 82104-74-3
Mol.F.	: C9H5NO2
Mol.Wt.	: 159.1
Inv. Status	: In Stock

SZ CAT No:	: SZ-C039029
CAS No	: 717133-25-0
Mol.F.	: C20H23FN2O2 : HCl
Mol.Wt.	: 342.4 : 36.5
Inv. Status	: In Stock
Rel. CAS No	: 103146-25-4 (free base) ; 103146-26-5 (HBr salt)

SZ CAT No:	: SZ-C039022
CAS No	: NA
Mol.F.	: C40H41F2N4O : C2F3O2
Mol.Wt.	: 631.8 : 113.0
Inv. Status	: In Stock
Rel. CAS No	: 1370687-55-0 (free base) ; 1370643-27-8 (chloride)

SZ CAT No:	: SZ-C039026
CAS No	: 3676-85-5
Mol.F.	: C8H6N2O2
Mol.Wt.	: 162.2
Inv. Status	: In Stock

SZ CAT No:	: SZ-C039021
CAS No	: 440121-09-5
Mol.F.	: C20H22FNO3
Mol.Wt.	: 343.4
Inv. Status	: In Stock

SZ CAT No:	: SZ-C039D01
CAS No	: 1309283-28-0
Mol.F.	: C18H17D3FNO
Mol.Wt.	: 288.4
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-C039D02
CAS No	: 1219908-84-5
Mol.F.	: C20H17D4FN2O
Mol.Wt.	: 328.4
Inv. Status	: Custom Synthesis
Rel. CAS No	: 1219803-58-3 (HBr salt)

SZ CAT No:	: SZ-C039D03
CAS No	: 1190003-26-9
Mol.F.	: C20H15D6FN2O
Mol.Wt.	: 330.4
Inv. Status	: Custom Synthesis
Rel. CAS No	: 2119948-08-0 (HBr salt)

SZ CAT No:	: SZ-C039039
CAS No	: 390817-87-5
Mol.F.	: C19H22FNO
Mol.Wt.	: 299.4
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-C039014
CAS No	: 1189694-81-2
Mol.F.	: C18H17FN2O : HCl
Mol.Wt.	: 296.3 : 36.5
Inv. Status	: Custom Synthesis
Rel. CAS No	: 62498-69-5 (free base)

SZ CAT No:	: SZ-C039015
CAS No	: 103146-26-5
Mol.F.	: C20H23FN2O2 : HBr
Mol.Wt.	: 342.4 : 80.9
Inv. Status	: In Stock
Rel. CAS No	: 103146-25-4 (free base) ; 717133-25-0 (HCl salt)

SZ CAT No:	: SZ-C039036
CAS No	: 1187671-15-3
Mol.F.	: C20H24N2O2
Mol.Wt.	: 324.4
Inv. Status	: In Stock
Rel. CAS No	: 1187582-64-4 (HBr salt)

SZ CAT No:	: SZ-C039003
CAS No	: 64372-56-1
Mol.F.	: C20H23FN2O2
Mol.Wt.	: 342.4
Inv. Status	: In Stock

SZ CAT No:	: SZ-C039004
CAS No	: 411221-53-9
Mol.F.	: C20H21FN2O2
Mol.Wt.	: 340.4
Inv. Status	: In Stock
Rel. CAS No	: 1332724-03-4 (oxalate salt)

SZ CAT No:	: SZ-C039006
CAS No	: 97743-99-2
Mol.F.	: C19H19FN2O : HCl
Mol.Wt.	: 310.4 : 36.5
Inv. Status	: In Stock
Rel. CAS No	: 62498-67-3 (free base) ; 1188264-72-3 (HBr salt)

SZ CAT No:	: SZ-C039007
CAS No	: 1332724-08-9
Mol.F.	: C19H21ClFNO : HBr
Mol.Wt.	: 333.8 : 80.0
Inv. Status	: Out of Stock, Custom Synthesis
Rel. CAS No	: 64169-45-5 (free base) ; 1329612-81-8 (oxalate salt)

SZ CAT No:	: SZ-C039008
CAS No	: 64372-43-6
Mol.F.	: C19H21BrFNO : C2H2O4
Mol.Wt.	: 378.3 : 90.0
Inv. Status	: In Stock
Rel. CAS No	: 64169-39-7 (free base) ; 479065-02-6 (HBr salt)

SZ CAT No:	: SZ-C039009
CAS No	: 1329745-98-3
Mol.F.	: C25H33FN2O2
Mol.Wt.	: 412.5
Inv. Status	: In Stock

SZ CAT No:	: SZ-C039016
CAS No	: 59729-32-7
Mol.F.	: C20H21FN2O : HBr
Mol.Wt.	: 324.4 : 80.9
Inv. Status	: In Stock
Rel. CAS No	: 59729-33-8 (free base) ; 85118-27-0 (HCl salt)

SZ CAT No:	: SZ-C039034
CAS No	: 1217846-84-8
Mol.F.	: C26H25F2NO2
Mol.Wt.	: 421.5
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-C039035
CAS No	: NA
Mol.F.	: C26H25FN2O
Mol.Wt.	: 400.5
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-C039038
CAS No	: 1370643-23-4
Mol.F.	: C20H21FN2O
Mol.Wt.	: 324.4
Inv. Status	: Limited Stock

SZ CAT No:	: SZ-C039041
CAS No	: 1329612-81-8
Mol.F.	: C19H21ClFNO : C2H2O4
Mol.Wt.	: 333.8 : 90.0
Inv. Status	: In Stock
Rel. CAS No	: 64169-45-5 (free base) ; 1332724-08-9 (HBr salt)

SZ CAT No:	: SZ-C039042
CAS No	: NA
Mol.F.	: C21H23ClFN2O : Cl
Mol.Wt.	: 373.9 : 35.5
Inv. Status	: In Stock
Rel. CAS No	: 2847776-07-0 (free base) ; 2847776-08-1 (bromide)