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Cefalexin EP Impurity E

SZ CAT No SZ-C018006
CAS No 146794-70-9
Mol.F. C13H18N2O4S 
Mol.Wt. 298.4
Inv. Status Custom Synthesis


Chemical Name: (6R,7R)-7-[(2,2-Dimethylpropanoyl)amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (as per EP)

Synonym: 7-ADCA Pivalamide

Multidimensional evaluation of impurity profiles for generic cephalexin and cefaclor antibiotics
B.A. Olsen*, S.W. Baertschi and R.M. Riggin
Journal of Chromatography, 648 (1993) 165-173
 
Chemistry of Cephalosporin Antibiotics. XIII. Ilesac-etoxycephalosporins. The Synthesis of Cephalexin' and Soine Analogs
Charles W. Ryan, R. L. Simon, and Earle M. Van Heyningen
J. Med. Chem. 1969, 12, 2, 310–313
 
Stress Studies and Identification of Degradation Products of Cephalexin Using LC–PDA and LC–MS/MS
V. T. Gawande, K. G. Bothara & A. M. Marathe
Chromatographia volume 80, pages1545–1552(2017)