Bosentan O-Desmethyl Impurity

SZ CAT No:	SZ-B017009
CAS No	253688-61-8
Mol.F.	C26H27N5O6S
Mol.Wt.	537.6
Inv. Status	Custom Synthesis

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Chemical Name: 4-(Tert-butyl)-N-(6-(2-hydroxyethoxy)-5-(2-hydroxyphenoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide

Synonym: O-Desmethyl Bosentan

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: O=[S](NC1=NC(C2=NC=CC=N2)=NC(OCCO)=C1OC(C=CC=C3)=C3O)(C4=CC=C(C(C)(C)C)C=C4)=O

Research and Development of a Second-Generation Process for Bosentan, an Endothelin Receptor Antagonist
Peter J. Harrington, Hiralal N. Khatri, Brad S. DeHoff, Martin R. Guinn, Mark A. Boehler, and Karl A. Glaser
Organic Process Research & Development 2002, 6, 120−124

Stability-Indicating Gradient RP-LC Method for the Determination of Process and Degradation Impurities in Bosentan Monohydrate: An Endothelin Receptor Antagonist
Sanjay A. Jadhav,1 Shashikant B. Landge,1 Sonali L. Jadhav,1 Navanath C. Niphade,1 Saroj R. Bembalkar,2 and Vijayavitthal T. Mathad1
E-Hindawi Access to Research Chromatography Research International Volume 2011, Article ID 929876, 9 pages

Development and validation of a stability indicating analytical method for the related substances of Bosentan drug substance by HPLC
Mubeen Ahmad Khan, Sukumar Sinha, Mangesh Todkar, Vikas Parashar, K. Swamy Reddy
Am. J. Sci. Ind. Res., 2012, 3(2): 69-80

Bosentan O-Desmethyl Impurity is chemically 4-(Tert-butyl)-N-(6-(2-hydroxyethoxy)-5-(2-hydroxyphenoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide. It is also known as O-Desmethyl Bosentan. Bosentan O-Desmethyl Impurity is supplied with detailed characterization data compliant with regulatory guideline. Bosentan O-Desmethyl Impurity can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Bosentan.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

Bosentan O-Desmethyl Impurity

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SZ CAT No:	: SZ-B017D01
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Mol.F.	: C27H25D4N5O6S
Mol.Wt.	: 555.6
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-B017002
CAS No	: 253688-60-7
Mol.F.	: C27H29N5O7S
Mol.Wt.	: 567.6
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-B017008
CAS No	: 253688-62-9
Mol.F.	: C26H27N5O7S
Mol.Wt.	: 553.6
Inv. Status	: Custom Synthesis

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CAS No	: 1257099-41-4
Mol.F.	: C22H27N5O6S
Mol.Wt.	: 489.6
Inv. Status	: Custom Synthesis

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Mol.F.	: C10H16N2
Mol.Wt.	: 164.3
Inv. Status	: Custom Synthesis

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CAS No	: NA
Mol.F.	: C10H17N3
Mol.Wt.	: 179.3
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-B017013
CAS No	: 1257099-42-5
Mol.F.	: C20H21N5O4S
Mol.Wt.	: 427.5
Inv. Status	: Custom Synthesis

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CAS No	: 1257099-43-6
Mol.F.	: C29H33N5O7S
Mol.Wt.	: 595.7
Inv. Status	: In Stock

SZ CAT No:	: SZ-B017015
CAS No	: 1257099-44-7
Mol.F.	: C27H27N5O5S
Mol.Wt.	: 533.6
Inv. Status	: Custom Synthesis

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CAS No	: 193013-72-8
Mol.F.	: C10H15NO2S
Mol.Wt.	: 213.3
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-B017017
CAS No	: NA
Mol.F.	: C15H13N5O3
Mol.Wt.	: 311.3
Inv. Status	: Custom Synthesis

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CAS No	: 174227-27-1
Mol.F.	: C17H17N5O4
Mol.Wt.	: 355.4
Inv. Status	: Custom Synthesis

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Mol.F.	: C26H27N5O5S
Mol.Wt.	: 521.6
Inv. Status	: Custom Synthesis

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Mol.F.	: C21H23ClN4O4
Mol.Wt.	: 430.9
Inv. Status	: Custom Synthesis

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CAS No	: 157212-55-0
Mol.F.	: C27H29N5O6S : H2O
Mol.Wt.	: 551.6 : 18.0
Inv. Status	: In Stock

SZ CAT No:	: SZ-B017009
CAS No	: 253688-61-8
Mol.F.	: C26H27N5O6S
Mol.Wt.	: 537.6
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-B017010
CAS No	: NA
Mol.F.	: C27H29N5O4S
Mol.Wt.	: 519.6
Inv. Status	: Custom Synthesis

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CAS No	: NA
Mol.F.	: C27H29N5O5S
Mol.Wt.	: 535.6
Inv. Status	: Custom Synthesis

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CAS No	: 150727-06-3
Mol.F.	: C25H24ClN5O4S
Mol.Wt.	: 526.0
Inv. Status	: Out of Stock, Custom Synthesis

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CAS No	: 174227-14-6
Mol.F.	: C25H25N5O5S
Mol.Wt.	: 507.6
Inv. Status	: In Stock

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CAS No	: 1097263-60-9
Mol.F.	: C52H52N10O10S2
Mol.Wt.	: 1041.2
Inv. Status	: In Stock

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CAS No	: 150728-13-5
Mol.F.	: C15H10Cl2N4O2
Mol.Wt.	: 349.2
Inv. Status	: In Stock

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CAS No	: 6292-59-7
Mol.F.	: C10H15NO2S
Mol.Wt.	: 213.3
Inv. Status	: In Stock

SZ CAT No:	: SZ-B017D04
CAS No	: NA
Mol.F.	: C2513C2H25D4N5O6S
Mol.Wt.	: 557.6
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-B017D02
CAS No	: 1065472-91-4
Mol.F.	: C27H25D4N5O7S
Mol.Wt.	: 571.6
Inv. Status	: Custom Synthesis

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Mol.F.	: C27H23D6N5O7S
Mol.Wt.	: 573.7
Inv. Status	: Custom Synthesis