Bortezomib Impurity 33

SZ CAT No:	SZ-B004038
CAS No	948294-96-0
Mol.F.	C14H23BN2O3
Mol.Wt.	278.2
Inv. Status	Custom Synthesis
Rel. CAS No	2413962-44-2 (HCl salt)

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SynZeal will update these details as per new development or finding in product specification without further noticed.

Chemical Name: ((R)-1-((S)-2-Amino-3-phenylpropanamido)-3-methylbutyl)boronic acid

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: O=C(N[C@H](B(O)O)CC(C)C)[C@@H](N)CC1=CC=CC=C1

Novel method development and validation of bortezomib in bulk and pharmaceutical dosage form by RP-HPLC
By Prasanna, Pasupuleti Laxmi; Sandhya, Pedapanga; Geetha, Pittala; Anuhya, Vallapatla M.
From Journal of Drug Delivery and Therapeutics (2019), 9(1), 17-22

Determination of bortezomib in API samples using HPLC: assessment of enantiomeric and diastereomeric impurities
By Kamalzadeh, Zahra; Babanezhad, Esmaeil; Ghaffari, Solmaz; Ezhiyeh, Alireza Mohseni; Mohammadnejad, Mahdieh; Naghibfar, Mehdi; Bararjanian, Morteza; Attar, Hossein
From Journal of Chromatographic Science (2017), 55(7), 697-705

Bortezomib Impurity 33 is chemically ((R)-1-((S)-2-Amino-3-phenylpropanamido)-3-methylbutyl)boronic acid. Bortezomib Impurity 33 is supplied with detailed characterization data compliant with regulatory guideline. Bortezomib Impurity 33 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Bortezomib.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

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(S,R)-Bortezomib Hydroxyisopentyl Amide Analog

SZ CAT No:	: SZ-B004005
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Mol.F.	: C19H24N4O3
Mol.Wt.	: 356.4
Inv. Status	: In Stock

Bortezomib

SZ CAT No:	: SZ-B004001
CAS No	: 179324-69-7
Mol.F.	: C19H25BN4O4
Mol.Wt.	: 384.2
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Bortezomib Amino R Isomer (TFA salt)

SZ CAT No:	: SZ-B004056
CAS No	: 179324-87-9
Mol.F.	: C15H28BNO2 : C2HF3O2
Mol.Wt.	: 265.2 : 114.0
Inv. Status	: In Stock
Rel. CAS No	: 179324-86-8 (Free base)

Bortezomib d5

SZ CAT No:	: SZ-B004D01
CAS No	: 1133706-15-6
Mol.F.	: C19H20D5BN4O4
Mol.Wt.	: 389.3
Inv. Status	: Custom Synthesis

Bortezomib Impurity (R,R-Isomer)

SZ CAT No:	: SZ-B004002
CAS No	: 1132709-15-9
Mol.F.	: C19H25BN4O4
Mol.Wt.	: 384.2
Inv. Status	: In Stock

Bortezomib Impurity (R,S-Isomer)

SZ CAT No:	: SZ-B004003
CAS No	: 1132709-16-0
Mol.F.	: C19H25BN4O4
Mol.Wt.	: 384.2
Inv. Status	: In Stock

Bortezomib Impurity (S,S-Isomer)

SZ CAT No:	: SZ-B004004
CAS No	: 1132709-14-8
Mol.F.	: C19H25BN4O4
Mol.Wt.	: 384.2
Inv. Status	: In Stock

Bortezomib Trimer

SZ CAT No:	: SZ-B004015
CAS No	: 390800-88-1
Mol.F.	: C57H69B3N12O9
Mol.Wt.	: 1098.7
Inv. Status	: In Stock

Bortezomib Impurity 11

SZ CAT No:	: SZ-B004016
CAS No	: 862895-00-9
Mol.F.	: C19H22N4O2
Mol.Wt.	: 338.4
Inv. Status	: Limited Stock

Bortezomib Impurity 14

SZ CAT No:	: SZ-B004019
CAS No	: 205393-22-2
Mol.F.	: C29H39BN4O4
Mol.Wt.	: 518.5
Inv. Status	: In Stock
Rel. CAS No	: 1187479-73-7 (HCl salt)

Bortezomib Impurity 15

SZ CAT No:	: SZ-B004096
CAS No	: 1259365-04-2
Mol.F.	: C11H24BNO2
Mol.Wt.	: 213.1
Inv. Status	: Custom Synthesis
Rel. CAS No	: 1259300-03-2 (HCl salt)

Bortezomib Impurity 16

SZ CAT No:	: SZ-B004021
CAS No	: NA
Mol.F.	: C19H24N4O3
Mol.Wt.	: 356.4
Inv. Status	: In Stock

Bortezomib Impurity 17

SZ CAT No:	: SZ-B004022
CAS No	: NA
Mol.F.	: C19H25BN4O5
Mol.Wt.	: 400.3
Inv. Status	: Custom Synthesis

Bortezomib Impurity 18

SZ CAT No:	: SZ-B004023
CAS No	: NA
Mol.F.	: C38H46N8O6
Mol.Wt.	: 710.8
Inv. Status	: Custom Synthesis

Bortezomib Impurity 2 (Mixture of (1S,2R)-Isomer and (1R,2R)-Isomer)

SZ CAT No:	: SZ-B004007
CAS No	: 2747958-64-9
Mol.F.	: C19H24N4O3
Mol.Wt.	: 356.4
Inv. Status	: In Stock

Bortezomib Impurity 2 (RR-Isomer)

SZ CAT No:	: SZ-B004006
CAS No	: NA
Mol.F.	: C19H24N4O3
Mol.Wt.	: 356.4
Inv. Status	: In Stock

Bortezomib Impurity 20

SZ CAT No:	: SZ-B004025
CAS No	: 89618-77-9
Mol.F.	: C14H24BClO2
Mol.Wt.	: 270.6
Inv. Status	: Custom Synthesis

Bortezomib Impurity 21

SZ CAT No:	: SZ-B004026
CAS No	: 94242-79-2
Mol.F.	: C20H42BNO2Si2
Mol.Wt.	: 395.6
Inv. Status	: Custom Synthesis

Bortezomib Impurity 23

SZ CAT No:	: SZ-B004028
CAS No	: NA
Mol.F.	: C14H24BClO2
Mol.Wt.	: 270.6
Inv. Status	: Custom Synthesis

Bortezomib Impurity 25

SZ CAT No:	: SZ-B004097
CAS No	: 94242-80-5
Mol.F.	: C14H26BNO2
Mol.Wt.	: 251.2
Inv. Status	: Custom Synthesis
Rel. CAS No	: 94242-81-6 (TFA salt)

Bortezomib Impurity 26

SZ CAT No:	: SZ-B004031
CAS No	: 78-77-3
Mol.F.	: C4H9Br
Mol.Wt.	: 137.0
Inv. Status	: In Stock, 3-4 days for Dispatch

Bortezomib Impurity 27

SZ CAT No:	: SZ-B004032
CAS No	: 63-91-2
Mol.F.	: C9H11NO2
Mol.Wt.	: 165.2
Inv. Status	: In Stock

Bortezomib Impurity 28

SZ CAT No:	: SZ-B004033
CAS No	: 18942-49-9
Mol.F.	: C14H19NO4
Mol.Wt.	: 265.3
Inv. Status	: Custom Synthesis
Rel. CAS No	: 169131-65-1 (HCl salt) ; 1013327-78-0 (Na salt)

Bortezomib Impurity 29

SZ CAT No:	: SZ-B004034
CAS No	: 89-01-0
Mol.F.	: C6H4N2O4
Mol.Wt.	: 168.1
Inv. Status	: Custom Synthesis
Rel. CAS No	: 93778-20-2 (Na salt) ; 859063-48-2 (K salt)

Bortezomib Impurity 3

SZ CAT No:	: SZ-B004008
CAS No	: NA
Mol.F.	: C14H14N4O2 : HCl
Mol.Wt.	: 270.3 : 36.5
Inv. Status	: In Stock
Rel. CAS No	: 2748159-75-1 (free base)

Bortezomib Impurity 30

SZ CAT No:	: SZ-B004035
CAS No	: 513-36-0
Mol.F.	: C4H9Cl
Mol.Wt.	: 92.6
Inv. Status	: Custom Synthesis

Bortezomib Impurity 31

SZ CAT No:	: SZ-B004036
CAS No	: 84110-40-7
Mol.F.	: C4H11BO2
Mol.Wt.	: 101.9
Inv. Status	: Custom Synthesis

Bortezomib Impurity 32

SZ CAT No:	: SZ-B004037
CAS No	: 2363753-29-9
Mol.F.	: C15H28BNO2 : C2HF3O2
Mol.Wt.	: 265.2 : 114.0
Inv. Status	: In Stock
Rel. CAS No	: 1173239-14-9 (Free base)

Bortezomib Impurity 33

SZ CAT No:	: SZ-B004038
CAS No	: 948294-96-0
Mol.F.	: C14H23BN2O3
Mol.Wt.	: 278.2
Inv. Status	: Custom Synthesis
Rel. CAS No	: 2413962-44-2 (HCl salt)

Bortezomib Impurity 34

SZ CAT No:	: SZ-B004039
CAS No	: NA
Mol.F.	: C15H14N4O3
Mol.Wt.	: 298.3
Inv. Status	: Custom Synthesis

Bortezomib Impurity 35

SZ CAT No:	: SZ-B004040
CAS No	: NA
Mol.F.	: C28H34BN5O5
Mol.Wt.	: 531.4
Inv. Status	: Custom Synthesis

Bortezomib Impurity 36

SZ CAT No:	: SZ-B004041
CAS No	: 114457-94-2
Mol.F.	: C14H13N3O3
Mol.Wt.	: 271.3
Inv. Status	: In Stock
Rel. CAS No	: 1093959-75-1 (Na salt) ; 1093959-76-2 (K salt)

Bortezomib Impurity 37

SZ CAT No:	: SZ-B004058
CAS No	: 1798895-16-5
Mol.F.	: C15H15N3O3
Mol.Wt.	: 285.3
Inv. Status	: In Stock

Bortezomib Impurity 38

SZ CAT No:	: SZ-B004059
CAS No	: 18680-27-8
Mol.F.	: C10H18O2
Mol.Wt.	: 170.3
Inv. Status	: In Stock, 3-4 days for Dispatch

Bortezomib Impurity 4

SZ CAT No:	: SZ-B004009
CAS No	: 862894-96-0
Mol.F.	: C19H22N4O3
Mol.Wt.	: 354.4
Inv. Status	: In Stock

Bortezomib Impurity 40

SZ CAT No:	: SZ-B004061
CAS No	: 85167-14-2
Mol.F.	: C15H26BClO2
Mol.Wt.	: 284.6
Inv. Status	: Custom Synthesis

Bortezomib Impurity 41

SZ CAT No:	: SZ-B004064
CAS No	: 514820-48-5
Mol.F.	: C21H44BNO2Si2
Mol.Wt.	: 409.6
Inv. Status	: Custom Synthesis

Bortezomib Impurity 42

SZ CAT No:	: SZ-B004070
CAS No	: 477254-69-6
Mol.F.	: C15H28BNO2 : C2HF3O2
Mol.Wt.	: 265.2 : 114.0
Inv. Status	: In Stock
Rel. CAS No	: 477254-68-5 (Free base)

Bortezomib Impurity 43

SZ CAT No:	: SZ-B004078
CAS No	: NA
Mol.F.	: C28H37BN4O4
Mol.Wt.	: 504.4
Inv. Status	: Custom Synthesis

Bortezomib Impurity 44

SZ CAT No:	: SZ-B004080
CAS No	: 2308-61-4
Mol.F.	: C18H18N2O2
Mol.Wt.	: 294.4
Inv. Status	: Custom Synthesis

Bortezomib Impurity 45

SZ CAT No:	: SZ-B004082
CAS No	: 1255646-95-7
Mol.F.	: C17H18N2O3
Mol.Wt.	: 298.3
Inv. Status	: Custom Synthesis

Bortezomib Impurity 46

SZ CAT No:	: SZ-B004083
CAS No	: 2577-40-4
Mol.F.	: C18H20N2O3
Mol.Wt.	: 312.4
Inv. Status	: Custom Synthesis
Rel. CAS No	: 68800-30-6 (HCl salt) ; 1087344-12-4 (HBr salt) ; 1841445-65-5 (Na salt) ; 1307315-69-0 (TFA salt)

Bortezomib Impurity 47

SZ CAT No:	: SZ-B004084
CAS No	: 1194235-14-7
Mol.F.	: C23H22N4O4
Mol.Wt.	: 418.5
Inv. Status	: Custom Synthesis

Bortezomib Impurity 48

SZ CAT No:	: SZ-B004085
CAS No	: NA
Mol.F.	: C57H69B3N12O9
Mol.Wt.	: 1098.7
Inv. Status	: In Stock

Bortezomib Impurity 49

SZ CAT No:	: SZ-B004086
CAS No	: NA
Mol.F.	: C57H69B3N12O9
Mol.Wt.	: 1098.7
Inv. Status	: In Stock

Bortezomib Hydroxy Ketone Analog

SZ CAT No:	: SZ-B004010
CAS No	: 2379402-85-2
Mol.F.	: C19H22N4O4
Mol.Wt.	: 370.4
Inv. Status	: Limited Stock

Bortezomib Impurity 50

SZ CAT No:	: SZ-B004087
CAS No	: NA
Mol.F.	: C57H69B3N12O9
Mol.Wt.	: 1098.7
Inv. Status	: In Stock

Bortezomib Impurity 51

SZ CAT No:	: SZ-B004088
CAS No	: NA
Mol.F.	: C27H35BN4O4
Mol.Wt.	: 490.4
Inv. Status	: Custom Synthesis

Bortezomib Impurity 53

SZ CAT No:	: SZ-B004090
CAS No	: 2364553-64-8
Mol.F.	: C14H13N3O3
Mol.Wt.	: 271.3
Inv. Status	: In Stock

Bortezomib Impurity 54

SZ CAT No:	: SZ-B004091
CAS No	: 110755-29-8
Mol.F.	: C14H22N2O
Mol.Wt.	: 234.3
Inv. Status	: In Stock
Rel. CAS No	: 292061-26-8 (HCl salt)

Bortezomib Impurity 56

SZ CAT No:	: SZ-B004093
CAS No	: 4664-57-7
Mol.F.	: C11H16O3S
Mol.Wt.	: 228.3
Inv. Status	: Custom Synthesis

Bortezomib Impurity 6

SZ CAT No:	: SZ-B004011
CAS No	: NA
Mol.F.	: C19H25BN4O5
Mol.Wt.	: 400.3
Inv. Status	: Custom Synthesis

Bortezomib Ester Impurity

SZ CAT No:	: SZ-B004106
CAS No	: NA
Mol.F.	: C29H39BN4O4
Mol.Wt.	: 518.5
Inv. Status	: Custom Synthesis

Bortezomib Impurity 7

SZ CAT No:	: SZ-B004012
CAS No	: NA
Mol.F.	: C10H16BN3O3
Mol.Wt.	: 237.1
Inv. Status	: In Stock

Bortezomib Impurity 70

SZ CAT No:	: SZ-B004107
CAS No	: NA
Mol.F.	: C19H25BN4O4
Mol.Wt.	: 384.2
Inv. Status	: In Stock

Bortezomib Impurity 71

SZ CAT No:	: SZ-B004108
CAS No	: 1579304-37-2
Mol.F.	: C29H39BN4O4
Mol.Wt.	: 518.5
Inv. Status	: Custom Synthesis

Bortezomib Impurity 72

SZ CAT No:	: SZ-B004109
CAS No	: NA
Mol.F.	: C22H30N4O4
Mol.Wt.	: 414.5
Inv. Status	: Custom Synthesis

Bortezomib Impurity 73

SZ CAT No:	: SZ-B004110
CAS No	: NA
Mol.F.	: C22H30N4O4
Mol.Wt.	: 414.5
Inv. Status	: Custom Synthesis

Bortezomib Impurity 74

SZ CAT No:	: SZ-B004111
CAS No	: NA
Mol.F.	: C22H30N4O4
Mol.Wt.	: 414.5
Inv. Status	: Custom Synthesis

Bortezomib Impurity 76

SZ CAT No:	: SZ-B004123
CAS No	: NA
Mol.F.	: C19H24N4O2
Mol.Wt.	: 340.4
Inv. Status	: In Stock

Bortezomib Impurity 77

SZ CAT No:	: SZ-B004124
CAS No	: NA
Mol.F.	: C19H24N4O3
Mol.Wt.	: 356.4
Inv. Status	: Custom Synthesis

Bortezomib Impurity 78

SZ CAT No:	: SZ-B004125
CAS No	: 1135491-84-7
Mol.F.	: C21H44BNO2Si2
Mol.Wt.	: 409.6
Inv. Status	: Custom Synthesis

Bortezomib Impurity 8

SZ CAT No:	: SZ-B004013
CAS No	: NA
Mol.F.	: C24H27BN6O5
Mol.Wt.	: 490.3
Inv. Status	: Custom Synthesis

Bortezomib Impurity 9

SZ CAT No:	: SZ-B004014
CAS No	: 1194235-41-0
Mol.F.	: C28H34BN5O5
Mol.Wt.	: 531.4
Inv. Status	: In Stock

Bortezomib Impurity A

SZ CAT No:	: SZ-B004044
CAS No	: 289472-80-6
Mol.F.	: C14H14N4O2
Mol.Wt.	: 270.3
Inv. Status	: In Stock

Bortezomib Impurity B

SZ CAT No:	: SZ-B004018
CAS No	: NA
Mol.F.	: C28H37BN4O5
Mol.Wt.	: 520.4
Inv. Status	: Custom Synthesis

Bortezomib Impurity C (Mixture of Isomers)

SZ CAT No:	: SZ-B004045
CAS No	: NA
Mol.F.	: C19H25BN4O4
Mol.Wt.	: 384.3
Inv. Status	: Out of Stock

Bortezomib Impurity F

SZ CAT No:	: SZ-B004046
CAS No	: 73058-37-4
Mol.F.	: C15H15N3O3
Mol.Wt.	: 285.3
Inv. Status	: In Stock

Bortezomib Impurity G

SZ CAT No:	: SZ-B004047
CAS No	: 289472-81-7
Mol.F.	: C19H24N4O3
Mol.Wt.	: 356.4
Inv. Status	: In Stock

Bortezomib Impurity H

SZ CAT No:	: SZ-B004048
CAS No	: 1446194-56-4
Mol.F.	: C19H24N4O2
Mol.Wt.	: 340.4
Inv. Status	: Limited Stock

Bortezomib Impurity M

SZ CAT No:	: SZ-B004049
CAS No	: NA
Mol.F.	: C19H24N4O4
Mol.Wt.	: 372.4
Inv. Status	: Custom Synthesis

Bortezomib Impurity N

SZ CAT No:	: SZ-B004050
CAS No	: NA
Mol.F.	: C19H24N4O4
Mol.Wt.	: 372.4
Inv. Status	: Custom Synthesis

Bortezomib Intermediate(R,S)

SZ CAT No:	: SZ-B004051
CAS No	: 2363753-37-9
Mol.F.	: C14H25BO2
Mol.Wt.	: 236.2
Inv. Status	: Custom Synthesis

Bortezomib Intermediate(S,R)

SZ CAT No:	: SZ-B004052
CAS No	: 84110-34-9
Mol.F.	: C14H25BO2
Mol.Wt.	: 236.2
Inv. Status	: Custom Synthesis

Bortezomib Isoamyl Impurity

SZ CAT No:	: SZ-B004057
CAS No	: 1375004-39-9
Mol.F.	: C29H39BN4O4
Mol.Wt.	: 518.5
Inv. Status	: Limited Stock

Bortezomib R and S Hydroperoxide

SZ CAT No:	: SZ-B004079
CAS No	: NA
Mol.F.	: 2(C19H24N4O4)
Mol.Wt.	: 2(372.4)
Inv. Status	: In Stock

Bortezomib Related Compaund K

SZ CAT No:	: SZ-B004069
CAS No	: NA
Mol.F.	: C38H47N8O6
Mol.Wt.	: 711.8
Inv. Status	: Out of Stock

Bortezomib Related Compound E

SZ CAT No:	: SZ-B004063
CAS No	: NA
Mol.F.	: C15H14N4O3
Mol.Wt.	: 298.3
Inv. Status	: In Stock

Bortezomib Related Compound P

SZ CAT No:	: SZ-B004074
CAS No	: NA
Mol.F.	: C28H34BN5O5
Mol.Wt.	: 531.4
Inv. Status	: In Stock

Bortezomib Related Impurity E

SZ CAT No:	: SZ-B004042
CAS No	: NA
Mol.F.	: C20H26N4O3
Mol.Wt.	: 370.5
Inv. Status	: In Stock

Bortezomib Related Impurity F

SZ CAT No:	: SZ-B004043
CAS No	: NA
Mol.F.	: C20H26N4O3
Mol.Wt.	: 370.5
Inv. Status	: In Stock

Bortezomib R-Hydroperoxide

SZ CAT No:	: SZ-B004054
CAS No	: 886979-78-8
Mol.F.	: C19H24N4O4
Mol.Wt.	: 372.4
Inv. Status	: In Stock

Bortezomib S-Hydroperoxide

SZ CAT No:	: SZ-B004055
CAS No	: 886979-81-3
Mol.F.	: C19H24N4O4
Mol.Wt.	: 372.4
Inv. Status	: In Stock

Bortezomib Stereo Isomers Mixture

SZ CAT No:	: SZ-B004094
CAS No	: NA
Mol.F.	: C19H25BN4O4
Mol.Wt.	: 384.2
Inv. Status	: Custom Synthesis

Desisobutyl-n-butyl Bortezomib

SZ CAT No:	: SZ-B004122
CAS No	: 1104011-35-9
Mol.F.	: C19H25BN4O4
Mol.Wt.	: 384.2
Inv. Status	: Custom Synthesis

N-(2-pyraziny| carbony|)-D-Phenylalanine

SZ CAT No:	: SZ-B004053
CAS No	: 1608986-16-8
Mol.F.	: C14H13N3O3
Mol.Wt.	: 271.3
Inv. Status	: In Stock

Phenylalanine Dimer Impurity

SZ CAT No:	: SZ-B004081
CAS No	: NA
Mol.F.	: C22H20N4O4
Mol.Wt.	: 404.4
Inv. Status	: Custom Synthesis

Bortezomib Impurity 33

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