Amlodipine

SZ CAT No:	SZ-A005066
CAS No	88150-42-9
Mol.F.	C20H25ClN2O5
Mol.Wt.	408.9
Inv. Status	In Stock
Rel. CAS No	111470-99-6 (Besylate salt) ; 88150-47-4 (Maleate salt) ; 246852-07-3 (HCl salt) ; 246852-09-5 (HBr salt)
Shipping Condition	Ambient Temperature

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SynZeal will update these details as per new development or finding in product specification without further noticed.

Chemical Name: 3-Ethyl 5-methyl (4RS)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate (as per EP)

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: O=C(C1=C(COCCN)NC(C)=C(C(OC)=O)C1C2=CC=CC=C2Cl)OCC

Identification and characterization of potential impurities of amlodipine maleate
P. Sudhakar a, M. Nirmala a, J. Moses Babu a,∗, K. Vyas a, Ganta Madhusudan Reddy b, B. Vijaya Bhaskar b, P. Pratap Reddy b, K. Mukkanti c
J. Braz. Chem. Soc., Vol. 19, No. 1, 35-41, 2008.

Determination of the Absolute Configuration of the Active Amlodipine Enantiomer as (-)-S: A Correction
Siegfried Goldmann,* Jiirgen Stoltefuss, and Liborius Born
J. Med. Chem. 1992,35,3341-3344

Development of a Stability-Indicating HPLC Method for Simultaneous Determination of Amlodipine Besylate and Atorvastatin Calcium in Bulk and Pharmaceutical Dosage Form
Hafez HM*, Elshanawany AA, Abdelaziz LM and Mohram MS
Hafez et al., Pharm Anal Acta 2014, 5:9

Amlodipine is chemically 3-Ethyl 5-methyl (4RS)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate (as per EP). Amlodipine is supplied with detailed characterization data compliant with regulatory guideline. Amlodipine can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Amlodipine.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

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3-O-Desethyl-5-O-desmethyl Amlodipine

SZ CAT No:	: SZ-A005040
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Mol.F.	: C17H19ClN2O5
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3-O-Desmethyl Amlodipine

SZ CAT No:	: SZ-A005036
CAS No	: 113994-37-9
Mol.F.	: C19H23ClN2O5
Mol.Wt.	: 394.9
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4-Chloro-3-oxobutanoyl Chloride

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Mol.F.	: C4H4Cl2O2
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5-O-Desethyl Amlodipine

SZ CAT No:	: SZ-A005037
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Mol.F.	: C18H21ClN2O5
Mol.Wt.	: 380.8
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Amlodipine

SZ CAT No:	: SZ-A005066
CAS No	: 88150-42-9
Mol.F.	: C20H25ClN2O5
Mol.Wt.	: 408.9
Inv. Status	: In Stock
Rel. CAS No	: 111470-99-6 (Besylate salt) ; 88150-47-4 (Maleate salt) ; 246852-07-3 (HCl salt) ; 246852-09-5 (HBr salt)

Amlodipine 4-Chloro Analogue

SZ CAT No:	: SZ-A005011
CAS No	: 90445-02-6
Mol.F.	: C20H25ClN2O5
Mol.Wt.	: 408.9
Inv. Status	: In Stock

Amlodipine Acetyl Impurity

SZ CAT No:	: SZ-A005047
CAS No	: 93848-82-9
Mol.F.	: C22H27ClN2O6
Mol.Wt.	: 450.9
Inv. Status	: In Stock

Amlodipine Aspartic Acid Impurity

SZ CAT No:	: SZ-A005023
CAS No	: 400602-35-9
Mol.F.	: C24H29ClN2O9
Mol.Wt.	: 525.0
Inv. Status	: In Stock

Amlodipine Azido Impurity

SZ CAT No:	: SZ-A005010
CAS No	: 88150-46-3
Mol.F.	: C20H23ClN4O5
Mol.Wt.	: 434.8
Inv. Status	: In Stock

Amlodipine Besylate

SZ CAT No:	: SZ-A005043
CAS No	: 111470-99-6
Mol.F.	: C20H25ClN2O5 : C6H6O3S
Mol.Wt.	: 408.9 : 158.2
Inv. Status	: In Stock
Rel. CAS No	: 88150-42-9 (free base) ; 88150-47-4 (Maleate salt) ; 246852-07-3 (HCl salt) ; 246852-09-5 (HBr salt)

Amlodipine Di-Phthalimide Impurity

SZ CAT No:	: SZ-A005022
CAS No	: 223734-98-3
Mol.F.	: C37H32ClN3O8
Mol.Wt.	: 682.1
Inv. Status	: Custom Synthesis

Amlodipine EP Impurity A

SZ CAT No:	: SZ-A005002
CAS No	: 88150-62-3
Mol.F.	: C28H27ClN2O7
Mol.Wt.	: 539.0
Inv. Status	: In Stock

Amlodipine EP Impurity B

SZ CAT No:	: SZ-A005003
CAS No	: 721958-72-1
Mol.F.	: C29H32ClN3O7
Mol.Wt.	: 570.1
Inv. Status	: In Stock

Amlodipine EP Impurity C

SZ CAT No:	: SZ-A005004
CAS No	: 721958-74-3
Mol.F.	: C22H30ClN3O6
Mol.Wt.	: 468.0
Inv. Status	: In Stock

Amlodipine EP Impurity D (Besylate salt)

SZ CAT No:	: SZ-A005005
CAS No	: 2733700-89-3
Mol.F.	: C20H23ClN2O5 : C6H6O3S
Mol.Wt.	: 406.9 : 158.2
Inv. Status	: In Stock
Rel. CAS No	: 113994-41-5 (free base) ; 2414962-06-2 (HCl salt)

Amlodipine EP Impurity D (Fumarate salt)

SZ CAT No:	: SZ-A005053
CAS No	: 2138811-33-1
Mol.F.	: C20H23ClN2O5 : C4H4O4
Mol.Wt.	: 406.9 : 116.1
Inv. Status	: In Stock

Amlodipine EP Impurity E

SZ CAT No:	: SZ-A005006
CAS No	: 140171-65-9
Mol.F.	: C21H27ClN2O5
Mol.Wt.	: 422.9
Inv. Status	: In Stock
Rel. CAS No	: 400024-12-6 (maleate Salt)

Amlodipine EP Impurity F

SZ CAT No:	: SZ-A005007
CAS No	: 140171-66-0
Mol.F.	: C19H23ClN2O5
Mol.Wt.	: 394.9
Inv. Status	: Limited Stock
Rel. CAS No	: 400024-11-5 (maleate salt)

Amlodipine EP Impurity G

SZ CAT No:	: SZ-A005008
CAS No	: 43067-01-2
Mol.F.	: C17H18ClNO4
Mol.Wt.	: 335.8
Inv. Status	: In Stock

Amlodipine EP Impurity H

SZ CAT No:	: SZ-A005009
CAS No	: 318465-73-5
Mol.F.	: C28H29ClN2O8
Mol.Wt.	: 557.0
Inv. Status	: In Stock

Ethyl benzenesulfonate

SZ CAT No:	: SZ-A005044
CAS No	: 515-46-8
Mol.F.	: C8H10O3S
Mol.Wt.	: 186.2
Inv. Status	: In Stock

Amlodipine Glucose + Galactose adduct

SZ CAT No:	: SZ-A005056
CAS No	: NA
Mol.F.	: C26H35ClN2O10
Mol.Wt.	: 571.0
Inv. Status	: In Stock

Amlodipine Impurity 1

SZ CAT No:	: SZ-A005020
CAS No	: 58509-24-3
Mol.F.	: C10H11NO4
Mol.Wt.	: 209.2
Inv. Status	: Custom Synthesis
Rel. CAS No	: 84308-80-5 (Na salt)

Amlodipine Impurity 10

SZ CAT No:	: SZ-A005029
CAS No	: 2170104-51-3
Mol.F.	: C19H22ClNO5
Mol.Wt.	: 379.8
Inv. Status	: Custom Synthesis

Amlodipine Impurity 11

SZ CAT No:	: SZ-A005030
CAS No	: NA
Mol.F.	: C12H20N2O3
Mol.Wt.	: 240.3
Inv. Status	: Custom Synthesis

Amlodipine Impurity 12

SZ CAT No:	: SZ-A005034
CAS No	: NA
Mol.F.	: C23H22ClNO7
Mol.Wt.	: 459.9
Inv. Status	: Custom Synthesis

Amlodipine Impurity 13

SZ CAT No:	: SZ-A005035
CAS No	: NA
Mol.F.	: C29H32ClN3O7
Mol.Wt.	: 570.0
Inv. Status	: Custom Synthesis

Amlodipine Impurity 16

SZ CAT No:	: SZ-A005038
CAS No	: NA
Mol.F.	: C20H23ClN2O7
Mol.Wt.	: 438.9
Inv. Status	: Custom Synthesis

Amlodipine Impurity 17

SZ CAT No:	: SZ-A005039
CAS No	: NA
Mol.F.	: C20H24ClNO6
Mol.Wt.	: 409.9
Inv. Status	: Custom Synthesis

Amlodipine Impurity 19

SZ CAT No:	: SZ-A005041
CAS No	: NA
Mol.F.	: C26H29ClN2O7S
Mol.Wt.	: 549.1
Inv. Status	: Custom Synthesis

Amlodipine Impurity 2

SZ CAT No:	: SZ-A005021
CAS No	: 400024-08-0
Mol.F.	: C23H20ClNO6
Mol.Wt.	: 441.9
Inv. Status	: Custom Synthesis

Amlodipine Impurity 20

SZ CAT No:	: SZ-A005042
CAS No	: 70677-78-0
Mol.F.	: C17H19NO4
Mol.Wt.	: 301.3
Inv. Status	: In Stock

Amlodipine Impurity 21

SZ CAT No:	: SZ-A005046
CAS No	: 79781-21-8
Mol.F.	: C18H20ClNO5
Mol.Wt.	: 365.8
Inv. Status	: In Stock

Amlodipine Impurity 23

SZ CAT No:	: SZ-A005049
CAS No	: 88150-75-8
Mol.F.	: C16H17NO6
Mol.Wt.	: 319.3
Inv. Status	: Custom Synthesis

Amlodipine Impurity 24

SZ CAT No:	: SZ-A005051
CAS No	: 34148-67-9
Mol.F.	: C19H22ClNO4
Mol.Wt.	: 363.9
Inv. Status	: In Stock

Amlodipine Impurity 26

SZ CAT No:	: SZ-A005063
CAS No	: 130161-00-1
Mol.F.	: C18H18ClNO4
Mol.Wt.	: 347.8
Inv. Status	: Custom Synthesis

Amlodipine Impurity 27

SZ CAT No:	: SZ-A005064
CAS No	: 2170104-02-4
Mol.F.	: C20H24ClNO5
Mol.Wt.	: 393.9
Inv. Status	: Custom Synthesis

Amlodipine Impurity 28

SZ CAT No:	: SZ-A005067
CAS No	: 111429-90-4
Mol.F.	: C15H15NO6
Mol.Wt.	: 305.3
Inv. Status	: Custom Synthesis

Amlodipine Impurity 3

SZ CAT No:	: SZ-A005028
CAS No	: 90445-05-9
Mol.F.	: C14H22N2O5
Mol.Wt.	: 298.3
Inv. Status	: Custom Synthesis

Amlodipine Impurity 30

SZ CAT No:	: SZ-A005070
CAS No	: 721958-75-4
Mol.F.	: C48H52Cl2N4O12
Mol.Wt.	: 947.9
Inv. Status	: Custom Synthesis

Amlodipine Impurity 31

SZ CAT No:	: SZ-A005071
CAS No	: 721958-75-4
Mol.F.	: C20H20ClNO5
Mol.Wt.	: 389.8
Inv. Status	: Custom Synthesis

Hydroxyethyl Phthalyl Amlodipine

SZ CAT No:	: SZ-A005072
CAS No	: NA
Mol.F.	: C30H34ClN3O8
Mol.Wt.	: 600.1
Inv. Status	: In Stock

Amlodipine Impurity 33

SZ CAT No:	: SZ-A005074
CAS No	: 140171-50-2
Mol.F.	: C27H25ClN2O7
Mol.Wt.	: 525.0
Inv. Status	: Custom Synthesis

Amlodipine Impurity 34

SZ CAT No:	: SZ-A005078
CAS No	: NA
Mol.F.	: C28H28ClN3O7
Mol.Wt.	: 554.0
Inv. Status	: Custom Synthesis

Amlodipine Impurity 35

SZ CAT No:	: SZ-A005079
CAS No	: NA
Mol.F.	: C28H28ClN3O7
Mol.Wt.	: 554.0
Inv. Status	: Custom Synthesis

Amlodipine Impurity 36

SZ CAT No:	: SZ-A005080
CAS No	: 2923811-73-6
Mol.F.	: C20H26ClN3O5
Mol.Wt.	: 423.9
Inv. Status	: Custom Synthesis

Amlodipine Impurity 37

SZ CAT No:	: SZ-A005081
CAS No	: NA
Mol.F.	: C36H30ClN3O9
Mol.Wt.	: 684.1
Inv. Status	: Custom Synthesis

Amlodipine Impurity 4

SZ CAT No:	: SZ-A005016
CAS No	: 103094-30-0
Mol.F.	: C25H34ClNO6
Mol.Wt.	: 480.0
Inv. Status	: Custom Synthesis

Amlodipine Impurity 6

SZ CAT No:	: SZ-A005024
CAS No	: 3891-07-4
Mol.F.	: C10H9NO3
Mol.Wt.	: 191.2
Inv. Status	: Custom Synthesis

Amlodipine Impurity 7

SZ CAT No:	: SZ-A005025
CAS No	: NA
Mol.F.	: C19H23ClN2O5
Mol.Wt.	: 394.9
Inv. Status	: Custom Synthesis

Amlodipine Impurity 8

SZ CAT No:	: SZ-A005026
CAS No	: 110962-94-2
Mol.F.	: C19H18Cl2N2O4
Mol.Wt.	: 409.3
Inv. Status	: Custom Synthesis

Amlodipine Impurity 9

SZ CAT No:	: SZ-A005027
CAS No	: 496024-43-2
Mol.F.	: C20H22ClNO5
Mol.Wt.	: 391.8
Inv. Status	: In Stock

Amlodipine Lactone Impurity

SZ CAT No:	: SZ-A005062
CAS No	: 100276-22-0
Mol.F.	: C16H14ClNO4
Mol.Wt.	: 319.7
Inv. Status	: Custom Synthesis

Amlodipine Mannitol Adduct

SZ CAT No:	: SZ-A005045
CAS No	: NA
Mol.F.	: C26H37ClN2O10
Mol.Wt.	: 573.0
Inv. Status	: In Stock

Amlodipine Metabolite

SZ CAT No:	: SZ-A005019
CAS No	: 113994-45-9
Mol.F.	: C20H20ClNO7
Mol.Wt.	: 421.9
Inv. Status	: Custom Synthesis

Amlodipine Metabolite 5

SZ CAT No:	: SZ-A005017
CAS No	: 114018-75-6
Mol.F.	: C19H18ClNO7
Mol.Wt.	: 407.8
Inv. Status	: Custom Synthesis

Amlodipine Methyl Ester

SZ CAT No:	: SZ-A005048
CAS No	: NA
Mol.F.	: C25H31ClN2O9
Mol.Wt.	: 539.0
Inv. Status	: In Stock

Amlodipine N-Glucose

SZ CAT No:	: SZ-A005031
CAS No	: NA
Mol.F.	: C26H35ClN2O10
Mol.Wt.	: 571.0
Inv. Status	: In Stock

N-Nitroso Amlodipine

SZ CAT No:	: SZ-A005057
CAS No	: NA
Mol.F.	: C20H24ClN3O6
Mol.Wt.	: 437.9
Inv. Status	: Inquire

Amlodipine Nitroso Impurity 1

SZ CAT No:	: SZ-A005076
CAS No	: NA
Mol.F.	: C20H26ClN3O6
Mol.Wt.	: 439.9
Inv. Status	: Inquire

Amlodipine Nitroso N-Lactoside

SZ CAT No:	: SZ-A005082
CAS No	: NA
Mol.F.	: C32H42ClN3O16
Mol.Wt.	: 760.1
Inv. Status	: In Stock

Amlodipine N-Lactoside

SZ CAT No:	: SZ-A005018
CAS No	: 2173291-00-2
Mol.F.	: C32H45ClN2O15
Mol.Wt.	: 733.2
Inv. Status	: In Stock

Amlodipine Related Compound K

SZ CAT No:	: SZ-A005012
CAS No	: 1621516-91-3
Mol.F.	: C18H20ClNO3
Mol.Wt.	: 333.8
Inv. Status	: Under Synthesis

Amlodipine-d4

SZ CAT No:	: SZ-A005D04
CAS No	: 1185246-14-3
Mol.F.	: C20H21D4ClN2O5
Mol.Wt.	: 412.9
Inv. Status	: Custom Synthesis

Atorvastatin Amlodipine Dimer

SZ CAT No:	: SZ-A005033
CAS No	: 425408-16-8
Mol.F.	: C53H58ClFN4O9
Mol.Wt.	: 949.5
Inv. Status	: In Stock

Dehydro Amlodipine N-oxide

SZ CAT No:	: SZ-A005069
CAS No	: 2418591-36-1
Mol.F.	: C20H23ClN2O6
Mol.Wt.	: 422.9
Inv. Status	: Custom Synthesis

Deschloro Amlodipine

SZ CAT No:	: SZ-A005050
CAS No	: 88150-52-1
Mol.F.	: C20H26N2O5
Mol.Wt.	: 374.4
Inv. Status	: In Stock

Deschloro Phthalimido Amlodipine

SZ CAT No:	: SZ-A005052
CAS No	: NA
Mol.F.	: C28H28N2O7
Mol.Wt.	: 504.5
Inv. Status	: In Stock

Levamlodipine Besylate Hemipentahydrate

SZ CAT No:	: SZ-A005075
CAS No	: 884648-62-8
Mol.F.	: C20H25ClN2O5 : C6H6O3S : 5/2(H2O)
Mol.Wt.	: 408.9 : 158.2 : 5/2(18.0)
Inv. Status	: In Stock
Rel. CAS No	: 103129-82-4 (free base) ; 135969-53-8 (Maleate salt)

N-Fomyl Amlodipine

SZ CAT No:	: SZ-A005015
CAS No	: 93848-81-8
Mol.F.	: C21H25ClN2O6
Mol.Wt.	: 436.9
Inv. Status	: In Stock

Nitroso Amlodipine EP Impurity B

SZ CAT No:	: SZ-A005059
CAS No	: NA
Mol.F.	: C29H31ClN4O8
Mol.Wt.	: 599.0
Inv. Status	: Inquire

N-Nitroso Amlodipine EP Impurity A

SZ CAT No:	: SZ-A005058
CAS No	: NA
Mol.F.	: C28H26ClN3O8
Mol.Wt.	: 568.0
Inv. Status	: Inquire

N-Nitroso Amlodipine Impurity-1

SZ CAT No:	: SZ-A005065
CAS No	: NA
Mol.F.	: C20H21ClN2O6
Mol.Wt.	: 420.8
Inv. Status	: Custom Synthesis

(R)-Amlodipine Besylate

SZ CAT No:	: SZ-A005013
CAS No	: 828247-64-9
Mol.F.	: C20H25ClN2O5 : C6H6O3S
Mol.Wt.	: 408.9 : 158.2
Inv. Status	: In Stock
Rel. CAS No	: 103129-81-3 (free base)

R-Amlodipine D4

SZ CAT No:	: SZ-A005D01
CAS No	: 1346616-97-4
Mol.F.	: C20H21D4ClN2O5
Mol.Wt.	: 412.9
Inv. Status	: Custom Synthesis

Levamlodipine Besylate

SZ CAT No:	: SZ-A005014
CAS No	: 150566-71-5
Mol.F.	: C20H25ClN2O5 : C6H6O3S
Mol.Wt.	: 408.9 : 158.1
Inv. Status	: In Stock
Rel. CAS No	: 103129-82-4 (free base)

S-Amlodipine D4

SZ CAT No:	: SZ-A005D03
CAS No	: 1346617-19-3
Mol.F.	: C20H21D4ClN2O5
Mol.Wt.	: 412.9
Inv. Status	: Custom Synthesis

Amlodipine

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