Acalabrutinib Dimer Impurity

SZ CAT No:	SZ-A078024
CAS No	NA
Mol.F.	C52H46N14O4
Mol.Wt.	931.0
Inv. Status	Custom Synthesis

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Chemical Name: 4-(8-(((E)-4-((S)-2-(8-amino-1-(4-(pyridin-2-ylcarbamoyl)phenyl)imidazo[1,5-a]pyrazin-3-yl)pyrrolidin-1-yl)-4-oxobut-2-en-2-yl)amino)-3-((S)-1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: O=C(NC1=CC=CC=N1)C(C=C2)=CC=C2C3=C4N(C([C@@H]5CCCN5C(/C=C(C)/NC6=NC=CN7C6=C(C8=CC=C(C(NC9=CC=CC=N9)=O)C=C8)N=C7[C@@H]%10CCCN%10C(C#CC)=O)=O)=N3)C=CN=C4N

Development and validation of novel HPLC bioanalytical analysis method for acalabrutinib: an anticancer drug in human plasma
By Krishna, G. Atchutarama; Srinivasarao, P.; Patrudu, T. Benarji; Chidanandaswamy, R.
From Asian Journal of Chemistry (2020), 32(10), 2606-2610

Development and validation of UV-spectrophotometric method for simultaneous determination of acamprosate calcium, disulfiram and ondansetron hydrochloride in bulk and tablet dosage forms
By Patil, Purushottam R.; Wagh, Milind P.; Chaudhari, Sanjay R.
From American Journal of PharmTech Research (2016), 6(2), 655-664

Acalabrutinib Dimer Impurity is chemically 4-(8-(((E)-4-((S)-2-(8-amino-1-(4-(pyridin-2-ylcarbamoyl)phenyl)imidazo[1,5-a]pyrazin-3-yl)pyrrolidin-1-yl)-4-oxobut-2-en-2-yl)amino)-3-((S)-1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide. Acalabrutinib Dimer Impurity is supplied with detailed characterization data compliant with regulatory guideline. Acalabrutinib Dimer Impurity can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Acalabrutinib.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

SZ CAT No:	: SZ-A078009
CAS No	: 1211531-66-6
Mol.F.	: C5H5Cl2N3
Mol.Wt.	: 178.0
Inv. Status	: Out of Stock
Rel. CAS No	: 2089319-25-3 (HCl salt)

SZ CAT No:	: SZ-A078021
CAS No	: 2089319-25-3
Mol.F.	: C5H5Cl2N3 : HCl
Mol.Wt.	: 178.0 : 36.5
Inv. Status	: Custom Synthesis
Rel. CAS No	: 1211531-66-6 (free base)

SZ CAT No:	: SZ-A078008
CAS No	: 1060814-53-0
Mol.F.	: C5H6ClN3
Mol.Wt.	: 143.6
Inv. Status	: Custom Synthesis
Rel. CAS No	: 1794737-26-0 (HCl salt)

SZ CAT No:	: SZ-A078020
CAS No	: 1794737-26-0
Mol.F.	: C5H6ClN3 : HCl
Mol.Wt.	: 143.6 : 36.5
Inv. Status	: Custom Synthesis
Rel. CAS No	: 1060814-53-0 (free base)

SZ CAT No:	: SZ-A078001
CAS No	: 1420477-60-6
Mol.F.	: C26H23N7O2
Mol.Wt.	: 465.5
Inv. Status	: Custom Synthesis
Rel. CAS No	: 2058092-05-8 (Sulfate salt)

Acalabrutinib Dimer Impurity

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SZ CAT No:	: SZ-A078D01
CAS No	: NA
Mol.F.	: C26H19D4N7O2
Mol.Wt.	: 469.5
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A078024
CAS No	: NA
Mol.F.	: C52H46N14O4
Mol.Wt.	: 931.0
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A078002
CAS No	: 2230757-47-6
Mol.F.	: C26H23N7O3
Mol.Wt.	: 481.5
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A078014
CAS No	: NA
Mol.F.	: C18H18BrN5O2
Mol.Wt.	: 416.3
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A078015
CAS No	: 2490433-97-9
Mol.F.	: C30H25N7O3
Mol.Wt.	: 531.6
Inv. Status	: In Stock

SZ CAT No:	: SZ-A078016
CAS No	: NA
Mol.F.	: C26H23N7O3
Mol.Wt.	: 481.5
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A078017
CAS No	: NA
Mol.F.	: C26H23N7O3
Mol.Wt.	: 481.5
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A078018
CAS No	: NA
Mol.F.	: C47H42N12O3
Mol.Wt.	: 822.9
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A078025
CAS No	: NA
Mol.F.	: C18H21BN2O3
Mol.Wt.	: 324.2
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A078026
CAS No	: 864759-38-6
Mol.F.	: C18H21BN2O3
Mol.Wt.	: 324.2
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A078027
CAS No	: 2412166-56-2
Mol.F.	: C30H25N7O3
Mol.Wt.	: 531.6
Inv. Status	: In Stock

SZ CAT No:	: SZ-A078028
CAS No	: 1148-11-4
Mol.F.	: C13H15NO4
Mol.Wt.	: 249.3
Inv. Status	: Custom Synthesis
Rel. CAS No	: 264197-10-6 (sodium salt)

SZ CAT No:	: SZ-A078029
CAS No	: 939412-86-9
Mol.F.	: C5H6ClN3 : HCl
Mol.Wt.	: 143.6 : 36.5
Inv. Status	: Custom Synthesis
Rel. CAS No	: 771581-15-8 (free base)

SZ CAT No:	: SZ-A078003
CAS No	: NA
Mol.F.	: C21H19N5O3
Mol.Wt.	: 389.4
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A078030
CAS No	: 1418307-17-1
Mol.F.	: C18H19ClN4O3
Mol.Wt.	: 374.8
Inv. Status	: In Stock

SZ CAT No:	: SZ-A078031
CAS No	: 1418307-18-2
Mol.F.	: C18H17ClN4O2
Mol.Wt.	: 356.8
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A078032
CAS No	: 1420478-87-0
Mol.F.	: C18H16BrClN4O2
Mol.Wt.	: 435.7
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A078033
CAS No	: NA
Mol.F.	: C18H17BrN4O3
Mol.Wt.	: 417.3
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A078034
CAS No	: 2198380-46-8
Mol.F.	: C18H18BrN5O2
Mol.Wt.	: 416.3
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A078004
CAS No	: NA
Mol.F.	: C36H40N10O8S
Mol.Wt.	: 772.8
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A078005
CAS No	: NA
Mol.F.	: C29H30N8O4S
Mol.Wt.	: 586.7
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A078006
CAS No	: NA
Mol.F.	: C26H25N7O3
Mol.Wt.	: 483.5
Inv. Status	: In Stock

SZ CAT No:	: SZ-A078007
CAS No	: NA
Mol.F.	: C31H33N9O5S
Mol.Wt.	: 643.7
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A078010
CAS No	: 2180911-32-2
Mol.F.	: C18H21BN2O3
Mol.Wt.	: 324.2
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A078011
CAS No	: 2180911-29-7
Mol.F.	: C18H21BN2O3
Mol.Wt.	: 324.2
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A078013
CAS No	: NA
Mol.F.	: C18H18BrN5O2
Mol.Wt.	: 416.3
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A078012
CAS No	: 471-25-0
Mol.F.	: C3H2O2
Mol.Wt.	: 70.0
Inv. Status	: Custom Synthesis
Rel. CAS No	: 920-38-7 (Na salt) ; 1968-46-3 (K salt)