Abemaciclib Impurity 11

SZ CAT No:	SZ-A077016
CAS No	1627082-92-1
Mol.F.	C21H18F2N6O
Mol.Wt.	408.4
Inv. Status	Custom Synthesis

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Chemical Name: 6-((5-Fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)nicotinaldehyde

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: FC1=C(C2=CC(F)=C3C(N(C(C)C)C(C)=N3)=C2)N=C(NC4=CC=C(C([H])=O)C=N4)N=C1

Development and validation of a bioanalytical method for the quantification of the CDK4/6 inhibitors abemaciclib, palbociclib, and ribociclib in human and mouse matrices using liquid chromatography-tandem mass spectrometry
By Martinez-Chavez, Alejandra; Rosing, Hilde; Hillebrand, Michel; Tibben, Matthijs; Schinkel, Alfred H.; Beijnen, Jos H.
From Analytical and Bioanalytical Chemistry (2019), 411(20), 5331-5345

Abemaciclib Impurity 11 is chemically 6-((5-Fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)nicotinaldehyde. Abemaciclib Impurity 11 is supplied with detailed characterization data compliant with regulatory guideline. Abemaciclib Impurity 11 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Abemaciclib.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

Abemaciclib Impurity 11

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